检索结果-南通市图书馆

Efficient Network Dismantling via Node Explosive Percolation

Communications in Theoretical Physics 2019年第6期71卷 764-772页

作者： Shao-Meng qin Xiao-Long Ren lin-yuan Lü College of Science Civil Aviation University of ChinaTianjin300300China Computational Social Science ETH ZurichClausiusstra■508092 ZurichSwitzerland Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu610065China Alibaba Research Center for Complexity Sciences Hangzhou Normal UniversityHangzhou310027China

The network dismantling problem asks the minimum separate node set of a graph whose removal will break the graph into connected components with the size not larger than the one percentage of the original *** problem has attracted much attention recently and a lot of algorithms have been proposed. However, most of the network dismantling algorithms mainly focus on which nodes are included in the minimum separate set but overlook how to order them for removal, which will lead to low general efficiency during the dismantling process. In this paper,we reformulate the network dismantling problem by taking the order of nodes’ removal into consideration. An efficient dismantling sequence will break the network quickly during the dismantling processes. We take the belief-propagation guided decimation(BPD) dismantling algorithm, a state-of-the-art algorithm, as an example, and employ the node explosive percolation(NEP) algorithm to reorder the early part of the dismantling sequence given by the BPD. The proposed method is denoted as the NEP-BPD algorithm(NBA) here. The numerical results on Erd¨os-R′enyi graphs,random-regular graphs, scale-free graphs, and some real networks show the high general efficiency of NBA during the entire dismantling process. In addition, numerical computations on random graph ensembles with the size from 210 to219 exhibit that the NBA is in the same complexity class with the BPD algorithm. It is clear that the NEP method we used to improve the general efficiency could also be applied to other dismantling algorithms, such as Min-Sum algorithm,equal graph partitioning algorithm and so on.

关键词： network dismantling explosive percolation network robustness feedback vertex set

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Clinically significant endoscopic findings in patients of dyspepsia with no warning symptoms:A cross-sectional study

引用

World Journal of Clinical Cases 2021年第15期9卷 3597-3606页

作者： Li-qi Mao Shuang-Shuang Wang Yan-lin Zhou lin Chen Lei-Min Yu Meng Li Bin Lv Department of Gastroenterology The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina Department of Gastroenterology Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical UniversityTaizhou 317000Zhejiang ProvinceChina Department of Gastroenterology Guangxing Hospital Affiliated to Zhejiang Chinese Medical UniversityHangzhou 310007Zhejiang ProvinceChina

BACKGROUND Dyspepsia is one of the commonest clinical ***,controversy remains over the role of endoscopy in patients with *** studies have evaluated the diagnostic value of endoscopy in patients with no warning symptoms according to the Rome IV *** To study the diagnostic value of endoscopy in dyspeptic patients with no warning *** This cross-sectional study included dyspeptic patients with no warning symptoms who met the inclusion and exclusion criteria at The First Affiliated Hospital,Zhejiang Chinese Medical University from April 2018 to February *** clinical data were collected using questionnaires,including dyspeptic information,warning symptoms,other diseases,family history and basic demographic *** on dyspeptic symptoms,patients can be divided into epigastric pain syndrome,postprandial distress syndrome or overlapping *** A total of 1016 cases were enrolled,304(29.9%)had clinically significant findings that were detectable by *** endoscopy findings included esophageal lesions in 180(17.7%)cases,peptic ulcers in 115(11.3%)cases and malignancy in 9(0.89%)*** logistic regression analysis showed that males[odds ratio(OR)=1.758,P25(OR=1.660;P=0.005),epigastric pain(OR=1.423;P=0.019)and Helicobacter pylori infection(OR=1.949;Plinically significant findings on *** Chinese patients with dyspepsia with no warning symptoms should undergo endoscopy,particularly males,patients with body mass index>25,epigastric pain or Helicobacter pylori infection.

关键词： Rome IV Dyspepsia Questionnaire Endoscopy Warning symptoms Diagnosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

四子散热奄包外敷联合运动疗法在胃癌根治术后化疗期间的应用研究

引用

中国疗养医学 2024年第9期33卷 37-41页

作者：黄娅琳李唯媛李丽丽河南省肿瘤医院中西医结合二病区河南郑州450000

目的探讨四子散热奄包联合运动疗法在胃癌根治术后化疗患者中的应用价值。方法本研究是一项随机对照试验,入选河南省肿瘤医院2021年1月至2023年1月收治的92例腹腔镜胃癌D2根治术后患者,采用随机数字表进行分组,分为试验组和对照组各46... 详细信息

目的探讨四子散热奄包联合运动疗法在胃癌根治术后化疗患者中的应用价值。方法本研究是一项随机对照试验,入选河南省肿瘤医院2021年1月至2023年1月收治的92例腹腔镜胃癌D2根治术后患者,采用随机数字表进行分组,分为试验组和对照组各46例。对照组化疗期间采用运动干预,试验组联合四子散热奄包外敷,干预至化疗结束时进行效果评价。评价指标包括化疗相关恶心呕吐(CINV)、癌因性疲乏、生活质量。结果化疗期间,试验组延迟期、全程期CINV发生率45.65%、28.26%低于对照组67.39%、52.17%,差异有统计学意义(P<0.05);试验组延迟期CINV频率6.00(5.00,7.00)次,严重程度3.00(3.00,4.00)分均低于对照组7.00(6.00,8.00)次、5.00(4.00,5.00)分,差异有统计学意义(P<0.05)。干预后,两组行为疲乏、情感疲乏、躯体感知疲乏、认知疲乏程度相比干预前均降低,试验组疲乏程度低于对照组,差异有统计学意义(P<0.05)。干预后,两组角色功能、整体生活质量得分相比干预前升高,疼痛、失眠得分相比干预前降低,试验组得分改善程度均大于对照组,差异有统计学意义(P<0.05)。结论四子散热奄包外敷联合运动疗法能减少胃癌根治术后患者化疗期间CINV发生频率,减轻CINV和癌因性疲乏程度,从而提高患者生活质量。

关键词：胃癌辅助化疗四子散热奄包运动疗法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Difference in CT texture analysis parameter of benign and malignant thyroid nodules and its correlation with the malignant biological behaviors of cancer cells

引用

Journal of Hainan Medical University 2018年第14期24卷 75-78页

作者： Jia-Xue qi Xiao-lin yuan Wen-Ze Wu Imaging Department Jingzhou Fifth Hospital in Hubei ProvinceJingzhouHubei Province434120China Clinical Laboratory Department Jingzhou Fifth Hospital in Hubei ProvinceJingzhouHubei Province434120China Imaging Department Jingzhou Central Hospital in Hubei ProvinceJingzhouHubei Province434120China

Objective:To investigate the difference in CT texture analysis parameter of benign and malignant thyroid nodules and its correlation with the malignant biological behaviors of cancer ***: A total of 228 patients with thyroid nodules who underwent thyroid surgery in this hospital between July 2015 and January 2018 were selected as the research subjects and divided into thyroid cancer group (n=140) and thyroid adenoma group (n=88) according to the pathological results. The differences in CT texture analysis parameter levels as well as the expression of thyroid cancer-related proliferation and invasion genes in lesions were compared between the two groups. Correlation analysis was used to further judge correlation of CT texture analysis parameter levels with proliferation and invasion ***:The lesion tissue entropy of thyroid cancer group was smaller than that of thyroid adenoma group;proliferation genes BRD4, TPX2, FoxM1, TBX2, MDM2 and CRNDE mRNA expressions in the lesion tissues were higher than those of thyroid adenoma group whereas ST7L mRNA expression was lower than that of thyroid adenoma group;invasion genes Six1, Stat5 and Twist1 mRNA expressions in the lesion tissues were higher than those of thyroid adenoma group whereas BRMS1, Cx43 and TSHR mRNA expressions were lower than those of thyroid adenoma group. Pearson test showed that the level of CT texture analysis parameter entropy of thyroid cancer tissue was directly correlated with the proliferation and invasion activity of cancer ***: CT texture analysis parameter entropy levels are significantly different between benign and malignant thyroid nodules, and the specific level can reflect the proliferation and invasion activity of cancer cells.

关键词： Thyroid cancer CT texture analysis Proliferation Invasion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Identification of Self-Incompatibility Genotypes in Some Sand Pears (Pyrus pyrifolia Nakai) by PCR-RFLP Analysis

引用

Agricultural Sciences in China 2009年第2期8卷 154-160页

作者： GU qing-qing ZHANG qing-lin HU Hong-jü CHEN qi-liang LUO Zheng-rong Key Laboratory for Horticultural Plant Biology of Ministry of Education （MOE）/Huazhong Agricultural University Wuhan 430070 P.R. China Department of Horticulture Jiangxi Agricultural University Nanchang 330045 P.R.China Fruit-Tree and Tea Research Institute Hubei Academy of Agricultural Sciences Wuhan 430209 P.R.China

The identification of self-incompatibility genotype （S-genotype） will be useful for selection of pollinizers and design of crossing in cultivar improvement of sand pear. This paper reported the identification of self-incompatibility genotypes of seven Chinese and two Japanese sand pear cultivars using PCR-RFLP analysis and S-RNase sequencing. The Sgenotypes of these cultivars were determined as follows： Huali 1 S1S3, Shounan S1S3, Xizilti S1S4, qingxiang S3S7, Sanhua S2S7, Huangmi （Imamuranatsu） S1S6, Huali 2 S3S4, Baozhuli S7S33, Cangxixueli S5S15. S-RNase alleles （S1 to S9） in sand pear could be identified effectively by PCR-RFLP analysis.

关键词： Pyrus pyrifolia Nakai self-incompatibility genotype S-allele S-RNase PCR-RFLP crossing experiment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于模糊数学感官评价法优化香辣牛肉牛肝菌酱工艺及游离氨基酸分析

引用

中国调味品 2024年第4期49卷 66-73,95页

作者：罗秀群孙光城林丹许程剑袁灿何莲贾洪锋四川旅游学院食品学院成都610100 郑州轻工业大学食品与生物工程学院郑州450001

以牛肉、牛肝菌为主要原料,制作香辣牛肉牛肝菌酱。在单因素试验的基础上进行正交试验,采用感官评定法结合模糊数学评定法,得到产品最佳的工艺和配方,再将最佳配方的产品与对照组、市售的其他3类食用菌产品的色泽、质构和游离氨基酸含... 详细信息

以牛肉、牛肝菌为主要原料,制作香辣牛肉牛肝菌酱。在单因素试验的基础上进行正交试验,采用感官评定法结合模糊数学评定法,得到产品最佳的工艺和配方,再将最佳配方的产品与对照组、市售的其他3类食用菌产品的色泽、质构和游离氨基酸含量进行比较分析。结果表明,在基础配方的基础上,香辣牛肉牛肝菌酱最佳牛肝菌添加量为120 g,辣椒粉添加量为9 g,五香粉添加量为2.5 g,炒制时间为8 min。香辣牛肉牛肝菌酱中的呈味氨基酸总含量占比为94.21%,其中鲜味氨基酸总含量占比最高,为51.40%。香辣牛肉牛肝菌酱中游离氨基酸以谷氨酸和精氨酸为主,此时酱体呈鲜甜味。产品A和产品B中TAV>1的氨基酸均为谷氨酸和精氨酸,鲜味氨基酸是香辣牛肉牛肝菌酱主要的风味成分。在聚类关系上,与市售产品相比,香辣牛肉牛肝菌酱与其他产品的风味差异明显。根据此配方制作出的香辣牛肉牛肝菌酱色泽红润,香气浓郁,酱体浓稠,氨基酸含量丰富,为牛肝菌酱产品的后续研究和工业化生产提供了配方优化和风味特征的理论依据,为牛肝菌新产品的研发和精深加工提供了数据参考。

关键词：牛肝菌牛肉酱模糊数学感官评价游离氨基酸

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Residue substitution enhances the immunogenicity of neoepitopes from gastric cancers

引用

Cancer Biology & Medicine 2021年第4期18卷 1053-1065页

作者： Huahui Yu Jieyu Li yuan yuan Yu Chen Jingwen Hong Chunmei Ye Wansong lin Huijing Chen Zengqing Guo Bo Li Yunbin Ye The School of Basic Medical Sciences Fujian Medical UniversityFuzhou 350122China Laboratory of Immuno-Oncology Fujian Cancer Hospital&Fujian Medical University Cancer HospitalFuzhou 350014China Fujian Key Laboratory of Translational Cancer Medicine Fuzhou 350014China BGI-Shenzhen Shenzhen 518083China BGI Education Center University of Chinese Academy of SciencesShenzhen 518083China Department of Oncology Fujian Cancer Hospital&Fujian Medical University Cancer HospitalFuzhou 350014China

Objective:Neoantigens arising from gene mutations in tumors can induce specific immune responses,and neoantigen-based immunotherapies have been tested in clinical ***,we characterized the efficacy of altered neoepitopes in improving immunogenicity against gastric ***:Raw data of whole-exome sequencing derived from a patient with gastric cancer were analyzed using bioinformatics methods to identify *** were modified by P1Y(the first amino acid was replaced by tyrosine)and P2L(the second amino acid was replaced by leucine).T2 binding and stability assays were used to detect the affinities between the neoepitopes and the HLA molecules,as well as the stabilities of *** cells(DCs)presented with neoepitopes stimulated naïve CD8+T cells to induce specific cytotoxic T *** and carboxyfluorescein succinimidyl ester were used to detect IFN-γand TNF-αlevels,and T cell *** was detected by flow *** cytotoxicity of T cells was determined using the lactate dehydrogenase ***:Bioinformatics analysis,T2 binding,and stability assays indicated that residue substitution increased the affinity between neoepitopes and HLA molecules,as well as the stabilities of *** presented with altered neoepitopes stimulated CD8+T cells to release more IFN-γand had a greater effect on promoting proliferation than wild-type ***8+T cells stimulated with altered neoepitopes killed more wild-type neoepitope-pulsed T2 cells than those stimulated with wild-type neoepitopes,by secreting more IFN-γ,TNF-α,and ***:Altered neoepitopes exhibited greater immunogenicity than wild-type *** substitution could be used as a new strategy for immunotherapy to target neoantigens.

关键词： Gastric cancer bioinformatics neoepitope residue substitution immunotherapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

配电站房数字化运维网关设计与实现

引用

工程建设与设计 2024年第3期 118-120页

作者：张斯淇郑翔天王小玄袁一飞袁文杰国网南京供电公司南京210017 南京工程学院南京211167 中国石油华北油田勘探开发研究院河北任丘062550

简述了电力配电网络站房运维管理系统的现状,包括配电房运维中存在人力资源不足、监测数据类型不全面、信息化程度低,数据应用程度不高等切实问题,需要结合各级配电站房的特点以及供电公司规划进行分级化设计。配电站房运维平台需要实... 详细信息

简述了电力配电网络站房运维管理系统的现状,包括配电房运维中存在人力资源不足、监测数据类型不全面、信息化程度低,数据应用程度不高等切实问题,需要结合各级配电站房的特点以及供电公司规划进行分级化设计。配电站房运维平台需要实现“就地”智能化,彰显数据价值,提升开放共享能力。采用分层建设思路,并遵循智慧物联体系云-边共建框架,以云监测为基础,以边缘计算为辅助为智能化配电房数字化运维提供了可行方案。

关键词：配电站房数字化运维管理系统设计

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

国内外孤儿药注册制度探究与启示

引用

中国新药杂志 2024年第10期33卷 978-983页

作者：方中坚林乐婷王彩依沈晨张亮汪颖霞朱思琪邵蓉邵明立樊玉录上海健康医学院药学院上海201318 中国药科大学南京211198 东南大学附属南京胸科医院南京210029

目前国外一些发达国家的儿童类孤儿药注册制度比较完善,如美国FDA建立了孤儿药的资格认证制度。欧美一些发达国家均建立了针对罕见病和孤儿药的专门监管机构和措施,我国与其不同,对罕见病的防治和孤儿药的注册还未给予足够关注,我国的... 详细信息

目前国外一些发达国家的儿童类孤儿药注册制度比较完善,如美国FDA建立了孤儿药的资格认证制度。欧美一些发达国家均建立了针对罕见病和孤儿药的专门监管机构和措施,我国与其不同,对罕见病的防治和孤儿药的注册还未给予足够关注,我国的孤儿药注册制度明显不如某些发达国家完善。本文通过文献综述对不同国家的孤儿药注册制度进行比较分析,并结合我国国情提出了促进我国孤儿药注册制度建立的方法。

关键词：新药研发药品注册孤儿药罕见病

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

TAR DNA-Binding Protein 43 is Cleaved by the Protease 3C of Enterovirus A71

引用

Virologica Sinica 2021年第1期36卷 95-103页

作者： Xiaoman Wo yuan yuan Yong Xu Yang Chen Yao Wang Shuoxuan Zhao Lexun lin Xiaoyan Zhong Yan Wang Zhaohua Zhong Wenran Zhao Department of Cell Biology Harbin Medical UniversityHarbin 150081China Department of Microbiology Harbin Medical UniversityHarbin 150081China

Enterovirus A71(EV-A71)is one of the etiological pathogens leading to hand,foot,and mouth disease(HFMD),which can cause severe neurological *** neuropathogenesis of EV-A71 infection is not well *** mislocalization and aggregation of TAR DNA-binding protein 43(TDP-43)is the pathological hallmark of amyotrophic lateral sclerosis(ALS).However,whether TDP-43 was impacted by EV-A71 infection is *** study demonstrated that TDP-43 was cleaved during EV-A71 *** cleavage of TDP-43 requires EV-A71 replication rather than the activated caspases due to viral ***-43 is cleaved by viral protease 3 C between the residues 331 Q and332 S,while mutated TDP-43(Q331 A)was not *** addition,mutated 3 C which lacks the protease activity failed to induce TDP-43 *** also found that TDP-43 was translocated from the nucleus to the cytoplasm,and the mislocalization of TDP-43 was induced by viral protease 2 A rather than 3 *** together,we demonstrated that TDP-43 was cleaved by viral protease and translocated to the cytoplasm during EV-A71 infection,implicating the possible involvement of TDP-43 in the pathogenesis of EV-A71 infection.

关键词： Enterovirus A71(EV-A71) TAR DNA-binding protein 43(TDP-43) 3C protease 2A protease

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：