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Quantitative Analysis of the Effectiveness of Antigen-and Polymerase Chain Reaction-Based Combination Strategies for Containing COVID-19 Transmission in a Simulated Community

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Engineering 2023年第9期28卷 234-242页

作者： qiangru huang Yanxia Sun Mengmeng Jia Ting Zhang Fangyuan Chen Mingyue Jiang Qing Wang Luzhao Feng Weizhong Yang School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China School of Arts and Sciences Beijing Institute of Fashion TechnologyBeijing 100105China

The number of coronavirus disease 2019(COVID-19)cases continues to surge,overwhelming healthcare systems and causing excess mortality in many *** of infectious populations remains a key strategy to contain the COVID-19 outbreak,delay the exponential spread of the disease,and flatten the epidemic *** the Omicron variant outbreak as a background,this study aimed to evaluate the effectiveness of testing strategies with different test combinations and frequencies,analyze the factors associated with testing effectiveness,and optimize testing strategies based on these influencing *** developed a stochastic,agent-based,discrete-time susceptible–latent–infectious–recovered model simulating a community to estimate the association between three levels of testing strategies and COVID-19 *** testing and its combination strategies were more efficient than polymerase chain reaction(PCR)-related *** testing also showed better performance in reducing the demand for hospital beds and intensive care unit *** delay in the turnaround time of test results had a more significant impact on the efficiency of the testing strategy compared to the detection limit of viral load and detection-related *** main advantage of antigen testing strategies is the short turnaround time,which is also a critical factor to be optimized to improve PCR *** modifying the turnaround time,the strategies with less frequent testing were comparable to daily *** choice of testing strategy requires consideration of containment goals,test efficacy,community prevalence,and economic *** study provides evidence for the selection and optimization of testing strategies in the post-pandemic era and provides guidance for optimizing healthcare resources.

关键词： COVID-19 Antigen testing PCR testing Testing strategies

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An effectiveness study of vaccination and quarantine combination strategies for containing mpox transmission on simulated college campuses

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Infectious Disease Modelling 2024年第3期9卷 805-815页

作者： qiangru huang Yanxia Sun Mengmeng Jia Mingyue Jiang Yunshao Xu Luzhao Feng Weizhong Yang School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100730China National Institute of Pathogen Biology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100730China

The ongoing transmission of mpox in specific countries and regions necessitates urgent *** is essential to implement targeted containment strategies that concentrate on high-risk populations and critical locations,such as college campuses,to effectively curb the spread of *** study is dedicated to evaluating the performance of various vaccination and quarantine strategies in curbing the spread of mpox and estimating the outbreak *** accomplish this,we constructed a stochastic,agent-based,discrete-time susceptible-latent-infectious-recovered(SLIR)model,to examine mpox transmission on a simulated college *** findings reveal that relying solely on PEP is insufficient in containing mpox *** bolster the population immunity and protect the vulnerable,pre-exposure vaccination among high-risk populations prior to an outbreak is *** study demonstrates that a pre-exposure vaccination rate of 50%in high-risk populations can led to a remarkable 74.2%reduction of *** translated to a mere 1.0%cumulative infection incidence in the overall *** cases where the desired vaccination coverage is not attainable,enhancing case detection and isolation measures can serve as an effective emergency response to contain mpox *** pre-exposure vaccination coverage of 20%or lower,a 40%isolation ratio is necessary to keep the cumulative number of infections in ***,when the coverage exceeds 30%,a reduced isolation ratio of 20%becomes sufficient to manage the outbreak *** insights underscore the importance of strategic pre-exposure vaccination in conjunction with robust surveillance and isolation protocols to safeguard public health and prevent the escalation of mpox outbreaks.

关键词： Infectious diseases Mpox Vaccination Quarantine

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A Large-Scale Online Survey on Clinical Severity and Associated Risk Factors for SARS-CoV-2 Omicron Infection — China, April–May 2023

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China CDC weekly 2024年第15期6卷 305-311,I0001-I0004页

作者： Yanxia Sun Yuping Duan Jie Qian Yimin Qu Ye Wang Guohui Fan qiangru huang Zhongjie Li Weizhong Yang Luzhao Feng State Key Laboratory of Respiratory Health and Multimorbidity Key Laboratory of Pathogen Infection Prevention and ControlMinistry of EducationSchool of Population Medicine and Public HealthChinese Academy of Medical Science&Peking Union Medical CollegeBeijingChina

What is already known about this topic?Individuals who initially contract severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)lack significant mixed ***,it is crucial to monitor the clinical characteristics and associated factors of these individuals in order to inform *** is added by this report?The common symptoms reported were fever,cough,and sore *** and receiving four vaccination doses within a 6-month period were found to be associated with a shorter duration of virus shedding,decreased hospitalization rate,and reduced risk of *** aged 60 years and older,as well as those with underlying medical conditions,had a higher risk of developing *** are the implication for public health practices?Online surveys conducted through social media platforms have the potential to complement disease surveillance and data collection *** terms of vaccination prioritization,it is recommended to prioritize older individuals and those with underlying diseases.

关键词： doses Online initially

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Long-term outcomes in COVID-19 patients who recovered from the first wave of the pandemic

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National Science Review 2022年第11期9卷 87-96页

作者： Dan Cui Simiao Chen Luzhao Feng Mengmeng Jia Yeming Wang Weijun Xiao Yanxia Sun qiangru huang Libing Ma Zhiwei Leng Hao Wang Bin Cao Weizhong Yang Juntao Yang Chen Wang Department of Pulmonary and Critical Care Medicine The Second Affiliated Hospital of Harbin Medical UniversityHarbin Medical University Department of Pulmonary and Critical Care Medicine National Center for Respiratory Medicine Center of Respiratory MedicineNational Clinical Research Center for Respiratory Diseases China-Japan Friendship Hospital Heidelberg Institute of Global Health Faculty of Medicine and University Hospital Heidelberg University School of Population Medicine and Public Health Chinese Academy of Medical Sciences &Peking Union Medical College Department of Respiratory and Critical Care Medicine the Affiliated Hospital of Guilin Medical University Institute of Respiratory Medicine Chinese Academy of Medical Science State Key Laboratory of Medical Molecular Biology Department of Biochemistry and Molecular BiologyInstitute of Basic Medical Sciences Chinese Academy of Medical Sciences & Peking Union Medical College

This cross-sectional study evaluated the long-term health effects of coronavirus disease 2019(COVID-19)in Jianghan District(Wuhan, China). The results showed that 61.4% of COVID-19 patients reported at least one symptom and 8.8% had depressive symptoms at the 17-month follow-up. The proportion of patients with chest radiographic abnormalities in Fangcang shelter hospitals and designated COVID-19hospitals was 31.6% and 41.1%, respectively, and the proportion of patients with impaired pulmonary diffusion capacity in these hospitals was 52.8% and 60.9%, respectively. Female sex(odds ratio[OR] = 1.48, 95% confidence interval [CI]: 1.16–1.88), severe disease(OR = 1.46, 95% CI: 1.01–2.10)and a higher number of initial symptoms(OR = 1.31, 95% CI: 1.23–1.40) were associated with the development of sequelae symptoms at 17 months. This study involving community-dwelling COVID-19adults may help determine the long-term effects of COVID-19 during the first pandemic ***, larger follow-up studies are needed to characterize the post-COVID-19 condition.

关键词： SARS-CoV-2 post-COVID-19 syndrome follow-up studies

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Association between influenza vaccination and SARS-CoV-2 infection and its outcomes: systematic review and meta-analysis

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Chinese Medical Journal 2022年第19期135卷 2282-2293页

作者： Binshan Jiang qiangru huang Mengmeng Jia Xinai Xue Qing Wang Weizhong Yang Luzhao Feng School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBejing 100730China Department of Medical Records Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China.

Background:World Health Organization recommends that influenza vaccines should benefit as much of the population as possible,especially where resources are *** virus disease 2019(COVID-19)has become one of the greatest threats to health systems *** present study aimed to extend the evidence of the association between influenza vaccination and COVID-19 to promote the ***:In this systematic review,four electronic databases,including the Cochrane Library,PubMed,Embase,and Web of Science,were searched for related studies published up to May *** odds ratios(ORs)with 95%confidence intervals(CIs)were pooled by ***:A total of 36 studies,encompassing 55,996,841 subjects,were included in this *** meta-analysis for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection provided an OR of 0.80(95%CI:0.73–0.87).The statistically significant estimates for clinical outcomes were 0.83(95%CI:0.72–0.96)for intensive care unit admission,0.69(95%CI:0.57–0.84)for ventilator support,and 0.69(95%CI:0.52–0.93)for fatal infection,while no effect seen in hospitalization with an OR of 0.87(95%CI:0.68–1.10).Conclusion:Influenza vaccination helps limit SARS-CoV-2 infection and severe outcomes,but further studies are ***:PROSPERO,CRD42022333747.

关键词： Influenza vaccine COVID-19 Infection Outcomes Prevention

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Mapping the Characteristics of Respiratory Infectious Disease Epidemics in China Based on the Baidu Index from November 2022 to January 2023

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China CDC weekly 2024年第37期6卷 939-945,I0001-I0007页

作者： Dazhu Huo Ting Zhang Xuan Han Liuyang Yang Lei Wang Ziliang Fan Xiaoli Wang Jiao Yang qiangru huang Ge Zhang Ye Wang Jie Qian Yanxia Sun Yimin Qu Yugang Li Chuchu Ye Luzhao Feng Zhongjie Li Weizhong Yang Chen Wang School of Health Policy and Management Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina School of Population Medicine and Public Health Chinese Academy of Medical Sciences(CAMS)&Peking Union Medical CollegeBeijingChina Yichang Center for Disease Prevention and Control Yichang CityHubei ProvinceChina Weifang Center for Disease Prevention and Control Weifang CityShandong ProvinceChina Beijing Center for Disease Prevention and Control BeijingChina School of Public Health Dali UniversityDali CityYunnan ProvinceChina Shanghai Pudong New Area Center for Disease Control and Prevention ShanghaiChina

Introduction:Infectious diseases pose a significant global health and economic burden,underscoring the critical need for precise predictive *** Baidu index provides enhanced real-time surveillance capabilities that augment traditional ***:Baidu search engine data on the keyword“fever”were extracted from 255 cities in China from November 2022 to January *** and peak dates for influenza epidemics were identified by testing various criteria that combined thresholds and consecutive ***:The most effective scenario for indicating epidemic commencement involved a 90th percentile threshold exceeded for seven consecutive days,minimizing false *** detection was optimized using a 7-day moving average,balancing stability and ***:The use of internet search data,such as the Baidu index,significantly improves the timeliness and accuracy of disease surveillance *** innovative approach supports faster public health interventions and demonstrates its potential for enhancing epidemic monitoring and response efforts.

关键词： faster precise false

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加强新型冠状病毒疫苗效果评价,助力科学精准防控

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中华预防医学杂志 2022年第6期56卷 861-863页

作者：冯录召黄蔷如杨维中中国医学科学院北京协和医学院群医学及公共卫生学院北京100730

新型冠状病毒肺炎疫情在全球范围持续蔓延,我国多地出现与输入病例关联的本土疫情。接种新型冠状病毒疫苗是预防新型冠状病毒发病、重症及死亡的最有效方法之一。针对我国研发和使用的疫苗种类,利用不同的疫情暴发现场对各类变异株进行... 详细信息

新型冠状病毒肺炎疫情在全球范围持续蔓延,我国多地出现与输入病例关联的本土疫情。接种新型冠状病毒疫苗是预防新型冠状病毒发病、重症及死亡的最有效方法之一。针对我国研发和使用的疫苗种类,利用不同的疫情暴发现场对各类变异株进行深入的真实世界研究,并进一步推进针对变异株的疫苗研发和技术储备,对科学精准防控尤为重要。本文探讨了新型冠状病毒病毒疫苗效果,并对未来的疫苗效果评价研究、免疫策略研究及疫苗研发进行了展望,为优化疫苗接种策略提供依据。

关键词：新型冠状病毒疫苗效果评价

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全生命期全人群预防接种策略的实施挑战与思考

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中国疫苗和免疫 2024年第5期30卷 508-516页

作者：贾萌萌黄蔷如杨维中中国医学科学院北京协和医学院病原生物学研究所北京102629 中国医学科学院北京协和医学院群医学及公共卫生学院北京100730 公共卫生应急管理创新中心北京100730

传染病一直威胁着人类健康、经济和社会稳定。预防接种是控制传染病最有效的公共卫生措施之一,在预防或减少疾病发病、重症和死亡及提升人群健康水平等方面发挥了重要作用。不同年龄阶段人群的传染病易感性不同,需要实施从婴幼儿到老年... 详细信息

传染病一直威胁着人类健康、经济和社会稳定。预防接种是控制传染病最有效的公共卫生措施之一,在预防或减少疾病发病、重症和死亡及提升人群健康水平等方面发挥了重要作用。不同年龄阶段人群的传染病易感性不同,需要实施从婴幼儿到老年人的全生命期预防接种策略。本文旨在总结不同生命阶段适宜接种的疫苗和实施全生命期预防接种策略面临的挑战,并提出针对性的对策思考。

关键词：预防接种全生命期全人群

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接种天花疫苗对猴痘病毒感染的保护作用研究进展

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中华流行病学杂志 2023年第4期44卷 673-676页

作者：徐韵韶姜明月曹琰琳孙艳侠黄蔷如杨维中冯录召中国医学科学院北京协和医学院群医学及公共卫生学院北京100730

2022年,猴痘疫情从区域的地方性流行扩大至全球暴发,并被WHO列为国际关注的突发公共卫生事件。由于正痘病毒之间的基因序列具有高度相似性且正痘病毒可诱发交叉反应型抗体,接种天花疫苗可能会影响猴痘病毒感染诱导的免疫应答水平及感染... 详细信息

2022年,猴痘疫情从区域的地方性流行扩大至全球暴发,并被WHO列为国际关注的突发公共卫生事件。由于正痘病毒之间的基因序列具有高度相似性且正痘病毒可诱发交叉反应型抗体,接种天花疫苗可能会影响猴痘病毒感染诱导的免疫应答水平及感染者的健康结局。分析天花疫苗接种对猴痘病毒感染的保护作用将有助于确定疫情防控策略和措施。因此,本文通过了解既往猴痘疫情中天花疫苗的接种情况及其健康结局,综述天花疫苗接种、免疫应答情况和临床数据之间的关联性,为猴痘疫情的预防控制策略提供科学证据。

关键词：猴痘病毒天花疫苗免疫应答

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阿米洛利介导PI3K/AKT信号通路对急性呼吸窘迫综合征大鼠肺损伤的作用机制

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暨南大学学报（自然科学与医学版） 2021年第1期42卷 1-11页

作者：朱磊郭鸿井高静帅佃奎熊怀玉黄蔷茹刘健兰州大学第一医院重症医学科甘肃兰州730030 兰州大学第一医院内分泌科甘肃兰州730030

目的:探讨阿米洛利介导PI3K/AKT信号通路对急性呼吸窘迫综合征(ARDS)大鼠肺损伤的作用机制,为ARDS患者临床诊疗提供新思路.方法:将96只雄性Wistar大鼠随机分为空白对照组、二甲基亚砜(DMSO)组、ARDS组、阿米洛利组,各组24只,空白对照组... 详细信息

目的:探讨阿米洛利介导PI3K/AKT信号通路对急性呼吸窘迫综合征(ARDS)大鼠肺损伤的作用机制,为ARDS患者临床诊疗提供新思路.方法:将96只雄性Wistar大鼠随机分为空白对照组、二甲基亚砜(DMSO)组、ARDS组、阿米洛利组,各组24只,空白对照组和DMSO组均不注射油酸,其余各组建立油酸型ARDS大鼠模型,分别在注射油酸4 h、8 h和12 h时取样肺组织和肺泡灌洗液(BALF),ELISA法检测大鼠BALF中肿瘤坏死因子(TNF-α)、白介素-6(IL-6)和白介素-10(IL-10)水平;HE染色观察大鼠肺组织病理变化;免疫组化法检测大鼠肺组织血管内皮细胞生长因子(VEGF)、血管细胞黏附因子(VCAM-1)和内皮素1(ET-1)阳性表达水平;Western blot和RT-PCR检测大鼠肺组织中PI3K/AKT信号通路相关因子PI3K、p-PI3K、AKT和p-AKT蛋白表达水平及mRNA表达水平.结果:注射油酸后的大鼠出现呼吸困难、呼吸频率明显加快、毛发直立、活动减少等急性呼吸窘迫症状,说明大鼠ARDS模型构建成功.ARDS组大鼠BALF中TNF-α和IL-6质量浓度显著上升(P<0.05),IL-10质量浓度显著下降(P<0.01);阿米洛利干预后大鼠BALF中TNF-α和IL-6质量浓度显著降低(P<0.01),IL-10质量浓度升高有统计学差异(P<0.01).HE染色ARDS组大鼠肺组织肺泡壁增厚,肺泡结构被破坏,炎性细胞浸润;免疫组化结果表明,ARDS组大鼠肺组织中VEGF阳性表达显著降低(P<0.01),VCAM-1和ET-1阳性表达显著升高(P<0.01),阿米洛利干预后VEGF表达显著上调(P<0.01),VCAM-1和ET-1阳性表达均显著下调(P<0.01);与ARDS组比较,阿米洛利组中p-PI3K和p-AKT蛋白相对表达降低(P<0.01);RT-PCR检测和Western blot变化趋势相同.结论:阿米洛利干预可以改善ARDS大鼠肺损伤,这可能是通过抑制PI3K/AKT信号通路实现的.

关键词：急性呼吸窘迫综合征油酸阿米洛利炎症反应 PI3K/AKT信号通路

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