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Jejunal sarcomatoid carcinoma:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3723-3731页

作者： qian feng Wei Yu jing-Hui feng Qiao Huang Gui-Xiang Xiao The First College of Clinical Medical Science China Three Gorges UniversityYichang 443000Hubei ProvinceChina Department of Oncology Yichang Central People's HospitalYichang 443000Hubei ProvinceChina Institute of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina

BACKGROUND Sarcomatoid carcinoma(SCA)of the jejunum is a rare and aggressive neoplasm affecting the smooth muscle cells of the *** study presents a recent case of jejunal SCA,detailing its diagnosis and treatment,thereby providing a reference for clinical *** SUMMARY A 65-year-old male presented to Yichang Central People's Hospital with a chief complaint of hemorrhoids.A computed tomography(CT)scan incidentally revealed multiple abnormal signals in the *** positron emission tomography/CT at Wuhan Union Hospital indicated malignant tumor progression,with a primary duodenal tumor and multiple metastases in the upper left ***,a large tumor was identified on the *** and immunohistochemical analyses of the resected specimen confirmed the diagnosis of jejunal *** patient received a combination therapy of sintilimab,nanoparticle albumin-bound paclitaxel,and ***-up imaging demonstrated significant reduction of hepatic and peritoneal *** patient has remained stable for over one year *** This case suggests that chemotherapy,immunotherapy,plus targeted therapy may represent an optimal treatment for intestinal SCA,meriting further investigation.

关键词： Jejunal sarcomatoid carcinoma Targeted therapy Immunotherapy Chemotherapy Case report

Exploration on electrical resistance tomography in characterizing the slurry spatial distribution in cemented granular materials

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Frontiers of Structural and Civil Engineering 2024年第3期18卷 365-379页

作者： Bohao WANG Wei WANG feng jin Handong TAN Ning LIU Duruo HUANG State Key Laboratory of Hydroscience and Engineering Tsinghua UniversityBeijing 100084China Institute of Science and Technology China Three Gorges CorporationBeijing 100038China School of Geophysics and Information Technology China University of GeosciencesBeijing 100083China

This study investigated the application of electrical resistance tomography(ERT)in characterizing the slurry spatial distribution in cemented granular materials(CGMs).For CGM formed by self-flow grouting,the voids in the accumulation are only partially filled and the bond strength is often limited,which results in difficulty in obtaining in situ samples for quality ***,it is usually infeasible to evaluate the grouting effect or monitor the slurry spatial distribution by a mechanical *** this research,the process of grouting cement paste into high alumina ceramic beads(HACB)accumulation is reliably monitored with *** shows that ERT results can be used to calculate the cement paste volume in the HACB accumulation,based on calibrating the saturation exponent n in Archie’s *** results support the feasibility of ERT as an imaging tool in CGM characterization and may provide guidance for engineering applications in the future.

关键词： electrical resistance tomography cemented granular material grouting spatial distribution Archie’s law

Layered metastructure containing freely-designed local resonators for wave attenuation

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Defence Technology（防务技术） 2024年第2期32卷 23-31页

作者： Yu Li Huguang He Jiang feng Hailong Chen fengnian jin Hualin Fan State Key Laboratory for Disaster Prevention&Mitigation of Explosion&Impact Army Engineering University of PLANanjing 210007China Rocket Force University of Engineering Xi'an 710025China Henan International Joint Laboratory of Dynamics of Impact and Disaster of Engineering Structures Department of Civil EngineeringNanyang Institute of TechnologyNanyang 473004China Guangxi Key Laboratory of Disaster Prevention and Engineering Safety and Key Laboratory of Disaster Prevention and Structural Safety of Ministry of EducationCollege of Civil Engineering and ArchitectureGuangxi UniversityNanning 530004China Research Center of Lightweight Structures and Intelligent Manufacturing State Key Laboratory of Mechanics and Control of Mechanical StructuresNanjing University of Aeronautics and AstronauticsNanjing 210016China

Combining periodic layered structure with three-dimensional cylindrical local resonators,a hybrid metastructure with improved wave isolation ability was designed and investigated through theoretical and numerical *** metastructure is composed of periodic rubber layers and concrete layers embedded with three-dimensional resonators,which can be freely designed with multi local resonant frequencies to attenuate vibrations at required frequencies and widen the attenuation *** metastructure can also effectively attenuate seismic *** with layered rubber-based structures,the metastructure has more excellent wave attenuation effects with greater attenuation and wider bandgap.

关键词： Layered metastructure Local resonator Wave attenuation

Accelerated reconstruction of ZIF-67 with significantly enhanced glucose detection sensitivity

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Nano Research 2024年第6期17卷 4737-4743页

作者： Huihui jin Weihao Zeng Wei qian Lun Li Pengxia Ji Zhengying Li Daping He School of Information Engineering Wuhan University of TechnologyWuhan 430070China Hubei Engineering Research Center of RF-Microwave Technology and Application Wuhan University of TechnologyWuhan 430070China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China

Research on metal-organic framework(MOF)-based non-enzymatic glucose sensors usually ignores the impact of the surface reconstruction degree of MOF on the activity of catalyzing glucose *** this work,we choose zeolitic imidazolate framework-67(ZIF-67),which is commonly used in glucose sensing,as a representative to investigate the influence of reconstruction degree on its structure and glucose catalytic *** employing the electrochemical activation strategy,the activity of ZIF-67 in catalyzing glucose gradually increased with the prolongation of the activation time,reaching the optimum after 2 h *** detection sensitivity of the activated ZIF-67 was 19 times higher than that of the initial ZIF-67,and the limit of detection(LOD)was lowered from 7 to 0.4μ*** findings demonstrate that the oxidation degree of ZIF-67 deepened rapidly with continuously activation and was basically reconstructed to CoOOH after 2 h activation,accompanied by a morphological change from cuboctahedral to ***,theoretical investigation revealed that ZIF-67 is not suitable as a stable glucose sensor electrode since the adsorbed glucose molecules hasten the dissociation of ligands and the breaking of Co-N bond in ***,our work has important implications for the rational design of next-generation MOF-based glucose sensors.

关键词： zeolitic imidazolate framework-67(ZIF-67) glucose oxidation electrochemical activation reconstruction CoOOH

Scalable graphene foam with ultrahigh conductivity for stabilizing Pt towards efficient hydrogen evolution

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Nano Research 2024年第8期17卷 6968-6976页

作者： Ming Zhao Meng Huang Huihui jin Dayin He Wei qian Zixin Zhang Daping He State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Hubei Engineering Research Center of RF-Microwave Technology and Application Wuhan University of TechnologyWuhan 430070China School of Information Engineering Wuhan University of TechnologyWuhan 430070China School of Chemistry and Materials Science University of Science and Technology of ChinaHefei 230026China Sanya Science and Education Innovation Park of Wuhan University of Technology Sanya 572000China

For the carbon-based catalyst to be active and stable,especially in harsh electrochemical environments,the key is to decrease the concentration of defects and raise the degree of graphitization of the carbon ***,we develop a highly graphitized graphene foam with multiplicated structure to fabricate self-supporting Pt-based catalysts for efficient and stable hydrogen evolution reaction(HER)*** foam(GO-2850)is obtained through an ultra-high temperature treatment at 2850℃,with perfect graphene structure and extremely low defect,ensuring high electrical conductivity and corrosion ***,its multiplicated structure provides an inherently favorable environment for the dispersion of Pt nanoparticles(Pt NPs)and offers abundant channels for electrolyte infiltration during the catalytic *** a result,the as-prepared Pt/GO-2850 is far active and stable than the Pt NPs supported on commercial carbon paper(Pt/CP)counterpart toward catalyzing HER,exhibiting an outstanding activity and long-term durability(300 h@10 mA·cm^(−2))in acidic/alkaline/seawater *** can be attributed to the stronger interaction between the lower-defect GO-2850 substrate and Pt,as evidenced by characterization and theoretical *** work extends further insight into the design self-supporting catalysts of high activity and stability with promising prominent application toward green energy devices.

关键词： graphene foam high graphitization Pt nanoparticles hydrogen evolution reaction long-term stability

Enhancing blocking temperature using inverse hydrogen bonds for non-radical bridged dimeric Dy(Ⅲ)single-molecule magnets

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Science China Chemistry 2024年第10期67卷 3328-3338页

作者： Peng-Bo jin qian-Cheng Luo Ye-Ye Liu Yan-Zhen Zheng Frontier Institute of Science and Technology State Key Laboratory of Electrical Insulation and Power EquipmentMOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed MatterXi’an Key Laboratory of Electronic Devices and Material Chemistry and School of ChemistryXi’an Jiaotong UniversityXi’an 710054China

Single-molecule magnets(SMMs)are a kind of nanosized magnetic materials that are capable of storing massive bytes of *** coupling the spin centers in a proper manner is a usual approach to promote the working temperature(or blocking temperature)for *** delocalized radicals have been widely employed to accomplish this ***,we show a new manner by using weak but multiple B–H^(δ-)···Dy^(3+)inverse hydrogen bonding(IHB)interactions to control the magnetic couplings in a series of dimeric dysprosiacaborane *** approach leads to a record high T_(B)^(100s)of 10 K among non-radical bridged dimeric SMMs,which is mainly ascribed to strong ferromagnetic coupling(4.38 cm^(-1))and the proper alignment of the magnetic principle axes of the adjacent dysprosium(Ⅲ)*** verifying by theoretical calculations,these results demonstrate that IHB interactions can be used to construct strong axial ferromagnetic coupling and enhancing magnetic blocking temperature for SMMs.

关键词： single-molecule magnets carborane dysprosium ferromagnetic coupling inverse hydrogen bond

Clinical and genomic analysis of baseline and acquired MET fusions with an intact kinase domain in lung cancer patients

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Genes & Diseases 2024年第1期11卷 76-79页

作者： Bo jin Yutong Ma qian Wu Qiuxiang Ou Yang Shao Shun Xu Department of Medical Oncology The First Hospital of China Medical UniversityShenyangLiaoning 110001China Geneseeq Research Institute Nanjing Geneseeq Technology Inc.NanjingJiangsu 210000China School of Public Health Nanjing Medical UniversityNanjingJiangsu 211166China Department of Thoracic Surgery The First Hospital of China Medical UniversityShenyangLiaoning110001China

MET gene alterations in lung cancer patients mainly include exon 14 skipping and gene amplification,which are the key therapeutic targets and drive resistance to tyrosine kinase inhibitors(TKls).1 However,the structural variants of MET,such as MET fusions,are much rarer(0.26%),as reported in a Chinese non-small cell lung cancer(NSCLC)cohort.2 Several recurrent MET fusions,such as KIF5B-MET and HLADRB1-MET,were reported as oncogenic drivers and showed favorable responses to crizotinib.

关键词： lung patients alterations

Recent advancement of sonogenetics:A promising noninvasive cellular manipulation by ultrasound

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Genes & Diseases 2024年第5期11卷 163-182页

作者： jin Tang Mingxuan feng Dong Wang Liang Zhang Ke Yang Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChongqing Engineering Research Center of Stem Cell TherapyChongqing 400014China Department of Ultrasound The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Tongji Medical College Huazhong University of Science and TechnologyWuhanHubei 430074China

Recent advancements in biomedical research have underscored the importance of noninvasive cellular manipulation ***,a method that uses genetic engineering to produce ultrasound-sensitive proteins in target cells,is gaining prominence along with optogenetics,electrogenetics,and *** stimulation with ultrasound,these proteins trigger a cascade of cellular activities and *** traditional ultrasound modalities,sonogenetics offers enhanced spatial selectivity,improving precision and safety in disease *** technology broadens the scope of non-surgical interventions across a wide range of clinical research and therapeutic applications,including neuromodulation,oncologic treatments,stem cell therapy,and *** current literature predominantly emphasizes ultrasonic neuromodulation,this review offers a comprehensive exploration of *** discuss ultrasound properties,the specific ultrasound-sensitive proteins employed in sonogenetics,and the technique’s potential in managing conditions such as neurological disorders,cancer,and ophthalmic diseases,and in stem cell *** objective is to stimulate fresh perspectives for further research in this promising field.

关键词： Mechanosensitive channel Neuromodulation Sonogenetics Ultrasound Ultrasound-sensitive protein

Lead-free BiFeO_(3)-BaTiO_(3) based high-Tc ferroelectric ceramics:Antiferroelectric chemical modification leading to high energy storage performance

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Journal of Materiomics 2024年第4期10卷 819-827页

作者： Hongliang Wang Liang Shu Liyu Wei Xin Zhang qian Li jing-feng Li State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing100084China

Dielectric capacitors have been widely used in pulsed power devices owing to their ultrahigh power density,fast charge/discharge speed,and excellent ***,developing lead-free dielectric materials with a combination of high recoverable energy storage density and efficiency remains a ***,a high energy storage density of 7.04 J/cm^(3) as well as a high efficiency of 80.5%is realized in the antiferroelectric Ag(Nb_(0.85)Ta_(0.15))O_(3)-modified BiFeO3-BaTiO3 ferroelectric *** achievement is mainly attributed to the combined effect of a high saturation polarization(Pmax),increased breakdown field(Eb),and reduction of the remnant polarization(Pr).The modification of pseudotetragonal BiFeO3 by Ag(Nb_(0.85)Ta_(0.15))O_(3) leads to a high Pmax,and the enhanced relaxor behavior gives rise to a small *** promoted microstructure(such as a dense structure,fine grains,and compact grain boundaries)after modification results in a high breakdown ***,both the recoverable energy density and efficiency exhibit high stability over a broad range of operating frequencies(1–50 Hz)and working temperatures(25–120℃).These results suggest that the(0.67–x)BiFeO_(3)-0.33BaTiO_(3)-xAg(Nb_(0.85)Ta_(0.15))O_(3) ceramics can be highly competitive as a lead-free relaxor for energy storage applications.

关键词： BiFeO_(3) Lead-free ceramics Dielectric capacitors Energy storage