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The biomethane producing potential in China： A theoretical and practical estimation

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Chinese Journal of Chemical Engineering 2016年第7期24卷 920-928页

作者： Chang Liu Jun Wang xiaoyan Ji Hongliang qian Liangliang Huang Xiaohua Lu College of Chemistry and Chemical Engineering Nanjing Tech University Nanjing210009 China School of Chemical Biological & Materials Engineering University of Oklahoma Norman 73019 United States Division of Energy Science Lulea University of Technology 97187 Lulea Sweden School of Pharmacy China Pharmaceutical University Nanjing 210009 China

Biomethane has been developed rapidly in many countries as a renewable energy which upgraded from biogas. China also began to pay attention to it even though we still at a initial stage, primarily, understanding the hiomethane potential and development prospect, choosing appropriate biomass as the biomethane source is very important. In this work, the theoretical and practical biomethane producing potential from five main bio- mass resources in China were estimated with appropriate methods based on the data collected, and during cal- culation, two appropriate energy crops were assumed to be planted on marginal lands for biomethane production. Our estimation showed that the theoretical and practical biomethane potentials in China can reach to 888.78 and 316.30 billion m3 per year, agricultural waste should be the preferential development biomass, and planting energy crops on marginal lands is the most promising way to enhance biomethane production in China. Finally, biomethane is compared with natural gas, and the result showed that 48.15% of the practical biomethane potential can meet the total Chinese natural gas consumption in 2013.

关键词： Biomethane potentialBiomassMarginal landEnergy crop

Metal-organic framework hybrid materials of ZIF-8/RGO for immobilization of D-amino acid dehydrogenase

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Nano Research 2024年第1期17卷 290-296页

作者： Hangbin Lei qian Zhang xiaoyan Xiang Liang Jiang Shiyan Wang Lingxuan Duan Shizhen Wang Department of Chemical and Biochemical Engineering College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Xiamen Key Laboratory of Synthetic Biotechnology Xiamen UniversityXiamen 361005China

Immobilization of D-amino acid dehydrogenase(DAADH)by the assembly of peptide linker was studied for the biosynthesis of *** material of zeolitic imidazolate framework-8(ZIF-8)combined with reduced graphene oxide(RGO)was applied for the immobilization of DAADH from Ureibacillus *** recovery rate of DAADH/ZIF-8/RGO was 165.6%.DAADH/ZIF-8/RGO remained 53.4%of its initial activity at 50°C for 10 h while the free enzyme was ***/ZIF-8/RGO maintained 70.5%activity in hyperalkaline solution with pH *** parameters indicated that DAADH/ZIF-8/RGO had greater affinity of phenylpyruvate as V_(max)/K_(m)of DAADH/ZIF-8/RGO was 1.27-fold than free *** seven recycles,the activity of DAADH/ZIF-8/RGO remained 64.3%.Furthermore,one-step separation and in situ immobilization of DAADH by ZIF-8/RGO/Ni was carried out with 1.5-fold activity *** peptide linker and metal-organic framework(MOF)immobilization,thermostability and activity of the immobilized DAADH were significantly improved.

关键词： D-Amino acid dehydrogenase immobilization metal-organic frameworks zeolitic imidazolate framework-8(ZIF-8) reduced graphene oxide

Network pharmacology approaches for research of Traditional Chinese Medicines

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Chinese Journal of Natural Medicines 2023年第5期21卷 323-332页

作者： LI Xiang LIU Ziqi LIAO Jie CHEN qian LU xiaoyan FAN Xiaohui School of Basic Medical Sciences and Forensic Medicine Hangzhou Medical CollegeHangzhou 311399China Department of Chinese Medicine Science&Engineering College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Innovation Center in Zhejiang University State Key Laboratory of Component-based Chinese MedicineHangzhou 310058China Future Health Laboratory Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100China

Pharmacodynamics material basis and effective mechanisms are the two main issues to decipher the mechnisms of action of Traditional Chinese medicines(TCMs)for the treatment of ***,in“multi-component,multi-target,multi-pathway”paradigm,show satisfactory clinical results in complex *** ideas and methods are urgently needed to explain the complex interactions between TCMs and *** pharmacology(NP)provides a novel paradigm to uncover and visualize the underlying interaction networks of TCMs against multifactorial *** development and application of NP has promoted the safety,efficacy,and mechanism investigations of TCMs,which then reinforces the credibility and popularity of *** current organcentricity of medicine and the“one disease-one target-one drug”dogma obstruct the understanding of complex diseases and the development of effective ***,more attentions should be paid to shift from“phenotype and symptom”to“endotype and cause”in understanding and redefining current *** the past two decades,with the advent of advanced and intelligent technologies(such as metabolomics,proteomics,transcriptomics,single-cell omics,and artificial intelligence),NP has been improved and deeply implemented,and presented its great value and potential as the next drug-discovery *** is developed to cure causal mechanisms instead of treating *** review briefly summarizes the recent research progress on NP application in TCMs for efficacy research,mechanism elucidation,target prediction,safety evaluation,drug repurposing,and drug design.

关键词： Network Pharmacology Single-Cell omics Artificial Intelligence Traditional Chinese Medicine Herbal Medicine Pharmacodynamics Material Basis Effective Mechanism Drug Repurposing

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关于城市商业超市火灾的预防

价值工程 2010年第18期29卷 146-146页

作者：钱笑岩辽宁省消防总队大连支队大连116000

随着商业超市规模越来越大,发展速度也越来越快,超市消防安全的问题也日益严重,所以超市消防安全的管理,必须引起消防监督人员的充分注意。

关键词：商业超市消防安全管理

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多模式睡眠:慢性失眠的创新疗法

中华麻醉学杂志 2020年第5期40卷 520-523页

作者：安建雄张建峰赵倩男张文浩刘辉钱晓焱刘颖王永方七五 Williams John P 中国科学院大学存济医学院北京101408 中国医科大学航空总医院暨中国科学院北京转化医学研究院麻醉、疼痛与睡眠医学中心 100012 北京航空航天大学医学科学与工程学院北京生物医学工程高精尖中心 100191 Department of Anesthesiology University of Pittsburgh School of Medicine15213 PittsburghUSA

麻醉术不仅能保障手术无痛,在其发展过程中所产生的新发明和新理念如血库的建立、心肺复苏术的发明和推广、疼痛诊疗的普及等,还为人类健康做出了更多的重大贡献。被誉为"疼痛医学之父"的Bonica教授和"心肺复苏术之父"的Safar教授早已... 详细信息

麻醉术不仅能保障手术无痛,在其发展过程中所产生的新发明和新理念如血库的建立、心肺复苏术的发明和推广、疼痛诊疗的普及等,还为人类健康做出了更多的重大贡献。被誉为"疼痛医学之父"的Bonica教授和"心肺复苏术之父"的Safar教授早已跨越时空和国界,成为全世界麻醉医师的骄傲。把麻醉技术用于失眠治疗一直是有远见的麻醉医务工作者探索的热点。美国著名麻醉学家、发明家和教育家Ralph Waters(1883—1979)教授,也是我国麻醉学科奠基者之一吴珏教授的导师,在1927年被聘任为世界首位麻醉学教授的仪式上,威斯康新大学校长幽默地称赞:Waters是大学聘任的第一位能让人睡觉的教授。事实上时至今日,即使最发达国家的公众,对一位麻醉医师的理解,也是能让人睡觉的人,这种现象揭示了公众对失眠问题的深刻认知和关注。据统计我国目前约有3.3亿人患有不同程度的失眠,其治疗是当今世界的医学难题。安建雄教授领衔的科研团队经过近10年的探索,率先提出并践行以病人自控睡眠为主导的多模式睡眠疗法,尽管在推广和广泛临床应用之前,还需要更多的研究和科学证据,但这种尝试不仅可以丰富麻醉学科内涵,还为严重失眠病人带来新的治疗选择。

关键词：慢性失眠麻醉学科心肺复苏术麻醉术吴珏医学难题麻醉技术科研团队

Aggregation-induced emission luminogen-assisted stimulated emission depletion nanoscopy for super-resolution mitochondrial visualization in live cells

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Nano Research 2018年第11期11卷 6023-6033页

作者： Dongyu Li Xiang Ni xiaoyan Zhang Liwei Liu Junle Qu Dan Ding Jun qian State Key Laboratory of Modern Optical Instrumentation Centre for Optical and Electromagnetic Research Zhejiang Provincial Key Laboratory for Sensing Technologies Zhejiang University Hangzhou 310058 China State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive Materials Ministry of Education and College of Life Sciences Nankai University Tianjin 300071 China Key Laboratory of Optoelectrical Devices and Systems Ministry of Education Shenzhen University Shenzhen 518060 China Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy Cancer Institute Xuzhou Medical University Xuzhou 221004 China

Aggregation-induced emission luminogens (AIEgens) are fluorescent agents that are ideal for bioimaging and have been widely used for organelle targeting, cellular mapping, and tracing. Owing to their promising characteristics, AIEgen-based nanoparticles have recently been used for the stimulated emission depletion (STED) super-resolution imaging of fixed cells. In the present study, and for the first time, we used an AIEgen for dynamic STED nanoscopic imaging of a specific organelle in live cancer cells. TPA-T-CyP is a synthetic red&NIR-emitting luminogen with AIE features that can spontaneously and specifically aggregate on mitochondria without the need for encapsulation or surface modification. The STED efficiency of aggregated TPA-T-CyP can reach more than 80%, and super-resolution imaging of TPA-T-CyP-stained mitochondria in live HeLa cells is possible, with a lateral spatial resolution of 74 nm. We found that TPA-T-CyP enabled the dynamic visualization of mitochondria, and the motion, fusion, and fission of mitochondria were clearly observable on a super-resolution scale. AIEgen-based super-resolution organelle visualization has great potential for many basic biomedical studies.

关键词： aggregation-induced emission stimulated emission depletion nanoscopy mitochondria dynamic visualization

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直肠三氧灌注疗法研究进展

转化医学杂志 2019年第6期8卷 377-380页

作者：张文浩钱晓焱刘辉李彤王永安建雄中国科学院大学存济医学院北京100049 中国医科大学航空总医院暨中国科学院北京转化医学研究院麻醉、疼痛与重症医学中心北京100012 兰州市妇幼保健院疼痛科兰州730030

直肠三氧灌注疗法是指将医用三氧通过直肠注入作用于人体,以达到预防和治疗疾病目的的一种疗法。近年来有关直肠三氧灌注的基础研究与临床报道越来越多。作者系统地综述该疗法在基础研究和临床工作中研究进展,有利于该疗法的研究和应用。

关键词：三氧直肠三氧灌注

An Improved CREAM Model Based on DS Evidence Theory and DEMATEL

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2597-2617页

作者： Zhihui Xu Shuwen Shang Yuntong Pu xiaoyan Su Hong qian Xiaolei Pan State Key Laboratory of Nuclear Power Safety Monitoring Technology and Equipment Shenzhen518172China School of Automation Engineering Shanghai University of Electric PowerShanghai200090China School of Safety and Management Engineering Hunan Institute of TechnologyHengyang421002China

Cognitive Reliability and Error Analysis Method(CREAM)is widely used in human reliability analysis(HRA).It defines nine common performance conditions(CPCs),which represent the factors thatmay affect human reliability and are used to modify the cognitive failure probability(CFP).However,the levels of CPCs are usually determined by domain experts,whichmay be subjective and ***’smore,the classicCREAMassumes that the CPCs are independent,which is *** the dependence among CPCs will result in repeated calculations of the influence of the CPCs on CFP and lead to unreasonable reliability *** address the issue of uncertain information modeling and processing,this paper introduces evidence theory to evaluate the CPC levels in specific *** address the issue of dependence modeling,the Decision-Making Trial and Evaluation Laboratory(DEMATEL)method is used to process the dependence among CPCs and calculate the relative weights of each CPC,thus modifying the multiplier of the *** detailed process of the proposed method is illustrated in this paper and the CFP estimated by the proposed method is more reasonable.

关键词： Human reliability analysis CREAM uncertainty modeling dependence Dempster-Shafer evidence theory DEMATEL

1例介入治疗法洛三联症并房性心动过速的护理

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护理研究 2008年第6期22卷 555-556页

作者：钱小燕曹爱芳陈文瑶王筱慧中国人民解放军第二军医大学附属长海医院

法洛三联症是一种复合的先天性心脏畸形,存在肺动脉狭窄和房间隔缺损或卵圆孔未闭,导致自右心房向左心房分流现象[1].

关键词：心动过速法洛三联症心搏过速心律失常房性导管室病人肺动脉瓣狭窄介入治疗