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Dcalycinumines A-E,Alkaloids with Cytotoxic Activities of Nasopharyngeal Carcinoma Cells from Daphniphyllum calycinum

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Chinese Journal of Chemistry 2024年第1期42卷 35-42页

作者： Qing Tang Xiao-Yong Dai qiang lin Zhi-Peng ling Yi-Kun Hao Tian-Xi Zhu Ji-Hui Zhang Yi-Bo Hou Yao-Lan Li Lai-qiang Huang Jing-Hao Wang Guo-Cai Wang Yu-Bo Zhang Guangdong Clinical Translational Centerfor Targeted Drug Department of PharmacologySchoolof MedicineJinan University GuangzhouGuangdong 510632China Institute of Traditional Chinese Medicine&Natural Products Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchCollegeof PharmacyJinan UniversityGuangzhouGuangdong511443China Institute of Biopharmaceutical and Health Engineering Shenzhen Key Laboratory of Gene and Antibody TherapyState Key Laboratory of Chemical OncogenomicsShenzhen International Graduate SchoolTsinghua UniversityShenzhenGuangdong 518055China The Guangzhou Key Laboratoryof Basic and Translational Research on Chronic Disease Department of PharmacyThe First Affiliated HospitalJinan UniversityGuangzhouGuangdong 510630China

Fivenovel Daphniphyllum alkaloids,named dcalycinumines A-E(1-4,6),andeight previously described Daphniphyllum alkaloids(5,7-13)were isolated from Daphniphyllum calycinum.Compound 1 is the first Daphniphyllum alkaloid possessing a highly rearranged 6/6/6/7/5/6 hexacyclic architecture with a unique 3-methyl-1-azabicyclo[4,4,0]decane ring system.Compound 2 represents a rare diamino Daphniphyllum alkaloid with an unprecedented 6/5/5/6/6/5 carbon skeleton featuring a unique 1-aza-6-azaspiro[4,5]decane unit,whereas 3 also represents a rare diamino Daphniphyllum alkaloid as a possible precursor of 2.Compound 4 is the second example of c-22-nor yuzurimine-type alkaloids.Their structures and absolute configurations were elucidated by HRESIMS,NMR spectroscopic analyses,EcD calculations,and single-crystal X-ray diffraction.Moreover,compound 1 showed remarkable antitumor activities,which could inhibit the proliferation,migration and invasion of nasopharyngeal carcinoma cells,and promoted nasopharyngeal carcinoma cells apoptosis.

关键词： Daphniphyllum calycinum Natural products Daphniphyllum alkaloid Structural elucidation Biological activity Apoptosis Nasopharyngealcarcinoma

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Incorporating physiological knowledge into correlative species distribution models minimizes bias introduced by the choice of calibration area

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Marine Life Science & Technology 2024年第2期6卷 349-362页

作者： Zhixin Zhang Jinxin Zhou Jorge García Molinos Stefano Mammola Ákos Bede‑Fazekas Xiao Feng Daisuke Kitazawa Jorge Assis Tianlong Qiu qiang lin CAS Key Laboratory of Tropical Marine Bio-resources and Ecology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Guangdong Provincial Key Laboratory of Applied Marine Biology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Marine Biodiversity and Ecological Evolution Research Center South China Sea Institute of OceanologyGuangzhou 510301China Global Ocean and Climate Research Center South China Sea Institute of OceanologyGuangzhou 510301China Institute of Industrial Science The University of Tokyo5-1-5 KashiwanohaKashiwaChiba 277-8574Japan Arctic Research Center Hokkaido UniversitySapporoHokkaido 001-0021Japan Finnish Museum of Natural History University of HelsinkiHelsinkiFinland Molecular Ecology Group(MEG) Water Research Institute(IRSA)National Research Council of Italy(CNR)28922 Verbania PallanzaItaly National Biodiversity Future Center(NBFC) PalermoItaly Institute of Ecology and Botany HUN-REN Centre for Ecological ResearchVácrátótHungary Department of Environmental and Landscape Geography ELTE Eötvös Loránd UniversityBudapestHungary Department of Biology University of North CarolinaChapel HillNC 27599USA Centre of Marine Sciences University of AlgarveCampus de GambelasFaroPortugal CAS Key Laboratory of Experimental Marine Biology Institute of OceanologyChinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China

Correlative species distribution models(SDMs)are important tools to estimate species’geographic distribution across space and time,but their reliability heavily relies on the availability and quality of occurrence data.Estimations can be biased when occurrences do not fully represent the environmental requirement of a species.We tested to what extent species’physiological knowledge might influence SDM estimations.Focusing on the Japanese sea cucumber Apostichopus japonicus within the coastal ocean of East Asia,we compiled a comprehensive dataset of occurrence records.We then explored the importance of incorporating physiological knowledge into SDMs by calibrating two types of correlative SDMs:a naïve model that solely depends on environmental correlates,and a physiologically informed model that further incorporates physiological information as priors.We further tested the models’sensitivity to calibration area choices by fitting them with different buffered areas around known presences.Compared with naïve models,the physiologically informed models successfully captured the negative influence of high temperature on A.japonicus and were less sensitive to the choice of calibration area.The naïve models resulted in more optimistic prediction of the changes of potential distributions under climate change(i.e.,larger range expansion and less contraction)than the physiologically informed models.Our findings highlight benefits from incorporating physiological information into correlative SDMs,namely mitigating the uncertainties associated with the choice of calibration area.Given these promising features,we encourage future SDM studies to consider species physi-ological information where available.

关键词： Bayesian approach Climate change Habitat suitability Physiological knowledge Species distribution model

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Slc43a2^(+)T cell metastasis from spleen to brain in RGNNV infected teleost

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Science China(Life Sciences) 2024年第4期67卷 733-744页

作者： Qing Wang Yali Liu Minlin Zhang Min Yang Jiantao Liang Xiaoling Zuo Shaowen Wang Xianze Jia Huihong Zhao Han Jiang qiang lin Qiwei Qin College of Marine Sciences South China Agricultural UniversityGuangzhou 510642China CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Nansha-South China Agricultural University Fishery Research Institute Guangzhou 511457China Joint University Laboratory of Guangdong Province Hong Kong and Marco Region on Marine Bioresource Conservation and ExploitationGuangzhou 510642China University of Chinese Academy of Sciences Beijing 100101China

The origin of T cells in the teleost's brain is unclear.While viewing the central nervous system(CNS)as immune privileged has been widely accepted,previous studies suggest that T cells residing in the thymus but not in the spleen of the teleost play an essential role in communicating with the peripheral organs.Here,we identified nine T cell subpopulations in the thymus and spleen of orange-spotted grouper(Epinephelus coioices)through single-cell RNA-sequencing analysis.After viral CNS infection with red-spotted grouper nervous necrosis virus(RGNNV),the number of slc43a2^(+)T cells synchronously increased in the spleen and brain.During the infection tests in asplenic zebrafish(tlx1^▲zebrafish model),no increase in the number of slc43a2^(+)T cells was observed in the brain.Single-cell transcriptomic analysis indicated that slc43a2^(+)T cells mature and functionally differentiate within the spleen and then migrate into the brain to trigger an immune response.This study suggests a novel route for T cell migration from the spleen to the brain during viral infection in fish.

关键词： central nervous system slc43a2^(+)T cell RGNNV T cell migration teleost

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U-Net Based Dual-Pooling Segmentation of Bone Metastases in Thoracic SPECT Bone Scintigrams

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Journal of Computer and Communications 2024年第4期12卷 60-71页

作者： Yang He qiang lin Yongchun Cao Zhengxing Man Key Laboratory of China’ s Ethnic Languages and Information Technology of Ministry of Education Northwest Minzu University Lanzhou China School of Mathematics and Computer Science Northwest Minzu University Lanzhou China

In order to enhance the performance of the CNN-based segmentation models for bone metastases, this study proposes a segmentation method that integrates dual-pooling, DAC, and RMP modules. The network consists of distinct feature encoding and decoding stages, with dual-pooling modules employed in encoding stages to maintain the background information needed for bone scintigrams diagnosis. Both the DAC and RMP modules are utilized in the bottleneck layer to address the multi-scale problem of metastatic lesions. Experimental evaluations on 306 clinical SPECT data have demonstrated that the proposed method showcases a substantial improvement in both DSC and Recall scores by 3.28% and 6.55% compared the baseline. Exhaustive case studies illustrate the superiority of the methodology.

关键词： Tumor Bone Metastasis Bone Scintigram Lesion Segmentation CNN Dual Pooling

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Slc43a2T cell metastasis from spleen to brain in RGNNV infected teleost

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Science China Life Sciences 2024年

作者： Qing Wang Yali Liu Minlin Zhang Min Yang Jiantao Liang Xiaoling Zuo Shaowen Wang Xianze Jia Huihong Zhao Han Jiang qiang lin Qiwei Qin CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology South China Sea Institute of Oceanology Chinese Academy of Sciences College of Marine Sciences South China Agricultural University Nansha-South China Agricultural University Fishery Research Institute 3. Joint University Laboratory of Guangdong Province Hong Kong and Marco Region on Marine Bioresource Conservation and Exploitation University of Chinese Academy of Sciences

The origin of T cells in the teleost’s brain is unclear. While viewing the central nervous system(CNS) as immune privileged has been widely accepted, previous studies suggest that T cells residing in the thymus but not in the spleen of the teleost play an essential role in communicating with the peripheral organs. Here, we identified nine T cell subpopulations in the thymus and spleen of orange-spotted grouper(Epinephelus coioices) through single-cell RNA-sequencing analysis. After viral CNS infection with red-spotted grouper nervous necrosis virus(RGNNV), the number of slc43a2+T cells synchronously increased in the spleen and brain. During the infection tests in asplenic zebrafish(tlx1▲zebrafish model), no increase in the number of slc43a2+T cells was observed in the brain. Single-cell transcriptomic analysis indicated that slc43a2+T cells mature and functionally differentiate within the spleen and then migrate into the brain to trigger an immune response. This study suggests a novel route for T cell migration from the spleen to the brain during viral infection in fish.

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Recent Advances in Pd-Catalyzed Reactions Involving the “On-Water” Mechanism

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Chinese Journal of Chemistry 2024年第5期42卷 533-542页

作者： Dong Wei Guo-qiang lin State Key Laboratory of Systems Medicine for Cancer Shanghai Cancer InstituteShanghai Key Laboratory of Systems Regulation and Clinical Translation for CancerRen Ji HospitalShanghai Jiao Tong University School of MedicineShanghai200127 China State Key Laboratory of Chemical Biology Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai200032 China

As the chemical industry grapples with the need for more eco-friendly practices,the use of water as a reaction medium is gaining attraction in organic transformations.This mini-review delves into Pd-catalyzed reactions that utilize the "on-water" mechanism,spanning from 2019 to late 2023.These reactions are neatly categorized into several types: (A) Catalytic C—H activations,(B) Mizoroki- Heck-type reactions,(C) Suzuki-Miyaura reactions,and (D) Cyclization reactions.By showcasing the potential of water as a sustainable reaction medium for organic transformations,these reactions leave no doubt about the importance of embracing eco-friendly practices in the chemical industry.Key Scientists In 1980,a seminal work by Breslow et al.showed an acceleration of reaction rate in the Diels-Alder reaction.Sharpless and co-workers noted a significant increase in the rate of the [2σ+2σ+2π] cycloaddition of quadricyclane and dimethyl azodicarboxylate (DMAD) when the reaction was conducted in water,as opposed to when it was carried out in organic solvents.The term "on-water" was then coined to describe this phenomenon.This strategy was further expanded to transition-metal catalyzed transformations by Ackermann in 2011.Later,Varma and Leazer disclosed a Pd-catalyzed Mizoroki-Heck type arylation of alkenes with diaryliodonium salts “on-water”.The enantioselective version of "on-water" process was not realized until 2014 by the Zhou group.Later on,the Schaub group described a Pd-catalyzed Suzuki–Miyaura coupling reaction of electron-poor aryl chlorides with water,using only 50 ppm of catalyst loading.Very recently,Liu and lin extended the "on-water" strategy to Pd-catalyzed double Mizoroki-Heck reactions.This mini-review has focused on Pd-catalyzed reactions involving the “on-water” mechanism.

关键词： Pd-catalyzed “On-water” Green chemistry Aqueous reactions Mechanism Methodology and reactions Mizoroki-Heck reaction Cross-coupling

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Horizontal Mergers between Asymmetric Low-Carbon Manufacturers

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Journal of Systems Science and Systems Engineering 2022年第5期31卷 619-647页

作者： Xiaogang lin Kangning Jin Wenhui Fu qiang lin School of Management Guangdong University of Technology Guangzhou 510520China School of Economics and Management South China Normal UniversityGuangzhou 510006China

Mergers have become an important means for low-carbon manufacturers to improve their efficiency and competitiveness.This paper studies the impact of horizontal mergers between asymmetric low-carbon manufacturers on product diversity,profits,consumer surplus,and the environment.In the premerger model,we consider two asymmetric manufacturers in terms of market potential that produce two products and compete on prices and carbon emissions.In the postmerger model,the two asymmetric manufacturers merge into one firm.The merged manufacturer can either continue to produce two products and collude on both products'prices and carbon emissions or enjoy both production and green technology investment cost savings to produce only one product.Our result suggests that when the merged manufacturer produces two products,the merger does not necessarily lead to higher prices,which stands in sharp contrast to the conventional wisdom.Furthermore,the merger always benefits the manufacturer but harms consumers.When the merged manufacturer chooses to produce only one product,however,we confirm that the merger can lead to a win-win-win outcome,i.e.,the manufacturer,customers,and environment all become better off if either the production or investment savings are salient.The conventional wisdom shows that salient costing savings lead to price reduction.Nevertheless,we show that the merged manufacturer can charge consumers higher prices to provide lower-emission products.In addition,we show that improving investment(production)cost savings is more effective for the merged manufacturer if these two cost savings are salient(not salient).Finally,the merged manufacturer should not reduce diversity if these two cost savings are relatively low because the profit and consumer surplus may be simultaneously lower.We also extend our base model to the case where there exist three manufacturers in the premerger model and the merged firm still operates in a competitive market.

关键词： Game theory asymmetric horizontal merger low-carbon manufacturing price and emission collusions productionand investmentcost synergies

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Evolutionary traits and functional roles of chemokines and their receptors in the male pregnancy of the Syngnathidae

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Marine Life Science & Technology 2023年第4期5卷 500-510页

作者： Han Jiang Zhanwei Zhao Haiyan Yu qiang lin Yali Liu CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Guangdong Provincial Key Laboratory of Applied Marine Biology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China University of Chinese Academy of Sciences Beijing 101400China

Vertebrates have developed various modes of reproduction,some of which are found in Teleosts.Over 300 species of the Syngnathidae(seahorses,pipefishes and seadragons)exhibit male pregnancies;the males have specialized brood pouches that provide immune protection,nourishment,and oxygen regulation.Chemokines play a vital role at the mammalian maternal–fetal interface;however,their functions in fish reproduction are unclear.This study revealed the evolutionary traits and potential functions of chemokine genes in 22 oviparous,ovoviviparous,and viviparous fish species through comparative genomic analyses.Our results showed that chemokine gene copy numbers and evolutionary rates vary among species with different modes of reproduction.Syngnathidae lost cxcl13 and cxcr5,which are involved in key receptor–ligand pairs for lymphoid organ development.Notably,Syngnathidae have site-specific mutations in cxcl12b and ccl44,suggesting immune function during gestation.Moreover,transcriptome analysis revealed that chemokine gene expression varies among Syngnathidae species with different types of brood pouches,suggesting adaptive variations in chemokine functions among seahorses and their relatives.Furthermore,challenge experiments on seahorse brood pouches revealed a joint immune function of chemokine genes during male pregnancy.This study provides insights into the evolutionary diversity of chemokine genes associated with different reproductive modes in fish.

关键词： Reproductive mode Immune response Seahorse Brood pouch

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Few-shot Named Entity Recognition with Joint Token and Sentence Awareness

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Data Intelligence 2023年第3期5卷 767-785页

作者： Wen Wen Yongbin Liu qiang lin Chunping Ouyang Computer School University of South ChinaChina Hunan provincial base for scientific and technological innovation cooperation HunanChina

Few-shot learning has been proposed and rapidly emerging as a viable means for completing various tasks.Recently,few-shot models have been used for Named Entity Recognition(NER).Prototypical network shows high efficiency on few-shot NER.However,existing prototypical methods only consider the similarity of tokens in query sets and support sets and ignore the semantic similarity among the sentences which contain these entities.We present a novel model,Few-shot Named Entity Recognition with Joint Token and Sentence Awareness(JTSA),to address the issue.The sentence awareness is introduced to probe the semantic similarity among the sentences.The Token awareness is used to explore the similarity of the tokens.To further improve the robustness and results of the model,we adopt the joint learning scheme on the few-shot NER.Experimental results demonstrate that our model outperforms state-of-the-art models on two standard Fewshot NER datasets.

关键词： Few-shot Learning Named Entity Recognition Prototypical Network

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Three Heads Better than One:Pure Entity,Relation Label and Adversarial Training for Cross-domain Few-shot Relation Extraction

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Data Intelligence 2023年第3期5卷 807-823页

作者： Wenlong Fang Chunping Ouyang qiang lin Yue Yuan School of Computer University of South ChinaHengyangHunan421001China

In this paper,we study cross-domain relation extraction.Since new data mapping to feature spaces always differs from the previously seen data due to a domain shif,few-shot relation extraction often perform poorly.To solve the problems caused by cross-domain,we propose a method for combining the pure entity,relation labels and adversarial(PERLA).We first use entities and complete sentences for separate encoding to obtain context-independent entity features.Then,we combine relation labels which are useful for relation extraction to mitigate context noise.We combine adversarial to reduce the noise caused by cross-domain.We conducted experiments on the publicly available cross-domain relation extraction dataset Fewrel 2.o[1]o,and the results show that our approach improves accuracy and has better transferability for better adaptation to cross-domain tasks.

关键词： Cross-domain Adversarial Learning Prototypical Networks Pure eatity Relation label Meta-learning

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