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World Journal of Gastroenterology 2024年第38期30卷 4239-4241页

作者： yao-qian Yuan qian-qian Chen Department of Gastroenterology The First Medical Center of Chinese PLA General HospitalBeijing 100853China

This letter comments on the article that developed and tested a machine learning model that predicts lymphovascular invasion/perineural invasion status by combining clinical indications and spectral computed tomography characteristics *** review the research content,methodology,conclusions,strengths and weaknesses of the study,and introduce follow-up research to this work.

关键词： Gastric cancer Spectral computed tomography Perineural invasion Lympho-vascular invasion Machine learning

Advancing precision oncology:Insights into the tumor microenvironment and immunotherapy outcomes

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The Innovation 2024年第4期5卷 21-22页

作者： Tomotaka Ugai qian yao Satoko Ugai Shuji Ogino Department of Pathology Brigham and Women’s Hospitaland Harvard Medical SchoolBostonMA 02115USA Department of Epidemiology Harvard T.H.Chan School of Public HealthBostonMA 02115USA Cancer Epidemiology Program Dana-Farber/Harvard Cancer CenterBostonMA 02215USA Broad Institute of MIT and Harvard CambridgeMA 02142USA Cancer Immunology Program Dana-Farber/Harvard Cancer CenterBostonMA 02215USA Tokyo Medical and Dental University(Institute of Science Tokyo) BunkyoTokyo 1138510Japan

The tumor microenvironment represents a dynamic and multifaceted milieu characterized by the complex interactions of diverse cellular and non-cellular constituents.1,2 These constituents include tumor cells,microorganisms,immune and other stromal cells,and extracellular *** orchestration of these components intricately contributes to tumor evolution and shapes responses to cancer treatment(Figure 1).A better understanding of the tumor microenvironment is critical to elucidate the etiology of cancer and develop more efficient therapeutic strategies.

关键词： microenvironment cancer tumor

Molecular mechanisms underlying the negative effects of transient heatwaves on crop fertility

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Plant Communications 2024年第9期5卷 101-115页

作者： qian yao Ping Li Xin Wang Shuhua Liao Pu Wang Shoubing Huang College of Agronomy and Biotechnology China Agricultural UniversityBeijing 100193China

Transient heatwaves occurring more frequently as the climate warms,yet their impacts on crop yield are severely underestimated and even *** lasting only a few days or even hours during sensitive stages,such as microgametogenesis and flowering,can significantly reduce crop yield by disrupting plant *** advances in multi-omics and GWAS analysis have shed light on the specific organs(e.g.,pollen,lodicule,style),key metabolic pathways(sugar and reactive oxygen species metabolism,Ca2+homeostasis),and essential genes that are involved in crop responses to transient heatwaves during sensitive *** review therefore places particular emphasis on heat-sensitive stages,with pollen development,floret opening,pollination,and fertilization as the central narrative *** multifaceted effects of transient heatwaves and their molecular basis are systematically reviewed,with a focus on key structures such as the lodicule and tapetum.A number of heat-tolerance genes associated with these processes have been identified in major crops like maize and *** mechanisms and key heat-tolerance genes shared among different stages may facilitate the more precise improvement of heat-tolerant crops.

关键词： heat stress floret fertility pollen pollen tube growth seed set molecular mechanism

The underappreciated role of fugitive VOCs in ozone formation and health risk assessment emitted from seven typical industries in China

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Journal of Environmental Sciences 2024年第2期136卷 647-657页

作者： Zhiling Liang Yunjiang Yu Bingbing Sun qian yao Xihua Lin Yongsheng Wang Jianping Zhang Yingzi Li Xuefeng Wang Zhengzheng Tang Shexia Ma College of Environmental and Chemical Engineering Shanghai University of Electric PowerShanghai 200090China State Environmental Protection Key Laboratory of Environmental Protection Health Risk Assessment South China Institute of Environmental SciencesMinistry of Ecology and EnvironmentGuangzhou 510535China Henan Jiyuan Ecological Environment Testing Center Jiyuan 454650China Ecological Environment Bureau of Jiyuan Production City Integration Demonstration Zone Jiyuan 454650China

Fugitive emission from industrial sources may result in ozone formation and health risk,while the exact contribution of this source remains incompletely *** this study,emission characteristics,ozone formation potential(OFP)and health risk of fugitive VOCs in7 representative industries were *** material industry was the dominant contributor to VOCs of fugitive emission in comparison with other *** OFP of VOCs from fugitive emission was in the range of 1.45×10^(3)-3.98×10^(5)μg/m^(3),with a higher value than that of organized emission in seven industries except for the coking industry and the chemical material industry,suggesting that fugitive VOCs should be taken into account while developing control ***,m,p-xylene,n-nonane,ethylene,vinyl chloridethe and other high OFP-contributing species were the major reactive species that should be *** risk assessment investigated non-cancer and cancer risks of fugitive VOCs in 7 industries were all above safe level(HR>1 and LCR>1×10^(-4)),posing remarkable health threats to human *** were the main contributor to non-cancer risk,while halohydrocarbons and aromatics contributed most to cancer risks,posing remarkable health threat on human *** findings highlighted the contribution of fugitive VOCs on ozone formation and health risk was underestimated,indicating which should be considered in emission control strategies of industrial sources.

关键词： Industrial sources Volatile organic compounds Fugitive emission Ozone formation potential Health risk assessment

Neuropathological characteristics of abnormal white matter functional signaling in adolescents with major depression

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World Journal of Psychiatry 2024年第2期14卷 276-286页

作者： Xin-Lin Huang Ju Gao Yong-Ming Wang Feng Zhu Jing Qin qian-Nan yao Xiao-Bin Zhang Hong-Yan Sun Imaging and Nuclear Medicine Jiamusi UniversityJiamusi 154000Heilongjiang ProvinceChina Department of Psychiatry The Affiliated Guangji Hospital of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina School of Biology&Basic Medical Sciences Medical College of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina Department of Radiology Shanghai Anting HospitalShanghai 20000China Department of Radiology The Affiliated Guangji Hospital of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina

BACKGROUND Major depression disorder(MDD)constitutes a significant mental health *** surveys indicate that the lifetime prevalence of depression in adolescents is much higher than that in adults,with a corresponding increased risk of *** studying brain dysfunction associated with MDD in adolescents,research on brain white matter(WM)is *** researchers even mistakenly regard the signals generated by the WM as noise *** fact,studies have shown that WM exhibits similar blood oxygen level-dependent signal *** alterations in WM signals and their relationship with disease severity in adolescents with MDD remain *** To explore potential abnormalities in WM functional signals in adolescents with *** This study involved 48 adolescent patients with MDD and 31 healthy controls(HC).All participants were assessed using the Patient Health Questionnaire-9 Scale and the mini international neuropsychiatric interview(MINI)suicide *** addition,a Siemens Skyra 3.0T magnetic resonance scanner was used to obtain the subjects'image *** DPABI software was utilized to calculate the WM signal of the fractional amplitude of low frequency fluctuations(fALFF)and regional homogeneity,followed by a two-sample t-test between the MDD and HC *** component analysis(ICA)was also used to evaluate the WM functional ***’s correlation was performed to assess the relationship between statistical test results and clinical *** Compared to HC,individuals with MDD demonstrated a decrease in the fALFF of WM in the corpus callosum body,left posterior limb of the internal capsule,right superior corona radiata,and bilateral posterior corona radiata[P<0.001,family-wise error(FWE)voxel correction].The regional homogeneity of WM increased in the right posterior limb of internal capsule and left superior corona radiata,and decreased in the left superior longitudinal fasciculus(P<0.001,FWE voxel corre

关键词： White matter Regional homogeneity The fractional amplitude of low-frequency fluctuations Independent component analysis Adolescents Major depression disorders

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加快行业公共智能算力平台建设

中国金融 2024年第5期 37-38页

作者：姚前中国证监会科技监管司

算力基础设施作为算力的主要载体,是支撑数字经济发展的重要平台。当前,在全国一体化数据要素体系布局下,“东数西算”工程建设为传统应用提供了高性能、大容量的算力资源。然而,随着以生成式人工智能(AIGC)为代表的AI大模型等新应用。

关键词：工程建设人工智能基础设施 AIG 一体化生成式平台体系布局

An unprotected vulnerable relict subtropical conifer-Keteleeria evelyniana: Its forests, populations, growth and endangerment by invasive alien plant species in China

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Plant Diversity 2024年第5期46卷 648-660页

作者： Cindy Q.Tang Min-Rui Du Huan-Chong Wang You-Cai Shi Jia-Le Zeng Shu-Li Xiao Peng-Bin Han Jian-Ran Wen Shi-qian yao Ming-Chun Peng Chong-Yun Wang Yong-Ping Li Jordi López-Pujol Institute of Ecology and Geobotany College of Ecology and Environmental ScienceYunnan UniversityBuilding#3Guozhong DalouDongwaihuan South RoadUniversity TownChenggong New DistrictKunming 650504YunnanChina College of Life Sciences Yunnan UniversityShengming Kexueyuan Building#2Chenggong CampusDongwaihuan South RoadUniversity TownChenggong New DistrictKunming 650504YunnanChina College of Natural Resources Yunnan UniversityChenggong CampusDongwaihuan South RoadUniversity TownChenggong New DistrictKunming 650504YunnanChina Botanic Institute of Barcelona(IBB CSIC-CMCNC)Passeig del Migdia s/nBarcelona 08038CataloniaSpain Escuela de Ciencias Ambientales Universidad Espíritu Santo(UEES)Samborondon 091650Ecuador

Relict subtropical coniferous forests in China face severe fragmentation,resulting in declining populations,and some are under significant threat from invasive alien *** the crucial importance of understanding forest dynamics,knowledge gaps persist,particularly regarding the impact of invasive plants on vulnerable natives like Keteleeria *** this study,we investigated the impact of invasive plants on the regeneration of forests dominated by ***,a subtropical relict species in southwestern *** this purpose,we characterized forest dynamics of 160 forest plots featuring *** as the primary dominant species and determined whether the presence of invasive plants was correlated with regeneration of *** identified four distinct forest types in which *** was *** found that radial growth of *** trees is faster in younger ageclasses today than it was for older trees at the same *** population structure of *** in each forest type exhibited a multimodal age-class ***,three forest types lacked established saplings younger than 10 years old,a situation attributed to the dense coverage of the invasive alien Ageratina *** invasive species resulted in a reduction of understory species ***,our analysis uncovered a significant negative correlation in phylogenetic relatedness(net relatedness index)between native and invasive alien plant species in eastern *** suggests closely related invasive species face heightened competition,hindering successful *** together,our findings indicate that successful establishment and habitat restoration of *** seedling/saplings require effective measures to control invasive plants.

关键词： Keteleeria evelyniana Age structure Regeneration Species diversity Invasive alien species Phylogenetic relatedness

Value of multiple models of diffusion-weighted imaging to predict hepatic lymph node metastases in colorectal liver metastases patients

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World Journal of Gastroenterology 2024年第4期30卷 308-317页

作者： Hai-Bin Zhu Bo Zhao Xiao-Ting Li Xiao-Yan Zhang qian yao Ying-Shi Sun Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of RadiologyPeking University Cancer Hospital and InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of PathologyPeking University Cancer Hospital and InstituteBeijing 100142China

BACKGROUND About 10%-31% of colorectal liver metastases(CRLM)patients would concomitantly show hepatic lymph node metastases(LNM),which was considered as sign of poor biological behavior and a relative contraindication for liver *** to now,there’s still lack of reliable preoperative methods to assess the status of hepatic lymph nodes in patients with CRLM,except for pathology examination of lymph node after *** To compare the ability of mono-exponential,bi-exponential,and stretchedexponential diffusion-weighted imaging(DWI)models in distinguishing between benign and malignant hepatic lymph nodes in patients with CRLM who received neoadjuvant chemotherapy prior to *** In this retrospective study,97 CRLM patients with pathologically confirmed hepatic lymph node status underwent magnetic resonance imaging,including DWI with ten b values before and after *** parameters,such as the apparent diffusion coefficient from the mono-exponential model,and the true diffusion coefficient,the pseudo-diffusion coefficient,and the perfusion fraction derived from the intravoxel incoherent motion model,along with distributed diffusion coefficient(DDC)andαfrom the stretched-exponential model(SEM),were *** parameters before and after chemotherapy were compared between positive and negative hepatic lymph node groups.A nomogram was constructed to predict the hepatic lymph node *** reliability and agreement of the measurements were assessed using the coefficient of variation and intraclass correlation *** Multivariate analysis revealed that the pre-treatment DDC value and the short diameter of the largest lymph node after treatment were independent predictors of metastatic hepatic lymph nodes.A nomogram combining these two factors demonstrated excellent performance in distinguishing between benign and malignant lymph nodes in CRLM patients,with an area under the curve of ***,parameters from SEM sho

关键词： Colorectal cancer Individualized treatment Diffusion magnetic resonance imaging Intravoxel incoherent motion Liver

模糊集定性比较分析方法下数字经济驱动乡村振兴的组态路径

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湖北农业科学 2024年第7期63卷 244-249页

作者：姚倩西安开放大学马克思主义学院西安710042

以构造数字经济综合评价指标的4个分指标及2个中介变量为条件变量,采用模糊集定性比较分析方法对组态路径进行探究。根据熵值法测度,2016—2022年数字经济发展水平综合得分呈上升趋势,其中全国数字经济发展水平综合得分从2016年的0.091... 详细信息

以构造数字经济综合评价指标的4个分指标及2个中介变量为条件变量,采用模糊集定性比较分析方法对组态路径进行探究。根据熵值法测度,2016—2022年数字经济发展水平综合得分呈上升趋势,其中全国数字经济发展水平综合得分从2016年的0.091上升至2022年的0.257。2016—2022年乡村振兴发展水平综合得分呈上升趋势,其中,全国乡村振兴发展水平的综合得分从2016年的0.228上升至2022年的0.394。在条件变量必要性验证中,一致性结果均低于0.900,表明所有条件变量都不是结果变量的必要条件。在充分性验证中,组态路径R1的原始覆盖度为0.513,组态路径R2的原始覆盖度为0.327,总体解覆盖度为0.566,表明这2个条件组态均能够对乡村振兴水平上升的原因进行解释。在组态路径R1中,发展环境、人力资本均为核心条件,数字产业化、数字金融和技术创新水平为边缘条件,发挥辅助作用,而产业数字化几乎不起作用;在组态路径R2中,发展环境、数字产业化、数字金融和技术创新水平属于核心条件,产业数字化程度相对较低,人力资本几乎不起作用,表明乡村振兴条件组态具有高数字经济、低产业数字化的特征。当一致性的阈值增加后,乡村振兴水平的条件组态结果保持不变,表明模型具有较高的稳定性。

关键词：模糊集定性比较分析数字经济乡村振兴组态路径

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传统文化元素在现代建筑装饰中的应用

佛山陶瓷 2024年第9期34卷 114-116页

作者：姚茜长江工程职业技术学院武汉430212

在全球化与技术进步的推动下,现代建筑装饰迅速发展,同时面临着如何在现代设计中融入传统文化元素的挑战。传统文化元素包括图案、色彩、材料和结构形式,是历史与地域文化深厚积淀的体现。现代建筑装饰则强调材料与技术的创新应用、环... 详细信息

在全球化与技术进步的推动下,现代建筑装饰迅速发展,同时面临着如何在现代设计中融入传统文化元素的挑战。传统文化元素包括图案、色彩、材料和结构形式,是历史与地域文化深厚积淀的体现。现代建筑装饰则强调材料与技术的创新应用、环境的可持续性以及文化与地域性的融合。本文深入探讨了传统文化元素在现代建筑装饰中的应用,从定义和分类入手,详述了现代建筑装饰的特点,并具体分析了如何将传统图案、色彩、材料及结构元素融入现代设计中。通过案例研究展示了这一融合对提升建筑美学与文化价值的重要性。

关键词：传统文化元素现代建筑装饰