Advancing precision oncology:Insights into the tumor microenvironment and immunotherapy outcomes

作     者：Tomotaka Ugai Qian Yao Satoko Ugai Shuji Ogino 

作者机构：Department of PathologyBrigham and Women’s Hospitaland Harvard Medical SchoolBostonMA 02115USA Department of EpidemiologyHarvard T.H.Chan School of Public HealthBostonMA 02115USA Cancer Epidemiology ProgramDana-Farber/Harvard Cancer CenterBostonMA 02215USA Broad Institute of MIT and HarvardCambridgeMA 02142USA Cancer Immunology ProgramDana-Farber/Harvard Cancer CenterBostonMA 02215USA Tokyo Medical and Dental University(Institute of Science Tokyo)BunkyoTokyo 1138510Japan 

出 版 物：《The Innovation》 (创新（英文）)

年 卷 期：2024年第5卷第4期

页      面：21-22页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported in part by the Cancer Research UK Cancer Grand Challenge Award(6340201/A27140) NIH grant(R01 CA248857) T.U.was supported by NIH grant R50 CA27412 a Brigham and Women’s Hospital Faculty Career Development Award,an Investigator Initiated Grant from the American Institute for Cancer Research(AICR),a Prevent Cancer Foundation Fellowship,and the Harvey V.Fineberg Fellowship in Cancer Prevention from Harvard T.H.Chan School of Public Health.S.U.was supported by a grant from the Uehara Memorial Foundation.S.O.is an American Cancer Society Clinical Research Professor 

主　　题：microenvironment cancer tumor 

摘      要：The tumor microenvironment represents a dynamic and multifaceted milieu characterized by the complex interactions of diverse cellular and non-cellular constituents.1,2 These constituents include tumor cells,microorganisms,immune and other stromal cells,and extracellular *** orchestration of these components intricately contributes to tumor evolution and shapes responses to cancer treatment(Figure 1).A better understanding of the tumor microenvironment is critical to elucidate the etiology of cancer and develop more efficient therapeutic strategies.