检索结果-南通市图书馆

Chimera states in Gaussian coupled map lattices

在线全文

学校读者我要写书评

暂无评论

Frontiers of physics 2018年第2期13卷 39-42页

作者： Xiao-Wen Li Ran Bi Yue-Xiang Sun Shuo Zhang qian-qian song Department of Physics Beijing Normal University Beijing 100875 China

We study chimera states in one-dimensional and two-dimensional Gaussian coupled map lattices through simulations and experiments. Similar to the case of global coupling oscillators, individual lattices can be regarded as being controlled by a common mean field. A space-dependent order pa- rameter is derived from a self-consistency condition in order to represent the collective state.

关键词： chimera state coupled map lattices nonlocal coupling

TRIPLET combined with microwave ablation:A novel treatment for advanced hepatocellular carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2025年第1期17卷 10-12页

作者： Fei-Yu Zhao Guo-Wei Si Nian-song qian Department of Thoracic Oncology Respiratory and Critical Care MedicineThe Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology Fourth Medical CentreGeneral Hospital of the People's Liberation ArmyBeijing 100142China Senior Department of Thoracic Oncology Respiratory and Critical Care MedicineThe Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100091China

This editorial comments on a study by Zuo et *** focus is on the efficacy of he-patic arterial infusion chemotherapy combined with camrelizumab and apatinib(the TRIPLET regimen),alongside microwave ablation therapy,in treating advanced hepatocellular carcinoma(HCC).The potential application of this combination therapy for patients with advanced HCC is evaluated.

关键词： Microwave ablation Hepatic arterial infusion chemotherapy Apatinib Camrelizumab Hepatocellular carcinoma

Sn-20Bi-xCu-yIn焊料在3.5%NaCl溶液中的腐蚀特性

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transactions of Nonferrous Metals Society of China 2023年第6期33卷 1827-1838页

作者：祁达杨文超蒋仕伟傅耀坤宋浅浅湛永钟广西大学资源环境与材料学院南宁530004 省部共建特色金属与组合结构全寿命安全国家重点实验室南宁530004 有色金属及材料加工新技术教育部重点实验室南宁530004

研究室温条件下Sn-20Bi-xCu-yIn(x=0.3%,0.5%,质量分数;y=1%,2%,3%,质量分数)合金在3.5%(质量分数)NaCl溶液中的腐蚀行为。采用电化学阻抗谱图(EIS)、动电位极化曲线和表面腐蚀产物表征研究焊料的耐腐蚀性能。EIS和极化曲线结果表明,随... 详细信息

研究室温条件下Sn-20Bi-xCu-yIn(x=0.3%,0.5%,质量分数;y=1%,2%,3%,质量分数)合金在3.5%(质量分数)NaCl溶液中的腐蚀行为。采用电化学阻抗谱图(EIS)、动电位极化曲线和表面腐蚀产物表征研究焊料的耐腐蚀性能。EIS和极化曲线结果表明,随着In和Cu含量的增加,焊料的耐腐蚀性能降低。采用扫描电镜、能量色散光谱、X射线衍射和X射线光电子能谱对腐蚀产物进行表征。腐蚀产物Sn_(3)O(OH)_(2)Cl_(2)结构松散,不能起到保护作用。Sn-20Bi-0.3Cu-1In的耐腐蚀性能最好。

关键词：无铅焊料腐蚀行为电化学阻抗谱极化曲线 Sn_(3)O(OH)_(2)Cl_(2)

在线全文

学校读者我要写书评

暂无评论

植物病理学领域蛋白乙酰化修饰研究进展

生物技术通报 2018年第2期34卷 96-101页

作者：郭倩倩杨倩倩宋丽敏梁文星青岛农业大学植物医学学院青岛266109

蛋白质乙酰化是一种普遍存在于真核与原核生物中且可逆的翻译后修饰方式,由乙酰基转移酶和去乙酰化酶共同调控,参与了转录、新陈代谢、细胞信号转导、细胞凋亡等多个生物学过程。随着检测技术的不断发展,目前已发现了大量的组蛋白及非... 详细信息

蛋白质乙酰化是一种普遍存在于真核与原核生物中且可逆的翻译后修饰方式,由乙酰基转移酶和去乙酰化酶共同调控,参与了转录、新陈代谢、细胞信号转导、细胞凋亡等多个生物学过程。随着检测技术的不断发展,目前已发现了大量的组蛋白及非组蛋白的乙酰化修饰,对其功能的研究也取得一定的进展。本文从乙酰化修饰研究进程出发,对植物病理学领域,包括植物抗病相关过程、植物病原菌和生防菌三个方面的乙酰化研究进展进行总结归纳,并对今后乙酰化修饰研究所需解决的问题进行了展望和讨论。

关键词：蛋白质乙酰化修饰组蛋白乙酰化植物病原菌生防菌

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

在线全文

学校读者我要写书评

暂无评论

Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei song Zheng-Zhi Wu qian-qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

西伯利亚鲟Sox9基因cDNA全长克隆、序列分析及其表达检测

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

水产学报 2010年第5期34卷 664-672页

作者：施志仪程千千宋佳坤轩兴荣上海海洋大学水产与生命科学学院

为了研究Sox9基因在西伯利亚鲟侧线神经发育过程当中所起的调控作用,本研究利用RT-PCR和RACE方法获得了西伯利亚鲟Sox9基因cDNA全长序列,经序列分析表明,所克隆Sox9cDNA全长为1409bp,包括开放阅读框(open reading frame,ORF)1083bp,5′... 详细信息

为了研究Sox9基因在西伯利亚鲟侧线神经发育过程当中所起的调控作用,本研究利用RT-PCR和RACE方法获得了西伯利亚鲟Sox9基因cDNA全长序列,经序列分析表明,所克隆Sox9cDNA全长为1409bp,包括开放阅读框(open reading frame,ORF)1083bp,5′端非翻译区(untranslate dregion,UTR)19bp和3′端非翻译区(untranslate dregion,UTR)307bp。1083bp的ORF共编码360个氨基酸,相对分子质量为41221.7U。序列分析表明,其与施氏鲟的亲缘关系较近,其次是斑马鱼。经实时荧光定量PCR技术对西伯利亚鲟Sox9基因在各组织以及在胚胎发育各时期中的相对表达量检测发现,Sox9在西伯利亚鲟中的表达具明显的组织差异性和时间差异性。其中,在肝,肾,肌肉,胰中的相对表达量较低。然而,大脑组织中的表达量与以上4个组织相比,处于极高水平,达到胰脏中相对表达量8.9倍,达到表达量最低点肾脏中的近21倍。在胚胎发育的不同阶段,Sox9均有表达。在原肠期、神经胚期及视泡形成期,Sox9基因的表达量均较高,特别是在原肠期其表达量达到西伯利亚鲟整个胚胎发育期的最高点,相当于表达量最低点心脏形成期的1.9倍。在神经胚期和视泡形成期,Sox9的相对表达量也相对处于较高水平,仅比原肠期略低,其相对表达量是心脏形成期1.2倍和1.4倍。本研究将为今后深入研究Sox9基因在西伯利亚鲟侧线神经节分化发育、细胞迁移过程中所起的调控作用积累资料。

关键词：西伯利亚鲟 Sox9 cDNA全长 cDNA末端快速扩增表达检测

Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran song qian-qian Wan Yu-Ming Wang Han-Zhou Li Wei-Quan Xu Jia-Bao Liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于IEC61850的变电站安全准入系统

计算机与现代化 2017年第3期 71-75页

作者：李牧野金倩倩宋述停南瑞集团公司(国网电力科学研究院) 江苏南京210000 国网山西省电力公司山西太原030001

目前,国内大部分变电站系统网络与计算机设备缺乏安全准入监测功能,对于接入各层网络进行运维调试的设备以及系统内各台计算机上的U盘设备尚没有规范的管控手段。为了保障变电站网络及业务系统安全运行,遵照IEC61850规约,在分析智能变... 详细信息

目前,国内大部分变电站系统网络与计算机设备缺乏安全准入监测功能,对于接入各层网络进行运维调试的设备以及系统内各台计算机上的U盘设备尚没有规范的管控手段。为了保障变电站网络及业务系统安全运行,遵照IEC61850规约,在分析智能变电站分层式结构的基础上,研发一种变电站安全准入系统,通过MMS协议实时上传网络设备及U盘拔插的监视信息至位于站控层的主站客户端。经过在南方电网公司的现场测试,该系统运行稳定符合预期,从源头上保证了变电站系统运行的安全性。

关键词：安全准入监测 IEC61850 智能变电站 MMS

Global trends and hotspots of type 2 diabetes in children and adolescents:A bibliometric study and visualization analysis

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2025年第1期16卷 140-168页

作者： Fang-Shuo Zhang Hai-Jing Li Xue Yu Yi-Ping song Yan-Feng Ren Xuan-Zhu qian Jia-Li Liu Wen-Xun Li Yi-Ran Huang Kuo Gao School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 100029China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China

BACKGROUND Epidemiological surveys indicate an increasing incidence of type 2 diabetes mellitus(T2DM)among children and adolescents *** to rapid disease progression,severe long-term cardiorenal complications,a lack of effective treatment strategies,and substantial socioeconomic burdens,it has become an urgent public health issue that requires management and *** T2DM differs from adult *** a significant increase in our understanding of youth-onset T2DM over the past two decades,the related review and evidence-based content remain *** To visualize the hotspots and trends in pediatric and adolescent T2DM research and to forecast their future research *** This study utilized the terms“children”,“adolescents”,and“type 2 diabetes”,retrieving relevant articles published between 1983 and 2023 from three citation databases within the Web of Science Core Collection(SCI,SSCI,ESCI).Utilizing CiteSpace and VoSviewer software,we analyze and visually represent the annual output of literature,countries involved,and participating *** allows us to predict trends in this research *** analysis encompasses co-cited authors,journal overlays,citation overlays,time-zone views,keyword analysis,and reference analysis,*** A total of 9210 articles were included,and the annual publication volume in this field showed a steady growth *** United States had the highest number of publications and the highest *** United States also had the most research institutions and the strongest research *** global hot journals were primarily diabetes professional journals but also included journals related to nutrition,endocrinology,and *** analysis showed that research related to endothelial dysfunction,exposure risk,cardiac metabolic risk,changes in gut microbiota,the impact on comorbidities and outcomes,etc.,were emerging *** have maintained their popularity in this field,sugges

关键词： Child Adolescent Type 2 diabetes mellitus Bibliometrics Knowledge mapping Visualization CiteSpace VOSviewer