Atomically Precise Water-Soluble Gold Nanoclusters:Synthesis and Biomedical Application

作     者：Qian Yan Zhaotong Yuan Yating Wu Chunmei Zhou Yihu Dai Xiaoyue Wan Dan Yang Xu Liu Nianhua Xue Yan Zhu Yanhui Yang 

作者机构：Institute of Advanced SynthesisSchool of Chemistry and Molecular EngineeringNanjing Tech UniversityNanjing 211816China School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210093China College of Material and Chemical EngineeringMinjiang UniversityFuzhou 350108China 

出 版 物：《Precision Chemistry》 (精准化学（英文）)

年 卷 期：2023年第1卷第8期

页      面：468-479页

学科分类：081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 

基　　金：financial support from the Foundation of the Jiangsu Higher Education Institutions of China(22KJB150026) the National Natural Science Foundation of China(22178161,22101128) 

主　　题：Gold nanocluster well-defined structure water-soluble biodiagnostic theranostic 

摘      要：Atomically precise water-soluble gold nanoclusters(Au NCs)protected by organic ligands have attracted growing attention in serving as unique nanomaterials with the potential to generate theranostic tools(bioimaging,biosensing,and biotherapy),due to their ultrasmall size,superior photoluminescence,good biocompatibility,and *** importantly,Au NCs afford a well-defined atomic packing structure and molecular purity,providing a superior platform to unravel the structure−performance correlations for biodistribution,biological pharmacokinetics,and excretion of Au *** this Review,we mainly survey the synthesis of water-soluble Au NCs and the recent progress in biomedicine of Au NCs,including bioimaging,biosensing,and *** effects of ligand and size on the biomedical properties are discussed in *** hope that the advances in this research area can expand the applications of Au NCs in biomedicine.