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Application of convolutional neural network-based endoscopic imaging in esophageal cancer or high-grade dysplasia: A systematic review and meta-analysis

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World Journal of Gastrointestinal Oncology 2023年第11期15卷 1998-2016页

作者： jun-qi zhang jun-Jie Mi Rong Wang The Fifth Clinical Medical College Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Gastroenterology Shanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina Department of Gastroenterology The Fifth Hospital of Shanxi Medical University(Shanxi Provincial People’s Hospital)Taiyuan 030012Shanxi ProvinceChina

BACKGROUND Esophageal cancer is the seventh-most common cancer type worldwide,accounting for 5%of death from *** of novel diagnostic techniques has facilitated screening,early detection,and improved *** neural network(CNN)-based image analysis promises great potential for diagnosing and determining the prognosis of esophageal cancer,enabling even early detection of *** PubMed,EMBASE,Web of Science and Cochrane Library databases were searched for articles published up to November 30,*** evaluated the diagnostic accuracy of using the CNN model with still image-based analysis and with video-based analysis for esophageal cancer or HGD,as well as for the invasion depth of esophageal *** pooled sensitivity,pooled specificity,positive likelihood ratio(PLR),negative likelihood ratio(NLR),diagnostic odds ratio(DOR)and area under the curve(AUC)were estimated,together with the 95%confidence intervals(CI).A bivariate method and hierarchical summary receiver operating characteristic method were used to calculate the diagnostic test accuracy of the CNN ***-regression and subgroup analyses were used to identify sources of *** A total of 28 studies were included in this systematic review and *** still image-based analysis for the diagnosis of esophageal cancer or HGD provided a pooled sensitivity of 0.95(95%CI:0.92-0.97),pooled specificity of 0.92(0.89-0.94),PLR of 11.5(8.3-16.0),NLR of 0.06(0.04-0.09),DOR of 205(115-365),and AUC of 0.98(0.96-0.99).When video-based analysis was used,a pooled sensitivity of 0.85(0.77-0.91),pooled specificity of 0.73(0.59-0.83),PLR of 3.1(1.9-5.0),NLR of 0.20(0.12-0.34),DOR of 15(6-38)and AUC of 0.87(0.84-0.90)were *** of invasion depth resulted in a pooled sensitivity of 0.90(0.87-0.92),pooled specificity of 0.83(95%CI:0.76-0.88),PLR of 7.8(1.9-32.0),NLR of 0.10(0.41-0.25),DOR of 118(11-1305),and AUC of 0.95(0.92-0.96).CONCLUSION CN

关键词： Esophageal cancer High-grade dysplasia Convolutional neural network Deep learning Systematic review Meta-analysis

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Synthesis and study of MPNS/SMA nano-composite tanning agent

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Chinese Chemical Letters 2008年第4期19卷 435-437页

作者： Hui Pan Mei qi Zhi jun zhang Laboratory of Special Functional Material Henan UniversityKaifeng 475004PR China

The radical polymerization of maleic anhydride（MA）,styrene（ST）with the vinyl groups introduced onto the surface of the nano-sized silica via solution polymerization method was *** methacryloxypropyl nano-sized silica（MPNS）was used as macromonomer and polymerized with maleic anhydride and styrene by initiating with BPO in *** structure and properties of MPNS/SMA nano-composite were characterized by FT-IR spectra and ***,it was applied as tanning agent compared with the traditional styrene-maleic anhydride copolymer in *** was found that the applied leather had better quality characteristics with the addition of the nano-sized silica.

关键词： Nano-composite Tanning agent Polymerization Leather

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Revealing the Structure-Property Difference of Natural Rubber Prepared by Different Methods: Protein and Gel Content are Key Factors

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Chinese Journal of Polymer Science 2024年第4期42卷 457-467页

作者： Shao-qi Huang jun-qi zhang Yong Zhu Ling-Min Kong Lu-Sheng Liao Fu-Quan zhang Zheng-Tian Xie Jin-Rong Wu State Key Laboratory of Polymer Materials Engineering College of Polymer Science and EngineeringSichuan UniversityChengdu610065China Hainan Provincial Key Laboratory of Natural Rubber Processing Agricultural Products Processing Research Institute of Chinese Academy of Tropical Agricultural SciencesZhanjiang524001China

Natural rubber (NR) is widely used in various fields including aerospace, military industry and transportation due to its superior elasticity and comprehensive mechanical properties. Nonetheless, the commercial NR prepared by different methods usually exhibits different mechanical properties, primarily due to variations in processing conditions during the conversion from latex to bulk rubber material. Consequently, this poses challenges in scientific research and industrial production of NR. In order to assess the properties of various commercially available NR and identify key structural and compositional components, this study systematically compares and analyzes four representative NR raw materials: air dried sheet (ADS), ribbed smoked sheets (RSS), constant viscidity NR (CV), and whole field latex rubber (WF). The investigation focuses on evaluating their static mechanical behavior, SIC behavior, wear resistance, and fatigue resistance. The findings indicate that protein and gel content exhibit a crucial influence on the NR properties. These constituents contribute to the formation of a high-crosslinking density region, generating a heterogeneous network structure within the rubber. This structure amplifies strains during deformation, leading to earlier and stronger strain-induced crystallization (SIC). Among the four commercial NR brands, RSS demonstrates superior overall mechanical and dynamic properties owing to its high protein and gel content. This study serves as a valuable reference for comprehending the differences in properties among various commercial NR, thereby offering guidance for the actual processing and selection of NR.

关键词： Natural rubber Processingmethod Protein Gel content Property

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Middle hepatic vein variation provides a safe path for anterior transection of hepatocellular carcinoma in caudate lobe

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 438-440页

作者： Bing-Yi Lin qi-jun zhang Zhe Yang Shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Thyroid Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Division of Hepatobiliary Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310000China

To the Editor:Hepatocellular carcinoma(HCC)is one of the main causes of cancer related death worldwide,and new cases are expected to continue to increase in future[1].Surgical resection is still the best way to remove the tumor and improve patient’s ***,resection of caudate lobe often presents a technical challenge,even to accomplished hepatic *** lobe is located anterior to the inferior vena cava(IVC)and posterior to the bifurcation of the portal vein(PV),generally consists of three regions:the paracaval portion,the left Spiegel lobe and the process portion[2].The anatomy of the paracaval portion includes the liver parenchyma ventral to the hepatic IVC and the area between the Spiegel lobe and the right lobe adjacent to the middle hepatic vein(MHV)ventrally,which was classified by Couinaud as segment IX[3].Here,we presented a case of HCC with successful downstaging therapy,as well as variation of MHV,which provides a safe path for anterior transection of segment IX.

关键词： hepatic anatomy Middle

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SNHG16 promotes hepatocellular carcinoma development via activating ECM receptor interaction pathway

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Hepatobiliary & Pancreatic Diseases International 2022年第1期21卷 41-49页

作者： qi-jun zhang Da-Zhi Li Bing-Yi Lin Lei Geng Zhe Yang Shu-Seng Zheng Department of Thyroid Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China NHC Key Laboratory of Combined Multi-organ Transplantation The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310000China

Background:Accumulating data have suggested that long non-coding RNAs(lncRNAs)play important roles in regulating tumor cell *** study was designed to investigate the role of SNHG16 in hep-atocellular carcinoma(HCC).Methods:SNHG16 expression was detected with real-time polymerase chain reaction(PCR).The cut-offvalue of SNHG16 for tumor-free survival(TFS)was determined with receiver operating characteristic curve *** interfering RNA was used to inhibit the expression of SNHG16 in HCC cell *** biologic behavior of HCC cell was determined with cell viability assay and Transwell assay in *** potential predictive value of SNHG16 on prognosis was analyzed by Kaplan-Meier curves and Cox proportional hazards regression ***:SNHG16 expression was upregulated in tumor tissues and HCC cell *** expression of SNHG16 was associated with tumor recurrence and poor prognosis after *** analysis revealed that SNHG16 was an independent prognostic factor for poor recurrence-free ***,inhibition of SNHG16 in HepG2,Hep3B,and BEL-7402 cells significantly reduced cell invasiveness and *** analyses indicated that the ECM-receptor interaction pathway was remarkably activated by ***:SNHG16 might be a promising biomarker for predicting tumor recurrence in HCC patients after surgery and a potential therapeutic target for HCC.

关键词： Hepatocellular carcinoma SNHG16 ECM-receptor interaction pathway Long non-coding RNA

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Super Strong and Tough Elastomers Enabled by Sacrificial Segregated Network

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Chinese Journal of Polymer Science 2021年第3期39卷 377-386,I0008页

作者： Yong Zhu Lai-Yun Wei Xuan Fu jun-qi zhang Ling-Min Kong Guang-Su Huang Jin-Rong Wi State Key Laboratory of Polymer Materials Engineering College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

The integration of high strength and toughness concurrently is a vital requirement for elastomers from the perspective of long-term durability and reliability. Unfortunately, these properties are generally conflicting in artificial materials. In the present work, we propose a facile strategy to simultaneously toughen and strengthen elastomers by constructing 3 D segregated filler network via a simple latex mixing *** as-fabricated elastomers are featured by a microscopic 3 D interconnected segregated network of rigid graphene oxide(GO) nanosheets and a continuous soft matrix of sulfur vulcanized natural rubber(NR). We demonstrate that the interconnected segregated filler network ruptures preferentially upon deformation, and thus is more efficient in energy dissipation than the dispersed filler network. Therefore, the segregated filler network exhibits better reinforcing effects for the rubber matrix. Moreover, the excellent energy dissipating ability also contributes to the outstanding crack growth resistance through the release of concentrated stress at the crack tip. As a result, the strength, toughness and fatigue resistance of the nanocomposites are concurrently enhanced. The methodology in this work is facile and universally applicable, which may provide new insights into the design of elastomers with both extraordinary static and dynamic mechanical performance for practical applications.

关键词： Elastomers Nanocomposites Segregated network Sacrificial bonds Mechanical properties

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Synthesis and Cytotoxicity Evaluation of Some Isoquinoline Derivatives Related to 1-Arylnaphthalene Lignans

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Chinese Chemical Letters 2005年第10期16卷 1279-1282页

作者： Hong Xia DING Wei LU Chang Xin ZHOU Hai Bo LI Lei Xiang YANG qi jun zhang Xiu Mei WU Olivier BAUDOIN jun Chao CAI Francoise GUERITTE Yu ZHAO Department of Traditional Chinese Medicine and Natural Drug Research College of Pharmaceutical Sciences Zhejiang University Hangzhou 31003 Shanghai Institute of Material Medica Chinese Academy of Sciences Shanghai 201203 Zhejiang Hisun Naturelite Pharmaceutical R＆D Co. Hangzhou 310006 Institute Chimie des Substances Naturelles CNRS AvenuedelaTerrasse 91198 Gif-sur-Yvette France

Two series of novel compounds designed as hybrids of 1-arylnaphthalene lignans with dihydroisoquinolines or isoquinolines were synthesized and evaluated for their cytotoxicities on human tumor cell lines, such as A549, Hela, PC-3 and KB. Some of the synthetic compounds exhibited their IC50 values on selected cell lines at μmol/L scale.

关键词： Isoquinoline derivatives 1-arylnaphthalene lignans synthesis cytotoxicity.

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Detection of CD59-deficient granulocytes in a patient with advanced myelodysplastic syndrome

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Chinese Medical Journal 2009年第17期122卷 2071-2073页

作者： zhang Li qi jun-yuan zhang Feng-kui qiU Lu-gui Institute of Hematology and Blood Diseases Hospital ChinaAcademy Medical Sciences and Peking Union Medical CollegeTianjin 300020 China

Aplastic anemia （AA）, myelodysplastic syndrome （MDS）, and paroxysmal noctumal hemoglobinuria （PNH） are bone marrow failure disorders closely related to each other. PNH often occurs in the course of AA or MDS-refractory anemia （RA）. Acquired AA patients, particularly with PNH clones, have benefited from the immunosuppressive therapy （IST）. Although the possible immune abnormality was not considered as the core mechanism in MDS pathology,1 MDS-RA cases with PNH clones also reflected a high probability of response to IST. We report here one rare case of advanced MDS with PNH clones diagnosed by flow cytometry （FCM）.

关键词： myelodysplastic syndrome paroxysmal nocturnal hemoglobinuria CD59-deficient granulocyte prognosis

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Synthesis and Biological Evaluation of Pyranone Analogues of Territrem B

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Chinese Chemical Letters 2005年第9期16卷 1189-1192页

作者： Xiang Rui JIANG Lei AO Chang Xin ZHOU Lei Xiang YANG Hai Bo LI Xiu Mei WU Hua BAI qi jun zhang Yu ZHAO Department of Traditional Chinese Medicine and Natural Drug Research. College of Pharmaceutical Sciences Zhejiang University Hangzhou 310031 Zhejiang Hisun Naturelite Pharmaceutical R＆D Co. Ltd. Hangzhou 310006

23 compounds containing pyranone pharmacophore of territrem B were designed and synthesized. Some of the analogues showed IC50 values of AChE inhibition at 10^-5 mol/L.

关键词： 2H-Pyran-2-one territrim B synthesis AChE inhibitor.

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A STUDY OF THE REACTIONS OF BENZYL ETHERS WITH DIBROMOCARBENE

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Chinese Chemical Letters 1992年第4期3卷 259-262页

作者： qi jun LIN & Miao zhang Department of chemistry and applied chemistry, Shandong University, Jinan, Shandong, 250100

Using potassium carbonate as base and a polyethylene glycol with an average molecular weight of 600 (PGE600) as phase transfer catalyst, reaction of benzyl ethers with dibromocarbene leads to benzylic C—H bond insert... 详细信息

关键词： A STUDY OF THE REACTIONS OF BENZYL ETHERS WITH DIBROMOCARBENE

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