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Creatine kinase in the diagnosis and prognostic prediction of amyotrophic lateral sclerosis:a retrospective case-control study

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Neural Regeneration Research 2021年第3期16卷 591-595页

作者： Xue-Ping Chen qian-qian Wei Ru-Wei Ou Yan-Bing Hou Ling-Yu Zhang Xiao-Qin Yuan Yun-qian yao De-Sheng Jia qian Zhang Wei-Xue Li Hui-Fang Shang Department of Neurology West China Hospital of Sichuan UniversityChengduSichuan ProvinceChina

Creatine kinase is a muscle enzyme that has been reported at various levels in different studies involving patients with amyotrophic lateral *** the present retrospective case-control study,we included 582 patients with amyotrophic lateral sclerosis and 582 age-and sexmatched healthy *** amyotrophic lateral sclerosis participants received treatment in the Department of Neurology,West China Hospital,China,between May 2008 and December *** creatine kinase levels in patients with amyotrophic lateral sclerosis were significantly higher than those in healthy *** analysis revealed that serum creatine kinase levels in men were higher than those in women in both amyotrophic lateral sclerosis patients and healthy *** with patients with bulbar-onset amyotrophic lateral sclerosis,patients with limb-onset amyotrophic lateral sclerosis had higher creatine kinase ***'s correlation analysis revealed that serum creatine kinase levels were not correlated with body mass index,Amyotrophic lateral Sclerosis Functional Rating ScaleRevised score,or progression *** adjusting for prognostic covariates,higher log creatine kinase values were correlated with higher overall survival in the amyotrophic lateral sclerosis *** also investigated the longitudinal changes in serum creatine kinase levels in 81 amyotrophic lateral sclerosis patients;serum creatine kinase levels were decreased at the second blood test,which was sampled at least 6 months after the first blood ***,our results suggest that serum creatine kinase levels can be used as an independent factor for predicting the prognosis of amyotrophic lateral sclerosis *** study received ethical approval from the Ethics Committee of West China Hospital,China(approval No.2015(236))on December 23,2015.

关键词： amyotrophic lateral sclerosis biomarker creatine kinase diagnosis epidemiological study prognosis serology survival

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Extracellular polymeric substance induces biogenesis of vivianite under inorganic phosphate-free conditions

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Journal of Environmental Sciences 2022年第10期34卷 115-124页

作者： Xinrui Hao Jie Tang Xiaoyun Yi Kun Gao qian yao Chunhua Feng Weilin Huang Zhi Dang School of Environment and Energy South China University of TechnologyGuangzhou 510006China The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters Ministry of EducationSouth China University of TechnologyGuangzhou 510006China Department of Environmental Science Rutgers UniversityNew BrunswickNJ 08901USA

Vivianite is often found in reducing environments rich in iron and phosphorus from organic debris degradation or phosphorus mineral dissolution. The formation of vivianite is essential to the geochemical cycling of phosphorus and iron elements in natural environments. In this study, extracellular polymeric substances(EPS) were selected as the source of phosphorus. Microcosm experiments were conducted to test the evolution of mineralogy during the reduction of polyferric sulfate flocs(PFS) by Shewanella oneidensis MR-1(S. oneidensis MR-1) at EPS concentrations of 0, 0.03, and 0.3 g/L. Vivianite was found to be the secondary mineral in EPS treatment when there was no phosphate in the media. The EPS DNA served as the phosphorus source and DNA-supplied phosphate could induce the formation of *** impedes PFS aggregation, contains redox proteins and stores electron shuttle, and thus greatly promotes the formation of minerals and enhances the reduction of Fe(Ⅲ). At EPS concentration of 0, 0.03, and 0.3 g/L, the produced HCl-extractable Fe(Ⅱ) was 107.9, 111.0,and 115.2 mg/L, respectively. However, when the microcosms remained unstirred, vivianite can be formed without the addition of EPS. In unstirred systems, the EPS secreted by S. oneidensis MR-1 could agglomerate at some areas, resulting in the formation of vivianite in the proximity of microbial cells. It was found that vivianite can be generated biogenetically by S. oneidensis MR-1 strain and EPS may play a key role in iron reduction and concentrating phosphorus in the oligotrophic ecosystems where quiescent conditions prevail.

关键词： Vivianite Phosphorous Extracellular polymeric substances Polyferric flocs Shewanella oneidensis MR-1

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Advancing precision oncology:Insights into the tumor microenvironment and immunotherapy outcomes

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The Innovation 2024年第4期5卷 21-22页

作者： Tomotaka Ugai qian yao Satoko Ugai Shuji Ogino Department of Pathology Brigham and Women’s Hospitaland Harvard Medical SchoolBostonMA 02115USA Department of Epidemiology Harvard T.H.Chan School of Public HealthBostonMA 02115USA Cancer Epidemiology Program Dana-Farber/Harvard Cancer CenterBostonMA 02215USA Broad Institute of MIT and Harvard CambridgeMA 02142USA Cancer Immunology Program Dana-Farber/Harvard Cancer CenterBostonMA 02215USA Tokyo Medical and Dental University(Institute of Science Tokyo) BunkyoTokyo 1138510Japan

The tumor microenvironment represents a dynamic and multifaceted milieu characterized by the complex interactions of diverse cellular and non-cellular constituents.1,2 These constituents include tumor cells,microorganisms,immune and other stromal cells,and extracellular *** orchestration of these components intricately contributes to tumor evolution and shapes responses to cancer treatment(Figure 1).A better understanding of the tumor microenvironment is critical to elucidate the etiology of cancer and develop more efficient therapeutic strategies.

关键词： microenvironment cancer tumor

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Parameters studies for rail wear in high-speed railway turnouts by unreplicated saturated factorial design

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Journal of Central South University 2017年第4期24卷 988-1001页

作者： XU Jing-mang WANG Ping MA Xiao-chuan qian yao CHEN Rong MOE Key Laboratory of High-speed Railway Engineering Southwest Jiaotong University Chengdu 610031 China School of Civil Engineering Southwest Jiaotong University Chengdu 610031 China

Rail wear is one of the main reasons for reducing the service life of high-speed railway turnouts in China. The rail wear characteristics of high-speed railway turnouts are influenced by a large number of input parameters of the complex train-turnout system. To reproduce the actual operation conditions of railway turnouts, random distributions of these inputs need to be considered in rail wear simulation. For a given nominal layout of the high-speed railway turnout, 19 input parameters for rail wear simulation in high-speed railway turnouts are investigated based on orthogonal design of experiment. Three dynamic responses(wheel-rail friction work, normal contact force and size of contact patch) are defined as observed values and the significant factors(direction of passage, axle load, running speed, friction coefficient, and wheel and rail profiles) are determined by two unreplicated saturated factorial design methods, including the half-normal probability plot method and Dong 93 method. As part of the associated rail wear simulation, the influence of the wear models and the local elastic deformation on the rail wear was separately investigated. The calculation results for the wear models are quite different, especially for large creep mode. The local elastic deformation has a large effect on the sliding speed and rail wear and needs to be considered in the rail wear simulation.

关键词： high-speed railway turnouts rail wear unreplicated saturated factorial design wear simulation

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Thermal Behavior,Sensitivity,Detonation Velocity and Pressure of a Nitrogen-Rich Compound

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Journal of Beijing Institute of Technology 2017年第3期26卷 311-317页

作者： Zhiyue Han Yupeng Zhang Zhiming Du Zengyi Li Yuezhen Yang qian yao State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China Xiamen Coffer Gas Dynamic Institute(Ltd.) XiamenFujian 361201China

The nitrogen content of tetrazolo triazines is 68.9%.In this paper,tetrazolotriazines was *** TG-DSC test indicated its decomposition process in *** non-isothermal kinetic parameters were speculated by Kissinger and Ozawa *** revealed the mechanism function of thermal *** impact and friction sensitivity were *** detonation pressure and velocity were *** has a wide range of potential applications as a kind of energetic material.

关键词： nitrogen-rich compounds thermal analysis activation energy mechanism function detonation pressure and velocity

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High-efficiency stretchable organic light-emitting diodes based on ultra-flexible printed embedded metal composite electrodes

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InfoMat 2023年第5期5卷 28-39页

作者： Lan-qian yao Yue Qin Xiang-Chun Li qian Xue Fang Liu Tao Cheng Guan-Jun Li Xinwen Zhang Wen-Yong Lai State Key Laboratory of Organic Electronics and Information Displays(SKLOEID) Institute of Advanced Materials(IAM)Nanjing University of Posts&TelecommunicationsNanjingthe People's Republic of China Frontiers Science Center for Flexible Electronics(FSCFE) MIIT Key Laboratory of Flexible Electronics(KLoFE)Northwestern Polytechnical UniversityXi'anthe People's Republic of China

Stretchable organic light-emitting diodes(OLEDs)are important components for flexible/wearable ***,the efficiency of the existing stretchable OLEDs is still much lower as compared with their rigid counterparts,one of the main reasons being the lack of ideal flexible transparent ***,we propose and develop a printed embedded metal composite electrode(PEMCE)strategy that enables the fabrication of ultra-thin,highly flexible transparent electrodes with robust mechanical *** the flexible transparent electrodes serves as the anodes,flexible/stretchable white OLEDs have been successfully constructed,achieving a current efficiency of up to 77.4 cd A^(-1)and a maximum luminance of 34787 cd m^(-2).The current efficiency of the resulting stretchable OLEDs is the highest ever reported for flexible/stretchable white OLEDs,which is about 1.2 times higher than that of the reference rigid devices based on ITO/glass *** excellent optoelectronic properties of the printed embedded transparent electrodes and the light extraction effect of the Ag-mesh account for the significant increase in current ***,the electroluminescence performance still retains~83%of the original luminance even after bending the device 2000 cycles at a radii of~0.5 *** importantly,the device can withstand tensile strains of up to~100%,and even mechanical deformation of 90%tensile strain does not result in a significant loss of electroluminescence performance with current efficiency and luminance maintained at over 85%.The results confirm that the PEMCE strategy is effective for constructing ultra-flexible transparent electrodes,showing great promise for use in a variety of flexible/stretchable electronics.

关键词： flexible electrodes flexible electronics printed embedded metal composite electrodes stretchable OLEDs transparent electrodes

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The COVID-19 Pandemic and Digital Infrastructure Construction

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China Economic Transition 2021年第1期4卷 94-101页

作者： yao qian Science and Technology Supervision Bureau China Securities Regulatory Commission

Social distancing to fight the COVID-19 pandemic has highlighted the importance of contactless technology,represented by remote work,video conferencing,online education,online payments,and so *** flourishing information infrastructure has supported the normal operations of social and economic order during the *** hedge against the risk of an economic downturn,the Chinese government has proposed accelerating the construction of new infrastructure,such as the fifth-generation mobile communication(5G)network and data centers,and cultivating a data factor ***,digital infrastructure construction is becoming a national development strategy.

关键词： becoming operations education

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High Quality Development of Blockchain and Data Governance

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China Economic Transition 2020年第2期3卷 18-29页

作者： yao qian of Science and Technology Supervision Bureau China Securities Regulatory Commission

While presiding over the 18th group study session of the Political Bureau of the Communist Party of China Central Committee,General Secretary Xi Jinping delivered a visionary and thought-provoking address,in which he emphasized the importance of facilitating blockchain de-velopment and industrial innovation-a hotspot issue in information *** also laid out the blockchain development blueprint to navigate China’s future ***,he emphasized the significance of an objective and dialectical attitude toward innovative technology,which he regarded as a double-edged *** ensure the secure and orderly development of blockchain technology,it is imperative to guide and regulate the blockchain develop-ment,study and analyze risks,enhance industrial discipline,strengthen accountability in security issues,and promote law-based blockchain governance.

关键词： Quality innovative sword

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Surface plasmon resonance of layer-by-layer gold nanoparticles induced photoelectric current in environmentally-friendly plasmon-sensitized solar cell

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Light(Science & Applications) 2012年第1期1卷 100-104页

作者： Yen-Hsun Su Yuan-Feng Ke Shi-Liang Cai qian-Yu yao Department of Materials Science and Engineering National Dong Hwa UniversityHualien Department of Physics National Dong Hwa UniversityHualien

Layer-by-layer gold nanoparticles are used to generate photocurrent in an environmentally-friendly plasmon-sensitized solar cell towing to surface plasmon *** efficiency of the photoelectric conversion of gold nanoparticle layers is increased as the intensity of surface plasmon resonance *** also explain the experimental results by modeling the phenomenon of charge separation and photocurrent formation,and the relationship between surface plasmon resonance and photocurrent formation,which has potential application in plasmon-sensitized solar cells and plasmonic solar cells in the future.

关键词： charge separation layer-by-layer gold nanoparticles plasmon-sensitized solar cells plasmonic solar cells surface plasmon resonance

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中央银行数字货币原型系统实验研究

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软件学报 2018年第9期29卷 2716-2732页

作者：姚前中国人民银行数字货币研究所北京100088

数字货币的出现被视为货币形态的又一次重大革命,有望成为数字经济时代的主流通货和重要金融基础设施.中央银行推动发行央行数字货币(central bank digital currency,简称CBDC)势在必行.根据中国人民银行法定数字货币原型系统实验,探索... 详细信息

数字货币的出现被视为货币形态的又一次重大革命,有望成为数字经济时代的主流通货和重要金融基础设施.中央银行推动发行央行数字货币(central bank digital currency,简称CBDC)势在必行.根据中国人民银行法定数字货币原型系统实验,探索了二元模式下法定数字货币发行、转移、回笼闭环流程,设计了CBDC的加密字符串表达形式、通过存款准备金等额兑换的发行回笼机制、CBDC在转移过程中的转换机制以及原型系统的总体架构、系统架构和技术架构,并在局部采用分布式账本技术基础上探讨增强其可用性的改进方法,最后还研究了在保护用户隐私前提下如何对CBDC进行数据分析.研究发现,基于分布式账本的共识记账和国密SM2运算是影响CBDC转移性能的关键操作,并提出优化改进思路.

关键词：中央银行数字货币原型系统分布式账本 SM2算法

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