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Development and validation of a novel non-invasive test for diagnosing nonalcoholic fatty liver disease in Chinese children

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World Journal of Pediatrics 2024年第4期20卷 413-421页

作者： Zhe-Wen Qin qian-Nan ren Hong-Xi Zhang Ya-Ru Liu Ke Huang Wei Wu Guan-Ping Dong Yan Ni Jun-Fen Fu Division of Endocrinology National Clinical Research Center for Child HealthNational Children’s Regional Medical CenterThe Children’s HospitalDepartment of EndocrinologyNational Clinical Research Center for Child HealthNational Children’s Regional Medical CenterThe Children’s HospitalZhejiang University School of MedicineHangzhou310052China

With the exploding prevalence of obesity,many children are at risk of developing nonalcoholic fatty liver disease.Using anthropometric and laboratory parameters,our study aimed to develop a model to quantitatively evaluate liver fat content(LFC)in children with obesity.Methods A well-characterized cohort of 181 children between 5 and 16 years of age were recruited to the study in the Endocrinology Department as the derivation cohort.The external validation cohort comprised 77 children.The assessment of liver fat content was performed using proton magnetic resonance spectroscopy.Anthropometry and laboratory metrics were measured in all subjects.B-ultrasound examination was carried out in the external validation cohort.The Kruskal-Wallis test,Spearman bivariate correlation analyses,univariable linear regressions and multivariable linear regression were used to build the optimal predictive model.Results The model was based on indicators including alanine aminotransferase,homeostasis model assessment of insulin resistance,triglycerides,waist circumference and Tanner stage.The adjusted R^(2)of the model was 0.589,which presented high sensitivity and specificity both in internal[sensitivity of 0.824,specificity of 0.900,area under curve(AUC)of 0.900 with a 95%confidence interval:0.783–1.000]and external validation(sensitivity of 0.918 and specificity of 0.821,AUC of 0.901 with a 95%confidence interval:0.818–0.984).Conclusions Our model based on five clinical indicators was simple,non-invasive,and inexpensive;it had high sensitivity and specificity in predicting LFC in children.Thus,it may be useful for identifying children with obesity who are at risk for developing nonalcoholic fatty liver disease.

关键词： Biochemical markers Children Magnetic resonance spectroscopy Nonalcoholic fatty liver disease Pediatric obesity

Catheter failure and mortality in hemodialysis patients with the tunneled-cuffed catheter tip positioned in the inferior vena cava

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Chinese Medical Journal 2022年第19期135卷 2369-2371页

作者： Lu Cheng qian ren Gang Yu Shenju Gou Tianlei Cui Ping Fu Kidney Research Insttion West China Hospital of Sichuan UniversitChengduSichuan 610041China Department of Nephrology West China School of MedicineSichuan UniversityChengduSichuan 610041China Division of Nephrology Kidney Research InstitutionWest China Hospital of Sichuan UniversityChengduSichuan 610041China.

To the Editor:Permanent vascular access is a lifesustaining measure for hemodialysis-dependent patients.Generally,tunneled cuffed catheters(TCCs)are regarded as a bridge access to arteriovenous fistula(AVF)or arteriovenous graft(AVG),and the guidelines discourage TCCs from being the first choice of permanent vascular access because of the higher,risk of complications and shorter expected service life.lilHowever,notably,a subset(<10%)of hemodialysis patients requirepermanent access through a TCC because they have exhausted other arteriovenous access options.

关键词： service permanent tunnel

Taurine attenuates activation of hepatic stellate cells by inhibiting autophagy and inducing ferroptosis

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World Journal of Gastroenterology 2024年第15期30卷 2143-2154页

作者： Sen Li qian-Jun ren Can-Hao Xie Yang Cui Li-Tao Xu Yi-Dan Wang Su Li Xing-Qiu Liang Bin Wen Ming-Kun Liang Xiao-Fang Zhao Department of Basic Science Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina Department of Science and Technology Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina Traditional Chinese Medicine Specialty Office Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina

BACKGROUND Liver fibrosis is a compensatory response during the tissue repair process in chronic liver injury,and finally leads to liver cirrhosis or even hepatocellular carcinoma.The pathogenesis of hepatic fibrosis is associated with the progressive accumulation of activated hepatic stellate cells(HSCs),which can transdiffer-entiate into myofibroblasts to produce an excess of the extracellular matrix(ECM).Myofibroblasts are the main source of the excessive ECM responsible for hepatic fibrosis.Therefore,activated hepatic stellate cells(aHSCs),the principal ECM producing cells in the injured liver,are a promising therapeutic target for the treatment of hepatic fibrosis.AIM To explore the effect of taurine on aHSC proliferation and the mechanisms involved.METHODS Human HSCs(LX-2)were randomly divided into five groups:Normal control group,platelet-derived growth factor-BB(PDGF-BB)(20 ng/mL)treated group,mmol/L,respectively)with PDGF-BB(20 ng/mL)treated group.Cell Counting Kit-8 method was performed to evaluate the effect of taurine on the viability of aHSCs.Enzyme-linked immunosorbent assay was used to estimate the effect of taurine on the levels of reactive oxygen species(ROS),malondialdehyde,glutathione,and iron concen-tration.Transmission electron microscopy was applied to observe the effect of taurine on the autophagosomes and ferroptosis features in aHSCs.Quantitative real-time polymerase chain reaction and Western blot analysis were performed to detect the effect of taurine on the expression ofα-SMA,Collagen I,Fibronectin 1,LC3B,ATG5,Beclin 1,PTGS2,SLC7A11,and p62.RESULTS Taurine promoted the death of aHSCs and reduced the deposition of the ECM.Treatment with taurine could alleviate autophagy in HSCs to inhibit their activation,by decreasing autophagosome formation,downregulating LC3B and Beclin 1 protein expression,and upregulating p62 protein expression.Meanwhile,treatment with taurine triggered ferroptosis and ferritinophagy to eliminate aHSCs characterized by iron overload,lipid ROS accumu-lation,glutathi

关键词： Hepatic stellate cells Autophagy Ferroptosis Molecular docking Taurine

On-demand assembly of polymeric nanoparticles for longer-blood-circulation and disassembly in tumor for boosting sonodynamic therapy

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Bioactive Materials 2022年第12期7卷 242-253页

作者： Mei Wen Nuo Yu Shiwen Wu Mengmeng Huang Pu Qiu qian ren Meifang Zhu Zhigang Chen State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai201620China

Sonodynamic therapy (SDT) is one of the promising strategies for tumor therapy, but its application is usually hindered by fast clearance in blood-circulation, abnormal tumor microenvironment, and inefficient generation of reactive oxygen species. To solve these problems, we proposed an on-demand assembly-disassembly strategy, where the assembly is favorable for longer-blood-circulation and then the disassembly in tumor is favorable for boosting SDT. Hematoporphyrin monomethyl ether (HMME) as the model of organic sonosensitizers were conjugated with hyaluronic acid (HA). Then HA-HMME was mixed with catalase (CAT) and assembled into polymeric nanoparticles (CAT@HA-HMME NPs) with size of ~80 nm. CAT@HA-HMME NPs exhibit good biocompatibility and a longer blood half-time (t1/2 = 4.17 h) which is obviously longer than that (~0.82 h) of HMME molecules. After HA receptor-mediated endocytosis of cancer cells, CAT@HA-HMME NPs can be cleaved by endogenous hyaluronidase, resulting in the on-demand disassembly in tumor to release HA-HMME molecules and CAT. The CAT catalyzes the endogenous H_(2)O_(2) into O_(2) to relieve the hypoxic microenvironment, and the released HA-HMME exhibits a higher ROS generation ability, greatly boosting SDT for the inhibition of tumor growth. Therefore, the on-demand assembly-disassembly strategy may provide some insight in the design and development of nanoagents for tumor therapy.

关键词： Polymeric nanoparticles On-demand assembly Longer-blood-circulation On-demand disassembly Sonodynamic therapy

A multiple-function fluorescent pillar[5]arene:Fe^(3+)/Ag^(+)detection and light-harvesting system

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Chinese Chemical Letters 2022年第12期33卷 5120-5123页

作者： Yang Luo Wei Zhang qian ren Guo-Rong Chen Jiang-Lian Ran Xin Xiao Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province Guizhou UniversityGuiyang 550025China

A novel pillar[5]arene(P5DPB)that includes a classicalπ-conjugated molecule,4,4'-(1,4-phenylenedi-2,1-ethenediyl)bis-pyridine(DPB),was designed and synthesized as a substituent.Because of this modification,P5DPB exhibits several unique properties that differ from those of common pillar[5]arenes.The P5DPB neutral pyridine shows good selectivity for Ag^(+)and Fe^(3+).The presence of Ag^(+)ions cause a blue shift(from yellow-green to green)and a decrease in the intensity of the P5DPB emission,while the addition of Fe^(3+)significantly quenches the P5DPB fluorescence.In addition,P5DPB satisfies the conditions for the construction of an energy transfer system with the commonly used Rhodamine B dye and shows great potential for the development of artificial light-harvesting systems.This work provides a new approach for the construction of energy transfer systems and a new reference for metal detection based on derivatized pillar[n]arenes,greatly enriching the applications of these systems.

关键词： Pillararene Modification Energy transfer system Metal detection

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辽宁赛马碱性岩体煌斑岩脉特征及成因研究

东华理工大学学报（自然科学版） 2024年第2期47卷 146-163页

作者：任倩邬斌东华理工大学核资源与环境国家重点实验室江西南昌330013

赛马煌斑岩脉与碱性岩(霞石正长岩)紧密共生,为研究煌斑岩脉成因,探讨其与碱性岩的关系,通过岩相学、岩石地球化学与年代学等研究,认为赛马煌斑岩属于钾质钾镁煌斑岩,岩石元素含量具有高Mg、K,低Ti的特征。该岩脉高(^(87)Sr/^(86)Sr)i... 详细信息

赛马煌斑岩脉与碱性岩(霞石正长岩)紧密共生,为研究煌斑岩脉成因,探讨其与碱性岩的关系,通过岩相学、岩石地球化学与年代学等研究,认为赛马煌斑岩属于钾质钾镁煌斑岩,岩石元素含量具有高Mg、K,低Ti的特征。该岩脉高(^(87)Sr/^(86)Sr)i、低ε_(Nd)(t)及Pb的正异常特征,暗示其来源于俯冲作用改造的岩石圈地幔,上侵过程经历了地壳混染。研究区煌斑岩脉斑晶为氟磷灰石和富镁黑云母,基质为钾长石、钠长石等。其中磷灰石富集S和Mn,指示相对氧化的结晶环境;黑云母成分环带发育,x(Fe^(2+))-x(Fe^(3+))-x(Mg^(2+))比例及钛温度计指示其氧逸度和温度均高于主体碱性岩。此外,黑云母Rb-Sr年龄((224.7±0.1)Ma)与主体碱性岩年龄(224~230 Ma)在误差范围内一致。相似的“年龄、地球化学特征及同位素组成”指示赛马煌斑岩脉与霞石正长岩均来源于富集岩石圈地幔,可能为碰撞伸展构造环境下不同期次岩浆作用的产物。

关键词：煌斑岩脉碱性岩赛马碱性岩体矿物学地球化学

Efficacy and mechanism of anti-vascular endothelial growth factor drugs for diabetic macular edema patients

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World Journal of Diabetes 2022年第7期13卷 532-542页

作者： Yun-Fei Li qian ren Chao-Hui Sun Li Li Hai-Dong Lian Rui-Xue Sun Xian Su Hua Yu Department of Ophthalmology Shijiazhuang City People’s HospitalShijiazhuang 050031Hebei ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Shihezi University School of MedicineShihezi 832061Xinjiang Uygur Autonomous RegionChina

BACKGROUND Diabetes is a serious public health concern in China,with 30%of patients developing retinopathy,and diabetic macular edema(DME)having the biggest impact on vision.High blood glucose level can cause retinal cell hypoxia,thus promoting vascular endothelial growth factor(VEGF)formation and increasing vascular permeability,which induces DME.Moreover,cell hypoxia can accelerate the rate of apoptosis,which leads to the aging of patients.In severe cases,optic cell apoptosis or retinal fibrosis and permanent blindness may occur.AIM To investigate and compare the efficacy,mechanism,and differences between two anti-VEGF drugs(Compaq and ranibizumab)in DME patients.METHODS Ninety-six patients with DME who attended our hospital from April 2018 to February 2020 were included and randomly divided into two groups(Compaq group and ranibizumab group).The groups received vitreal cavity injections of 0.5 mg Compaq and 0.5 mg ranibizumab,respectively,once a month.The best corrected visual acuity(BCVA),intraocular pressure(IOP),macular retinal thickness(CMT),macular choroidal thickness(SFCT),foveal no perfusion area(FAZ),superficial capillary density,deep capillary density,treatment effect,and adverse reactions were compared before and after treatment and between the two groups.RESULTS Before treatment and 1-mo post-treatment,there was no statistically significant difference in the estimated BCVA in both groups(P>0.05).BCVA decreased in the Compaq group 3 mo after treatment,and the difference was statistically significant(Prence in the estimated IOP in either group(P>0.05).Before treatment and 1-mo post-treatment,there was no statistically significant difference in the estimated CMT,SFCT,or FAZ in either group(P>0.05).CMT and SFCT values decreased in the Compaq group 3 mo post-treatment,and the difference was statistically significant(P<0.05).Before treatment,and 1 mo and 3 mo post-treatment,there were no statistically sign

关键词： Diabetic macular edema Vascular endothelial growth factor Compaq Ranibizumab Optimally correct vision Diabetes

The RNA-binding protein Musashi2 governs osteoblast-adipocyte lineage commitment by suppressing PPARγsignaling

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Bone Research 2022年第3期10卷 536-547页

作者： Jinlong Suo Sihai Zou Jinghui Wang Yujiao Han Lingli Zhang Chenchen Lv Bo Jiang qian ren Long Chen Lele Yang Ping Ji Xianyou Zheng Ping Hu Weiguo Zou Department of Orthopedic Surgery and Institute of Microsurgery on Extremities Shanghai Jiaotong University Affiliated Sixth People’s Hospital200233 ShanghaiChina Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher EducationStomatological Hospital of Chongqing Medical University401147 ChongqingChina State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCAS Center for Excellence in Molecular Cell SciencesChinese Academy of SciencesUniversity of Chinese Academy of Sciences200031 ShanghaiChina Guangzhou Laboratory No.9 XingDaoHuan RoadGuanghzou International Bio lsland510005 GuangzhouChina Colorectal Cancer Center/Department of Gastrointestinal Surgery Shanghai Tenth People’s Hospital Affiliated to Tongji UniversityShanghaiChina Institute for Stem Cell and Regeneration Chinese Academy of Sciences100101 BeijingChina Bio-Research Innovation Center Shanghai Institute of Biochemistry and Cell BiologySuzhouChina

Osteoporosis caused by aging is characterized by reduced bone mass and accumulated adipocytes in the bone marrow cavity. How the balance between osteoblastogenesis and adipogenesis from bone marrow mesenchymal stem cells(BMSCs) is lost upon aging is still unclear. Here, we found that the RNA-binding protein Musashi2(Msi2) regulates BMSC lineage commitment. Msi2 is commonly enriched in stem cells and tumor cells. We found that its expression was downregulated during adipogenic differentiation and upregulated during osteogenic differentiation of BMSCs. Msi2 knockout mice exhibited decreased bone mass with substantial accumulation of marrow adipocytes, similar to aging-induced osteoporosis. Depletion of Msi2 in BMSCs led to increased adipocyte commitment. Transcriptional profiling analysis revealed that Msi2 deficiency led to increased PPARγ signaling.RNA-interacting protein immunoprecipitation assays demonstrated that Msi2 could inhibit the translation of the key adipogenic factor Cebpα, thereby inhibiting PPAR signaling. Furthermore, the expression of Msi2 decreased significantly during the aging process of mice, indicating that decreased Msi2 function during aging contributes to abnormal accumulation of adipocytes in bone marrow and osteoporosis. Thus, our results provide a putative biochemical mechanism for aging-related osteoporosis, suggesting that modulating Msi2 function may benefit the treatment of bone aging.

关键词： adipocyte osteoporosis inhibiting

Nutation instability of spinning solid rocket motor spacecraft

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Chinese Journal of Aeronautics 2017年第4期30卷 1363-1372页

作者： Dan YANG Yongliang XIONG qian ren Xianyong WANG School of Naval Architecture and Ocean Engineering Huazhong University of Science and Technology Wuhan 430074 China Department of Mechanics Huazhong University of Science and Technology Wuhan 430074 China Hubei Key Laboratory of Engineering Structural Analysis and Safety Assessment Luoyu Road 1037 Wuhan 430074 China

The variation of mass, and moment of inertia of a spin-stabilized spacecraft leads to concern about the nutation instability. Here a careful analysis on the nutation instability is performed on a spacecraft propelled by solid rocket booster（SRB）. The influences of specific solid propellant designs on transversal angular velocity are discussed. The results show that the typical SRB of End Burn suppresses the non-principal axial angular velocity. On the contrary, the frequently used SRB of Radial Burn could amplify the transversal angular velocity. The nutation instability caused by a design of Radial Burn could be remedied by the addition of End Burn at the same time based on the study of the combination design of both End Burn and Radial Burn.The analysis of the results proposes the design conception of how to control the nutation motion.The method is suitable to resolve the nutation instability of solid rocket motor with complex propellant patterns.

关键词： Attitude control Nutation dampers Payloads Solid rocket booster Spin stabilization of spacecraft