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Helicobacter pylori intragastric colonization and migration:Endoscopic manifestations and potential mechanisms

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World Journal of Gastroenterology 2023年第30期29卷 4616-4627页

作者： Tong Mu Zhi-Ming Lu Wen-Wen Wang Hua Feng Yan Jin qian Ding li-Fen Wang Department of Gastroenterology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Clinical Laboratory Medicine Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina

After being ingested and entering the human stomach,Helicobacter pylori(***)adopts several effective strategies to adhere to and colonize the gastric mucosa and move to different regions of the stomach to obtain more nutrients and escape from the harsher environments of the stomach,leading to acute infection and chronic gastritis,which is the basis of malignant gastric *** endoscopic manifestations and pathological features of *** infection are diverse and vary with the duration of *** this review,we describe the endoscopic manifestations of each stage of *** gastritis and then reveal the potential mechanisms of bacterial intragastric colonization and migration from the perspective of endoscopists to provide direction for future research on the effective therapy and management of *** infection.

关键词： Helicobacter pylori Colonization Endoscopy Gastritis Infection

Circulating copeptin level and the clinical prognosis of patients with chronic liver disease

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世界胃肠病学杂志:英文版 2023年第31期29卷 4797-4808页

作者： Hao-qian Tan Ming Zhao Zan Huang Yang liu Han li Long-Hui Ma Jun-Ying liu Department of Gastroenterology Zhoukou Central Hospital Affiliated to Xinxiang Medical UniversityZhoukou 466000Henan ProvinceChina Department of Gastroenterology Zhoukou Central HospitalZhoukou 466000Henan ProvinceChina Department of Teaching and Research Zhoukou Central HospitalZhoukou 466000Henan ProvinceChina

BACKGROUND The relationship between copeptin and the severity of circulatory dysfunction and systemic stress response in patients with chronic liver disease(CLD)has been ***,the potential of serum copeptin levels to predict the prognosis of CLD patients remains *** To conduct a systematic review and meta-analysis to investigate the correlation between serum copeptin and transplant-free survival(TFS)in this *** To achieve the objective of the meta-analysis,PubMed,Embase,the Cochrane library,and the Web of Science were searched to identify observational studies with longitudinal *** Cochrane Q test was utilized to assess betweenstudy heterogeneity,and the I2 statistic was ***-effects models were employed to combine the outcomes,taking into account the potential influence of *** Ten datasets including 3133 patients were *** follow-up durations were 1 to 48 mo(mean:12.5 mo).Overall,it was shown that a high level of serum copeptin was associated with a poor TFS[risk ratio(RR):1.82,95%confidence interval:1.52-2.19,Plity score also showed similar results(P for subgroup difference all>0.05).CONCLUSION Patients with CLD who have high serum copeptin concentrations may be associated with a poor clinical prognosis.

关键词： Chronic liver disease liver cirrhosis Copeptin Prognosis Mortality Meta-analysis

转化生长因子-β受体Ⅱ环状RNA通过调节核糖核酸结合蛋白2/胚胎致死性异常视觉样蛋白1促进前列腺癌发生发展

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中华实验外科杂志 2024年第2期41卷 286-290页

作者：杜蕾李谦马子越常学良齐进春薛文勇河北医科大学第二医院泌尿外科石家庄050000

目的探讨前列腺癌细胞中转化生长因子-β受体Ⅱ环状RNA(circTGFBR2)调节核糖核酸结合蛋白2(PTBP2)/胚胎致死性异常视觉样蛋白1(ELAVL1)激活SMAD2信号途径促进前列腺癌发生发展。方法利用生物信息学方法, 寻找与circTGFBR2结合microRNA... 详细信息

目的探讨前列腺癌细胞中转化生长因子-β受体Ⅱ环状RNA(circTGFBR2)调节核糖核酸结合蛋白2(PTBP2)/胚胎致死性异常视觉样蛋白1(ELAVL1)激活SMAD2信号途径促进前列腺癌发生发展。方法利用生物信息学方法, 寻找与circTGFBR2结合microRNA以及其他相关蛋白结合位点, 以及与PTBP2存在相互作用的RNA结合蛋白。PC3转染pcDNA3.1-circTGFBR2后, 实时定量反转录聚合酶链反应(RT-qPCR)检测circTGFBR2的表达。PC3细胞过表达circTGFBR2同时敲低微小RNA(microRNA, miR)-29b, 蛋白质印迹法(Western blot)检测ALK5、SMAD2及p-SMAD2表达。PC3分别转染pcDNA3.1-circTGFBR2及对照质粒后, 利用circTGFBR2特异性探针进行pulldown, 检测PTBP2与circTGFBR2的相互作用。过表达circTGFBR2与ELAVL1, 检测细胞上皮-间充质转化(EMT)的标志基因E-钙黏蛋白(E-cadherin)、波形蛋白(Vimentin)及ZMYM1表达, 以及Transwell检测细胞迁移。组间比较应用单因素方差分析。结果分析结果显示circTGFBR2存在多个miR-29b结合的位点, ALK5(又名TGFBR1)mRNA 3’端非编码区(3’UTR)同样存在miR-29b的结合位点, 并证实PTBP2与另一个RNA结合蛋白ELAVL1存在相互作用。用转化生长因子-β1(TGF-β1)刺激PC3细胞发现, circTGFBR2的表达高于对照组(1.83±0.02比1.03±0.02, F=2 832.200, P<0.01)。PC3分别转染pcDNA3.1-circTGFBR2及对照质粒后, RT-qPCR检测circTGFBR2的表达, 可见circTGFBR2组高于对照组(176.41±1.21比1.04±0.02, F=63 426.15, P<0.01)。应用miR-29b抑制剂或circTGFBR2处理细胞后ALK5的蛋白水平明显高于对照组, 应用miR-29b抑制剂同时过表达circTGFBR2后进一步增加ALK5的表达(分别为0.15±0.01、0.48±0.02、0.55±0.01、0.74±0.01, F=1268.314, P<0.01), 并且SMAD2(分别为1.14±0.02、1.28±0.02、1.42±0.01、1.5±0.25, F=4.852, P<0.01)和p-SMAD2(分别为0.18±0.02、0.36±0.01、0.65±0.01、0.94±0.02, F=1663.667, P<0.01)的磷酸化水平也呈相同趋势。Pulldown-MS实验, 多个蛋白质能与circTGFBR2结合, 并证实PTBP2与circTGFBR2相互作用。与对照组比较, 敲低前列腺癌细胞PTBP2或过表达circTGFBR2时, 间质标志基因Vimentin表达高于对照组, 而上皮样标志基因E-cadherin表达低于对照组, 当同时过表达circTGFBR2并敲低PTBP2会逆转上述结果(Vimentin分别为0.22±0.02、0.87±0.02、0.85±0.02、0.6±0.01, F=1319.52, P<0.01;E-cadherin分别为0.80±0.01、0.45±0.03、0.36±0.02、0.9±0.02, F=614.919, P<0.01)。当过表达circTGFBR2或高表达ELAVL1时, PTBP2与ELAVL1的相互作用减弱, 细胞EMT的标志基因E-cadherin表达低于对照组, Vimentin及ZMYM1表达高于对照组, Transwell检测细胞迁移高于对照组, 而当同时高表达ELAVL1及circTGFBR2时, 上述趋势会进一步增强(Vimentin分别为0.22±0.02、0.87±0.02、0.85±0.02、0.6±0.01, F=1 319.52, P<0.01;E-cadherin分别为0.93±0.02、0.76±0.02、0.43±0.02、0.27±0.01, F=1 108.46, P<0.01;ZMYM1分别为0.24±0.01、0.53±0.02、0.32±0.01、1.04±0.02, F=2 023.794, P<0.01)。结论 circTGFBR2通过调节PTBP2/ELAVL1激活SMAD2信号途径促进前列腺癌发生发展。

关键词：转化生长因子-β受体Ⅱ环状RNA 前列腺癌核糖核酸结合蛋白2 胚胎致死性异常视觉样蛋白1

P2X7 Receptor in Alcoholic Steatohepatitis and Alcoholic liver Fibrosis

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Journal of Clinical and Translational Hepatology 2022年第6期10卷 1205-1212页

作者： Guo-Qing Xia qian Fang Jun-Nan Cai Zi-Xuan li Feng-Zhi Zhang Xiong-Wen Lv Institute for liver Diseases of Anhui Medical University HefeiAnhuiChina The Key Laboratory of Anti-inflammatory and Immune Medicines Ministry of EducationHefeiAnhuiChina Inflammation and Immune-Mediated Diseases Laboratory of Anhui Province Anhui Institute of Innovative DrugsSchool of PharmacyAnhui Medical UniversityHefeiAnhuiChina Wannan Medical College Yijishan HospitalAffiliated Hospital 1WuhuAnhuiChina

Alcoholic liver disease is one of the most common chronic liver diseases in the *** is a liver disease caused by prolonged heavy drinking and its main clinical features are nausea,vomiting,enlargement of the liver,and *** studies suggest that Kupffer cell-mediated inflam-matory response is a core driver in the development of alco-holic steatohepatitis and alcoholic liver *** a danger signal,extracellular ATP activates the assembly of NLPR3 inflammasome by acting on purine P2X7 receptor,the ac-tivated NLRP3 inflammasome prompts ASC to cleave pro-cCaspase-1 into active caspase-1in *** caspase-1 promotes the conversion of pro-IL-1βto IL-1β,which fur-ther enhances the inflammatory ***,we briefly review the role of the P2X7R-NLRP3 inflammasome axis in the pathogenesis of alcoholic liver disease and the evolution of alcoholic steatohepatitis and alcoholic liver ***-ulation of the inflammasome axis of P2X7R-NLRP3 may be a new approach for the treatment of alcoholic liver disease.

关键词： ATP P2X7 receptor Kupffer cells NLRP3 inflammasome Alcoholic steatohepatitis Alcoholic liver fibrosis

新冠疫情流行期间COVID-19感染与诱发皮肤病的关联

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中华医院感染学杂志 2024年第11期34卷 1720-1724页

作者：陈思珏曹炜肖显俊石云舟邹子豪杨茜陈明岭李瑛成都中医药大学针灸推拿学院四川成都610075 四川省中医院皮肤科四川成都610075 成都中医药大学养生康复学院四川成都610075

目的评估新冠病毒感染期间出现的皮肤病,确定与之相关的风险因素.方法通过"易表达"网页发放、回收问卷,收集人口统计学、基础病史和新冠病毒病史等信息.结果在1047份问卷中,有827份纳入分析,性别、慢性病史和年龄与新冠病毒期间的皮肤... 详细信息

目的评估新冠病毒感染期间出现的皮肤病,确定与之相关的风险因素.方法通过"易表达"网页发放、回收问卷,收集人口统计学、基础病史和新冠病毒病史等信息.结果在1047份问卷中,有827份纳入分析,性别、慢性病史和年龄与新冠病毒期间的皮肤病无关;在多元逻辑分析中,有皮肤病史的受试者在感染新冠病毒期间出现皮肤病的概率是无皮肤病史的3.998倍(OR=3.998,95%CI:2.234~7.157),其中有疱疹病史的受试者出现皮肤病的概率是4.434倍(OR=4.434,95%CI:1.277~15.403),而荨麻疹史的受试者出现皮肤病的概率高达4.907倍(OR=4.907,95%CI:2.755~8.740);过敏史也是感染新冠病毒期间出现皮肤病的危险因素,有过敏史的患者出现皮肤病的概率是无过敏史的1.807倍(CR=1.807,95%CI:1.049~3.113).结论过敏史和皮肤病史是感染新冠病毒期间出现皮肤病的危险因素,尤其是荨麻疹和疱疹史,在感染SARS-CoV-2期间应注意可能出现皮肤病.

关键词：新冠病毒感染慢性疾病过敏史皮肤病史皮肤病

Meta-analysis of randomized trials comparing the effectiveness of on-pump and off-pump coronary artery bypass

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Chinese Medical Journal 2012年第2期125卷 338-344页

作者： Chen Yong-bing Shu Jian Yang Wen-tao Shi li Guo Xu-feng Wang Fei-ge qian Yong-yue Soochow Univ Affiliated Hosp 2 Dept Cardiothorac Surg Suzhou 215004 Jiangsu Peoples R China

Background The growing enthusiasm for coronary artery bypass grafting （CABG） without cardiopulmonary bypass （CPB） is emerging,but the role of off-pump coronary artery bypass （OPCAB） in clinical practice remains *** purpose of this study was to assess differences in the incidences of stroke,atrial fibrillation （AF）,and myocardial infarction （MI） between OPCAB and conventional coronary artery bypass grafting （CCABG） by meta-analyses of randomized clinical *** A literature search for the period before March 2010 supplemented with manual bibliographic review was performed for all Chinese or English publications in Medline,the Science Citation Index Expanded,the Cochrane Central Register of Controlled Trials （CENTRAL） and CBMdisc.A systematic overview （meta-analyses） of randomized clinical trials was conducted to evaluate the differences between OPCAB and CCABG in the incidences of stroke,AF,and *** meta-analysis was performed using RevMan 5 *** Forty-three randomized clinical trials were selected for meta-analysis after screening a total of 356 references,with 8104 patients in the OPCAB group and 8724 cases in the CCABG *** meta-analyses of these trials showed no significant difference between OPCAB and CCABG in the incidences of stroke （odds ratio （OR）=0.80,95% confidence interval （CI）=0.52-1.22,P=0.30） and MI （OR=0.73,95%CI=0.52-1.02,P=0.06）.However,we found a significantly reduced risk of AF （OR=0.65,95%CI =0.52-0.82,P=0.0002）in off-pump *** Our meta-analyses suggest that OPCAB reduces the risk of postoperative AF compared with CCABG,but there is no significant difference in the incidences of stroke and MI between OPCAB and CCABG.

关键词： coronary artery bypass grafting off pump stroke atrial fibrillation myocardial infarction randomized clinical trials

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中西医结合呼吸康复学教学探索与实践

中医教育 2024年第2期43卷 110-113页

作者：蔡倩蔡书宾张溪陈剑坤荆纯祥李际强广州中医药大学第二附属医院广州510006 广州中医药大学体育健康学院广州510006

中医康复是呼吸康复医学的重要组成部分,其独特的医学理论与现代康复医学相辅相成。康复的发展离不开人才的培养,而人才的培养离不开教育。根据《中西医结合呼吸康复学》《中医肺康复学》的编写经验、结合广州中医药大学中西医结合呼吸... 详细信息

中医康复是呼吸康复医学的重要组成部分,其独特的医学理论与现代康复医学相辅相成。康复的发展离不开人才的培养,而人才的培养离不开教育。根据《中西医结合呼吸康复学》《中医肺康复学》的编写经验、结合广州中医药大学中西医结合呼吸康复学课程的教学实践及临床经验,深入探讨如何更有效地推进中西医结合呼吸康复学的教学工作,以期培养出更多具备专业素养和实践能力的康复专业优秀人才。

关键词：中西医结合呼吸康复肺康复教学研究

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Numerical study on the characteristics of natural supercavitation by planar symmetric wedge-shaped cavitators for rotational supercavitating evaporator

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Science China(Technological Sciences) 2015年第6期58卷 1072-1083页

作者： ZHENG ZhiYing li FengChen li qian KULAGIN Vladimir A School of Energy Science and Engineering Harbin Institute of Technology Department of Heat Technology and Fluid Dynamics Siberian Federal University

With the application of supercavitation effect, a novel device named rotational supercavitating evaporator(RSCE) was recently designed for desalination. In order to improve the blade shape of rotational cavitator in RSCE for performance optimization and then design three-dimensional blades, numerical simulations are conducted on the supercavitating flows(with cavitation number ranging from 0.055 to 0.315) around two-dimensional planar symmetric wedge-shaped cavitators with different wedge angles varied from 10 to 180 degrees. Proper numerical method for simulating supercavitating flows around planar symmetric cavitator is established, and assessment of k-ε-v2 -f turbulence model in simulating cavitating flows is conducted. It shows that the size of computational domain would affect the simulation result. Empirical formulae for supercavity dimensions about cavitation number at different wedge angles are obtained, which are of significant importance in the subsequent design of three-dimensional blade. The characteristics of resistance at different wedge angles are discussed, which, together with the characteristics of supercavity dimensions, play important roles in the optimal design of RSCE.

关键词：旋转蒸发器数值研究超空泡面对称特征楔形优化再设计数值模拟

Network pharmacology and molecular docking-based analyses to predict the potential mechanism of Huangqin decoction in treating colorectal cancer

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World Journal of Clinical Cases 2023年第19期11卷 4553-4566页

作者： Ying-Jie li Dong-Xin Tang Hong-Ting Yan bing Yang Zhu Yang Feng-Xi Long Guizhou University of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyang 550005Guizhou ProvinceChina Digestive Department The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang 550001Guizhou ProvinceChina Guizhou University of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyang 550001Guizhou ProvinceChina Guizhou University of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGui Yang 550001Guizhou ProvinceChina

BACKGROUND To analyze the potential action mechanism of Huangqin decoction(HQD)in colorectal cancer(CRC)treatment on the basis of network pharmacology and molecular *** To investigate the molecular mechanisms of HQD for CRC treatment by using network pharmacology and molecular *** All HQD active ingredients were searched using the Systematic Pharmacology and Traditional Chinese Medicine Systems Pharmacology databases and the Bioinformatics Analysis Tool for Molecular Mechanisms in traditional Chinese ***,the targets of the active ingredients were *** abbreviations of protein targets were obtained from the UniProt database.A“drug–compound–target”network was constructed to screen for some main active *** targets related to the therapeutic effect of CRC were obtained from the GeneCards,DisGeNET,Therapeutic Target Database,and Online Mendelian Inheritance in Man *** intersection of targets of Chinese herbs and CRC was taken.A Venn diagram was drawn to construct the intersection target interactions network by referring to the STRING *** analysis of the protein interaction network was performed using Cytoscape 3.7.2 software to screen the core HQD targets for *** core targets were imported into the DAVID 6.8 analysis website for gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses and ***,molecular docking was performed using AutoDockTool and PyMOL for *** In total,280 potential drug-active ingredients were present in HQD,including 1474 targets of the drug-active *** main active ingredients identified were betulin,tetrahydropalmatine,and *** total,10249 CRC-related targets and 1014 drug-disease intersecting targets were identified,including 28 core targets of action such as Jun proto-oncogene,AP-1 transcription factor subunit,signal transducer and activator of transcription 3,tumor protein p53,vascular endothelia

关键词： Huangqin decoction Colorectal cancer Network pharmacology