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Journal of Iron and Steel Research(International) 2024年第3期31卷 608-621页

作者： Zhe Wang qi-long wei Cheng-bin Shi Zhan-cheng Guo State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

The effect of Al_(2)O_(3)/SiO_(2) mass ratio and CaO content on the viscosity and structure of the CaO-Al_(2)O_(3)-SiO_(2)-6MgO-1.5ZrO_(2)-1.5CeO_(2) slag was investigated.The results show that with the increase in Al_(2)O_(3)/SiO_(2) mass ratio,the viscous flow units within the slag gradually change from Si-O-Si to Al-O-Al and Al-O-Si.Furthermore,the substitution of Al_(2)O_(3) for SiO_(2) leads to the transformation of Si-O bonds towards weaker Al-O bonds,which weaken the bond strength of the aluminosilicate networks,thus leading to a decrease in the viscosity of slag.The increase in CaO content effectively promotes the depolymerization of the aluminosilicate networks,resulting in a significant decrease in the viscosity of the slag.The slag with Al_(2)O_(3)/SiO_(2) of 0.7-1.5 and CaO of 30 wt.%shows promise as the reference slag system for the Fe-collection smelting of spent automotive catalysts due to its good comprehensive performance.

关键词： Aluminosilicate slag Al_(2)O_(3)/SiO_(2)mass ratio CaO content Viscosity Slag structure

Alloy strategy to synthesize Pt-early transition metal oxide interfacial catalysts

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Nano Research 2024年第4期17卷 3390-3397页

作者： Shi-long Xu Hang Nan Wanqun Zhang Yue Lin Sheng-qi Chu Hai-wei Liang Hefei National Research Center for Physical Sciences at the Microscale Department of ChemistryUniversity of Science and Technology of ChinaHefei 230026China School of Materials and Chemical Engineering Anhui Jianzhu UniversityHefei 230601China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Metal oxide supported metal catalysts show promising catalytic performance in many industry-relevant reactions.However,the enhancement of performance is often limited by the insufficient metal/metal oxide interface.In this work,we demonstrate a general synthesis of Pt-early transition metal oxide(Pt-MO_(x),M=Ti,Zr,V,and Y)catalysts with rich interfacial sites,which is based on the air-induced surface segregation and oxidation of M in the supported Pt-M alloy catalysts.Systematic characterizations verify the dynamic structural response of Pt-M alloy catalysts to air and the formation of Pt-MO_(x) catalysts with abundant interfacial sites.The prepared Pt-TiO_(x) interfacial catalysts exhibit improved performance in hydrogenation reactions of benzaldehyde,nitrobenzene,styrene,and furfural,as a result of the heterolytic dissociation of H_(2) at Pt-metal oxide interfacial sites.

关键词： Pt-early transition metal oxide interfacial catalyst alloy oxidation strategy interfacial sites hydrogenation reactions heterolytic dissociation

Klebsiella pneumoniae infections after liver transplantation:Drug resistance and distribution of pathogens,risk factors,and influence on outcomes

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World Journal of Hepatology 2024年第4期16卷 612-624页

作者： long Guo Peng Peng wei-Ting Peng Jie Zhao qi-Quan Wan Department of Respiratory and Critical Care Medicine The Third Xiangya Hospital of Central South UniversityChangsha 410013Hunan ProvinceChina Clinical Laboratory Medicine Center Zhuzhou Hospital Affiliated to Xiangya School of MedicineCentral South UniversityZhuzhou 421007Hunan ProvinceChina The Second Affiliated Hospital Class Xiangya School of MedicineCentral South UniversityChangsha 410013Hunan ProvinceChina Department of Liver Surgery Renji HospitalShanghai Jiaotong University School of MedicineShanghai 200127China Department of Transplant Surgery The Third Xiangya Hospital of Central South UniversityChangsha 410013Hunan ProvinceChina Engineering and Technology Research Center for Transplantation Medicine of National Health Commission The Third Xiangya Hospital of Central South UniversityChangsha 410013Hunan ProvinceChina

BACKGROUND Liver transplantation(LT)is the only curative treatment for end-stage liver disease.However,LT recipients are susceptible to infection,which is the leading cause of early mortality after LT.Klebsiella pneumoniae infections(KPIs)in the bloodstream are common in LT recipients.We hypothesized that KPIs and carbapenemresistant Klebsiella pneumoniae(CRKP)infections may affect the outcomes of LT recipients.AIM To assess KPI incidence,timing,distribution,drug resistance,and risk factors following LT and its association with outcomes.METHODS This retrospective study included 406 patients undergoing LT at The Third Xiangya Hospital of Central South University,a tertiary hospital,from January 2015 to January 2023.We investigated the risk factors for KPIs and assessed the impact of KPIs and CRKP infections on the prognosis of LT recipients using logistic regression analysis.RESULTS KPI incidence was 7.9%(n=32),with lung/thoracic cavity the most frequent site of infection;the median time from LT to KPI onset was 7.5 d.Of 44 Klebsiella pneumoniae isolates,43(97.7%)and 34(77.3%)were susceptible to polymyxin B or ceftazidime/avibactam and tigecycline,respectively;>70%were resistant to piperacillin/tazobactam,ceftazidime,cefepime,aztreonam,meropenem,and levofloxacin.Female sex[odds ratio(OR)=2.827,95%confidence interval(CI):1.256-6.364;P=0.012],pre-LT diabetes(OR=2.794,95%CI:1.070-7.294;P=0.036),day 1 post-LT alanine aminotransferase(ALT)levels≥1500 U/L(OR=3.645,95%CI:1.671-7.950;P=0.001),and post-LT urethral catheter duration over 4 d(OR=2.266,95%CI:1.016-5.054;P=0.046)were risk factors for KPI.CRKP infections,but not KPIs,were risk factors for 6-month all-cause mortality post-LT.CONCLUSION KPIs occur frequently and rapidly after LT.Risk factors include female sex,pre-LT diabetes,increased post-LT ALT levels,and urethral catheter duration.CRKP infections,and not KPIs,affect mortality.

关键词： Liver transplantation Klebsiella pneumoniae infections Carbapenem-resistant Klebsiella pneumoniae Risk factors Outcomes

In Situ Deposition of Drug and Gene Nanoparticles on a Patterned Supramolecular Hydrogel to Construct a Directionally Osteochondral Plug

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Nano-Micro Letters 2024年第1期16卷 341-359页

作者： Jiawei Kang Yaping Li Yating qin Zhongming Huang Yifan Wu long Sun Cong Wang wei Wang Gang Feng Yiying qi Department of Orthopaedic Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhou City 310009Zhejiang ProvincePeople’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310027People’s Republic of China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311215ZhejiangPeople’s Republic of China The Affiliated Nanhua Hospital Orthopedic Research CentreHengyang Medical SchoolUniversity of South ChinaHengyang 421001HunanPeople’s Republic of China Department of Radiology Jining No.1 People’s HospitalJining Medical UniversityJining 272000ShandongPeople’s Republic of China

The integrated repair of bone and cartilage boasts advantages for osteochondral restoration such as a long-term repair effect and less deterioration compared to repairing cartilage alone.Constructing multifactorial,spatially oriented scaffolds to stimulate osteochondral regeneration,has immense significance.Herein,targeted drugs,namely kartogenin@polydopamine(KGN@PDA)nanoparticles for cartilage repair and miRNA@calcium phosphate(miRNA@CaP)NPs for bone regeneration,were in situ deposited on a patterned supramolecular-assembled 2-ureido-4[lH]-pyrimidinone(UPy)modified gelation hydrogel film,facilitated by the dynamic and responsive coordination and complexation of metal ions and their ligands.This hydrogel film can be rolled into a cylindrical plug,mimicking the Haversian canal structure of natural bone.The resultant hydrogel demonstrates stable mechanical properties,a self-healing ability,a high capability for reactive oxygen species capture,and controlled release of KGN and miR-26a.In vitro,KGN@PDA and miRNA@CaP promote chondrogenic and osteogenic differentiation of mesenchymal stem cells via the JNK/RUNX1 and GSK-3β/β-catenin pathways,respectively.In vivo,the osteochondral plug exhibits optimal subchondral bone and cartilage regeneration,evidenced by a significant increase in glycosaminoglycan and collagen accumulation in specific zones,along with the successful integration of neocartilage with subchondral bone.This biomaterial delivery approach represents a significant toward improved osteochondral repair.

关键词： Osteochondral regeneration Oriented hydrogel Kartogenin miRNA-26a

Interface Design Strategy for GNS/AZ91 Composites with Semi-Coherent Structure

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 467-483页

作者： Jing-Peng Xiong Yi-qi Zeng Jin-long Liu wei-Cheng Wang Lan Luo Yong Liu Key Laboratory of Lightweight and High Strength Structural Materials of Jiangxi Province School of Advanced ManufacturingNanchang UniversityNanchang 330031China School of Physics and Materials Science Nanchang UniversityNanchang 330031China

The interfacial structure plays an important role in the mechanical properties of magnesium matrix composite(MMCs)reinforced with graphene nanosheet(GNS)due to their poor wettability with the Mg matrix.An interface design strategy was proposed to form the semi-coherent interfacial structure with superior bonding strength.The lattice mismatch and interfacial bonding strength between Mg/rare earth oxide/carbon were utilized as key characteristics to evaluate the interfacial structure.Lanthanum oxide(La2O3)was selected as the intermediate candidate due to its low lattice mismatch and high interfacial bonding strength.To identify the interfacial structure of Mg/La2O3/graphene,first-principles calculations were conducted to calculate the ideal work of separation and electronic structure of the interfaces.Results demonstrated the presence of strong ionic and covalent interactions at the interface,which theoretically verified the strong interfacial bonding strength among Mg/La2O3/graphene interfaces.To experimentally validate the interface strength,MMCs with the interface structure of Mg/La2O3/GNS were developed.The formation of in-situ La2O3 led to the successful attainment of semi-coherent structures between Mg/La2O3 and La2O3/GNS,resulting in high strength and good ductility of the composite.Overall,this work proposes a new approach to interface design in MMCs with an enhancement of mechanical properties.

关键词： Interface design strategy Magnesium matrix composite Graphene nanosheets Semi-coherent interface Mechanical properties

Immune checkpoint inhibition mediated with liposomal nanomedicine for cancer therapy

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Military Medical Research 2024年第1期11卷 98-114页

作者： Guang-long Ma wei-Feng Lin Faculty of Medicine Centre for Cancer ImmunologyUniversity of SouthamptonSouthampton SO166YDUK Department of Molecular Chemistry and Materials Science Weizmann Institute of Science76100 RehovotIsrael Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191China

Immune checkpoint blockade(ICB)therapy for cancer has achieved great success both in clinical results and on the market.At the same time,success drives more attention from scientists to improve it.However,only a small portion of patients are responsive to this therapy,and it comes with a unique spectrum of side effects termed immunerelated adverse events(irAEs).The use of nanotechnology could improve ICBs’delivery to the tumor,assist them in penetrating deeper into tumor tissues and alleviate their irAEs.Liposomal nanomedicine has been investigated and used for decades,and is well-recognized as the most successful nano-drug delivery system.The successful combination of ICB with liposomal nanomedicine could help improve the efficacy of ICB therapy.In this review,we highlighted recent studies using liposomal nanomedicine(including new emerging exosomes and their inspired nanovesicles)in associating ICB therapy.

关键词： Liposome Exosome Immune checkpoint blockade(ICB)

X-box binding protein 1 caused an imbalance in pyroptosis and mitophagy in immature rats with di-(2-ethylhexyl)phthalate-induced testis toxicity

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Genes & Diseases 2024年第2期11卷 935-951页

作者： Yifan Hong Xiazhu Zhou qi Li Jing Chen Yuexin wei Chunlan long Lianju Shen Xiangqin Zheng Dinggang Li Xia Wang Chenjun Yu Shengde Wu Guanghui wei Department of Urology Children's Hospital of Chongqing Medical UniversityChongqing 400014China Pediatric Research Institute Children's Hospital of Chongqing Medical UniversityChongqing 400014China Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering Children's Hospital of Chongqing Medical UniversityChongqing 400014China Chongqing Key Laboratory of Pediatrics Children's Hospital of Chongqing Medical UniversityChongqing 400014China Ministry of Education Key Laboratory of Child Development and Disorders Children's Hospital of Chongqing Medical UniversityChongqing 400014China National Clinical Research Center for Child Health and Disorders Children's Hospital of Chongqing Medical UniversityChongqing 400014China China International Science and Technology Cooperation Base of Child Development and Critical Disorders Children's Hospital of Chongqing Medical UniversityChongqing 400014China

As a widely used plasticizer,di-(2-ethylhexyl)phthalate(DEHP)is known to induce significant testicular injury.However,the potential mechanism and effects of pubertal exposure to DEHP on testis development remain unclear.In vivo,postnatal day(PND)21 male rats were gavaged with 0,250,and 500 mg/kg DEHP for ten days.Damage to the seminiferous epithelium and disturbed spermatogenesis were observed after DEHP exposure.Meanwhile,oxidative stress-induced injury and pyroptosis were activated.Both endoplasmic reticulum(ER)stress and mitophagy were involved in this process.Monoethylhexyl phthalate(MEHP)was used as the biometabolite of DEHP in vitro.The GC-1 and GC-2 cell lines were exposed to 0,100μM,200μM,and 400μM MEHP for 24 h.Reactive oxygen species(ROS)generation,oxidative stress damage,ER stress,mitophagy,and pyroptosis were significantly increased after MEHP exposure.The ultrastructure of the ER and mitochondria was destroyed.X-box binding protein 1(XBP1)was observed to be activated and translocated into the nucleus.ROS generation was inhibited by acetylcysteine.The levels of antioxidative stress,ER stress,mitophagy,and pyroptosis were decreased as well.After the administration of the ER stress inhibitor 4-phenyl-butyric acid,both mitophagy and pyroptosis were inhibited.Toyocamycin-induced XBP1 down-regulation decreased the levels of mitophagy and pyroptosis.The equilibrium between pyroptosis and mitophagy was disturbed by XBP1 accumulation.In summary,our findings confirmed that DEHP induced a ROS-mediated imbalance in pyroptosis and mitophagy in immature rat testes via XBP1.Moreover,XBP1 might be the key target in DEHP-related testis dysfunction.

关键词： DEHP Mitophagy Pyroptosis Testicular development XBP1

Almost Periodic Type Group Actions on Compact Quantum Metric Spaces

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Acta Mathematica Sinica,English Series 2024年第2期40卷 568-594页

作者： Bo Tao long wei WU College of Mathematics MIIT Key Laboratory of Mathematical Modelling and High Performance Computing of Air VehiclesNanjing University of Aeronautics and AstronauticsNanjing 211106P.R.China School of Mathematical Sciences Shanghai Key Laboratory of Pure Mathematics and Mathematical PracticeEast China Normal UniversityShanghai 200241P.R.China

A compact quantum metric space is a complete order unit space A endowed with a Lipnorm L.We give some characterizations of almost periodic type group actions on a compact quantum metric space(A,L)by means of several kinds of subsets of A,its induced equicontinuous actions on several important subsets of the dual Banach space A*,and the Lip-norm L with its induced metric space structures on the state space S(A)of A.

关键词： Lip-norm compact quantum metric space Lipschitz isomorphism almost periodicity Arzela-Ascoli theorem metric set

Comprehensive Evaluation Method for Traffic Flow Data Quality Based on Grey Correlation Analysis and Particle Swarm Optimization

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Journal of Systems Science and Systems Engineering 2024年第1期33卷 106-128页

作者： wei Ba Baojun Chen qi Li School of Automation and Electrical Engineering Dalian Jiaotong UniversityDalian116028China Faculty of Electronic Information and Electrical Engineering Dalian University of TechnologyDalian116023China

Nowadays,data are more and more used for intelligent modeling and prediction,and the comprehensive evaluation of data quality is getting more and more attention as a necessary means to measure whether the data are usable or not.However,the comprehensive evaluation method of data quality mostly contains the subjective factors of the evaluator,so how to comprehensively and objectively evaluate the data has become a bottleneck that needs to be solved in the research of comprehensive evaluation method.In order to evaluate the data more comprehensively,objectively and differentially,a novel comprehensive evaluation method based on particle swarm optimization(PSO)and grey correlation analysis(GCA)is presented in this paper.At first,an improved GCA evaluation model based on the technique for order preference by similarity to an ideal solution(TOPSIS)is proposed.Then,an objective function model of maximum difference of the comprehensive evaluation values is built,and the PSO algorithm is used to optimize the weights of the improved GCA evaluation model based on the objective function model.Finally,the performance of the proposed method is investigated through parameter analysis.A performance comparison of traffic flow data is carried out,and the simulation results show that the maximum average difference between the evaluation results and its mean value(MDR)of the proposed comprehensive evaluation method is 33.24%higher than that of TOPSIS-GCA,and 6.86%higher than that of GCA.The proposed method has better differentiation than other methods,which means that it objectively and comprehensively evaluates the data from both the relevance and differentiation of the data,and the results more effectively reflect the differences in data quality,which will provide more effective data support for intelligent modeling,prediction and other applications.

关键词： Data quality comprehensive evaluation particle swarm optimization grey correlation analysis traffic flow data

long-time Asymptotics for the Reverse Space-time Nonlocal Hirota Equation with Decaying Initial Value Problem:without Solitons

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 708-727页

作者： wei-qi PENG Yong CHEN School of Mathematical Sciences East China Normal UniversityShanghai 200241China College of Mathematics and Systems Science Shandong University of Science and TechnologyQingdao 266590China

In this work,we mainly consider the Cauchy problem for the reverse space-time nonlocal Hirota equation with the initial data rapidly decaying in the solitonless sector.Start from the Lax pair,we first construct the basis Riemann-Hilbert problem for the reverse space-time nonlocal Hirota equation.Furthermore,using the approach of Deift-Zhou nonlinear steepest descent,the explicit long-time asymptotics for the reverse space-time nonlocal Hirota is derived.For the reverse space-time nonlocal Hirota equation,since the symmetries of its scattering matrix are different with the local Hirota equation,the v(λ_(i))(i=0,1)would like to be imaginary,which results in theδ_(λi)^(0)contains an increasing t(±Imv(λ_(i)))/2,and then the asymptotic behavior for nonlocal Hirota equation becomes differently.

关键词： Riemann-Hilbert problem reverse space-time nonlocal Hirota equation long-time asymptotics nonlinear steepest descent method