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Biliary Cast Syndrome： Hepatic Artery Resistance Index, Pathological Changes, Morphology and Endoscopic Therapy

Chinese Medical Journal 2015年第14期128卷 1910-1915页

作者： Hu Tian qian-de liao Nian-Feng Li Jian Peng Lian-Sheng Gong Ju Liu Hepatobiliary and Enteric Surgery Research Center Xiangya Hospital Central South University Changsha Hunan 410008 China Medical Research Center Shandong Provincial Qiantoshan Hospital Shandong University Jinan Shandong 250014 China

Background： BiNary cast syndrome （BCS） was a postoperative complication of orthotopic liver transplantation （OLT）, and the reason for BSC was considered to relate with ischemic type biliary lesions. This study aimed to evaluate the relationship between BCS following OLT and the hepatic artery resistance index （HARt）, and to observe pathological changes and morphology of biliary casts. Methods： Totally, 18 patients were diagnosed with BCS by cholangiography following OLT using choledochoscope or endoscopic retrograde cholangiopancreatography. In addition, 36 patients who did not present with BCS in the corresponding period had detectable postoperative HARI on weeks I, 2, 3 shown by color Doppler flow imaging. The compositions ofbiliary casts were analyzed by pathological examination and scanning electron microscopy. Results： HARI values of the BCS group were significantly decreased as compared with the non-BCS group on postoperative weeks 2 and 3 （P 〈 0.05）. Odds ratio （OR） analysis of HARI 1, HARI 2, HARI 3 following the operation was 〉1 （OR = 1.300： 1.223 and 1.889, respectively）. The OR of HARI 3 was statistically significant （OR - 1.889; 95% confidence interval - 1.166-7.490; P - 0.024）. The compositions of biliary casts were different when bile duct stones wcrc present. Furthermore, vascular epithelial cells were found by pathological examination in binary casts. Conclusions： HARI may possibly serve as an independent risk factor and early predictive factor of BCS. Components and formation of binary casts and bile duct stones are different.

关键词： Biliary Cast Syndrome Endoscopic Therapy Hepatic Artery Resistance Index lschemic Type Biliary Lesions: OrthotopicLiver Transplantation

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miR-100通过靶向IGF2调控非小细胞肺癌A549细胞迁移和侵袭

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中国现代医学杂志 2015年第21期25卷 1-5页

作者：凌东进廖前德施天生中南大学湘雅医院湖南长沙410008 江西省胸科医院胸外科江西南昌330048

目的探讨mi R-100对非小细胞肺癌(NSCLC)细胞迁移和侵袭能力的影响及其作用机制。方法通过Real time PCR和Western blot检测mi R-100和IGF2在人非小细胞肺癌细胞系中的表达;建立了稳定过表达成熟mi R-100的非小细胞肺癌A549细胞系,通过... 详细信息

目的探讨mi R-100对非小细胞肺癌(NSCLC)细胞迁移和侵袭能力的影响及其作用机制。方法通过Real time PCR和Western blot检测mi R-100和IGF2在人非小细胞肺癌细胞系中的表达;建立了稳定过表达成熟mi R-100的非小细胞肺癌A549细胞系,通过细胞划痕实验和Boyden chamherr检测细胞迁移和侵袭能力的改变;在此基础上,通过报告基因分析和Western blot探讨mi R-100引起非小细胞肺癌细胞生物学功能改变的作用机制。结果 Real time PCR结果表明mi R-100在高转移潜能的非小细胞肺癌细胞A549中呈低表达,而IGF2在A549中呈高表达;在非小细胞肺癌细胞A549中过表达mi R-100后降低了细胞的迁移和侵袭能力,双荧光素酶报告基因分析表明成熟的mi R-100能够作用于IGF2的3’UTR区降低荧光素酶的活性,Western blot进一步证实了mi R-100能够抑制内源性IGF2的表达。结论 Mi R-100在高转移能力的非小细胞肺癌细胞A549中呈低表达,具有类似抑癌基因作用,并调控IGF2表达,降低了非小细胞肺癌细胞A549的迁移和侵袭能力,IGF2是mi R-100的靶基因,有望成为肿瘤生物治疗的靶点。

关键词：非小细胞肺癌侵袭迁移 IGF2

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Mechanism of action of Linggui Zhugan decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song qian-qian Wan Yu-Ming Wang Han-Zhou Li Wei-Quan Xu Jia-Bao liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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Paper evolution graph: multi-view structural retrieval for academic literature

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Frontiers of Information Technology & Electronic Engineering 2019年第2期20卷 187-205页

作者： Dan-ping liao Yun-tao qian College of Computer Science and Technology Zhejiang University

Academic literature retrieval concerns about the selection of papers that are most likely to match a user's information needs. Most of the retrieval systems are limited to list-output models, in which the retrieval results are isolated from each other. In this paper, we aim to uncover the relationships between the retrieval results and propose a method to build structural retrieval results for academic literature, which we call a paper evolution graph(PEG).The PEG describes the evolution of diverse aspects of input queries through several evolution chains of papers. By using the author, citation, and content information, PEGs can uncover various underlying relationships among the papers and present the evolution of articles from multiple viewpoints. Our system supports three types of input queries: keyword query, single-paper query, and two-paper query. The construction of a PEG consists mainly of three steps. First, the papers are soft-clustered into communities via metagraph factorization, during which the topic distribution of each paper is obtained. Second, topically cohesive evolution chains are extracted from the communities that are relevant to the query. Each chain focuses on one aspect of the query. Finally, the extracted chains are combined to generate a PEG, which fully covers all the topics of the query. Experimental results on a real-world dataset demonstrate that the proposed method can construct meaningful PEGs.

关键词： Paper evolution graph Academic literature retrieval Metagraph factorization Topic coherence

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STACKING SEQUENCE OPTIMIZA-TION OF LAMINATED COMPOSITE CYLINdeR SHELL FOR MAXIMAL BUCKLING LOAD

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Chinese Journal of Mechanical Engineering 2008年第4期21卷 31-34页

作者： TANG qian liao Xiaoyun GAO Zhan State Key Laboratory of Mechanical Transmission Chongqing University Chongqing 400044 China Motor Coach Industries Winnipeg R3T IT5 Canada

A new optimization method for the optimization of stacking of composite glass fiber laminates is developed. The fiber orientation and angle of the layers of the cylindrical shells are sought considering the buckling load. The proposed optimization algorithm applies both finite element analysis and the mode-pursuing sampling （MPS）method. The algorithms suggest the optimal stacking sequence for achieving the maximal buckling load. The procedure is implemented by integrating ANSYS and MATLAB. The stacking sequence designing for the symmetric angle-ply three-layered and five-layered composite cylinder shells is presented to illustrate the optimization process, respectively. Compared with the genetic algorithms, the proposed optimization method is much faster and efficient for composite staking sequence plan.

关键词： Composite Laminated cylindrical shell Stacking sequence optimization Buckling load Sampling algorithms

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Multi-Objective Optimization for an Industrial Grinding and Classification Process Based on PBM and RSM

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IEEE/CAA Journal of Automatica Sinica 2023年第11期10卷 2124-2135页

作者： Xiaoli Wang Luming Liu Lian Duan qian liao School of Automation Central South universityChangsha 410083China Changsha Research Institute of Mining and Metallurgy Changsha 410012China

The grinding and classification process is one of the key sub-processes in mineral processing, which influences the final process indexes significantly and determines energy and ball consumption of the whole plant. Therefore, optimal control of the process has been very important in practice. In order to stabilize the grinding index and improve grinding capacity in the process,a process model based on population balance model(PBM) is calibrated in this study. The correlation between the mill power and the operating variables in the grinding process is modelled by using the response surface method(RSM), which solves the problem where the traditional power modeling method relies on some unobservable mechanism-related parameters. On this basis, a multi-objective optimization model is established to maximize the useful power of the grinding circuit to improve the throughput of the grinding operation and improve the fraction of –0.074 mm particles in the hydrocyclone overflow to smooth the subsequent flotation operation. The elite non-dominated sorting genetic algorithm-II(NSGA-II) is then employed to solve the multi-objective optimization problem. Finally, subjective and objective weighting methods and integrated multi-attribute decision-making methods are used to select the optimal solution on the Pareto optimal solution set. The results demonstrate that the throughput of the mill and the fraction of –0.074 mm particles in the overflow of the cyclone are increased by 3.83 t/h and 2.53%, respectively.

关键词： decision-making technique grinding process multiobjective optimization response surface method(RSM)

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CuCl-catalyzed Oxidative N-demethylation of Arylamines with tButyl Hydroperoxide

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Chemical Research in Chinese Universities 2009年第6期25卷 861-865页

作者： liao qian XI Chan-juan Key Laboratory of Bioorganic Phosphorus Chemistry ＆ Chemical Biology Ministry of Education Department of Chemistry Tsinghua University Beoing 100084 P. R. China

CuCl-catalyzed oxidative N-demethylation of arylamines proceeded in the presence of tert-butyl hydroperoxide. The one-electron transfer route of oxidative N-demethylation competed favorably with the H-atom abstraction... 详细信息

关键词： Arylamine Cuprous chloride Catalytic oxidation N-demethylation tert-Butyl hydroperoxide

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dendronized Polymers with High FTC-chromophore Loading density:Large Second-order Nonlinear Optical Effects, Good Temporal and Thermal Stability

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Chinese Journal of Polymer Science 2020年第2期38卷 118-125,I0005页

作者： Meng Jin Zhao-Chen Zhu Qiu-Yan liao qian-qian Li Zhen Li department of Chemistry Sauvage Center for Molecular SciencesWuhan UniversityWuhan 430072China Institute of Molecular Aggregation Science Tianjin UniversityTianjin 300072China

In this study,two new dendronized nonlinear optical(NLO)polymers were synthesized with high FTC chromophore loading density by introduction of high generation chromophore dendrons on the side *** to their suitable molecular weights,both of them possessed good solubility in common *** also inherited the advantages of dendrimers(large NLO coefficient),especially for PG2 whose NLO coefficient d33 value was as high as 282 pm·V^–***,PG2 had a good temporal stability with 80%of its maximum value being retained at the temperature as high as 129℃.

关键词： Second-order nonlinear optics dendronized polymers Chromophore

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Influence of Kinematic Analysis Parameters of Drag Anchor Trajectory Prediction Using Yield Envelope Method

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China Ocean Engineering 2020年第2期34卷 257-266页

作者： WU Xiao-ni WANG Teng liao qian LI Ye State Key Laboratory of Ocean Engineering School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China department of Naval Architecture and Offshore Engineering China University of Petroleum(East China)Qingdao 266580China

Drag anchor is widely applied in offshore engineering for offshore mooring *** prediction of the invisible trajectory during its drag-in installation is challenging for anchor design in determining the anchor final position for ensuring sufficient holding *** yield envelope method based on deep anchor failure for kinematic analysis was proposed as a promising trajectory prediction method for drag ***,there is a lack of analysis on the effects of the parameters applied in the kinematic *** current work studies the effects of the yield envelope parameters,anchor line bearing capacity factor and the anchor/soil interface *** is found that the accuracy of the yield envelope parameters has large impact on the prediction results based on deep yield *** of cases with smooth fluke predict deeper embedment depth than that from analyses of cases with rough *** decrease of the capacity factor results in the increase of the anchor embedment depth,the anchor line load,the anchor chain angle and the stable value of the normalized horizontal load component for the same drag length,while the stable value of the normalized vertical load component decreases when the capacity factor *** illustrates the importance in applying reasonable parameters and improving the method for more reliable prediction of the anchor trajectory.

关键词： trajectory prediction kinematic analysis drag anchor yield envelope

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Non-scanning systems for far-infrared radiation detection from laser-induced plasmas

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High Power Laser Science and Engineering 2015年第2期3卷 1-5页

作者： Chun Li Guo-qian liao Yu-Tong Li Beijing National Laboratory of Condensed Matter Physics Institute of Physics CAS IFSA Collaborative Innovation Center Shanghai Jiao Tong University

With the development of ultraintense terawatt(TW) and petawatt(PW) laser systems, powerful terahertz(THz) radiation from laser–plasma interactions has been reported. Plasma-based THz systems, which are usually operated at extremely low repetition rates, call for single-shot diagnostics. In this paper, various state-of-the-art single-shot detection methods are introduced or designed for measurements and applications involved in high-power plasma-based THz sciences.

关键词： laser–plasma interaction single-shot detection ter

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