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Trends and hotspots in gastrointestinal neoplasms risk assessment: A bibliometric analysis from 1984 to 2022

World Journal of Gastrointestinal Oncology 2024年第6期16卷 2842-2861页

作者： qiang-qiang fu Le Ma Xiao-Min Niu Hua-Xin Zhao Xu-Hua Ge Hua Jin De-Hua Yu Sen Yang Department of General Practice Yangpu HospitalSchool of MedicineTongji UniversityShanghai 200090China Shanghai General Practice and Community Health Development Research Center Shanghai 200090China Department of Shanghai Lung Cancer Center Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Department of Oncology Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200090China

BACKGROUND Gastrointestinal neoplasm(GN)significantly impact the global cancer burden and mortality,necessitating early detection and *** the evolution and current state of research in this field is *** To conducts a comprehensive bibliometric analysis of publications from 1984 to 2022 to elucidate the trends and hotspots in the GN risk assessment research,focusing on key contributors,institutions,and thematic *** This study conducted a bibliometric analysis of data from the Web of Science Core Collection database using the"bibliometrix"R package,VOSviewer,and *** analysis focused on the distribution of publications,contributions by institutions and countries,and trends in *** methods included data synthesis,network analysis,and visualization of international collaboration *** This analysis of 1371 articles on GN risk assessment revealed a notable evolution in terms of research focus and *** highlights the United States'critical role in advancing this field,with significant contributions from institutions such as Brigham and Women's Hospital and the National Cancer *** last five years,substantial advancements have been made,representing nearly 45%of the examined *** rates have dramatically increased,from 20 articles in 2002 to 112 in 2022,reflecting intensified research *** study underscores a growing trend toward interdisciplinary and international collaboration,with the Journal of Clinical Oncology standing out as a key publication *** shift toward more comprehensive and collaborative research methods marks a significant step in addressing GN *** This study underscores advancements in GN risk assessment through genetic analyses and machine learning and reveals significant geographical disparities in research *** calls for enhanced global collaboration and integration of artificial intelligence to improve cancer p

关键词： Gastrointestinal neoplasms Bibliometric analysis Risk assessment Network analysis Research trends

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SOOJI CHIM (Koryo hand acupuncture) for perimenopausal insomnia:Evidence from actigraphy and serum hormone testing

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World Journal of Acupuncture-Moxibustion 2019年第4期29卷 274-278页

作者： Fei-Yi Zhao Jin-Hyeok Kim Li-Ping Yue Hai-Xia Yan Hua-Ling Song Yan Xu Hong Xu Yu-Fang Hong qiang-qiang fu Nursing Department Shanghai SANDA UniversityShanghai 201209China Shanghai University of Traditional Chinese Medicine Shanghai 201203China Shanghai Municipal Hospital of TCM Affiliated to Shanghai TCM University Shanghai 200071China Research Department Yangpu HospitalTongji UniversityShanghai 200090China

Objective:This study is conducted to determine the effects of SOOJI CHIM(Koryo hand acupuncture,KHA)therapy on sleep structures and perimenopause symptoms among ***:Totally 49 participants who met the inclusion criteria were enrolled in a two-arm randomized,placebo controlled,patients-blind trial,with 24 cases allocated to a real-KHA group and 25 cases allocated to a sham-KHA *** in each group received corresponding treatment every other day,three times a week for total eight *** actigraphy and testing of serum hormones level reflected by biological markers such as follicle-stimulating hormone(FSH),luteinizing hormone(LH)and estradiol(E2)were performed at pre-and ***,the scores of Pittsburgh sleep quality index(PSQI)was used for assessing the subjective sleep experience of ***,adverse effects were monitored and ***:After eight-week treatment,the global scores of PSQI declined significantly(P0.05).According to the outcomes of actigraphy,a striking increase was observed in both sleep efficiency(SE)and total sleep time(TST)in the real-KHA group(both P0.05).However,no significant changes of sleep awakenings(SA)in both groups was found after treatment(both P>0.05).Meanwhile,FSH and LH in the real-KHA group decreased markedly after intervention(both P0.05).The fluctuation of E2 levels were not significant in both groups(both P>0.05).No serious adverse event was reported in either real-or sham-KHA ***:KHA may be a potential alternative therapy for improving perimenopausal insomnia via down regulating the levels of FSH and LH.

关键词： Perimenopausal insomnia SOOJI CHIM(Koryo hand acupuncture,KHA) Actigraphy Serum hormone testing

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An analysis of patents for anesthetic laryngoscopes

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第9期18卷 825-832页

作者： Cheng-dong JI Xin PAN Yuan-chang XIONG Xuan GUO Shu-wen QIAN Chang XU qiang-qiang fu Zhi-ping YANG Yu MA Yue-zhu WAN Department of Anesthesiology Yangpu Hospital School of Medicine Tongji University Central Laboratory Yangpu Hospital School of Medicine Tongji University Department of Anesthesiology Changhai Hospital the Second Military Medical University

The anesthetic laryngoscope is one of the most popular medical tools for obtaining a clear view of the larynx and facilitates tracheal intubation. The number of anesthetic laryngoscope patents, coming mainly from the anesthesiologists, has rapidly increased. Each product has a specialized use for particular patients. However, it is unclear to what extent anesthetic laryngoscopy gained acceptance in operating theaters. By retrieving patent data for more than 90 countries from the Online Retrieval of Bibliographic Information Time-share(ORBIT) system, we reviewed the anesthetic laryngoscope patent literature published before July 6, 2015, and manually analyzed patent status, general development trends, areas of competition, technology patentees, and technology classifications. The study showed that the number of anesthetic laryngoscope patent applications has stayed at a high level in the last decade. Most patent activity was carried out in the USA, with China and a number of European countries trailing behind. In addition, the patent analysis provided an opportunity to understand the trends in the development of anesthetic laryngoscope technology, to identify shortcomings in clinical use of anesthetic laryngoscopes, to assist medical manufacturing specialists in improving the design and products, and to suggest to anesthesiologists modifications of the clinical signs of difficult tracheal intubation based on the new commercial anesthetic laryngoscopes applied in the front-line.

关键词： Patent literature analysis Anesthetic laryngoscope Technology Data analysis Innovation dynamics

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Post-schizophrenia comorbid depressive disorder and insomnia treated by acupuncture combined with Chinese medicine:A retrospective case series based on JBI reporting checklist

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World Journal of Acupuncture-Moxibustion 2021年第4期31卷 314-319页

作者： Fei-yi ZHAO Hong XU Hui-ru WANG qiang-qiang fu Wen-jing ZHANG Department of Nursing School of International Medical TechnologyShanghai Sanda UniversityShanghai201209China Shanghai Municipal Hospital of Traditional Chinese Medicine Shanghai University of Traditional Chinese MedicineShanghai200071China Yangpu Hospital Tongji University School of MedicineShanghaiChina

Background:Acupuncture combined with Chinese herbal medicine was performed on 24 patients with post-schizophrenia comorbid depressive disorder and insomnia admitted to the Psychiatry Department,Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine from 2016 to 2020,and provided satisfactory *** post-schizophrenia comorbid depressive disorder and insomnia is not a common clinical disorder in hospital of traditional Chinese medicine,the treatment and follow-up cycle is long,and the dropout rate is high,a retrospective case series based on Joanna Briggs Institute(JBI) reporting checklist were conducted instead of a randomized controlled ***:To retrospectively summary the short-,mid-and long-term effects of acupuncture combined with Chinese herbal medicine for post-schizophrenia comorbid depressive disorder and insomnia,and analyze the principles of the ***:A retrospective analysis based on case series JBI reporting checklist were performed to investigate effects of 24 patients with post-schizophrenia comorbid depressive disorder and insomnia undergoing 12-week combined acupuncture and Chinese herbal medicine treatment(patients did not receive full dosage treatments,or received western medicine or other physical and psychological therapies during the treatment period were excluded).The psychotic symptoms,depression,insomnia,and self-care ability for daily living were measured by the Positive and Negative Syndrome Scale(PANSS),Calgary Depression Scale for Schizophrenia(CDSS),Pittsburgh Sleep Quality Index(PSQI),and Activity of Daily Living Questionnaire(ADL-Q),***-ups were conducted at 8 and 16 weeks after ***,Acupuncture Beliefs Scale(ABS) was assessed at pre-and post-treatment as well as 16-week follow-up to investigate patients’ beliefs and expectations for acupuncture ***:(1) compared with pre-treatment,the PANSS global

关键词： Case series Chailong-Muli decoction Insomnia Joanna Briggs Institute(JBI)reporting checklist Manual acupuncture Post-schizophrenia depressive disorder

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Occupational therapy with or without combined acupuncture on upper limb pain and hand functions in children with spastic hemiplegic cerebral palsy:A three-arm randomized,placebo-controlled trial

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World Journal of Acupuncture-Moxibustion 2022年第1期32卷 1-8页

作者： Fei-yi ZHAO Yan XU Li-ping YUE Si-han CHEN Xiao-jie XIA Ci HAN qiang-qiang fu Department of Nursing School of International Medical TechnologyShanghai Sanda UniversityShanghai 201209China Shanghai Xieai TCM Hospital Shanghai University of Traditional Chinese MedicineShanghai 201499China Faculty of Education East China Normal UniversityShanghai 200062China Yangpu Hospital School of MedicineTongji UniversityShanghai 200090China

Objective:This study is conducted to investigate the effects of occupational therapy(OT) with or without combined acupuncture for upper limb pain and hand functions among children with spastic hemiplegic cerebral ***:A total of 90 patients who met the inclusion criteria were enrolled in a three-arm randomized,placebo-controlled trial,and were allocated to mono-occupational therapy(OT) group(patients=30),OT combined with real-acupuncture(ORA) group(patients=30),and OT combined with placeboacupuncture(OPA) group(patients=30),*** addition to receiving the conventional OT program as the basic treatment for total 8 weeks,patients in ORA and OPA group also received corresponding acupuncture treatment 5 days per week for the first two weeks,3 days per week for the next two weeks,2 days per week for another two weeks,and 1 day per week for the last two ***-communicating children’s pain checklist-revised scale(NCCPC-R) was used for assessing the upper limb pain among *** dynamometry,modified Ashworth scale(MAS),manual muscle testing(MMT),JebsenTaylor hand function test(JTHFT) and box and block test(BBT) were used for assessing various aspects of upper limb and hand functions among ***,adverse effects were monitored and ***:After 8-week treatment,NCCPC-R global scores witnessed a dramatic decline in ORA group(P 0.05) or OT group(P> 0.05).Dramatic increases were identified in both squeeze dynamometry scores and MMT scores in all three groups(all P furthermore,the increases of ORA group were more significant than those of another two groups(both P 0.05).The BBT global scores of all three groups significantly increased(all P <0.05) after *** them,the increase of the ORA group was more than that of the other two groups(P <0.05).The 8-week treatment also had a significant impact on

关键词： Occupational therapy Acupuncture Placebo-acupuncture Pain Hand functions Spastic hemiplegic cerebral palsy

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Does acupuncture response increase with the increasing dosage:A preclinical study investigating rats with sleep deprivation

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World Journal of Acupuncture-Moxibustion 2020年第3期30卷 207-216页

作者： Fei-yi ZHAO Yan XU Guo-hua WANG Qia-yi MA qiang-qiang fu Zhi-min LI Hong XU Li-ping YUE Department of Nursing School of International Medical TechnologyShanghai Sanda UniversityShanghai 201209China Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 200071China Shanghai Tianshan Hospital of Traditional Chinese Medicine Shanghai 200051China Research Department Yangpu hospitalTongji University School of MedicineShanghai 200090China

Background:The effectiveness of acupuncture for insomnia and insomnia-related anxiety and depression has been widely investigated in clinical ***,whether higher dosage(more frequent)acupuncture can bring greater responses(a greater size of effect)is less ***:This study is designed to investigate whether a five-times weekly(5 Ts/w)electroacupuncture(EA)treatment is better than a three-times weekly(3 Ts/w)EA in alleviating sleep deprivation,and sleep disturbance-induced cognitive dysfunctions and negative emotions in rats through four various behavioral te ***:Forty-six male Sprague-Dawley rats were randomly divided into control group(n=10),model group(n=12),EA-3 Ts/w group(n=12),and EA-5 Ts/w group(n=12).Except for the control group,the other three groups were established as chronic sleep deprivation models via the modified multi-platform water environment ***,rats in both EA-3 Ts/w group and EA-5 Ts/w group received corresponding dosage of EA therapy,*** modeling and interventions,all four groups received four behavioral tests as follows:(1)sleep behavioral monitoring and evaluation was achieved by Comprehensive Lab Animal Monitoring System(CLAMS).(2)Cognitive functions were assessed by Novel Object Recognition(NOR)test.(3)Depressive-like behaviors was evaluated by Open-Field(OF)test.(4)Anxietylike behaviors was appraised by Elevated Plus-Maze(EPM)*** finishing the behavioral tests,the hippocampus of each rat was removed and its synaptic structure changes were observed under electron ***:(1)CLAMS:two EA groups derived more sleep time within 24 h than the model group(both P0.05).(2)NOR test:NOR ratio in the EA-3 Ts/w group was higher than that of the model group(P<0.05)but lower than that of either the control group(P<0.05)or the EA-5 Ts/w group(P<0.05).(3)OF test:the difference of horizontal movements bet

关键词： Electroacupuncture Sleep deprivation Depressive-like behaviors Anxiety-like behaviors Behavioral test

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Manual acupuncture for patients with major depressive disorder and comorbid insomnia:Evidence from polysomnography and serum biomarkers

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World Journal of Acupuncture-Moxibustion 2020年第1期30卷 5-12页

作者： Fei-yi ZHAO Yan XU Li-ping YUE Ying-xia ZHAO Ying WANG Hua-ling SONG Hong XU Si-han CHEN qiang-qiang fu Department of Nursing School of International Medical TechnologyShanghai Sanda UniversityShanghai 201209China Shanghai University of Traditional Chinese Medicine Shanghai 201203China Department Meilong Community Healthcare Service CenterShanghai 201100China Shanghai Municipal Hospital of TCM Affiliated to Shanghai TCM University Shanghai 200071China Research Department Yangpu HospitalTongji UniversityShanghai 200090China

Objective:This study is conducted to determine effects of manual acupuncture(MA)in patients with a diagnosis of major depressive disorder(MDD)and comorbid ***:A total of 67 participants who met the inclusion criteria were randomly enrolled in a two-arm randomized,placebo controlled,patients-blind trial and allocated to a real-MA group(patients=34)and a sham-MA group(patients=33).Patients in the real-MA group were treated on‘Five-shen acupoints’,including Sishencong(四神聪EX-HN 1),Shenting(神庭GV 24),Shendao(神道GV 11),bilateral Benshen(本神GB 13),and bilateral Shenmen(神门HT 7).Though being punctured on the same acupoints,patients in the sham-MA group were treated by a placebo acupuncture approach(Streitberger Placeboneedle).Each group received corresponding interventions every other day,three times a week for total eight *** polysomnography(PSG)and testing of serum biological markers such as neuropeptide Y(NPY)and substance P(SP)were performed at pre-and ***,the global scores of Pittsburgh sleep quality index(PSQI)and the global scores of 17-items Hamilton Depression Rating Scale(HAMD17)were used for assessing the subjective sleep and emotion experience of patients,***,adverse effects were monitored and ***:After eight-week treatment,the global scores of PSQI and global scores of HAMD17 declined significantly(both P0.05).According to the parameters of PSG,striking decline were observed in sleep latency(SL)and wake after sleep onset(WASO)and striking climb were observed in total sleep time(TST)and sleep efficiency(SE)in the real-MA group after treatment(P0.05,respectively).Additionally,there were no significant differences in awakening times(ATs)and rapid eyes movement sleep latency(REM-SL)in both two groups after treatment(both P>0.05).Meanwhile,the expression of NPY increased significantly

关键词： Major depressive disorder Insomnia Manual acupuncture Polysomnography Neuropeptide Y Substance P

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Escitalopram with or without combined electroacupuncture on protracted alcohol withdrawal symptoms(PAWS)among male inpatients with alcohol dependence

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World Journal of Acupuncture-Moxibustion 2020年第2期30卷 90-96页

作者： Fei-yi ZHAO Yan XU Li-ping YUE Fang-lei CHEN Zhe-yuan ZHANG Hua-ling SONG Hong XU Guo-hua WANG qiang-qiang fu Department of Nursing School of International Medical TechnologyShanghai Sanda UniversityShanghai 201209China Haiyan People’s Hospital Haiyan 314300Zhejiang ProvinceChina College of Public Health Shanghai University of Traditional Chinese MedicineShanghai 201203China Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 200071China Research Department Yangpu HospitalTongji University School of MedicineShanghai 200090China

Objective:This study is conducted to investigate the effects differences of escitalopram with or without combined electroacupuncture(EA)among male inpatients with a diagnosis of alcohol dependence and comorbid protracted alcohol withdrawal symptoms(PAWS).Methods:A total of 62 participants who met the inclusion criteria were enrolled in a two-arm randomized,placebo controlled,patients-blind trial and allocated to an escitalopram with real-EA group(realEA group,patients=31)and an escitalopram with sham-EA group(sham-EA group,patients=31),*** addition to the oral administration of escitalopram for total four weeks,patients in each group received corresponding EA treatment five days per week and two days off for consecutive four *** serum homocysteine(Hcy)test and electrophysiological tests,including event-related potentials(ERPs)and exploratory eye movement(EEM)were performed at pre-and ***,the global scores of Penn Alcohol Craving Scale(PACS),17-items Hamilton Depression Rating Scale(HAMD-17),and Hamilton Anxiety Scale(HAMA)were used for assessing the subjective emotion experience of patients,***,adverse effects were monitored and ***:After four-week treatment,the global scores of PACS and HAMD-17 declined significantly in both groups(both Pfurthermore,the decline in the real-EA group was superior to that in the shamEA group(P0.05).According to the parameters of ERPs,significant declines for N2PL,P3PL,and P3amp were observed in both two groups(all P<0.05),and the decreases for P3PL and P3amp in the real-EA group was much superior to that in the sham-EA group(both P<0.05).According to the parameters of EEM,significant increase for NEF was observed only in the real-EA group(P<0.05).Besides,there was a dramatic decline for serum Hcy level only in the real-EA group(P<0.05).One

关键词： Alcohol dependence Protracted alcohol withdrawal symptoms(PAWS) Escitalopram Electroacupuncture

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页岩气地面集输工艺及配套技术探讨

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现代化工 2017年第1期37卷 206-208页

作者：张立强周强金福龙高晓雷方海波孟广伟中国石油管道局工程有限公司天津分公司天津300457 中国石油管道局工程有限公司河北廊坊065000

结合我国页岩气气田的现状,对开发地面集输工艺及配套技术进行了简要探讨,并对未来技术发展方向提出一些建议。

关键词：页岩气地面集输工艺配套技术技术开发

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急性心肌梗死相关线粒体基因的生物信息学鉴定与验证

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中国组织工程研究 2025年第31期29卷 6697-6707页

作者：田宇诗付强李冀黑龙江中医药大学基础医学院黑龙江省哈尔滨市150040 黑龙江中医药大学黑龙江省哈尔滨市150040

背景:线粒体在急性心肌梗死损伤和修复中具有重要意义,因此基于线粒体基因探索急性心肌梗死发病进展具有重要的临床意义。目的:探究线粒体基因是否可以作为评估急性心肌梗死进展的可靠生物标志物。方法:从高通量基因表达数据库下载急性... 详细信息

背景:线粒体在急性心肌梗死损伤和修复中具有重要意义,因此基于线粒体基因探索急性心肌梗死发病进展具有重要的临床意义。目的:探究线粒体基因是否可以作为评估急性心肌梗死进展的可靠生物标志物。方法:从高通量基因表达数据库下载急性心肌梗死数据集GSE66360,GSE12288,在线粒体蛋白质数据库获取人类线粒体基因集;对急性心肌梗死数据集GSE66360进行差异基因分析及加权基因共表达网络分析,两者取交集后获得基因进行蛋白质-蛋白质相互作用分析、基因本体论和京都基因与基因组百科全书分析;将交集基因与人类线粒体基因取交集以获得差异线粒体基因,对差异线粒体基因进行基因集富集分析和免疫浸润分析,并在外部数据集GSE12288中进行受试者工作特征曲线分析,验证线粒体差异基因的表达特征。结果与结论:①获得急性心肌梗死差异基因548个,差异基因分析及加权基因共表达网络分析显示Blue模块包含基因最多(4992个),二者交集基因共有116个,其中肿瘤坏死因子、白细胞介素1B、白细胞介素6、Toll样受体4和白细胞介素10为核心基因;②基因本体论分析显示生物过程主要涉及炎症反应、肿瘤坏死因子产生的正调控及细胞表面受体信号通路,细胞组成主要涉及三级颗粒膜、质膜外层和质膜等,分子功能主要涉及免疫球蛋白G结合、跨膜信号受体活性及趋化因子活性等,京都基因与基因组百科全书分析显示,这些基因主要涉及肿瘤坏死因子、白细胞介素17及核转录因子κB通路;③共获得8个差异线粒体基因,经过最小绝对收缩和选择算子和比例风险回归模型分析后筛选出4个特征基因,包括佛波醇-12-肉豆酸酯-13-乙酰基诱导蛋白1、BCL2-相关蛋白A1、溶质载体家族25成员37和脱氧核糖核酸聚合酶β,并分别对应了肿瘤蛋白53、氧化磷酸化、硫代谢及甘油磷脂代谢通路;④受试者工作特征曲线分析显示4个特征基因均具有诊断意义,并与静息树突状细胞、幼稚B细胞呈显著负相关性;⑤提示佛波醇-12-肉豆酸酯-13-乙酰基诱导蛋白1、BCL2-相关蛋白A1、溶质载体家族25成员37和脱氧核糖核酸聚合酶β表达特征可作为预测急性心肌梗死中线粒体功能的潜在生物标志物,可进一步提高急性心肌梗死预测的准确性。

关键词：线粒体急性心肌梗死生物信息学机器学习免疫浸润分析氧化应激炎症凋亡

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