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The sensitivity difference between the glans penis and penile shaft in primary premature ejaculation

Asian Journal of Andrology 2023年第4期25卷 487-491页

作者： Lei zheng Le-Tian Wei qi-zhen tang Chun-Li Song Wen-Rong Liu Ke-Nan Wang Hui Jiang Tao Jiang Department of Andrology Second Hospital of Dalian Medical UniversityDalian 116000China Department of Urology First Hospital of Dalian Medical UniversityDalian 116000China Department of Neuroelectrophysiology First Hospital of Dalian Medical UniversityDalian 116000China Department of Andrology Peking University First HospitalBeijing 100191China.

The penis is a vital organ of perception that transmits perceived signals to ejaculation-related *** penis consists of the glans penis and penile shaft,which differ considerably in both histology and *** paper aims to investigate whether the glans penis or the penile shaft is the main source of sensory signals from the penis and whether penile hypersensitivity affects the whole organ or only part of *** thresholds,latencies,and amplitudes of somatosensory evoked potentials(SSEPs)were recorded in 290 individuals with primary premature ejaculation using the glans penis and penile shaft as the sensory *** thresholds,latencies,and amplitudes of SSEPs from the glans penis and penile shaft in patients were significantly different(all P<0.0001).The latency of the glans penis or penile shaft was shorter than average(indicating hypersensitivity)in 141(48.6%)cases,of which 50(35.5%)cases were sensitive in both the glans penis and penile shaft,14(9.9%)cases were sensitive in the glans penis only,and 77(54.6%)cases were sensitive in the penile shaft only(P<0.0001).There are statistical differences in the signals perceived through the glans penis and the penile *** hypersensitivity does not necessarily mean that the whole penis is *** classify penile hypersensitivity into three categories,namely,glans penis,penile shaft,and whole-penis hypersensitivity,and we propose the new concept of penile hypersensitive zone.

关键词： neuroelectrophysiology perceptive zone premature ejaculation sensitivity sensory perception

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Prediction and optimization of flue pressure in sintering process based on SHAP

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 346-359页

作者： Mingyu Wang Jue tang Mansheng Chu Quan Shi zhen Zhang School of Metallurgy Northeastern UniversityShenyang 110819China Liaoning Low-Carbon Steelmaking Technology Engineering Research Center Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-Carbon Steelmaking(Ministry of Education) Shenyang 110819China

Sinter is the core raw material for blast *** pressure,which is an important state parameter,affects sinter *** this paper,flue pressure prediction and optimization were studied based on the shapley additive explanation(SHAP)to predict the flue pressure and take targeted adjustment ***,the sintering process data were collected and processed.A flue pressure prediction model was then constructed after comparing different feature selection methods and model algorithms using SHAP+extremely random-ized trees(ET).The prediction accuracy of the model within the error range of±0.25 kPa was 92.63%.SHAP analysis was employed to improve the interpretability of the prediction *** effects of various sintering operation parameters on flue pressure,the relation-ship between the numerical range of key operation parameters and flue pressure,the effect of operation parameter combinations on flue pressure,and the prediction process of the flue pressure prediction model on a single sample were analyzed.A flue pressure optimization module was also constructed and analyzed when the prediction satisfied the judgment *** operating parameter combination was then *** flue pressure was increased by 5.87%during the verification process,achieving a good optimization effect.

关键词： sintering process flue pressure shapley additive explanation prediction optimization

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Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo qi Han tang Jianian Hu Siying Kang Song qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

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Staged dendrite suppression for high safe and stable lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： Jun Jiang zhenjie Lu Yanwen Ding Shujun Liu Zhijie qi Tian tang Yunfan Zhang Zhiyuan Ma Jingwen Sun Liang Xue Wenyao Zhang Pan Xiong Xin Wang Junwu Zhu Yongsheng Fu Key Laboratory for Soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and Technology Jiangsu Pylon Battery Co.Ltd

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene （PP） *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance（145.88 MPa） of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm-2with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Lithium-sulfur batteries Staged dendrite suppression Shuttle effect Surface-negatively-charged nanodiamond

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Pulp health and calcific healing of a complicated crown–root fracture with additional root fracture in a maxillary incisor: A case report

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World Journal of Clinical Cases 2025年第3期13卷 42-49页

作者： Na Li Yue-Yue Ren Ying tang qi Yang Tian-Tian Meng Song Li Jing Zhang Stomatological Hospital and College Anhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Endodontics The Affiliated Stomatological Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Complicated crown–root fracture (CRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and teenagers, but the maintenance of pulphealth and the calcific healing of multiple root fractures are rarely reported in *** SUMMARY This case reports healing of a permanent tooth with complicated crown–root andadditional root fractures, in which pulp health was maintained. A 10-year-old girlfell and fractured the root of her maxillary left central incisor at the cervical *** the coronal fragment was repositioned, the tooth was splinted until thetooth was no longer mobile, 2 years later. Eight years after treatment, the toothhas remained asymptomatic with vital pulp and localized gingival ***-beam computed tomography revealed not only calcified healing of the CRFbut also spontaneous healing in an additional undiagnosed root fracture. Thefracture line on the enamel could not be healed by hard tissue and formed agroove in the cervical crown. It was speculated that the groove was related to thelocalized gingival *** This case provides a clinical perspective of the treatment of a tooth with acomplicated CRF and an additional root fracture.

关键词： Complicated crown-root fracture Multiple root fracture Spontaneous healing Cone-beam computed tomography Long-term follow-up Case report

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Effects of initial grain size and strain on grain boundary engineering of high-nitrogen CrMn austenitic stainless steel

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International Journal of Minerals,Metallurgy and Materials 2018年第8期25卷 922-929页

作者： zhen-hua Wang Jian-jun qi Wan-tang Fu School of Mechanical Engineering Yanshan UniversityQinhuangdao 066004China State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004China HBIS Group Technology Research Institute Shijiazhuang 050023China

18 Mn18 Cr0.5 N steel with an initial grain size of 28–177 μm was processed by 2.5%–20% cold rolling and annealing at 1000°C for 24 h,and the grain boundary character distribution was examined via electron backscatter *** strain(2.5%) favored the formation of low-Σ *** this strain,the fraction of low-Σ boundaries was insensitive to the initial grain ***,specimens with fine initial grains showed decreasing grain size after grain boundary engineering *** fraction of low-Σ boundaries and the(Σ9 + Σ27)/Σ3 value decreased with increasing strain; furthermore,the specimens with fine initial grain size were sensitive to the ***,the effects of the initial grain size and strain on the grain boundary engineering were discussed in detail.

关键词： grain boundary engineering grain boundary character distribution grain size strain austenitic stainless steel

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A compact electron storage ring for lithographical applications

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Nuclear Science and Techniques 2021年第9期32卷 16-26页

作者： Si-qi Shen Da-Zhang Huang zhen-tang Zhao qing-Lei Zhang Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China

The physical design for a novel low-energy compact-storage-ring-based extreme ultraviolet(EUV)light source was systemically *** design process considers the linear and nonlinear beam optics,including transverse matching and the optimization of the dynamic aperture,momentum aperture,and beam *** a total circumference of 36.7 m and a beam energy of 400 MeV,the storage ring can operate with an average beam current of up to 1 *** the undulator as the radiator,this facility has the potential to emit EUV radia-tion at 13.5 nm with an average power exceeding 10 W within the *** addition,the collective instabili-ties of the lattice at high beam current were analyzed;it was found that the typical instabilities which may occur in an electron storage ring can be reasonably controlled in our *** the advantages of variable beam energy and current,this design exhibits great promise as a new can-didate for various EUV lithographical applications requir-ing tunable radiation power.

关键词： Storage ring Extreme ultraviolet(EUV) EUV lithography(EUVL)

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一种具有全方向运动功能的电动轮椅的设计

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沈阳工业大学学报 2004年第6期26卷 612-615页

作者：袁世奇宫兴祯唐宗军沈阳工业大学机械工程学院辽宁沈阳110023

对全方向电动轮椅的结构、运动学性能进行了分析,提出了一种可行的总体运动控制方案,并对轮椅的直线运动、全方向运动以及初始化运动的环节给出了控制模型,同时对直线运动速度补偿系统、角位置系统进行了仿真,其结果证明了该控制策略的... 详细信息

对全方向电动轮椅的结构、运动学性能进行了分析,提出了一种可行的总体运动控制方案,并对轮椅的直线运动、全方向运动以及初始化运动的环节给出了控制模型,同时对直线运动速度补偿系统、角位置系统进行了仿真,其结果证明了该控制策略的可行性.

关键词：全方向运动轮椅伺服系统速度补偿差动

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Design of a 162.5 MHz continuous-wave normal-conducting radiofrequency electron gun

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Nuclear Science and Techniques 2020年第11期31卷 50-59页

作者： Cheng Wang Zi-Han Zhu Zeng-Gong Jiang qi-Sheng tang zhen-tang Zhao qiang Gu Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China

A high-gradient radiofrequency(RF)gun operated in continuous-wave(CW)mode is required in various accelerating *** to the high RF power loss,a traditional normal-conducting(NC)RF electron gun has difficulty meeting the requirement of generating a high-repetition-rate electron *** development of a scheme for a CW NC-RF gun is urgently *** as a photoinjector of a high-repetition-rate free-electron laser(FEL),an electron gun operated in CW mode and the VHF band is *** analysis of the reentrant gun cavity is presented in this paper to increase the gradient and decrease the power density and power *** to the analysis results,the design of a162.5 MHz gun cavity is optimized by a multi-objective evolutionary algorithm to achieve better performance in CW *** and thermal analyses are also deliberated in the design to coordinate with RF and mechanical *** optimized 162.5 MHz gun cavity can be operated in CW mode to generate a high-repetition-rate beam with voltage up to 1 MV and gradient up to 32.75 MV/m at the cathode.

关键词： High-repetition-rate beam Radiofrequency gun Continuous-wave mode Multi-objective evolutionary algorithm

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A Review of Methods Based on Nanofluids and Biomimetic Structures for the Optimization of Heat Transfer in Electronic Devices

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Fluid Dynamics & Materials Processing 2022年第5期18卷 1205-1227页

作者： Lanqi Chen Yuwei Wang Cong qi Zhibo tang zhen Tian School of Low-Carbon Energy and Power Engineering China University of Mining and TechnologyXuzhou221116China

Nowadays,the utilization rate of electronic products is increasing while showing no obvious sign of reaching a *** solve the associated“internal heat generation problem”,scientists have proposed two methods or *** first approach consists of replacing the heat exchange medium with a ***,the high surface energy of the nanoparticles makes them prone to accumulate along the heat transfer *** second method follows a different *** tries to modify the surface structure of the electronic components in order to reduce the fluid-dynamic drag and improve the rate of heat *** article reviews these effects considering different types of nanofluid and different shapes,sizes,and arrangements of“biomimetic grooves”.The idea to use these two methods in a combined fashion(to improve heat transfer and reduce flow resistance at the same time)is also developed and discussed critically to a certain extent.

关键词： Nanofluids biomimetic structure drag reduction characteristic thermal management

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