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Development and validation of tongue imaging-based radiomics tool for the diagnosis of insomnia degree:a two-center study

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Medical Data Mining 2024年第1期7卷 24-31页

作者： Rui Ye Ze-Kun Jiang Rong Shao qian yan Li-Juan Zhou Ting-Rui Zhang Ying-Chun Sun Department of Gynecology Qingdao Hiser Hospital Affiliated of Qingdao University(Qingdao Traditional Chinese Medicine Hospital)Qingdao 266000China Department of Traditional Chinese Medicine Jiaozhou Traditional Chinese Medicine HospitalQingdao 266000China College of Computer Science Sichuan UniversityChengdu 610000China Adult Traditional Chinese Medicine Department Qingdao Women and Children’s HospitalQingdao 266000China College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan 250000China Sichuan University-Pittsburgh Institute Sichuan UniversityChengdu 610000China.

Background:Traditional Chinese medicine(TCM)is commonly used for the diagnosis and treatment of insomnia,with tongue diagnosis being particularly important.The aim of our study was to develop and validate a novel tongue imaging-based radiomics(TIR)method for accurately diagnosing insomnia severity.Methods:This two-center analysis prospectively enrolled 399 patients who underwent tongue imaging between July and October 2021 and divided them into primary and validation cohorts by study center.Here,we referred to the Insomnia Severity Index(ISI)standard and the degree of insomnia was evaluated as absent,subthreshold,moderate,or severe.For developed the TIR diagnostic tool,a U-Net algorithm was used to segment tongue images.Subsequently,seven imaging features were selected from the extracted high-throughout radiomics features using the least absolute shrinkage and selection operator algorithm.Then,the final radiomics model was developed in the primary cohort and tested in the independent validation cohort.Finally,we assessed and compared the diagnostic performance differences between TCM tongue diagnosis and our TIR diagnostic tool with the ISI gold standard.The confusion matrix was calculated to evaluate the diagnostic performance.Results:Seven tongue imaging features were selected to build the TIR tool,with showing good correlations with the insomnia degree.The TIR method had an accuracy of 0.798,a macro-average sensitivity of 0.78,a macro-average specificity of 0.906,a weighted-average sensitivity of 0.798,and a weighted specificity of 0.916,showing a significantly better performance compared to the average performance of three experienced TCM physicians(mean accuracy of 0.458,P<0.01).Conclusions:The preliminary study demonstrates the potential application of TIR in the diagnosis of insomnia degree and measurement of sleep health.The integration of quantitative imaging analysis and machine learning algorithms holds promise for advancing both of TCM and precision sleep medicine.

关键词： insomnia tongue image radiomics machine learning traditional Chinese medicine

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On Convexification for a Class of Global Optimization Problems

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Journal of the Operations Research Society of China 2022年第3期10卷 427-446页

作者： qian yan Xin-Min yang Zhi-You Wu College of Mathematics Sichuan UniversityChengdu610065SichuanChina School of Mathematical Science Chongqing Normal UniversityChongqing401331China

In this paper,firstly,we give a counterexample to point out there exist deficiencies in our previous works(Wu et al.in J Glob Optim 31:45-60,2005).In addition,we improve the corresponding results.Finally,an example is presented to illustrate how a monotone non-convex optimization problem can be transformed into an equivalent convex minimization problem.

关键词： Global optimization Deficiency Counterexample Monotone optimization Convexification method

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Application of neutrophil-lymphocyte ratio and red blood cell distribution width in diabetes mellitus complicated with heart failure

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World Journal of Diabetes 2024年第6期15卷 1226-1233页

作者： Jie Pang Lin-yan qian Ping Lv Xiao-Ru Che Heart Center Department of Cardiovascular MedicineZhejiang Provincial People’s Hospital(The Affiliated People’s Hospital)Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina

BACKGROUND Accumulating clinical evidence has shown that diabetes mellitus(DM)is a serious risk factor for cardiovascular disorders and an important factor for adverse cardiovascular events.AIM To explore the value of the combined determination of the neutrophil-lymphocyte ratio(NLR)and red blood cell distribution width(RDW)in the early diagnosis and prognosis evaluation of DM complicated with heart failure(HF).METHODS We retrospectively analyzed clinical data on 65 patients with type 2 DM(T2DM)complicated with HF(research group,Res)and 60 concurrent patients with uncomplicated T2DM(control group,Con)diagnosed at Zhejiang Provincial People’s Hospital between January 2019 and December 2021.The NLR and RDW values were determined and comparatively analyzed,and their levels in T2DM+HF patients with different cardiac function grades were recorded.The receiver operating characteristic(ROC)curves were plotted to determine the NLR and RDW values(alone and in combination)for the early diagnosis of HF.The correlation between NLR and RDW with the presence or absence of cardiac events was also investigated.RESULTS Higher NLR and RDW levels were identified in the Res vs the Con groups(P<0.05).The NLR and RDW increased gradually and synchronously with the deterioration of cardiac function in the Res group,with marked differences in their levels among patients with grade II,III,and IV HF(P<0.05).ROC curve analysis revealed that NLR combined with RDW detection had an area under the curve of 0.915,a sensitivity of 76.9%,and a specificity of 100%for the early diagnosis of HF.Furthermore,HF patients with cardiac events showed higher NLR and RDW values compared with HF patients without cardiac events.CONCLUSION NLR and RDW were useful laboratory indicators for the early diagnosis of DM complicated with HF,and their joint detection was beneficial for improving diagnostic efficiency.Additionally,NLR and RDW values were directly proportional to patient outcomes.

关键词： Neutrophil-lymphocyte ratio Red blood cell distribution width Type 2 diabetes Heart failure Early diagnosis

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基于随附原则的同一性认知方案

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自然辩证法研究 2024年第4期40卷 43-48页

作者：钱彦臣南京大学哲学系南京210023

个体同一性是当代分析形而上学的核心论题。借助可能世界语义学的装置,该论题的紧迫性进一步暴露,其本身并不能被简单的形式化手段所回答,其真正面临的是:如何在纷繁复杂的变化中,给予个体存在的标准。本质主义似乎是首选方案,然而,基... 详细信息

个体同一性是当代分析形而上学的核心论题。借助可能世界语义学的装置,该论题的紧迫性进一步暴露,其本身并不能被简单的形式化手段所回答,其真正面临的是:如何在纷繁复杂的变化中,给予个体存在的标准。本质主义似乎是首选方案,然而,基于模态逻辑的必然属性却无法真正地刻画本质。出于认知上对空同一的拒斥,随附原则承诺个体同一性理应以其他可感知的质的属性为基础。借此,立足于主体实际的同一性判断,可构建一种“自下而上”的动态认知途径,为找寻个体同一性标准提供认知上的参考。

关键词：个体同一性可能世界随附性

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蚕丝基生物材料精准和功能性组装的3D打印策略

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Engineering 2024年第3期34卷 92-108页

作者： Xiaoliang Cui Jun Zhang yan qian Siqi Chang Benjamin J.Allardyce Rangam Rajkhowa Hui Wang Ke-Qin Zhang National Engineering Laboratory for Modern Silk College of Textile and Clothing EngineeringSoochow UniversitySuzhou 215123China Institute for Frontier Materials Deakin UniversityGeelongVIC 3216Australia

In recent years,significant progress has been made in both three-dimensional(3D)printing technologies and the exploration of silk as an ink to produce biocompatible constructs.Combined with the unlimited design potential of 3D printing,silk can be processed into a broad range of functional materials and devices for various biomedical applications.The ability of silk to be processed into various materials,including solutions,hydrogels,particles,microspheres,and fibers,makes it an excellent candidate for adaptation to different 3D printing techniques.This review presents a didactic overview of the 3D printing of silk-based materials,major categories of printing techniques,and their prototyping mechanisms and structural features.In addition,we provide a roadmap for researchers aiming to incorporate silk printing into their own work by summarizing promising strategies from both technical and material aspects,to relate state-of-the-art silk-based material processing with fast-developing 3D printing technologies.Thus,our focus is on elucidating the techniques and strategies that advance the development of precise assembly strategies for silk-based materials.Precise printing(including high printing resolution,complex structure realization,and printing fidelity)is a prerequisite for the digital design capability of 3D printing technology and would definitely broaden the application era of silk,such as complex biomimetic tissue structures,vasculatures,and transdermal microneedles.

关键词： 3D printing Bioink Bioprinting Silk fibroin

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Comparative study of performance comparison of AlSi10Mg alloy prepared by selective laser melting and casting

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Journal of Materials Science & Technology 2020年第6期41卷 199-208页

作者： qian yan Bo Song Yusheng Shi State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan430074China

The influence of the microstructure on mechanical properties of AlSi10Mg fabricated by casting and selective laser melting(SLM)were investigated and contrasted in this work,with an emphasis on understanding the forming mechanism.The microstructure,phase structure and mechanical properties were characterized by scanning electron microscopy/field-emission Transmission Electron Microscopy(SEM/TEM),X-Ray Diffraction(XRD),tensile and fatigue tests.The results indicated that the SLM AlSi10Mg exhibited a supersaturated Si network structure precipitated alongα-Al cell.Brittleβ-Al5FeSi andπ-Al8FeMg3Si6 phases were found in the as-cast and SLM AlSi10Mg respectively due to different thermal histories during processing.The SLM AlSi10Mg showed higher tensile strength but lower elongation than the casting,as the result of grain refinement and tortuous crack path.The fatigue results revealed that unmelted powder,oxide inclusion and pores can considerably degrade the fatigue properties for the SLM AlSi10Mg.The SLM process offered a new method for material processing that would avoid harmful Fe-bearing intermetallic compounds and refine the microstructures for enhancing strength.

关键词： Selective laser melting Casting AlSi10Mg Intermetallic compound Mechanical properties

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基于全变分加权差正则的高光谱图像去噪算法

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合肥工业大学学报（自然科学版） 2024年第1期47卷 47-53,76页

作者：钱妍张莉合肥工业大学数学学院安徽合肥230601

针对现有全变分模型在高光谱图像中出现的伪影、边缘结构消失等问题,文章提出一种增强型三维全变分加权差正则模型。首先,该模型并非直接将稀疏性强加于梯度映射本身,而是对梯度映射的基矩阵添加稀疏性约束。此外,与一般稀疏约束方法不... 详细信息

针对现有全变分模型在高光谱图像中出现的伪影、边缘结构消失等问题,文章提出一种增强型三维全变分加权差正则模型。首先,该模型并非直接将稀疏性强加于梯度映射本身,而是对梯度映射的基矩阵添加稀疏性约束。此外,与一般稀疏约束方法不同的是,为避免由l_(1)范数自身局限性带来的去噪不良影响,利用l_(1)范数与l_(2)范数的全变分加权差(简记为l_(1-2))分别对高光谱图像的空间域与光谱域施加稀疏约束。实验结果表明,该文提出的算法有效避免了伪影的产生以及图像细节丢失的问题,具有更优的去噪效果。

关键词：高光谱图像混合噪声全变分模型稀疏性梯度映射

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调整细胞培养条件提高间充质干细胞外泌体治疗骨关节炎的潜能

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中国组织工程研究 2025年第1期29卷 164-174页

作者：钱燕刘启颂深圳国家感染性疾病临床医学研究中心南方科技大学深圳市第三人民医院广东省深圳市518112

背景:间充质干细胞外泌体有望发展成为治疗骨关节炎的无细胞疗法,而通过调整细胞培养条件,可以进一步提高其治疗活性和临床转化潜能。目的:综述分析细胞培养条件对外泌体活性的影响,分析其临床转化潜力。方法:查阅国内外有关骨关节炎/... 详细信息

背景:间充质干细胞外泌体有望发展成为治疗骨关节炎的无细胞疗法,而通过调整细胞培养条件,可以进一步提高其治疗活性和临床转化潜能。目的:综述分析细胞培养条件对外泌体活性的影响,分析其临床转化潜力。方法:查阅国内外有关骨关节炎/软骨损伤修复与间充质干细胞来源外泌体的文献。检索词分别为“外泌体,间充质干细胞,骨关节炎,软骨修复”和“exosomes,extracellular vesicles,mesenchymal stem cells,osteoarthritis,cartilage repair”,检索数据库分别为PubMed和中国知网数据库,检索时限为2010-2023年,最后纳入100篇文献进行总结和分析。结果与结论:(1)在间充质干细胞的培养过程中,提供有利于软骨细胞生长的物理环境,或添加软骨保护小分子、成软骨诱导因子和炎症因子等刺激细胞,可以进一步提高间充质干细胞外泌体在维持软骨细胞表型、促进软骨再生和免疫抑制等方面的调控活性;因此,其他具有相似特征的物理或化学因素,也有可能提升间充质干细胞外泌体治疗骨关节炎的疗效。(2)低氧诱导、脉冲电磁场刺激、生物反应器及软骨保护分子(如人甲状旁腺素1-34)刺激等细胞培养方案具有安全、可规模化生产等优点,可用于制备临床用途的、疗效好的间充质干细胞外泌体。(3)间充质干细胞外泌体有望实现骨关节炎的修正治疗,通过调整细胞培养方案提升治疗活性,可进一步提高其临床转化的可行性。

关键词：间充质干细胞外泌体骨关节炎软骨修复细胞培养低氧诱导预处理三维培养软骨保护因子炎症因子

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某型电子设备机箱散热结构设计及试验测试

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机械设计 2024年第1期41卷 218-224页

作者：姜慧枫张萌颜倩中国地质大学(武汉)机械与电子信息学院湖北武汉430074

针对某型医用电子设备要兼顾内部散热及外形美观紧凑的要求,采用热仿真软件Flotherm对该医用电子设备的温度场进行了仿真。根据仿真结果,提出增加GPU散热背板、箱体上层开通风孔、箱体下层增加通风格栅及增加风扇等改进措施,通过综合分... 详细信息

针对某型医用电子设备要兼顾内部散热及外形美观紧凑的要求,采用热仿真软件Flotherm对该医用电子设备的温度场进行了仿真。根据仿真结果,提出增加GPU散热背板、箱体上层开通风孔、箱体下层增加通风格栅及增加风扇等改进措施,通过综合分析与对比,得到适用于该设备的最佳散热方案。根据散热方案对机箱进行结构改进设计,呈现箱体散热结构与外形的协调美。通过对实际样机进行热试验测试,对比样机实测温度数据与最终改进方案的热仿真结果,表明相同工况下医用电子设备内各主要发热器件的温差均处于可接受的差异范围内,验证了热设计的正确性。该设计增强了设备的运行稳定性与可靠性,也为同类型的医疗电子设备热设计提供了参考。

关键词：热设计结构设计 Flotherm 散热方案热测试

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Atomically Precise Water-Soluble Gold Nanoclusters:Synthesis and Biomedical Application

Precision Chemistry

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Precision Chemistry 2023年第8期1卷 468-479页

作者： qian yan Zhaotong Yuan Yating Wu Chunmei Zhou Yihu Dai Xiaoyue Wan Dan yang Xu Liu Nianhua Xue yan Zhu yanhui yang Institute of Advanced Synthesis School of Chemistry and Molecular EngineeringNanjing Tech UniversityNanjing 211816China School of Chemistry and Chemical Engineering Nanjing UniversityNanjing 210093China College of Material and Chemical Engineering Minjiang UniversityFuzhou 350108China

Atomically precise water-soluble gold nanoclusters(Au NCs)protected by organic ligands have attracted growing attention in serving as unique nanomaterials with the potential to generate theranostic tools(bioimaging,biosensing,and biotherapy),due to their ultrasmall size,superior photoluminescence,good biocompatibility,and nontoxicity.More importantly,Au NCs afford a well-defined atomic packing structure and molecular purity,providing a superior platform to unravel the structure−performance correlations for biodistribution,biological pharmacokinetics,and excretion of Au NCs.In this Review,we mainly survey the synthesis of water-soluble Au NCs and the recent progress in biomedicine of Au NCs,including bioimaging,biosensing,and biotherapy.The effects of ligand and size on the biomedical properties are discussed in detail.We hope that the advances in this research area can expand the applications of Au NCs in biomedicine.

关键词： Gold nanocluster well-defined structure water-soluble biodiagnostic theranostic

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