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DTL facilitates the Fanconi anemia pathway for ultraviolet-induced DNA repair in retinal pigment epithelial cells

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BIOCELL 2022年第2期46卷 505-510页

作者： JIUCHUN guo JIE PAN qianqian guo Binzhou Second People’s Hospital Binzhou256800China Department of Ophthalmology Zibo Central HospitalZibo255000China

The excessive energy of light,especially the invisible rays with lower wavelength,is basically absorbed by retinal pigment epithelium(RPE)and usually causes DNA damage.The molecular mechanism behind DNA damage repair response to this frequent stress in RPE is not clearly understood.In this study,we determined that the Fanconi anemia(FA)pathway was activated in human RPE ARPE-19 cells after ultraviolet(UV)B and C treatment.Moreover,immunoprecipitation(IP)of FANCD2 indicated that denticleless E3 ubiquitin protein ligase homolog(DTL)closely interacted with FANCD2.Knockdown of DTL weakened the activity of the FA pathway in ARPE-19 cells responding to UV treatment.Finally,the DTL promoter was incubated with a biotin-labeled probe and pulled down by streptavidin beads followed by the genomic DNA sonication.p53 was indicated by mass spectrum and further determined by chromatin IP assay.Taken together,our results demonstrated that DTL regulated by p53 could activate the FA pathway for UV-induced DNA damage repair in retinal pigment epithelial cells.

关键词： DTL Fanconi anemia pathway Retinal pigment epithelial p53

Release behavior of soluble salts in MSWI bottom ash used as road basement materials under continuous rainfall conditions

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Waste Disposal and Sustainable Energy 2023年第4期5卷 525-534页

作者： Lingqin Zhao Dongming Zhang Yanjun Hu qianqian guo Long Jiao Nan Zhou Francesco Di Maio Institute of Thermal and Power Engineering Zhejiang University of TechnologyLiuhe Road 28#310023HangzhouChina Zhejiang Zheneng Xingyuan Energy Saving Technology Co.Ltd Gongshu District310011HangzhouChina Delft University of Technology P.O.Box 50482628DelftThe Netherlands

The bottom ash is increasingly used as a substitute aggregate material in road construction in China,and road salting is the major salt source in groundwater.Continuous rainfall releases soluble salts from the bottom ash subgrade into the surrounding soil and groundwater,resulting in potential hazards.Different methods were employed to simulate and collect runoff water during rainfall events,including batch leaching test,dynamic leaching test and constant head test,to assess environmental impact of bottom ash as road basement materials under continuous rainfall conditions.This study simulated the seepage of bottom ash backfill roads under different rainfall intensities,rainfall times,and rainfall pH values.A comprehensive sampling and laboratory testing program was undertaken to characterize the environmental impact of soluble salts from bottom ash.The obtained results reveal that the leaching concentrations of Cl^(−)and SO_(4)^(2−)exceed the limit specified in the class V standard of surface water,which are 2.06–2.17 times and 1.08–1.25 times,respectively.By examining the long-term environmental influence under the condition of continuous rainfall,the leaching of Cl^(−)mainly occurs in the early leaching stage,and the maximum leaching concentration reaches 19,700 mg/L.The release concentration of Cl^(−)begins to be lower than the class V standard of surface water when continuous rainfall approaches the total rainfall for 13 months.The cumulative release of Cl^(−)in the bottom ash is 2.8–5.4 mg/g.Both rainfall intensity and rain pH affect the release of Cl^(−).The obtained results derived from the constant head tests indicate that stagnant water caused by rainfall deteriorates the release of soluble salt into the groundwater in only 1 day,especially at the early stage of 12 h.This work provides some basic information about how to minimize damage to the surrounding environment caused by the leaching of salt in bottom ash.

关键词： Municipal solid waste Incineration bottom ash Salts Leaching Continuous rainfall

Quantification and distribution of extractable metals of MSWI bottom ash in view of its valorization in China

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Waste Disposal and Sustainable Energy 2022年第3期4卷 169-178页

作者： Yanjun Hu Lingqin Zhao qianqian guo Lianming Li Yihong Wang Yufan Ye Fuzhi Mao Wangyang Tian Institute of Thermal and Power Engineering Zhejiang University of TechnologyLiuhe Road 28#HangZhou310023China Jiaxing New Jies Heat&Power Company Limited Qiumao Road 55#Jiaxing314016China Zhejiang Eco Environmental Technology Company Limited Qufu Road 1188#Huzhou313000China

Metal recovery from bottom ash was deemed to be significant to achieve a higher stability of bottom ash and recycle valuable extractable metals.In China,the existing rugged industrial production ignores the actual metal distribution and thus fails to exploit the utilization potential of recoverable metals in bottom ash.Based on these findings,this work was proposed to obtain a comprehensive and in-depth study on the recoverability of metals in bottom ash.First,the particle size distribution and elemental composition of the bottom ash were analyzed.Then,complete information on the recoverable metals in bottom ash fractions with different sizes was obtained by washing,sorting,crushing,density separation and XRF(X Ray Fluorescence)analysis.The results showed that the smaller than 5 mm fraction accounted for up to 60%of the bottom ash,and the 5–20 mm fractions accounted for about 15%.The material characterization revealed that the contents of recoverable Fe,stainless steel,Al and Cu in bottom ash were averagely 9.01%,0.136%,0.78%and 0.08%,respectively.About 50%of Fe,68%of Al,61%of Cu,and 22%of stainless steel were distributed in smaller than 10 mm fraction.Particularly,Fe was evenly distributed among 0–2 mm,2–5 mm,5–10 mm fractions,and the content was between 5.41%and 7.5%.Non-magnetic stainless steel was mainly distributed in 20–40 mm and larger than 40 mm fractions.The highest share of Al was present in the fractions between 5 mm and 20 mm,accounting for 48%of the total aluminum.About 45.6%of the Cu was enriched in the 5–10 mm fraction.However,the Zn content was less than 0.01%.This work provides an in-depth understanding and information on metal recovery as well as promisingly guide ash utilization.

关键词： Municipal solid waste incineration Bottom ash Extractable metals Particle size

Crystal-to-crystal transformation from the triclinic to the cubic crystal system by partial desolvation

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Frontiers of Chemical Science and Engineering 2018年第3期12卷 433-439页

作者： qianqian guo Irmgard Kalf Ulli Englert Institute of Inorganic Chemistry RWTH Aachen University Aachen Germany

Diffusion reaction of the labile building block Mg（acacCN）2 （acacCN= 3-cyanoacetylacetonate） with silver salts leads to a series of solvated Mg/Ag bimetallic coordination polymers with composition [Mg（acacCN）aAg].solvent. Despite their common stoichiometry, the topology of these polymers depends on the solvent of crystallization. The two-dimensional coordination compound [Mg（acacCN）aAg]-4CHCl3 in space group P]- is obtained as platelet-shaped crystals from a mixture of methanol and chloroform. When kept in the reaction mixture, these thin plates within one week convert to isometric tetrahedral crystals of the 3D network [Mg（acacCN）3Ag]. 2CHC13 in the cubic space group/9213. The transformation reaction proceeds via dissolution and recrystallization. The co-crystallized solvent molecules play an important role for stabilizing the target structure： They subtend Cl...Cl contacts and interact via non- classical C-H.-. O hydrogen bonds with the coordination framework. In the new cubic coordination network, both Mg（II） and Ag（I） adopt octahedral coordination, with unprecedented face-sharing by bridging O atoms of three acetylacetonato moieties. Prolonged standing of [Mg（acacCN）3Ag]-2CHCl3 in the reaction medium leads to further degradation, under formation of [Ag（acacCN）].

关键词： ditopic ligand substituted acetylacetone desolvation diffraction

农业全球价值链嵌入、产业融合与产业结构转型升级——基于全球60个国家2007—2019年的经验证据

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南方经济 2024年第4期 132-150页

作者：文春晖郭骞谦湖南农业大学经济学院湖南省长沙市410128

农业全球价值链(AGVC)作为全球国际分工的载体对各国现代产业体系和产业结构转型升级产生重要影响。文章在构建农业全球价值链促进产业结构转型升级理论模型的基础上,运用2007—2019年全球60个国家的面板数据,检验了农业全球价值链嵌入... 详细信息

农业全球价值链(AGVC)作为全球国际分工的载体对各国现代产业体系和产业结构转型升级产生重要影响。文章在构建农业全球价值链促进产业结构转型升级理论模型的基础上,运用2007—2019年全球60个国家的面板数据,检验了农业全球价值链嵌入对产业结构转型升级的影响及其作用机制。研究发现:①AGVC嵌入通过产业融合中的农业工业化和农业服务业化两条途径促进产业结构合理化和高级化,从而实现产业结构转型升级,AGVC参与度越高的国家,农业工业化与农业服务业化程度越高,产业结构转型升级也更快;②AGVC上游嵌入对结构高级化和结构合理化均产生较明显的促进作用,而AGVC下游嵌入仅对产业结构合理化产生影响,对产业结构高级化影响不显著;③AGVC嵌入对发展中国家产业结构合理化和产业结构高级化均存在显著的正向影响,而对于发达国家而言,AGVC嵌入仅通过农业服务业化带动产业结构高级化。未来,基于我国新发展格局和产业结构发展阶段判断,需要坚定不移地构建以国内大循环为主体的双循环发展战略,形成高水平的农业对外开放发展新格局;加快农业领域科技创新与国际合作,增强国际市场竞争力;坚持农业工业化和农业服务业化双轮驱动,推动产业结构转型升级。

关键词：农业全球价值链产业融合产业结构转型

引种捕食螨胡瓜新小绥螨在中国的适生区分布预测

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生态学报 2024年第12期44卷 5219-5229页

作者：李玉闯郭倩倩刘怀李广云西南大学植物保护学院昆虫学及害虫控制工程重庆市重点实验室重庆400715 西南大学长江上游农业生物安全与绿色生产教育部重点实验室重庆400715

胡瓜新小绥螨(Neoseiulus cucumeris)是一种商业化的广食性生防天敌,可以防治多种农业害螨和害虫,具有重要的经济和生态价值。但是作为一种外来引种的捕食螨,它在我国的适生区域分布以及气候变化对其分布的影响尚不明确。根据胡瓜新小... 详细信息

胡瓜新小绥螨(Neoseiulus cucumeris)是一种商业化的广食性生防天敌,可以防治多种农业害螨和害虫,具有重要的经济和生态价值。但是作为一种外来引种的捕食螨,它在我国的适生区域分布以及气候变化对其分布的影响尚不明确。根据胡瓜新小绥螨的现有分布点和19个生物气候因子,利用刀切法评估关键气候因素的重要性,并采用Maxent生态位模型分别预测了目前和未来气候条件下它在中国分布情况,分析了其在中国的潜在适生区域的变化。结果表明模型预测得到的受试者工作特征曲线ROC曲线下的面积AUC(Area under curve)值为0.87,表明模型的准确度好。最冷季节的降水量(Bio_19)、等温性(Bio_3)和气温季节性(Bio_4)是影响胡瓜新小绥螨适生性的最重要的环境因子,对模型的贡献率分别为36.2%、25%和18.1%。目前胡瓜新小绥螨的适生区面积约占我国陆地面积的60%,在未来气候条件下,其适生区域有进一步扩大的趋势,在2050年其中高度适生区域扩张至63%。不同时期胡瓜新小绥螨的分布中心比较稳定,均分布于四川省内,但有向东北迁移的趋势。本研究明确了胡瓜新小绥螨在中国适宜的释放区域及可能定殖的区域,为该引种天敌的合理利用提供了理论依据。

关键词：胡瓜新小绥螨 MaxEnt模型潜在分布环境因子

Ab initio calculation of the ground and first excited states of the lithium dimer

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Communications in Theoretical Physics 2021年第12期73卷 129-136页

作者： JianJun Qi YuYao Bai qianqian guo Yong-Chang Han Maksim B Shundalau Department of Physics Dalian University of TechnologyDalian 116024China DUT-BSU Joint Institute Dalian University of TechnologyDalian 116024China Physics Department Belarusian State UniversityMinskBelarus

Based on a high level ab initio calculation which is earned out with the multireference configuration interaction method under the aug-cc-pVXZ(AVXZ)basis sets,X=T,Q,5,the accurate potential energy curves(PECs)of the ground state X^(1)Σ_(g)^(+)and the first excited state A^(1)Σ_(u)^(+)of Li_(2)are constructed.By fitting the ab initio potential energy points with the MurrellSorbie potential function,the analytic potential energy functions(APEFs)are obtained.The molecular bond length at the equilibnum(R_(e)),the potential well depth(D_(e)),and the spectroscopic constants(B_(e),ω_(e),α_(e),andω_(e)χ_(e))for the X^(1)Σ_(g)^(+)state and the A^(1)Σ_(u)^(+)state are deduced from the APEFs.The vibrational energy levels of the two electronic states are obtained by solving the time-independent Schrodmger equation with the Founer gnd Hamiltonian method.All the spectroscopic constants and the vibrational levels agree well with the experimental results.The Franck-Condon factors(FCFs)corresponding to the transitions from the vibrational level(v’=0)of the ground state to the vibrational levels(v"=0-74)of the first excited state have been calculated.The FCF for the vibronic transition of A^(1)Σ_(u)^(+)(v"=0)←X^(1)Σ_(g)^(+)(v’=0)is the strongest.These PECs and corresponding spectroscopic constants provide reliable theoretical references to both the spectroscopic and the molecular dynamic studies of the Li_(2)dimer.

关键词： potential energy curve spectroscopic constants vibrational levels

激励式心理护理在外伤性鼓膜穿孔患者中的应用效果

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中国民康医学 2024年第2期36卷 169-172页

作者：郭倩倩济源市人民医院耳鼻喉科河南济源454650

目的:观察激励式心理护理在外伤性鼓膜穿孔患者中的应用效果。方法:选取2017年3月至2022年3月该院收治的120例外伤性鼓膜穿孔患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各60例。对照组实施常规护理,观察组在对照组基... 详细信息

目的:观察激励式心理护理在外伤性鼓膜穿孔患者中的应用效果。方法:选取2017年3月至2022年3月该院收治的120例外伤性鼓膜穿孔患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各60例。对照组实施常规护理,观察组在对照组基础上实施激励式心理护理,比较两组护理前后Connor-Davidson心理弹性量表(CD-RISC)评分、症状自评量表(SCL-90)评分、应对方式[特质应对方式问卷(TCSQ)]评分、生命质量[简明健康调查量表(SF-36)]评分,并发症发生率和护理满意度。结果:护理后,两组坚韧、自强、乐观评分均高于护理前,且观察组高于对照组,差异有统计学意义(P<0.05);两组精神、偏执、躯体化、强迫症、人际关系敏感、抑郁、焦虑、敌对、恐怖评分均低于护理前,且观察组低于对照组,差异有统计学意义(P<0.05);两组积极应对评分均高于护理前,且观察组高于对照组,两组消极应对评分均低于护理前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组并发症发生率为1.67%,低于对照组13.33%,差异有统计学意义(P<0.05);两组生理职能、健康状况、情感职能、精神健康等各项SF-36评分均高于护理前,且观察组高于对照组,差异有统计学意义(P<0.05);观察组护理满意度为96.67%,高于对照组的75.00%,差异有统计学意义(P<0.05)。结论:在常规护理基础上采用激励式心理护理可提高外伤性鼓膜穿孔患者CD-RISC评分、生命质量评分和护理满意度,改善TCSQ评分,以及降低SCL-90评分和并发症发生率的效果优于单纯常规护理效果。

关键词：激励式心理护理外伤性鼓膜穿孔心理弹性生命质量应对方式并发症

辣椒EIL基因家族的鉴定及其在盐碱胁迫下的表达分析

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河南农业科学 2024年第5期53卷 123-132页

作者：吴鹏李冬雪郭茜茜齐齐哈尔大学生命科学与农林学院黑龙江齐齐哈尔161006

EIL(Ethylene-insensitive 3-like)基因在参与植物乙烯信号通路的转导和生长发育过程中发挥着重要作用。为了解辣椒EIL基因家族成员信息,利用生物信息学手段对辣椒EIL基因家族成员的理化性质、蛋白质结构、系统进化、基因结构、保守域... 详细信息

EIL(Ethylene-insensitive 3-like)基因在参与植物乙烯信号通路的转导和生长发育过程中发挥着重要作用。为了解辣椒EIL基因家族成员信息,利用生物信息学手段对辣椒EIL基因家族成员的理化性质、蛋白质结构、系统进化、基因结构、保守域、启动子顺式作用元件及CaEILs基因在不同组织部位和不同非生物胁迫条件下的表达模式进行分析。同时使用实时荧光定量PCR(qRT-PCR)对辣椒叶片中CaEILs在盐碱胁迫下的表达模式进行研究。结果表明,辣椒9个CaEILs分布在6条染色体上,氨基酸数目、蛋白质理论分子质量和脂肪系数分别介于209~677、23.77~76.07 ku和63.10~87.75,且主要为酸性、亲水的不稳定性核蛋白。系统进化分析显示,CaEILs被分成了4个亚家组,9个CaEILs在根、茎、叶、花蕾、花中具有不同程度的表达,而低温、高温、高盐、干旱胁迫下均能诱导CaEILs的表达,其对以上非生物胁迫均具有不同程度的响应。此外,利用qRT-PCR对盐碱胁迫下辣椒叶片中CaEILs进行了检测,结果发现,随着处理时间的延长,CaEIL1、CaEIL2、CaEIL4、CaEIL5、CaEIL8的表达量整体呈上升趋势,而CaEIL3、CaEIL6、CaEIL7、CaEIL9的表达量整体呈下降趋势。

关键词：辣椒 EIL基因家族基因结构盐碱胁迫表达