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Deciphering gastric inflammation-induced tumorigenesis through multi-omics data and AI methods

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Cancer Biology & Medicine 2024年第4期21卷 312-330页

作者： qian Zhang Mingran Yang Peng Zhang Bowen Wu Xiaosen Wei shao Li Institute for TCM-X MOE Key Laboratory of BioinformaticsBioinformatics DivisionBNRISTDepartment of AutomationTsinghua UniversityBeijing 100084China

Gastric cancer(GC), the fifth most common cancer globally, remains the leading cause of cancer deaths worldwide. Inflammation-induced tumorigenesis is the predominant process in GC development;therefore, systematic research in this area should improve understanding of the biological mechanisms that initiate GC development and promote cancer hallmarks. Here, we summarize biological knowledge regarding gastric inflammation-induced tumorigenesis, and characterize the multi-omics data and systems biology methods for investigating GC development. Of note, we highlight pioneering studies in multi-omics data and state-of-the-art network-based algorithms used for dissecting the features of gastric inflammation-induced tumorigenesis, and we propose translational applications in early GC warning biomarkers and precise treatment strategies. This review offers integrative insights for GC research, with the goal of paving the way to novel paradigms for GC precision oncology and prevention.

关键词： Gastric cancer inflammation-induced tumorigenesis multi-omics artificial intelligence network-based methods

参芪益心汤治疗心力衰竭合并利尿剂抵抗患者的临床疗效及对其心功能、NT-proBNP水平的影响

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世界中西医结合杂志 2024年第5期19卷 971-974,981页

作者：王琪吴限刘丰苗永悦孙少谦刘莉黑龙江中医药大学附属第一医院心血管内科黑龙江哈尔滨150040

目的探讨参芪益心汤加减治疗心力衰竭合并利尿剂抵抗患者的疗效。方法选取2021年12月—2022年12月期间黑龙江中医药大学附属第一医院收治的心力衰竭合并利尿剂抵抗患者100例作为研究对象,按照随机数字表法分为对照组和试验组,每组各5... 详细信息

目的探讨参芪益心汤加减治疗心力衰竭合并利尿剂抵抗患者的疗效。方法选取2021年12月—2022年12月期间黑龙江中医药大学附属第一医院收治的心力衰竭合并利尿剂抵抗患者100例作为研究对象,按照随机数字表法分为对照组和试验组,每组各50例。对照组予常规治疗,试验组在对照组基础上加用参芪益心汤,两周为1个疗程,两组患者均治疗4周。观察比较两组患者治疗前后心功能指标[左心室舒张末期内径(Left ventricular end-diastolic diameter,LVDD)、左房内径(Left atrial diameter,LAD),计算左室射血分数(Left ventricular ejection fraction,LVEF)]、血清指标[N端脑钠肽前体(N-terminal pro-brain natriuretic peptide,NT-proBNP)、肌钙蛋白T(Cardiac troponin T,CTnT)、肌酸磷化脢同功脢(Creatine kinase isoenzyme,Ck-MB)]、中医证候积分,比较两组患者临床疗效及不良反应。结果治疗后两组患者心功能LVDD、LAD水平均较治疗前降低,LVEF水平均较治疗前升高,差异有统计学意义(P0.05);且试验组心悸、气短、气喘、胸闷评分均明显低于对照组,差异有统计学意义(P0.05)。结论应用参芪益心汤能够显著改善心功能,缓解临床症状,疗效显著,值得临床应用。

关键词：心力衰竭利尿剂抵抗参芪益心汤中医证候积分

Influence of mass ratio and calcination temperature on physical and photoelectrochemical properties of ZnFe-layered double oxide/cobalt oxide heterojunction semiconductor for dye degradation applications

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Particuology 2023年第3期74卷 141-155页

作者： Yufei Zhang Junjie Zheng Jiejie Nan Chengjie Gai qian shao Vignesh Murugadoss Srihari Maganti Nithesh Naik Hassan Algadi Mina Huang Ben Bin Xu Zhanhu Guo College of Chemical and Biological Engineering Shandong University of Science and TechnologyQingdao266590China College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan030024China Integrated Composites Laboratory(ICL) Department of Chemical and Bimolecular EngineeringUniversity of TennesseeKnoxvilleTN37996United States Department of Mechanical&Manufacturing Engineering Manipal Institute of TechnologyManipal Academy of Higher EducationManipal576104KarnatakaIndia Mechanical and Construction Engineering Faculty of Engineering and EnvironmentNorthumbria UniversityNewcastle Upon TyneNE18STUK Department of Electrical Engineering Faculty of EngineeringNajran UniversityNajran11001Saudi Arabia

A visible light-active photoelectrocatalyst,ZnFe-layered double oxide(LDO)/cobalt(II,III)oxide(Co_(3)O_(4))composites were obtained by calcining the Co loaded ZnFe-layered double hydroxide(LDH)prepared by a hydrothermal and microwave hydrothermal *** morphological studies revealed that the ZnFe-LDO/Co_(3)O_(4) composites exhibited a flower-like structure comprising Co_(3)O_(4) nanowires and ZnFe-LDO ***,when the mass ratio of Co(NO_(3))_(2)·6H_(2)O/LDH was 1:1.8 and the calcination temperature was 550℃,the ZnFe-LDO/Co_(3)O_(4) composite exhibited 93.3%degradation efficiency for methylene blue(MB)at the applied voltage of 1.0 V under visible light after 3 ***,the Mott-Schottky model experiments showed that the formation of a p-n heterojunction between ZnFe-LDO and Co_(3)O_(4) could effectively inhibit the recombination of electrons and holes in the photoelectrocatalytic ***,free radical scavenging experiments showed that the active radicals of⋅OH played an important role in the degradation of ***,the photoelectrocatalytic effect of ZnFe-LDO/Co_(3)O_(4) provides a simple and effective strategy for the removal of organic pollutants.

关键词： ZnFe-LDO/Co_(3)O_(4) Photoelectrocatalytic p-n heterojunction Methylene blue

Clinical and genomic analysis of baseline and acquired MET fusions with an intact kinase domain in lung cancer patients

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Genes & Diseases 2024年第1期11卷 76-79页

作者： Bo Jin Yutong Ma qian Wu Qiuxiang Ou Yang shao Shun Xu Department of Medical Oncology The First Hospital of China Medical UniversityShenyangLiaoning 110001China Geneseeq Research Institute Nanjing Geneseeq Technology Inc.NanjingJiangsu 210000China School of Public Health Nanjing Medical UniversityNanjingJiangsu 211166China Department of Thoracic Surgery The First Hospital of China Medical UniversityShenyangLiaoning110001China

MET gene alterations in lung cancer patients mainly include exon 14 skipping and gene amplification,which are the key therapeutic targets and drive resistance to tyrosine kinase inhibitors(TKls).1 However,the structural variants of MET,such as MET fusions,are much rarer(0.26%),as reported in a Chinese non-small cell lung cancer(NSCLC)cohort.2 Several recurrent MET fusions,such as KIF5B-MET and HLADRB1-MET,were reported as oncogenic drivers and showed favorable responses to crizotinib.

关键词： lung patients alterations

Highly ordered arrangement of meso-tetrakis(4-aminophenyl)porphyrin in self-assembled nanoaggregates via hydrogen bonding

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Chinese Chemical Letters 2014年第5期25卷 752-756页

作者： Qing-Yun Liu Qing-Yan Jia Ji-Qin Zhu qian shao Jun-Feng Fan Dong-Mei Wang Yan-Sheng Yin College of Chemistry and Chemical Engineering Ocean University of China College of Chemical and Environmental Engineering Shandong University of Science and Technology Institute of Marine Materials Science and Engineering Shanghai Maritime University

meso-Tetrakis（4-aminophenyl）porphyrin（TAPP） can self-assemble into nanostructures with different morphologies by a phase-transfer *** morphologies（nanospheres,nanorods and nanothorns）of porphyrin nanoaggregates could be easily tuned just by changing the concentration of porphyrin in a proper solvent at room *** images revealed the formation of highly ordered supramolecular arrays of TAPP,i.e. superlattice of TAPP molecules in nanoaggregates,which agreed well with the size of one molecule of ***–vis absorption spectra showed an obvious red shift of the Soret band of TAPP,indicating the formation of J-aggregates of TAPP in nanoaggregates.

关键词： Porphyrin Self-assembly Nanoaggregates Highly ordered Hydrogen bonding

Optimization for Planning Programs of Fire Stations in Main Districts of Hangzhou Based on GIS Analysis

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Journal of Landscape Research 2018年第4期10卷 63-66页

作者： shao qian LI Zhi College of City Construction Jiangxi Normal University

As an important part of the city＇s compfehensive disaster prevention and alleviation security system, dty fite control system has diawn increasing attention 〇￡ the community. The planning of dty fife stations is an important safeguard to improve the city fire security. Whetiief the planning is scientific and rational will affect the fire security of the entire dty directly. In this papei; road networks were built based on GIS, the service range of fire stations was calculated based on time cost, and the planning of fire stations in main districts of Hangzhou was evaluated in terms of security, efficiency,and balance The results showed that this planning made significant improvements in security and balance of fke fighting service provided by the main districts of Hangzhou, but few improvements were high in efficiency. On. tiie whole, Xiacheng District did the best job in fire control, and Xihu District was expected to make efforts to improve its fire security.

关键词： Fire station Layoutj GIS Hangzhou

Time-dependent model for two-phase flow in ultra-high water-cut reservoirs: Time-varying permeability and relative permeability

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Petroleum Science 2024年第4期21卷 2536-2553页

作者： shao-Chun Wang Na Zhang Zhi-Hao Tang Xue-Fei Zou qian Sun Wei Liu College of Energy Resources Chengdu University of Technology College of Petroleum Engineering Shandong Institute of Petroleum and Chemical Technology

For the ultra-high water-cut reservoirs, after long-term water injection exploitation, the physical properties of the reservoir change and the heterogeneity of the reservoir becomes increasingly severe, which further aggravates the spatial difference of the flow field. In this study, the displacement experiments were employed to investigate the variations in core permeability, porosity, and relative permeability after a large amount of water injection. A relative permeability endpoint model was proposed by utilizing the alternating conditional expectation(ACE) transformation to describe the variation in relative permeability based on the experimental data. Based on the time dependent models for permeability and relative permeability, the traditional oil-water two-phase model was improved and discretized using the mimetic finite difference method(MFD). The two cases were launched to confirm the validation of the proposed model. The impact of time-varying physical features on reservoir production performance was studied in a real water flooding reservoir. The experimental results indicate that the overall relative permeability curve shifts to the right as water injection increases. This shift corresponds to a transition towards a more hydrophilic wettability and a decrease in residual oil saturation. The endpoint model demonstrates excellent accuracy and can be applied to time-varying simulations of reservoir physics. The impact of variations in permeability and relative permeability on the reservoir production performance yields two distinct outcomes. The time-varying permeability of the reservoir results in intensified water channeling and poor development effects. On the other hand, the time-varying relative permeability enhances the oil phase seepage capacity, facilitating oil displacement. The comprehensive time-varying behavior is the result of the combined influence of these two parameters, which closely resemble the actual conditions observed in oil field expl

关键词： Mimetic finite difference Water flooding reservoir Time-varying physical properties Numerical simulation

Correlation between single nucleotide polymorphisms of 17β-HSD-1 and endometrial adenocarcinoma

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现代妇产科进展 2011年第8期20卷 670-672页

作者： qian shao Zhang Hong Han Wenfei Jian Yan Fu Weijiang Yang Xingsheng Jinan Maternal and Infant Hospital Jinan 250001 Qilu Hospital of Shandong University

Objective: To investigate the correlation between 17-beta-hydroxysteroid dehydrogenase type1(17β-HSD-1) gene polymorphisms and risk of endometrial ***: Forty-one patients with endometrial adenocarcinoma were selected as experimen-tal group and twenty-seven healthy women were selected as control *** three common single nucleotide polymorphism of 17β-HSD-1 gene at sites + 1004,+ 1322 and + 1954 were detected by allele-specific PCR(ASA-PCR).The allele frequencies were analyzed by SPSS13.0 software between endometrial cancer cases and ***: We observed no significant difference in various frequency distribution between experimental group and control group.P1004= 0.994,P1322 = 0.974,and P1954 = ***: We found that three common SNPs with the 17β-HSD-1 gene were not associated with endometrial *** suggest that more research for 17β-HSD needs to explore.

关键词： 17-beta-hydroxysteroid dehydrogenase-type 1 Gene polymorphisms Endometrial neoplasms

基于SBAS-InSAR技术的小龙潭露天矿地表形变监测

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云南地质 2024年第2期43卷 296-302页

作者：芮昌龙陈路良钱绍友苏志强曾富帅云南小龙潭矿务局有限责任公司云南开远661600

以云南小龙潭露天采煤引起地表形变引发地质灾害为例,开展矿区形变监测和地质灾害隐患监测示范研究,对2023年4月至2023年12月21景Sentinel-1A遥感影像利用SBAS-InSAR技术处理。结果表明:露天采场东南帮和北平坝排土场中央偏南区域形变明... 详细信息

以云南小龙潭露天采煤引起地表形变引发地质灾害为例,开展矿区形变监测和地质灾害隐患监测示范研究,对2023年4月至2023年12月21景Sentinel-1A遥感影像利用SBAS-InSAR技术处理。结果表明:露天采场东南帮和北平坝排土场中央偏南区域形变明显,监测采样点D12、E1、IE2形变速率-43.57mm/a、-159.07mm/a和-166.49mm/a,累积形变量-24.6mm、-104.3mm和-115.2mm,监测结果与实地形变趋势一致。SBAS-InSAR技术可及时精准发现和识别矿区边坡灾害集中区,为矿山提供地质灾害工程防治信息。具有借鉴价值和推广应用前景。

关键词： SBAS-InSAR 地表形变地质灾害小龙潭露天矿北平坝排土场云南开远