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New role of platelets in schizophrenia:predicting drug response

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General Psychiatry 2024年第2期37卷 197-206页

作者： Yamin Zhang Yanghao Zheng Peiyan Ni Sugai Liang Xiaojing Li Hua yu Wei Wei Xueyu qi Xueli yu Rui Xue Liansheng Zhao Wei Deng qiang Wang Wanjun Guo Tao Li Department of Neurobiology Zhejiang University School of Medicine Affiliated Mental Health Centre&Hangzhou Seventh People's HospitalHangzhouZhejiangChina Liangzhu Laboratory Zhejiang University MOE Frontier Science Center for Brain Science and Brain Machine IntegrationHangzhouZhejiangChina Mental Health Center and Psychiatric Laboratory West China Hospital of Sichuan UniversityChengduSichuanChina

Background Elevated platelet count(PLTc)is associated with first-episode schizophrenia and adverse outcomes in individuals with precursory ***,the impact of antipsychotic medications on PLTc and its association with symptom improvement remain *** We aimed to investigate changes in PLTc levels following antipsychotic treatment and assess whether PLTc can predict antipsychotic responses and metabolic changes after accounting for other related *** A total of 2985 patients with schizophrenia were randomised into seven *** group received one of seven antipsychotic treatments and was assessed at 2,4 and 6 *** symptoms were evaluated using the positive and negative syndrome scale(PANSS).Additionally,we measured blood cell counts and metabolic parameters,such as blood *** measures analysis of variance was used to examine the effect of antipsychotics on PLTc changes,while structural equation modelling was used to assess the predictive value of PLTc on PANSS *** PLTc significantly increased in patients treated with aripiprazole(F=6.00,p=0.003),ziprasidone(F=7.10,p<0.001)and haloperidol(F=3.59,p=0.029).It exhibited a positive association with white blood cell count and metabolic *** baseline PLTc was observed in non-responders,particularly in those defined by the PANSS-negative *** the structural equation model,PLTc,white blood cell count and a latent metabolic variable predicted the rate of change in the PANSS-negative subscale ***,higher baseline PLTc was observed in individuals with less metabolic change,although this association was no longer significant after accounting for baseline metabolic *** Platelet parameters,specifically PLTc,are influenced by antipsychotic treatment and could potentially elevate the risk of venous thromboembolism in patients with *** PLTc levels and associated factors may impede symptom improvement by

关键词： schizophrenia assessed treatment

Influence of oxygen-rich hot air composite gas medium on sintering performance and function mechanism

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Journal of Iron and Steel Research International 2024年第5期31卷 1071-1081页

作者： Min Gan Hao-xiang Zheng Xiao-hui Fan Zhi-yun Ji qiang Li Ming Wu Yi-fan Wang Xiao-long Wang yu-feng Wu Xu-ling Chen zeng-qing Sun Xiao-xian Huang School of Minerals Processing and Bioengineering Central South UniversityChangsha410083HunanChina Shanxi Taigang Stainless Steel Co. Ltd.Taiyuan030003ShanxiChina

Hot air sintering technology is used to improve the quality and production efficiency of sintered ***,the current thick layer condition highlights the disadvantage of the low oxygen potential of the hot air sintering ***,it is considered to use oxygen enrichment sintering to improve the environment of hot air *** sintering,hot air sintering,and oxygen-rich hot air sintering were compared through sintering cup experiments,and the influence of hot air and oxygen-rich hot air on sintering indexes was *** air reduced the vertical sintering velocity,while improved the yield and tumbler ***-rich hot air sintering contributed to improving the vertical sintering velocity while ensuring the quality of sintered ore,thus comprehensively improving production *** the action of hot air,the highest temperature of the sintering layer increased and the high-temperature holding time was *** oxygen enrichment,the combustion efficiency of fuels in the upper layer of materials was promoted,which optimized heat distribution in the middle and lower layers of materials and increased the content of calcium ferrite in the sintered ore,thus strengthening the sintering process.

关键词： Iron ore sintering Hot air sintering Oxygen enrichment Function mechanism

Particulate matter exposure exacerbates susceptibility to SARS-CoV-2 infection in humanized ACE2 mice

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Zoological Research 2021年第3期42卷 335-338页

作者： Teng-yu Zhu Huan qiu qi-qi Cao Zi-Lei Duan Feng-Liang Liu Tian-Zhang Song Yang Liu Ya-Qun Fang Guang-Ming Wu Yong-Tang Zheng Wen-Jun Ding Ren Lai Lin Jin College of Life Sciences Nanjing Agricultural UniversityNanjingJiangsu 210095China Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China Centre for Cell Lineage and Atlas Bioland LaboratoryGuangzhouGuangdong 510530China Laboratory of Environment and Health University of Chinese Academy of SciencesBeijing 100049China Kunming National High-level Biosafety Research Center for Non-Human Primates Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China

The global outbreak of coronavirus disease 2019(COVID-19),which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),as of 8 May 2021,has surpassed 150700000 infections and 3279000 deaths *** indicates that SARS-CoV-2 RNA can be detected on particulate matter(PM),and COVID-19 cases are correlated with levels of air ***,the mechanisms of PM involvement in the spread of SARS-CoV-2 remain poorly ***,we found that PM exposure increased the expression level of angiotensin-converting enzyme 2(ACE2)and transmembrane serine protease 2(TMPRSS2)in several epithelial cells and increased the adsorption of the SARS-CoV-2 spike *** of PM in a hACE2 mouse model significantly increased the expression of ACE2 and Tmprss2 and viral replication in the ***,PM exacerbated the pulmonary lesions caused by SARS-CoV-2 infection in the hACE2 *** conclusion,our study demonstrated that PM is an epidemiological factor of COVID-19,emphasizing the necessity of wearing anti-PM masks to cope with this global pandemic.

关键词： ACE2 infection involvement

NOVEL REACTIONS BETWEEN CHROMIUM CARBYNE COMPOUNDS AND DICOBALT OCTACRBONYL

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Chinese Chemical Letters 1995年第12期6卷 1069-1072页

作者： Hong Sui SUN yuan qi YIN Xiao zeng YOU and Yong Jiang LIU.(State key laboratory of Coordination Chemistry, Coordination Chemistry Institute, Nanjing University,Nanjing 210093)(Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 7 Nanjing Univ Inst Coordinat Chem State Key Lab Coordinat Chem Nanjing 210093 Peoples R China Chinese Acad Sci Lanzhou Inst Chem Phys Lanzhou 730000 Peoples R China

The carbyne compounds(1), and (bipy=α,α'-dipyridyl) (2) react with dicobalt octacarbonyl in dichloromethane at room temperature, after chromatography on silica gel column, to give compounds [Co3(μ3-CC6H5)(CO)9] (3),[Co2Cr(μ3-CC6H5)Br(CO)8(Py)2] (4), and [Co2Cr(μ3-CC6H5)Br(CO)8(bipy)](5). Their structures were deduced from elemental analyses, IR, HNMR, 13C-{1H}NMR, and mass spectra.

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The MdABI5 transcription factor interacts with the MdNRT1.5/MdNPF7.3 promoter to fine-tune nitrate transport from roots to shoots in apple

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Horticulture Research 2021年第1期8卷 3131-3143页

作者： Ya-Jing Liu Ning Gao qi-Jun Ma Jiu-Cheng Zhang Xun Wang Jing Lu yu-Jin Hao Xiao-Fei Wang Chun-Xiang You State Key Laboratory of Crop Biology Shandong Collaborative Innovation Center of Fruit&Vegetable Quality and Efficient ProductionCollege of Horticulture Science and EngineeringShandong Agricultural UniversityTai-AnShandong 271018China

Nitrate is a major nitrogen resource for plant growth and development and acts as both a crucial nutrient and a signaling molecule for plants;hence,understanding nitrate signaling is important for crop *** acid(ABA)has been demonstrated to be involved in nitrate signaling,but the underlying mechanism is largely unknown in *** this study,we found that exogenous ABA inhibited the transport of nitrate from roots to shoots in apple,and the transcription of the nitrate transporter MdNRT1.5/MdNPF7.3 was noticeably reduced at the transcriptional level by ABA,which inhibited the transport of nitrate from roots to ***,it was found that the ABA-responsive transcription factor MdABI5 bound directly to the ABRE recognition site of the MdNRT1.5 promoter and suppressed its *** of MdABI5 inhibited ABA-mediated transport of nitrate from roots to ***,these results demonstrate that MdABI5 regulates the transport of nitrate from roots to shoots partially by mediating the expression of MdNRT1.5,illuminating the molecular mechanism by which ABA regulates nitrate transport in apple.

关键词： ABI5 nitrate roots

金属-有机骨架材料MOF-5的改进与吸附甲烷的巨正则蒙特卡罗模拟

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物理化学学报 2008年第8期24卷 1493-1497页

作者：曾余瑶张秉坚浙江大学化学系杭州310027

根据金属-有机骨架材料(MOFs)的设计思想,在MOF-5(对苯二甲酸为桥联配体,Zn4O金属簇为中心的配位化合物)的基础上设计了10种以Zn4O金属簇为中心(Corner),以不同基团单取代的对苯二甲酸(BDC)衍生物为桥联配体(Linker)的多孔材料.用巨正... 详细信息

根据金属-有机骨架材料(MOFs)的设计思想,在MOF-5(对苯二甲酸为桥联配体,Zn4O金属簇为中心的配位化合物)的基础上设计了10种以Zn4O金属簇为中心(Corner),以不同基团单取代的对苯二甲酸(BDC)衍生物为桥联配体(Linker)的多孔材料.用巨正则蒙特卡罗(GCMC)模拟方法,计算了这些材料在298K、1-10MPa条件下对甲烷的吸附量,讨论了不同取代基与甲烷吸附量的关系.结果发现,在298K、3.5MPa时甲烷的吸附量主要取决于吸附热,并且以硝基取代的配体构成的MOF分子吸附甲烷效果最好.在此基础上,进一步设计了以四硝基取代对苯二甲酸为桥联配体的MOF-4NO2,该结构在相同条件下对甲烷的超额吸附量为209cm3·cm-3,总吸附量达到228cm3·cm-3,比美国能源部(DOE)提出的甲烷吸附材料应用要求标准高26%.

关键词：甲烷金属-有机骨架材料吸附巨正则蒙特卡罗

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Meliolales

Fungal Diversity 2015年第5期74卷 91-141页

作者： Sinang Hongsanan qing Tian Derek Peršoh Xiang-yu zeng Kevin D.Hyde Putarak Chomnunti Saranyaphat Boonmee Ali H.Bahkali Ting-Chi Wen Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Institute of Excellence in Fungal Research Chiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Ruhr-Universität Bochum GeobotanyUniversitätsstraße 15044780 BochumGermany Botany and Microbiology Department College of ScienceKing Saud UniversityRiyadhKSA 11442Saudi Arabia The Engineering and Research Center of Southwest Bio-Pharmaceutical Resource Ministry of EducationGuizhou UniversityGuiyang 550025China

The order Meliolales comprises the families Armatellaceae and *** are black mildews that grow on the surface of host plants,often regarded as minor plant *** this study,types or specimens of 17 genera of Armatellaceae and Meliolaceae were borrowed from herbaria and *** is accepted in Armatellaceae and Amazonia,Appendiculella,Asteridiella,Cryptomeliola,Endomeliola,Irenopsis and Meliola are accepted in the family *** is synonymized under ***,Ectendomeliola,Haraea,Hypasteridium,Leptascospora,Metasteridium,Ophiociliomyces,Ophioirenina,Ophiomeliola,Parasteridium,Pauahia,Pleomeliola,Pleomerium,Prataprajella,Ticomyces,Urupe and Xenostigme are excluded from Meliolaceae,and are treated as doubtful genera or placed in ascomycetes genera incertae *** type species of each genus is re-described and illustrated with *** are provided and comparisons *** new species of Meliola and one new species of Irenopsis are also introduced with molecular data and we provide the most populated phylogenetic tree of Meliolomycetidae to *** thailandicum was found on Dimocarpus longan(Sapindales)and Acacia auriculiformis(Fabales)and confirmed to be the same species in the molecular *** has important implications as the several hundred Meliola species are recognized based on host *** the same species being recorded from two unrelated hosts sheds doubt on Meliola species being host-specific.

关键词： Armatella Armatellaceae Ascomycota Black mildews Meliola Meliolaceae Meliolomycetidae Sordariomycetes Morphology Type Species Taxonomy

多体动力学的键合图表达及其在Modelica中的实现

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中国机械工程 2006年第S2期17卷 320-323页

作者：于涛曾庆良山东科技大学青岛266510

给出了多体动力学第一类拉格朗日方程的键合图表达,并采用键合图的Modelica库在Dymola中对示例进行了建模和仿真,结果表明,多体动力学拉格朗日方程的键合图表示是非常简单的,清晰地表明了拉格朗日乘子的物理含义,可将其容易地扩展到柔... 详细信息

给出了多体动力学第一类拉格朗日方程的键合图表达,并采用键合图的Modelica库在Dymola中对示例进行了建模和仿真,结果表明,多体动力学拉格朗日方程的键合图表示是非常简单的,清晰地表明了拉格朗日乘子的物理含义,可将其容易地扩展到柔性多体动力学领域,是一种非常合适的多体动力学表达方法。

关键词：键合图多体动力学 Modelica 多领域建模

拉曼光谱的16种多环芳烃(PAHs)特征振动光谱辨识

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光谱学与光谱分析 2014年第11期34卷 2999-3004页

作者：曾娅玲姜龙蔡啸宇李鱼华北电力大学资源与环境研究院华北电力大学区域能源系统优化教育部重点实验室北京102206

借助密度泛函理论中B3LYP/6-311++G(d,p)方法对美国EPA优先控制污染物中的16种多环芳烃(PAHs):萘、苊烯、苊、芴、菲、蒽、荧蒽、芘、苯并[a]蒽、稠二萘、苯并[b]荧蒽、苯并[k]荧蒽、苯并[a]芘、二苯并(a,h)蒽、二苯并[g,h,i]芘以及茚苯... 详细信息

借助密度泛函理论中B3LYP/6-311++G(d,p)方法对美国EPA优先控制污染物中的16种多环芳烃(PAHs):萘、苊烯、苊、芴、菲、蒽、荧蒽、芘、苯并[a]蒽、稠二萘、苯并[b]荧蒽、苯并[k]荧蒽、苯并[a]芘、二苯并(a,h)蒽、二苯并[g,h,i]芘以及茚苯(1,2,3-cd)芘进行结构优化,并计算拉曼光谱振动频率和去偏振度,在此基础上辨识多环芳烃的拉曼特征光谱。研究显示,16种PAHs的拉曼振动主要分布在3个频区:200~1 000cm-1(指纹区)、1 000~1 700和3 000~3 200cm-1(基团频率区),3个频区主要振动归属分别为环变形(ring def),碳碳伸缩(CCStr)、碳氢摇摆(CHw)及其耦合振动(CCStrCCw),碳氢伸缩(CHStr)。进一步分析显示,指纹区16种PAHs的去偏振度随苯环变形振动对称性增强而降低,在该频区去偏振度最小的频移处苯环呼吸振动的对称性最强,指纹区的峰强也在此处出现最大值。任意PAHs在指纹区的最强峰之间的波数差较大,在显微拉曼光谱的可分辨范围内,因而利用指纹区的去偏振度和最强峰可将16种PAHs逐一识别。烷烃、烯烃、炔烃、醇类和酚类、脂肪醚、芳基烷基醚、醛类、酮类、羧酸、酯类、胺类、腈类、酰胺类、酸酐、芳烃的振动频率和峰强分布不完全一致,利用PAHs与这几类物质拉曼频率和峰强分布的差异可以逐一排出干扰。

关键词：多环芳烃拉曼振动归属拉曼特征光谱识别指纹区去偏振度