Efficacy and mechanism of anti-vascular endothelial growth factor drugs for diabetic macular edema patients
作者机构：Department of OphthalmologyShijiazhuang City People’s HospitalShijiazhuang 050031Hebei ProvinceChina Department of OphthalmologyThe First Affiliated Hospital of Shihezi University School of MedicineShihezi 832061Xinjiang Uygur Autonomous RegionChina
出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)
年 卷 期：2022年第13卷第7期
页 面：532-542页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100212[医学-眼科学] 10[医学]
主 题：Diabetic macular edema Vascular endothelial growth factor Compaq Ranibizumab Optimally correct vision Diabetes
摘 要：BACKGROUND Diabetes is a serious public health concern in China,with 30%of patients developing retinopathy,and diabetic macular edema(DME)having the biggest impact on *** blood glucose level can cause retinal cell hypoxia,thus promoting vascular endothelial growth factor(VEGF)formation and increasing vascular permeability,which induces ***,cell hypoxia can accelerate the rate of apoptosis,which leads to the aging of *** severe cases,optic cell apoptosis or retinal fibrosis and permanent blindness may *** To investigate and compare the efficacy,mechanism,and differences between two anti-VEGF drugs(Compaq and ranibizumab)in DME *** Ninety-six patients with DME who attended our hospital from April 2018 to February 2020 were included and randomly divided into two groups(Compaq group and ranibizumab group).The groups received vitreal cavity injections of 0.5 mg Compaq and 0.5 mg ranibizumab,respectively,once a *** best corrected visual acuity(BCVA),intraocular pressure(IOP),macular retinal thickness(CMT),macular choroidal thickness(SFCT),foveal no perfusion area(FAZ),superficial capillary density,deep capillary density,treatment effect,and adverse reactions were compared before and after treatment and between the two *** Before treatment and 1-mo post-treatment,there was no statistically significant difference in the estimated BCVA in both groups(P0.05).BCVA decreased in the Compaq group 3 mo after treatment,and the difference was statistically significant(P0.05).Before treatment and 1-mo post-treatment,there was no statistically significant difference in the estimated CMT,SFCT,or FAZ in either group(P0.05).CMT and SFCT values decreased in the Compaq group 3 mo post-treatment,and the difference was statistically significant(P0.05).Before treatment,and 1 mo and 3 mo
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