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Comparison of coronary DES and BMS in octogenarians: A systematic review and meta-analysis

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Journal of Geriatric Cardiology 2013年第4期10卷 336-343页

作者： Lei Gao Xin Hu yu-qi liu qiao Xue yu Wang Institute of Geriatric Cardiology Chinese PLA General Hospital No.28 Fuxing Road Haidian District Beijing 100853 China

OBJECTIVE: Uncertainty exists regarding the relative performance of drug-eluting stents (DES) versus bare-metal stents (BMS) in octogenarians undergoing percutaneous coronary intervention (PCI)。 We undertook a meta-analysis to assess outcomes for DES and BMS in octogenarians undergoing PCI。 METHODS: Electronic data bases of PubMed, Cochrane, and EMBASE were searched。 We included randomized, controlled clinical trials (RCT) and observational studies comparing DES and BMS in octogenarians receiving PCI。 The methodological qualities of eligible trials were assessed using a 'risk of bias' tool。 The endpoints included all-cause death, major adverse cardiac events (MACE), myocardial infarction (MI), target vessel revascularization (TVR), major bleeding, and stent thrombosis (ST)。 Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated for each endpoint。 RESULTS: A total of one RCT and six observational studies were included and analyzed in this meta-analysis。 All trials were of acceptable quality。 At 30 days, compared with DES-treated patients, BMS-treated patients had a higher incidence of mortality (OR:3.91,95% CI:1.10-13.91; P =0.03)。 The OR for MACE (1.52,95% CI:0.56-4.17; P =0.13), MI (0.81,95% CI:0.37-2.17; P =0.23), TVR (0.75,95% CI:0.17-3.41; P=0.41), major bleeding (0.77,95% CI:0.35-1.68; P =0.43),and ST (1.44,95% CI:0.32-6.45; P =0.33) did not reach statistical significance。 At one year follow-up, the OR did not favor BMS over MACE (MACE, defined as the composite of death, myocardial infarction, and TVR) (1.87,95% CI:1.22-2.87; P 1 year follow-up, the OR for all endpoints, including mortality, MACE, MI, TVR, major bleeding, and ST, did not reach statistical significance。 CONCLUSI

关键词： Bare-metal stents Drug-eluting stents Meta-analysis Octogenarians Percutaneous coronary intervention

Congenital tuberculosis with tuberculous meningitis and situs inversus totalis:A case report

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World Journal of Clinical Cases 2022年第16期10卷 5495-5501页

作者： Hu Lin Shuang Teng Zhong Wang qi-yu liu Department of Radiology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Clinical Medicine Chengdu University of Traditional Chinese MedicineChengdu 610036Sichuan ProvinceChina Department of Radiology Mianyang Central HospitalMianyang 621000Sichuan ProvinceChina

BACKGROUND Congenital tuberculosis(TB),tuberculous meningitis,and situs inversus totalis are rare *** here report a patient who simultaneously suffered from these three rare *** is currently no such report in the *** TB is easily misdiagnosed and has a high case fatality *** anti-TB treatment is *** SUMMARY A 19-day-old male newborn was admitted to hospital due to a fever for 6 *** blood tests and chest X-rays suggested infection,and he was initially considered to have neonatal pneumonia and *** did not respond to conventional antiinfective ***,Mycobacterium tuberculosis was found in sputum lavage fluid on the 10th day after *** addition,the mother's tuberculin skin test was positive,with an induration of 22 mm,and her pelvic computed tomography scan suggested the possibility of tuberculous pelvic inflammatory *** child was diagnosed with congenital TB and immediately managed with anti-TB therapy and symptomatic supportive ***,the infant's condition gradually worsened and he developed severe tuberculous pneumonia and tuberculous meningitis,and eventually died of respiratory *** If conventional anti-infective treatment is ineffective in neonatal pneumonia,anti-TB treatment should be considered.

关键词： Tuberculosis Congenital Situs inversus Newborn Infant Case report

One-pot synthesis of N-aryl propargylamine from aromatic boronic acid,aqueous ammonia,and propargyl bromide under microwave-assisted conditions

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Chinese Chemical Letters 2014年第5期25卷 779-782页

作者： yu-Bo Jiang Wen-Sheng Zhang Hui-Ling Cheng yu-qi liu Rui Yang Faculty of Science Kunming University of Science and Technology School of Science and Technology Jiaozuo Teachers’ College

A facile,one-pot synthesis of N-aryl propargylamine from aromatic boronic acid,aqueous ammonia,and propargyl bromide has been achieved under microwave-assisted *** reactions can be smoothly completed within a total 10 min through a two-step procedure,including copper-catalyzed coupling of aromatic boronic acids with aqueous ammonia and following propargylation by propargyl bromide.

关键词： One-pot Microwave N-Aryl propargylamine Aromatic boronic acid Aqueous ammonia Propargyl bromide

Predictive validation of existing bleeding and thromboembolic scores in elderly patients with comorbid atrial fibrillation and acute coronary syndrome

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Journal of Geriatric Cardiology 2023年第5期20卷 330-340页

作者： Hong-Hong ZHANG qi liu Hai-Jing ZHAO Ya-Ni yu liu-Yang TIAN Ying-yue ZHANG Zi-Hao FU Li ZHENG yue ZHU yu-Han MA Shuang LI Yang-Yang MA yu-qi liu Medical School of Chinese PLA BeijingChina Department of Cardiology&National Clinical Research Center of Geriatrics Disease Beijing Key Laboratory of Chronic Heart Failure Precision MedicineNational Key Laboratory of Kidney DiseasesChinese PLA General HospitalBeijingChina Department of Cardiology the Sixth Medical CenterChinese PLA General HospitalBeijingChina Department of Information Chinese PLA General HospitalBeijingChina

BACKGROUND The validation of various risk scores in elderly patients with comorbid atrial fibrillation(AF)and acute coron-ary syndrome(ACS)has not been *** present study compared the predictive performance of existing risk scores in *** METHODS A total of 1252 elderly patients with AF and ACS comorbidities(≥65 years old)were consecutively enrolled from January 2015 to December *** patients were followed up for one *** predictive performance of risk scores in predict-bleeding and thromboembolic events was calculated and *** RESULTS During the 1-year follow-up,183(14.6%)patients had thromboembolic events,198(15.8%)patients had BARC class≥2 bleeding events,and 61(4.9%)patients had BARC class≥3 bleeding *** the BARC class≥3 bleeding events,discrimina-tion of the existing risk scores was low to moderate,PRECISE-DAPT(C-statistic:0.638,95%CI:0.611-0.665),ATRIA(C-statistic:0.615,95%CI:0.587-0.642),PARIS-MB(C-statistic:0.612,95%CI:0.584-0.639),HAS-BLED(C-statistic:0.597,95%CI:0.569-0.624)and CRUSADE(C-statistic:0.595,95%CI:0.567-0.622).However,the calibration was ***-DAPT showed a higher in-tegrated discrimination improvement(IDI)than PARIS-MB,HAS-BLED,ATRIA,and CRUSADE(P<0.05)and the best decision curve analysis(DCA).For thromboembolic events,the discrimination of GRACE(C-statistic:0.636,95%CI:0.608-0.662)was higher than CHA2DS2-VASc(C-statistic:0.612,95%CI:0.584-0.639),OPT-CAD(C-statistic:0.602,95%CI:0.574-0.629)and PARIS-CTE(C-statistic:0.595,95%CI:0.567-0.622).The calibration was *** to OPT-CAD and PARIS-CTE,the IDI of the GRACE score slightly improved(P<0.05).However,NRI analysis showed no significant *** showed that the clinical practic-of thromboembolic risk scores was *** CONCLUSIONS The discrimination and calibration of existing risk scores in predicting 1-year thromboembolic and bleeding events were unsatisfactory in elderly patients with comorbid AF and ***-DAPT showed

关键词： patients bleeding thrombo

Developing single-atom catalyst-based epoxy coating with active nanocatalytic anticorrosion performance in oxygen environment

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Petroleum Science 2023年第5期20卷 3251-3263页

作者： Meng Cheng yu-qi liu Hao Jiang Jun-Hao liu Chun-Ling Li Shuang-qing Sun Song-qing Hu School of Materials Science and Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Institute of Advanced Materials China University of Petroleum(East China)Qingdao266580ShandongChina

The stimuli-responsive anticorrosion coatings have drawn great attention as a prospective corrosion protection approach due to their smart self-repairing *** contrast to passive protection mechanism based on post-corrosion microenvironmental changes,a unique active protection strategy based on nanocatalytic oxygen depletion is proposed in this work to inhibit the occurrence of *** FeeNeC catalysts with outstanding oxygen reduction reaction(ORR)activity(half-wave potential of 0.89 V)is firstly synthesized through pre-coordination with organosilane precursor to obtain homogeneously distributed active *** this catalyst is introduced into the coating matrix,uniformly distributed FeeNeC not only compensates the defects but plays a crucial role in adsorption and consumption of diffused oxygen in the *** this dual action,the penetration of corrosive medium,especially oxygen,through coating to metal substrate is greatly suppressed,resulting in effective corrosion inhibition and a significant increase in corrosion resistance of the composite coating compared to pure epoxy *** work provides a new perspective and the starting point for the design of high-performance smart coating with active anticorrosion properties.

关键词： Nanocatalytic anticorrosion Pre-constrained metal ions Single-atom FeeNeC Deoxygenation agent Smart coatings

Cerebral proliferative angiopathy in pediatric age presenting as neurological disorders:A case report

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World Journal of Clinical Cases 2023年第33期11卷 8071-8077页

作者： Fu-Ren Luo Ying Zhou Zhong Wang qi-yu liu Department of Radiology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Radiology Mianyang Central HospitalMianyang 621000Sichuan ProvinceChina

BACKGROUND Cerebral proliferative angiopathy(CPA)is a rare subtype of arteriovenous *** is extremely rare in pediatric patients and has serious implications for developing ***,reports of these disorders worldwide are limited,and no uniform reference for diagnosis and treatment options *** report the case of a 6-year-old with CPA having predominantly neurological dysfunction and review the literature on pediatric *** SUMMARY We report the case of a pediatric patient with CPA analyzed using digital subtraction angiography(DSA)who presented initially with a neurological disorder as the main *** case is the basis for further discussion of the clinical presentation,pathogenesis,diagnosis,and treatment of CPA in *** the cerebral DSA,the patient was treated conservatively with sedation,fluid replacement,and blood *** could not cooperate with the followup magnetic resonance imaging examination because of her young age,and her family declined further treatment because of the surgery’s high *** was followed up for 3 months;her symptoms did not *** This report of rare pediatric CPA can inform and advance clinical research on congenital cerebrovascular diseases.

关键词： Pediatric cerebral proliferative angiopathy Pathogenesis Diagnosis Treatment Case report

Online Learning a Binary Classifier for Improving Google Image Search Results

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自动化学报 2014年第8期40卷 1699-1708页

作者： WAN yu-Chai liu Xia-Bi HAN Fei-Fei TONG Kun-qi liu yu Beijing Laboratory of Intelligent Information Technology School of Computre Science Beijing Institute of Technology Bei- jing 100081 China

It is promising to improve web image search results through exploiting the results' visual contents for learning a binary classifier which is used to refine the results' relevance degrees to the given query. This paper proposes an algorithm framework as a solution to this problem and investigates the key issue of training data selection under the framework. The training data selection process is divided into two stages: initial selection for triggering the classifier learning and dynamic selection in the iterations of classifier learning. We investigate two main ways of initial training data selection, including clustering based and ranking based, and compare automatic training data selection schemes with manual manner. Furthermore, support vector machines and the max-min pseudo-probability (MMP) based Bayesian classifier are employed to support image classification, respectively. By varying these factors in the framework, we implement eight algorithms and tested them on keyword based image search results from Google search engine. The experimental results confirm that how to select the training data from noisy search results is really a key issue in the problem considered in this paper and show that the proposed algorithm is effective to improve Google search results, especially at top ranks, thus is helpful to reduce the user labor in finding the desired images by browsing the ranking in depth. Even so, it is still worth meditative to make automatic training data selection scheme better towards perfect human annotation.

关键词：搜索结果在线学习二元分类贝叶斯分类器算法框架训练数据图片支持向量机

Quantitative characterization of shale pore connectivity and controlling factors using spontaneous imbibition combined with nuclear magnetic resonance T_(2)and T_(1)-T_(2)

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Petroleum Science 2023年第4期20卷 1947-1960页

作者： Peng-Fei Zhang Shuang-Fang Lu Jun-qian Li Xiang-Chun Chang Jun-Jian Zhang yu-Mao Pang Zi-Zhi Lin Guo Chen Ya-Jie Yin yu-qi liu College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao266590ShandongChina Sanya Offshore Oil&Gas Research Institute Northeast Petroleum UniversitySanyaHainan572025China Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao266580ShandongChina College of Resources and Environment Yangtze UniversityWuhan430100HubeiChina

Shale oil can be extracted from shale by using interconnected pore *** migration of hydrocarbon molecules within the shale is controlled by pore ***,assessing the pore connectivity of shale oil reservoirs is *** characterize pore connectivity and clarify its controlling factors,this study used spontaneous imbibition(SI)combined with nuclear magnetic resonance(NMR)T_(2)and T_(1)-T_(2)technologies on shale oil reservoirs selected from the Shahejie Formation in the Dongying Sag,Bohai Bay *** to the findings,the SI processes of shales include fast-rising,slow-rising,and stable *** fast-rising stage denotes pore *** shales studied have poor connectivity,with lower imbibition slopes and connected porosity ratios,but large effective *** the SI process,micropores have the highest imbibition saturation,followed by mesopores and ***,n-dodecane ingested into micropores appears primarily as adsorbed,whereas n-dodecane appears primarily as free states in mesopores and macropores during the SI *** pore connectivity of the shales under study is primarily controlled by inorganic *** and feldspar develop large and regular pores,resulting in better pore connectivity,whereas clay minerals and calcite with plenty of complex intragranular pores do *** matter negatively influences pore connectivity because the dissolution of calcite by organic acid produced during hydrocarbon generation leads to a more complex and heterogeneous pore *** study sheds light on the pore connectivity and controlling factors of the shale oil reservoir and aids in the understanding of shale oil mobility.

关键词： Pore connectivity Spontaneous imbibition Nuclear magnetic resonance Mercury intrusion capillary pressure Shale oil reservoir

Mutational analysis of KCNJll in Chinese elderly essential hypertensive patients

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Journal of Geriatric Cardiology 2012年第2期9卷 153-157页

作者： Jia-yue Li Zong-Bin Li Mei Zhu yu-qi liu Yang Li Shi-Wen Wang qing-Lei Zhu Institute of Geriatric Cardiology Chinese PLA General Hospital28 Fuxing RoadBeijing 100853China

Objective To compare the distribution ofKCNJll polymorphisms between elderly Chinese population with and without hypertension. Methods We examined the mutation of KCNJll gene by directly sequencing. Data for the present study were obtained from 250 hypertensive subjects （60 to 83 years old） as well as 250 normotensive subjects （60 to 86 years old）. Results We found nine different mutations in KCNJ11, including six novel mutations （1131M, L1471, L147V, L147L, Q235H, G245C）. None of the novel mutations were found in the normotensive subjects, and all the residues were conserved in other species. These sequence variants in Chinese population indicate the diversity of the human library and the complexity of hypertension. Conclusions The consistent finding of our present study provided a basis for the development of new strategies to diagnosis and treat hypertension in the elderly.

关键词： Essential hypertension Phenotype Genotype Mutation The elderly