P2X7 Receptor in Alcoholic Steatohepatitis and Alcoholic Liver Fibrosis
作者机构：Institute for Liver Diseases of Anhui Medical UniversityHefeiAnhuiChina The Key Laboratory of Anti-inflammatory and Immune MedicinesMinistry of EducationHefeiAnhuiChina Inflammation and Immune-Mediated Diseases Laboratory of Anhui ProvinceAnhui Institute of Innovative DrugsSchool of PharmacyAnhui Medical UniversityHefeiAnhuiChina Wannan Medical CollegeYijishan HospitalAffiliated Hospital 1WuhuAnhuiChina
出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)
年 卷 期：2022年第10卷第6期
页 面：1205-1212页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：the National Natural Science Foundation of China(Grant No.81270498) the National Natural Science Foundation of China(Grant No.81970518)
主 题：ATP P2X7 receptor Kupffer cells NLRP3 inflammasome Alcoholic steatohepatitis Alcoholic liver fibrosis
摘 要：Alcoholic liver disease is one of the most common chronic liver diseases in the *** is a liver disease caused by prolonged heavy drinking and its main clinical features are nausea,vomiting,enlargement of the liver,and *** studies suggest that Kupffer cell-mediated inflam-matory response is a core driver in the development of alco-holic steatohepatitis and alcoholic liver *** a danger signal,extracellular ATP activates the assembly of NLPR3 inflammasome by acting on purine P2X7 receptor,the ac-tivated NLRP3 inflammasome prompts ASC to cleave pro-cCaspase-1 into active caspase-1in *** caspase-1 promotes the conversion of pro-IL-1βto IL-1β,which fur-ther enhances the inflammatory ***,we briefly review the role of the P2X7R-NLRP3 inflammasome axis in the pathogenesis of alcoholic liver disease and the evolution of alcoholic steatohepatitis and alcoholic liver ***-ulation of the inflammasome axis of P2X7R-NLRP3 may be a new approach for the treatment of alcoholic liver disease.
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