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Acta Pharmaceutica Sinica B 2024年第2期14卷 729-750页

作者： Xin Chen Xianggang Mu Lele Ding Xi Wang Fei mao Jinlian Wei qian Liu Yixiang Xu Shuaishuai Ni Lijun Jia Jian Li State Key Laboratory of Bioreactor Engineering Shanghai Frontiers Science Center of Optogenetic Techniques for Cell MetabolismFrontiers Science Center for Materiobiology and Dynamic ChemistryShanghai Key Laboratory of New Drug DesignSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China Cancer Institute Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China College of Pharmacy Jinan UniversityGuangzhou 510632China

Chemotherapy-induced complications,particularly lethal cardiovascular diseases,pose significant challenges for cancer *** intertwined adverse effects,brought by cancer and its complication,further complicate anticancer therapy and lead to diminished clinical *** supplementation of cardioprotective agents falls short in addressing these *** bifunctional co-therapy agents provided another potential solution to consolidate the chemotherapy and reduce cardiac events *** repurposing was naturally endowed with co-therapeutic potential of two indications,implying a unique chance in the development of bi-functional ***,we further proposed a novel“trilogy of drug repurposing”strategy that comprises function-based,targetfocused,and scaffold-driven repurposing approaches,aiming to systematically elucidate the advantages of repurposed drugs in rationally developing bi-functional *** function-based repurposing,a cardioprotective agent,carvedilol(CAR),was identified as a potential neddylation inhibitor to suppress lung cancer *** target-focused SAR studies and scaffold-driven drug design,we synthesized 44 CAR derivatives to achieve a balance between anticancer and ***,optimal derivative 43 displayed promising bi-functional effects,especially in various self-established heart failure mice models with and without ***,the present study validated the practicability of the“trilogy of drug repurposing”strategy in the development of bi-functional cotherapy agents.

关键词： Anticancer Heartfailure Complication Drug repurposing Bi-functional drug

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人牙釉质在柠檬酸介质中的摩擦磨损行为研究

摩擦学学报 2011年第2期31卷 104-109页

作者：黄欢郑靖钱林茂西南交通大学材料先进技术教育部重点实验室摩擦学研究所成都610031

采用往复滑动摩擦磨损试验台,以TC4钛合金球为摩擦偶件,考察了人牙釉质在pH为3.2的柠檬酸介质中的摩擦磨损行为,并与人工唾液介质中的结果进行对比.结果表明:牙釉质在不同介质中的摩擦磨损行为存在显著差异.在柠檬酸介质中,鉴于柠檬酸... 详细信息

采用往复滑动摩擦磨损试验台,以TC4钛合金球为摩擦偶件,考察了人牙釉质在pH为3.2的柠檬酸介质中的摩擦磨损行为,并与人工唾液介质中的结果进行对比.结果表明:牙釉质在不同介质中的摩擦磨损行为存在显著差异.在柠檬酸介质中,鉴于柠檬酸对牙釉质表面的酸蚀软化和脱矿作用,牙釉质的摩擦系数低于人工唾液介质,但伴随显著波动,磨损机制以黏着剥落为主,磨损体积随循环次数增加几乎呈线性增长,磨损量明显大于人工唾液介质.

关键词：人牙釉质柠檬酸腐蚀摩擦磨损

Progress of the bolometer diagnostic system on EAST

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Plasma Science and Technology 2024年第9期26卷 125-132页

作者： Wen WEN Yanmin DUAN Shanshan PAN Yan CHAO Songtao mao Jing qian Lingyi MENG Panjun TANG Shiyao LIN Institute of Plasma Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031People’s Republic of China University of Science and Technology of China Hefei 230026People’s Republic of China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China

Measurements of the total radiated power and its spatial distribution are crucial for fusion *** the experimental advanced superconducting tokamak(EAST),both the metal foil resistive bolometer and the absolute extreme ultraviolet(AXUV)photodiodes have been used to quantify the radiated *** article introduces the latest improvement of the bolometer diagnostic system on *** also details the successful design and installation of new divertor AXUV cameras,which are dedicated to the investigation of divertor *** shielding components of the bolometer detector have been refined,and the article provides a detailed exposition of the double shielding structures that have been verified as effective in microwave ***,the changes in the radiated power distribution in the divertor region during the plasma detachment process are measured using the divertor AXUV ***,the radiated power measured by the AXUV detector and metal foil resistive bolometer are compared,and different detector performances are presented.

关键词： radiated power bolometer diagnostic microwave shielding plasma detachment sensitivity degradation

对接“一带一路”的内在逻辑与推进策略——以中国(河南)自由贸易试验区为例

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河南大学学报（社会科学版） 2020年第5期60卷 52-57页

作者：孟茂倩河南工程学院外语学院河南郑州451191

中国(河南)自由贸易试验区建设与"一带一路"建设存在紧密的内在联系,二者产生的时代背景相同、价值功能相近、角色功能互补,具有彼此相互对接的逻辑基础和内在动能。中国(河南)自由贸易试验区建立伊始即探索对接"一带一路"的有效路径和... 详细信息

中国(河南)自由贸易试验区建设与"一带一路"建设存在紧密的内在联系,二者产生的时代背景相同、价值功能相近、角色功能互补,具有彼此相互对接的逻辑基础和内在动能。中国(河南)自由贸易试验区建立伊始即探索对接"一带一路"的有效路径和方式,目前还存在诸如制度创新有待强化,产业结构不尽合理、发展水平相对滞后,辐射带动功能较弱、溢出效应相对有限等突出问题。在深入分析上述问题生成逻辑的基础上,提出了加快制度创新、加快产业转型升级和高端产业集聚、增强辐射带动功能和溢出效应等举措与路径。

关键词： “一带一路” 中国(河南)自由贸易试验区融合对接问题治理

FERROTAAFFEITE-2N2S,A NEW MINERAL SPECIES,AND THE CRYSTAL STRUCTURE OF Fe2+-RICH MAGNESIOTAAFFEITE-2N'2S FROM THE XIANGHUALING TIN-POLYMETALLIC ORE FIELD,HUNAN PROVINCE,CHINA

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FERROTAAFFEITE-2N2S,A NEW MINERAL SPECIES,AND THE CRYSTAL ST...

中国科学院地质与地球物理研究所2012年度（第12届）学术年会

作者： ZHUMING YANG KUISHOU DING JEFFREY DE FOURESTIER qian mao HE LI Key Laboratory of Engineering Geomechanics Institute of Geology and GeophysicsChinese Academy of Sciences

Ferrotaaffeite-2N’2S,ideally BeFeAlO with hexagonal symmetry P6mc,is a new mineral species of the taaffeite group(IMA No,2011-025) occurring as a skarn mineral in the Xianghualing Sn-polymetallic ore field,Linwu County,Hunan Province,People’s Republic of *** was found near the outer contact of the Laizhiling A-type granite pluton and in the Middle-Upper Devonian carbonate rocks of the Qiziqiao *** associated minerals are Fe-rich magnesiotaaffeite- 2N’2S,ferronigerite-2N1s,cassiterite,liberite,pyrite,sphalerite,pyrrhotite,galena,spinel,and *** mineral forms tabular crystals about 100μm in *** is dark green to dark grey with a white streak,transparent,and has a vitreous lustre. Cleavage is fair on {001}.It is brittle,with a conchoidal *** hardness is VHN 1801-2404 kg/mm(8.5-9 on the Mohs scale).No fluorescence in long- or short-wave ultraviolet radiation was *** calculated density from the empirical chemical formula is 3.99 g/*** Gladstone-Dale relationship gives N= *** empirical formula for the investigated ferrotaaffeite-2N’2S is Be(FeMgZnMnSn)AlO,.The simplified formula is Be(Fe,Mg,Zn)*** strongest five reflections in the X-ray powder diffraction pattern[d in A(I) hkl]are:2.43(100) 114,2.60(90) 016,1.425(90)220, 2.86(80) 110,and 1.473(80) *** unit-cell parameters refined from the powder data are a 5.706(8),c 18.352(3) A,and V 517.46(8) ,Z = *** associated Fe-rich magnesiotaaffeite-2N’2S has empirical formula Be(MgFeZnMn Sn)*** structure was solved and refined in space group P6mc,with a 5.6978(8),b 5.6978(8),c 18.373(4) A, 7516.57(15) ,to R = 0.043,wR = 0.137.

关键词： ferrotaaffeite-2N’2S new mineral species magnesiotaaffeite-2N’2S’ taaffeite group Xianghualing tin mine Tanzanian LM felsic inaginatisin China

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氮化铬薄膜的径向纳动损伤机制研究

摩擦学学报 2008年第4期28卷 316-321页

作者：张爽钱林茂莫继良西南交通大学牵引动力国家重点实验室摩擦学研究所四川成都610031

采用纳米压痕仪和曲率半径为20μm的金刚石球形压头研究了40Cr基体和CrNx薄膜的径向纳动行为,并探讨其损伤机制.结果表明:CrNx薄膜能够提高40Cr基体的抗压性能,提高其接触刚度,降低残余压痕深度,减少在纳动循环过程中的能量耗散;增大载... 详细信息

采用纳米压痕仪和曲率半径为20μm的金刚石球形压头研究了40Cr基体和CrNx薄膜的径向纳动行为,并探讨其损伤机制.结果表明:CrNx薄膜能够提高40Cr基体的抗压性能,提高其接触刚度,降低残余压痕深度,减少在纳动循环过程中的能量耗散;增大载荷或增加循环次数均可加剧材料的纳动损伤;40Cr基体的纳动损伤表现为压痕边缘的塑性堆积;而CrNx薄膜的纳动损伤由表面的径向和环向拉应力所引起,表现为环向裂纹和径向裂纹的萌生与扩展.

关键词：径向纳动氮化铬薄膜纳米摩擦学

大兴安岭南段东麓中生代O型埃达克质火山岩及其成因、古构造环境和找矿意义

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岩石学报 2006年第9期22卷 2289-2304页

作者：张永北孙世华毛骞中国科学院地质与地球物理研究所矿物资源重点实验室

蒙东西拉禾伦河北侧查干木伦河流域,属中生代大兴安岭火山-侵入杂岩带南段。最近区内晚侏罗世满克头鄂博组陆相火山杂岩火山盾中,发现有埃达克质火山岩,与少量钠质流纹岩和玄武岩共生。埃达克岩 Al_2O_3>15%,MgO1,LREE 富集,HREE 及 LI... 详细信息

蒙东西拉禾伦河北侧查干木伦河流域,属中生代大兴安岭火山-侵入杂岩带南段。最近区内晚侏罗世满克头鄂博组陆相火山杂岩火山盾中,发现有埃达克质火山岩,与少量钠质流纹岩和玄武岩共生。埃达克岩 Al_2O_3>15%,MgO1,LREE 富集,HREE 及 LIRE 强烈亏损,无负铕异常,高 Sr(497.91～896.40×10^(-6)),低 Y(4.33～15.77<18×10^(-6)),低 Yb(0.35～1.54<1.9×10^(-6)),I_(Sr)=0.70374～0.70594,ε_(Nd)(t)为-0.45～+6.58,在 K-Na-Ca、Rb-Sr-Ba、Sr/Y-Y 和 Sr/Yb-Yb 等图中属埃达克岩,具奥长花岗岩演化趋势,是典型的 O 型埃达克岩。其与共生岩石ε_(Nd)(t)、I_(Sr)与晚古生代玄武岩的接近,部分岩石 t_(DM)(677～845Ma)与晚古生代俯冲洋壳(t_(DM)=627～998Ma)相同,Sr-Nd 同位素及Zr/Hf-Nb/Ta 比值具有亏损地幔与下地壳混合特征,另有岩石(t_(DM)=343～453Ma)源于古生代年轻地幔。据此推论其源岩是以晚元古代俯冲洋壳为主,多源物质混合的增生地体下地壳。La_N/Yb_N-Yb_N 及 La/Sm-La 图证明埃达质岩浆是榴辉岩化源岩部分熔融的原始岩浆,钠质流纹岩是该原始岩浆分离结晶产物,玄武岩浆则可能是源岩深度熔融的结果。岩石成分及微量元素判别该火山活动环境是大陆边缘弧。大兴安岭地区在中生代出现埃达克质火山岩及该类火山弧,未必与环太平洋或者鄂霍茨克海俯冲构造直接相关,而是晚古生代古亚洲洋残存洋壳在中生代沿续存俯冲断裂继续向增生地体下地壳俯冲并发生部分熔融结果。区内与满克头鄂博组有关的铁、铜、金矿化,应有大矿前景。

关键词： O型埃达克岩中生代火山岩大兴安岭南段岩石成因大陆动力学环境成矿作用

Precise prediction model and simplified scoring system for sustained combined response to interferon-α

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World Journal of Gastroenterology 2010年第27期16卷 3465-3471页

作者： qian-Guo mao Ru-Mian Zhang Jin-Shui Pan Kuang-Nan Fang Jian-Ping Zhu Qing-Yang Hong Hepatology Unit and Department of Infectious Diseases Xiamen Hospital of Traditional Chinese Medicine Xiamen 361000 Fujian Province China Division of Gastroenterology Zhongshan Hospital Xiamen University Gastroenterology Institute of Xiamen University Gastroenterology Center of Xiamen Xiamen 361004 China Department of Planning and Statistics Xiamen University Xiamen 361005 China College of Information Science and Technology Xiamen UniversityXiamen 361005Fujian ProvinceChina

AIM:To establish a predictive algorithm which may serve for selecting optimal candidates for interferon-α(IFN-α) ***:A total of 474 IFN-α treated hepatitis B virus e antigen(HBeAg)-positive patients were enrolled in the present *** patients' baseline characteristics,such as age,gender,blood tests,activity grading(G) of intrahepatic inflammation,score(S) of liver fibrosis,hepatitis B virus(HBV) DNA and genotype were evaluated;therapy duration and response of each patient at the 24th wk after cessation of IFN-α treatment were also recorded.A predictive algorithm and scoring system for a sustained combined response(CR) to IFN-α therapy were *** 10% of the patients were randomly drawn as the test *** to IFN-α therapy were divided into CR,partial response(PR) and non-response(NR).The mixed set of PR and NR was recorded as PR+***:Stratified by therapy duration,the most significant baseline predictive factors were alanine aminotransferase(ALT),HBV DNA level,aspartate aminotransferase(AST),HBV genotype,S,G,age and *** to the established model,the accuracies for sustained CR and PR+NR,respectively,were 86.4% and 93.0% for the training set,81.5% and 91.0% for the test *** the scoring system,the sensitivity and specificity were 78.8% and 80.6%,*** were positive correlations between ALT and AST,and G and S,***:With these models,practitioners may be able to propose individualized decisions that have an integrated foundation on both evidence-based medicine and personal characteristics.

关键词： Chronic hepatitis B Interferon-α Patient selection Predictive model Scoring system Treatment outcome

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基于强度折减法的框架式海堤稳定性分析

水利水电科技进展 2021年第2期41卷 70-74页

作者：郑安兴毛前浙江水利水电学院水利与环境工程学院浙江杭州310018 浙江水利水电学院浙江省农村水利水电资源配置与调控关键技术重点实验室浙江杭州310018

以温州框架式海堤为研究对象,采用有限元强度折减法,分析密排桩排数和背水坡土方填筑高度对框架式海堤变形、稳定性的影响。结果表明:与双排密排桩情况下相比,单排密排桩情况下桩顶附近的水平位移减小,框架式海塘整体稳定安全系数有较... 详细信息

以温州框架式海堤为研究对象,采用有限元强度折减法,分析密排桩排数和背水坡土方填筑高度对框架式海堤变形、稳定性的影响。结果表明:与双排密排桩情况下相比,单排密排桩情况下桩顶附近的水平位移减小,框架式海塘整体稳定安全系数有较大幅度减小;随着背水坡土方填筑高度增加,密排桩桩身水平位移不断增大,增大幅度最大位置发生在桩顶,框架式海堤整体稳定安全系数急剧降低。

关键词：框架式海堤变形稳定性土方填筑强度折减法