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Quality evaluation of Huaijiao pill by chromatographic fingerprint and simultaneous determination of its major bioactive components

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Journal of Pharmaceutical Analysis 2016年第4期6卷 249-255页

作者： Shuangqin wang Jingjing Zhang Juan Liu Guangsheng qian Chunmei fu West China School of Pharmacy Sichuan University

For quality control purpose,an approach of combining chromatographic fingerprint of Huaijiao pill（HP）and simultaneous determination of its major bioactive components was developed using high performance liquid chromatography coupled with diode array detector（HPLC-DAD）.For fingerprint analysis,16 peaks were selected as the characteristic peaks to evaluate the similarities of different samples collected from different batches of three *** similarities of 17 Huaijiao pill samples were beyond 0.966,indicating that samples from different batches and manufacturers were,to some extent,***,simultaneous quantification of seven bioactive markers,namely sophoricoside,baicalin,naringin,genistein,rutin,quercetin and 5-O-methylvisammioside,in HP was performed to interpret the quality *** validation of the proposed approach was acceptable,with the accuracy of 90.2%-106.9%in recovery *** intra-day and inter-day precisions of the method were evaluated and the RSD values were less than 2.81%.The results from the quantitative data showed that the contents of six marker compounds（except for 5-O-methylvisammioside） were quite consistent between batches produced by one manufacturer and significantly distinctive among different *** proposed approach was expected to be developed as a powerful tool for the quality control of HP.

关键词： Chromatographic fingerprint HPLC-DAD Huaijiao pill

A Preliminary Review of the Metallogenic Regularity of Nickel Deposits in China

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Acta Geologica Sinica(English Edition) 2015年第4期89卷 1375-1397页

作者： SUN Tao wang Denghong qian Zhuangzhi fu Yong CHEN Zhenghui LOU Debo School of Resource Environment and Earth Sciences Yunnan University MRL Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesChinese Academy of Geological Sciences MOE Key Laboratory of Western China's Mineral Resources and Geological Engineering College of Earth Science and ResourcesChang'an University College of Resource and Environmental Engineering Guizhou University

The nickel deposits mainly distributed in 19 provinces and autonomous regions in China are 339 ore deposits/occurrences, including 4 super large-scale deposits, 14 large-scale deposits, 26 middle- scale deposits, 75 small-scale deposits, and 220 mineralized occurrences. The prediction types of mineral resources of nickel deposits are magmatic type, marine sedimentary type and regolith type. The formation age is from the Neoarchean to the Cenozoic with two peaks in the Neoproterozoic and the late Paleozoic. The nickel deposits formed in the Neoproterozoic are located on the margin of the North China Block and Yangtze Block, and those formed in the late Paleozoic are mainly distributed in the Central Asian Orogenic Belt （CAOB）, Emeishan and the Tarim Large Igneous Provinces （LIPs）. Magmatic nickel deposits are mainly related with broken-up continental margin, post-collision extension of the orogenic belt and mantle plume. According to different tectonic backgrounds and main characteristics of magmatism, the Ni-Cu-Co-PGE metallogenie series types of ore deposits related with mantle-derived mafic-ultramafic rocks can be divided into 4 subtypes：（1） the Ni-Cu-Co- PGE metallogenic series subtype of ore deposits related with mantle-derived mafic-ultramafic rocks in the broken-up continental margin, （2） the Ni-Cu-Co-PGE metallogenic series subtype of ore deposits related with mantle-derived mafic-ultramafic rocks in mantle plume magmatism, （3） the Ni-Cu-Co- PGE metallogenic series subtype of ore deposits related with mantle-derived mafic-ultramafic rocks in the subduction of the orogenic belt, and （4） the Ni-Cu-Co-PGE metallogenic series subtype of ore deposits related with mantle-derived mafic-ultramafic rocks in post-collision extension of the orogenic belt. We have discussed in this paper the typical characteristics and metaliogenic models for Neoproterozoic Ni-Cu-（PGE） deposits related with broken-up continental margin, Cambrian marine sedimentary Ni-Mo-V deposits relat

关键词： prediction type of mineral resources metallogenic condition metallogenic regularity,nickel deposits China

Glypican-3 is a biomarker and a therapeutic target of hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2015年第4期14卷 361-366页

作者： Li wang Min Yao Liu-Hong Pan Qi qian Deng-fu Yao Research Center of Clinical Medicine Affiliated Hos-pital of Nantong University Departments of Medical Informatics Medical School of Nantong University Departments of Immunology Medical School of Nantong University

BACKGROUND： The carcinogenesis of hepatocellular car- cinoma （HCC） is a multi-factorial, multi-step and complex process. Early diagnosis and effective treatments are of utmost importance. This review summarized the recent studies of on- cofetal glypican-3 （GPC-3）, a membrane-associated heparan sulfate proteoglycan, in the diagnosis and treatment of HCC. DATA SOURCES： English-language reports published from Iune 2001 to September 2014 were searched from MEDLINE. The key words searched included： GPC-3, biomarker, target and HCC. The sensitivity, specificity, positive and negative predictive values were extracted, and the effect of GPC-3 tar- geted therapy on HCC was also evaluated. RESULTS： GPC-3 plays a crucial role in HCC cell prolifera- tion and metastasis. It mediates oncogenesis involving signal- ing pathways during hepatocyte malignant transformation. GPC-3 expression is increased in atypical hyperplasia and cancerous tissues. GPC-3 levels in HCC patients are related to HBV infection, TNM stage, periportal cancerous embolus, and extrahepatic metastasis. The diagnostic accuracy of the combination of serum GPC-3 and alpha-fetoprotein in HCC is up to 94.3%. Down-regulation of GPC-3 with specific siRNA or anti-GPC-3 antibody alters cell migration, metastasis and invasion behaviors. The nude mice xenograft tumor growth is inhibited by silencing GPC-3 gene ***： Oncofetal GPC-3 is a highly specific biomark- er for the diagnosis of HCC and a promising target molecule for HCC gene therapy.

关键词： hepatocellular carcinoma glypican-3 signal pathways diagnosis targeted therapy

EFFECTS OF HIGH-ENERGY BALL MILLING ON STRUCTURE AND MECHANICAL PROPERTIES OF L1_2 INTERMETALLIC COMPOUND Al_(67)Mn_8Ti_(25)

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中国有色金属学会会刊：英文版 1998年第3期8卷 57-61页

作者： Yunyi, fu qian, Wan Gengxiang, Hu Shanghai Jiao Tong Univ Shanghai China

１ＩＮＴＲＯＤＵＣＴＩＯＮＴｈｅｏｒｄｅｒｅｄｉｎｔｅｒｍｅｔａｌｉｃｃｏｍｐｏｕｎｄＡｌ３Ｔｉｉｓｎｏｔｉｃｅａｂｌｅｂｅｃａｕｓｅｏｆｉｔｓｌｏｗｄｅｎｓｉｔｙ（３．４ｇ／ｃｍ３），ｅｘｃｅｌｅｎｔｈｉｇｈｔｅ... 详细信息

１ＩＮＴＲＯＤＵＣＴＩＯＮＴｈｅｏｒｄｅｒｅｄｉｎｔｅｒｍｅｔａｌｉｃｃｏｍｐｏｕｎｄＡｌ３Ｔｉｉｓｎｏｔｉｃｅａｂｌｅｂｅｃａｕｓｅｏｆｉｔｓｌｏｗｄｅｎｓｉｔｙ（３．４ｇ／ｃｍ３），ｅｘｃｅｌｅｎｔｈｉｇｈｔｅｍｐｅｒａｔｕｒｅｏｘｉｄａｔｉｏ...

关键词： Al 67 Mn 8Ti 25 alloy high energy ball milling powder metallurgy structure evolution intermetallic compound

Holocene sea level trend on the west coast of Bohai Bay,China: reanalysis and standardization

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Acta Oceanologica Sinica 2021年第7期40卷 198-248页

作者： Jianfen Li Zhiwen Shang fu wang Yongsheng Chen Lizhu Tian Xingyu Jiang qian Yu Hong wang Tianjin Center China Geological SurveyTianjin 300170China Key Laboratory of Coast Geo-Environment China Geological SurveyTianjin 300170China Key Laboratory for Coast and Island Development(Nanjing University) Ministry of EducationNanjing 210023China School of Geographic and Oceanographic Sciences Nanjing UniversityNanjing 210023China

Using 110 newly revised Holocene sea level indicators categorized into three types,sediments(67),shelly cheniers(27)and oyster reefs(16),this paper firstly provides a Holocene relative sea level curve,based on multiple approaches of litho-and biostratigraphies and sedimentary faces analysis,for the west coast of Bohai Bay,*** considerations,including indicative meaning,the paleo tidal pattern and range and conversion from mean tidal level to mean sea level,an apparent relative mean sea level(RMSL)curve was further *** systematical calibration using CALIB,those of the 48 reworked samples were further corrected for the residence-time ***,the younger ages for another 35 samples were chosen at the subsample *** result in a younger-oriented shift for about 0.5 *** local spatial factors,including neotectonic subsidence(average rate about 0.1 mm/a),self-compaction of unconsolidated sediments(between a few decimeters to about 6 m)and subsidence due to groundwater withdrawal(between a few centimeters to about 2.5 m),were quantitatively ***,the amended RMSL curve after eliminating all these local temporo-spatial factors is very likely to show non-existence of mid-Holocene highstand and imply potential influences of both ice-volume equivalent sea level and regional glacial isostatic *** it is still unable to divide both global and regional factors,the slowdown of sea level rise,in 7.5–6.8 ka with a maximum height less than+1 m,may constrain the model effort in the near future.

关键词： cheniers oyster reefs sediments temporospatial corrections local RMSL

An Efficient Solid-State Synthesis of N-Aryl-2-phenyldiazenecarboxamides

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Chinese Chemical Letters 2001年第2期12卷 107-108页

作者： Jian Ping LI qian fu LUO Yi Yang SHEN Yu Lu wang Hong wang College of Chemistry and Environmental Science Henan Normal UniversityXinxiang 453002 Department of Chemistry Luoyang Teacher’s CollegeLuoyang 471000

A new and ancient solid-state reaction using K3Fe(CN)(6)/KOII to oxidize diaryl semicarbazides for preparing azo compounds has been reported. Nine N-aryl-2-phenyl-diazenecarboxamides have been synthesized in excellent... 详细信息

关键词： Solid-state synthesis diaryl semicarbazide N-Aryl-2-phenyldiazenecarboxamide

A large-scale clustering and 3D trajectory optimization approach for UAV swarms

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Science China(Information Sciences) 2021年第4期64卷 84-99页

作者： Ting MA Haibo ZHOU Bo qian Aiyong fu School of Electronic Science and Engineering Nanjing University

With the significant development of unmanned aerial vehicles(UAVs) technologies, a rapid increase on the use of UAV swarms in a wide range of civilian and emergency applications has been ***, how to efficiently network the large-scale UAVs and implement the swarms applications without infrastructure support in remote areas is challenging. In this paper, we investigate a hierarchal large-scale infrastructure-less UAV swarm scenario, where numerous UAVs surveil and collect data from the ground and a ferry UAV(Ferry UAV) is designated to carry back all their collected data. We can divide UAV swarms into different areas based on their geographic locations due to the wide range of surveillance. To improve data collection efficiency of Ferry UAV, we introduce a single super cluster head(Super-CH) UAV in each area which can be selected by the proposed modified k-means clustering algorithm with low latency. Then,we design an iterative approach to optimize the 3-dimensional(3D) trajectory of Ferry UAV such that its data collection mission completion time is minimized. Numerical results show the efficiency and low-latency of the proposed clustering algorithm, and the proposed 3D optimal trajectory design for large-scale UAV swarms data collection admits better performance than that with fixed altitude.

关键词： large-scale UAV swarms clustering super-CH selection 3D trajectory design

QTL editing confers opposing yield performance in different rice varieties

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Journal of Integrative Plant Biology 2018年第2期60卷 89-93页

作者： Lan Shen Chun wang Yaping fu Junjie wang Qing Liu Xiaoming Zhang Changjie Yan qian qian Kejian wang Key Laboratory of Plant functional Genomics Ministry of Education Yangzhou University State Key Laboratory of Rice Biology China National Rice Research Institute Chinese Academy of Agricultural Sciences State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control Institute of Crop and Nuclear Technology Utilization Zhejiang Academy of Agricultural Sciences

Grain yield is one of the most important and complex trait for genetic improvement in crops; it is known to be controlled by a number of genes known as quantitative trait loci（QTLs）. In the past decade, many yield-contributing QTLs have been identified in ***, it remains unclear whether those QTLs confer the same yield performance in different genetic backgrounds. Here, we performed CRISPR/Cas_9-mediated QTL editing in five widely-cultivated rice varieties and revealed that the same QTL can have diverse, even opposing, effects on grain yield in different genetic backgrounds.

关键词： QTL editing confers opposing yield performance in different rice varieties Figure

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农村慢性病患者在多类医疗机构就诊情况分析

中国卫生经济 2008年第12期27卷 35-37页

作者：钱东福王伟尹爱田孟庆跃南京医科大学医政学院南京210029 潍坊医学院卫生管理学院山东潍坊261000 山东大学卫生管理与政策研究中心济南250012

根据甘肃省4个县农村居民的抽样调查资料,对农村慢性病患者在不同类型医疗机构的就诊情况进行描述性统计分析,指出了有关的现状和问题,并提出了相应的政策建议。

关键词：慢性病农村居民卫生服务需求就诊单位选择