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Smaller, faster, lower-power analog RRAM matrix computing circuits without performance compromise

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Science China(Information Sciences) 2025年第2期68卷 293-306页

作者： Yubiao LUO Pushen ZUO Shiqing WANG zhong SUN Ru HUANG School of Integrated Circuits Peking University Institute for Artificial Intelligence Peking University Beijing Advanced Innovation Center for Integrated Circuits

Recently, the analog matrix computing(AMC) concept has been proposed for fast, efficient matrix operations, by configuring global feedback loops with crosspoint resistive memory arrays and operational amplifiers(OAs). The implementation of a general real-valued matrix(containing both positive and negative elements) is enabled by using a set of analog inverters,which, however, is considered inefficient regarding circuit compactness, power consumption, and temporal response. Here, with the assistance of the conductance compensation(CC) strategy to take full advantage of the inherent differential inputs of OAs,new AMC circuits without analog inverters are designed. Such a design saves the area occupation and power dissipation of analog inverters, and thus turns to be smaller and lower-power. Simulation results reveal that the new circuit also shows a faster response towards the steady state, thanks to the reduction of poles in the circuit, which, again, is contributed by the elimination of analog inverters. Along with all of these benefits, extensive simulations demonstrate that the CC-AMC circuits do not compromise the computing performance in terms of relative error caused by various non-ideal factors in the circuit.

关键词： analog computing in-memory computing matrix resistive memory conductance compensation

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大采高工作面支架回撤通道围岩变形分析及支护优化研究

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煤炭技术 2020年第12期39卷 4-7页

作者：洪启忠赵伟刘辉枣庄矿业集团新安煤业有限公司山东枣庄277642 中国矿业大学江苏徐州221116

针对大采高工作面支架回撤通道围岩变形强烈、支护困难等问题,基于新安煤业有限公司3313综采工作面地质情况,运用离散元数值模拟分析了预掘回撤通道、采煤机截煤形成回撤通道和分步掘进回撤通道3种掘进方式下回撤通道围岩变形情况,并提... 详细信息

针对大采高工作面支架回撤通道围岩变形强烈、支护困难等问题,基于新安煤业有限公司3313综采工作面地质情况,运用离散元数值模拟分析了预掘回撤通道、采煤机截煤形成回撤通道和分步掘进回撤通道3种掘进方式下回撤通道围岩变形情况,并提出分步掘进回撤通道支护设计方案。模拟和现场监测结果表明:预掘回撤通道受采动影响较大,围岩变形量最大;采煤机截煤和分步掘进形成回撤通道2种方式围岩变形较小,通道稳定性较好,但采煤机截煤形成回撤通道时,顶板锚索梯网支护实施困难,且对施工人员的安全带来极大威胁;分步掘进回撤通道及相应支护设计方案较好控制了回撤通道的变形,保证了工作面液压支架的快速安全回撤。

关键词：大采高回撤通道围岩变形分步掘进支护设计

Endoscopic treatment outcome of oesophageal gastrointestinal stromal tumours

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World Journal of Gastroenterology 2025年第10期31卷 62-70页

作者： En-Pan Xu Zhi-Peng qi Jia-Wei Zhang Bing Li zhong Ren Ming-Yan Cai Shi-Lun Cai Zhen-Tao Lv Zhang-Han Chen Jing-Yi Liu Yun-Shi zhong Ping-hong Zhou qiang Shi Endoscopy Center and Endoscopy Research Institute Zhongshan HospitalFudan UniversityShanghai 200032China Department of Gastroenterology The First Affiliated Hospital of Ningbo UniversityNingbo 315000Zhejiang ProvinceChina Endoscopy Center Shanghai Xuhui District Central HospitalShanghai 200030China Endoscopy Center and Endoscopy Research Institute Shanghai Collaborative Innovation Center of EndoscopyZhongshan HospitalFudan UniversityShanghai 200032China

BACKGROUND There are few clinicopathologic characteristics and clinical results for oesophageal gastrointestinal stromal tumours(GISTs).Thus,the objective of this study was to identify the clinicopathologic characteristics and clinical results of oesophageal *** To investigate endoscopic treatment effective of oesophageal *** It was retrospective research that collected 32 patients with oesophageal GISTs treated by endoscopic resection(ER)between January 2012 and January 2023 in two ***,endoscopic records,and follow-up data were collected and *** Thirty-one patients underwent en bloc resection and 24(75.0%)lesions underwent R0 *** size of GISTs was 2.12±1.88 *** overall complication rate was 25.0%,including hydrothorax and post-endoscopic submucosal dissection electrocoagulation *** mean mitotic index was 3.34±5.04(median,1.50;range,1.00-4.00).Eighteen(56.3%),6(18.8%),2(6.3%),and 6(18.8%)patients were identified as very low,low,intermediate,and high risk,*** patients developed recurrence after a median follow-up of 64.69±33.13 *** 5-year overall survival rate was 100%,and the disease-free survival rate was 90.6%.CONCLUSION ER is safe and effective for patients with low-risk oesophageal *** detection of oesophageal GISTs is essential to achieve a favourable prognosis.

关键词： Gastrointestinal stromal tumours Oesophageal Endoscopic resection Treatment outcome Survival

qishen Granule protects against myocardial ischemia by promoting angiogenesis through BMP2-Dll4-Notch1 pathway

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Chinese Herbal Medicines 2025年第1期17卷 139-147页

作者： Yiqin hong Hui Wang Hanyan Xie Xinyi zhong Xu Chen Lishuang Yu Yawen Zhang Jingmei Zhang qiyan Wang Binghua Tang Linghui Lu Dongqing Guo School of Life Sciences Beijing University of Chinese Medicine School of Traditional Chinese Medicine Beijing University of Chinese Medicine

Objective:Therapeutic angiogenesis has become a promising approach for treating ischemic heart disease(IHD).The present study aims to investigate the effects of qishen Granule(QSG) on angiogenesis in myocardial ischemia(MI) and the potential ***:In vivo study was conducted on rat model of myocardial *** was performed daily at a dose of 2.352 g/kg for four *** function was assessed by echocardiogram and pro-angiogenic effects were evaluated by Laser Doppler and CD31 ***-glucose deprivation(OGD) was applied in cultured human umbilical vein endothelial cells(HUVECs).Cell viability,wound healing and tube formation assay were used to test functions of *** and Western blots were used to assess protein expressions of bone morphogenetic protein 2-delta-like 4-notch homolog 1(BMP2-Dll4-Notchl)signaling ***:The results showed that QSG improved heart function,cardiac blood flow and microvessel density in myocardial ischemic *** vitro,QSG protected HUVECs by promoting the cell viability and tube *** upregulated bone morphogenetic protein-2(BMP2) and downregulated delta-like 4(Dll4) and notch homolog 1(Notch1) expressions both in rats and ***:QSG protected against MI by promoting angiogenesis through BMP2-Dll4-Notch1 ***2 might be a promising therapeutic target for IHD.

关键词： angiogenesis bone morphogenetic protein-2 delta-like 4 myocardial ischemia notch homolog 1 qishen Granule

Efficacy of ultrasound cyclo-plasty in patients with refractory glaucoma

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International Journal of Ophthalmology(English edition) 2025年第3期18卷 420-423页

作者： Hui-Min zhong Xiao-hong Liu Shou-Yue Huang Hui-Ping Yao Yi-Sheng zhong Jing Wang Department of Ophthalmology Ruijin Hospital Affiliated Medical SchoolShanghai Jiao Tong UniversityShanghai 200025China Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong UniversityShanghai 200080China

AIM:To assess the efficacy and safety of ultrasound cycloplasty(UCP)in lowering intraocular pressure(IOP)among Chinese patients suffering from refractory ***:In this 12-month retrospective study,28 patients with refractory glaucoma(IOP≥25 mm Hg)were treated with 8-second UCP using either 8 or 10 probe *** principal measure of efficacy was the decrease in IOP at the following intervals after UCP:1d,1,3,6,and 12mo,with each measurement compared to ***:Mean IOP(in mm Hg)was reduced from 46.8±8.9 to 24.5±3.2,27.0±4.8,29.1±4.6,26.1±4.5,and 28.3±4.8 at 1d,1,3,6,and 12mo postoperatively,*** to baseline,IOP reductions at these time points were 45.0%,39.9%,35.3%,41.4%,and 36.7%,*** patients experienced relief from ocular pain after *** cases of choroidal detachment or hypotony was ***:UCP is effective in reducing IOP among Chinese patients with refractory glaucoma and shows a favorable safety profile.

关键词： ultrasound cyclo-plasty refractory glaucoma intraocular pressure

Recent Advances in Artificial Sensory Neurons:Biological Fundamentals,Devices,Applications,and Challenges

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Nano-Micro Letters 2025年第3期17卷 168-216页

作者： Shuai zhong Lirou Su Mingkun Xu Desmond Loke Bin Yu Yishu Zhang Rong Zhao Guangdong Institute of Intelligence Science and Technology HengqinZhuhai 519031People’s Republic of China College of Integrated Circuits Zhejiang UniversityHangzhou 3112000People’s Republic of China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 310027People’s Republic of China Department of Science Mathematics and TechnologySingapore University of Technology and DesignSingapore 487372Singapore Department of Precision Instruments Tsinghua UniversityBeijing 100084People’s Republic of China Center for Brain‑Inspired Computing Research Tsinghua UniversityBeijing 100084People’s Republic of China IDG/McGovern Institute for Brain Research Tsinghua UniversityBeijing 100084People’s Republic of China

Spike-based neural networks,which use spikes or action potentialsto represent information,have gained a lot of attention because of their high energyefficiency and low power *** fully leverage its advantages,convertingthe external analog signals to spikes is an essential *** including analog-to-digital converters or ring oscillators,and sensorssuffer from high power and area *** efforts are devoted to constructingartificial sensory neurons based on emerging devices inspired by the biologicalsensory *** can simultaneously perform sensing and spike conversion,overcoming the deficiencies of traditional sensory *** review summarizesand benchmarks the recent progress of artificial sensory *** starts with thepresentation of various mechanisms of biological signal transduction,followed bythe systematic introduction of the emerging devices employed for artificial ***,the implementations with different perceptual capabilitiesare briefly outlined and the key metrics and potential applications are also ***,we highlight the challenges and perspectives for the future development of artificial sensory neurons.

关键词： Artificial intelligence Emerging devices Artificial sensory neurons Spiking neural networks Neuromorphic sensing

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基于滚动时域控制的飞机维修路径恢复策略

系统工程与电子技术 2025年第1期47卷 164-172页

作者：胥洪胡家文钟罡电子科技大学航空航天学院四川成都611731 南京航空航天大学民航学院江苏南京211106

在航司日常运营过程中,经常面临不正常航班导致的飞机维修路径恢复问题,传统的研究往往只考虑航班的延误成本或者取消成本,忽略了对原有维修路径计划造成扰动的影响。面向最常见的临时检修引发的航班不正常情况,基于飞机短期维修计划,... 详细信息

在航司日常运营过程中,经常面临不正常航班导致的飞机维修路径恢复问题,传统的研究往往只考虑航班的延误成本或者取消成本,忽略了对原有维修路径计划造成扰动的影响。面向最常见的临时检修引发的航班不正常情况,基于飞机短期维修计划,以最大化飞机在定检前的累计飞行小时数以及最小化航班扰动次数为目标函数,考虑航班覆盖约束、飞行任务衔接约束、飞机定检等约束,对飞机维修路径恢复问题进行建模。同时,提出一种针对性的滚动时域控制算法对模型进行求解。通过实例分析证明,所提策略及算法能够在短时间内有效完成飞机维修路径恢复,为航司调度提供指导。

关键词：不正常航班飞机维修路径恢复临时检修短期维修计划滚动时域控制

Improving precision base editing of the zebrafish genome by Rad51DBD-incorporated single-base editors

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Journal of Genetics and Genomics 2025年第1期52卷 105-115页

作者： Zhilin zhong Xueli Hu Renjie Zhang Xu Liu Wenqi Chen Shubin Zhang Jianjian Sun Tao P.zhong Shanghai Frontiers Science Center of Genome Editing and Cell Therapy Shanghai Key Laboratory of Regulatory BiologyInstitute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China Guangdong Cardiovascular Institute Guangdong Provincial People's HospitalSouthern Medical UniversityGuangzhouGuangdong 510100China

Single-base editors,including cytosine base editors(CBEs)and adenine base editors(ABEs),facilitate accurate C·G to T·A and A·T to G·C,respectively,holding promise for the precise modeling and treatment of human hereditary *** base editing and expanded base conversion range have been achieved in human cells through base editors fusing with Rad51 DNA binding domain(Rad51DBD),such as ***,we show that hyA3A-BE4max catalyzes C-to-T substitution in the zebrafish genome and extends editing positions(C_(12)-C_(16))proximal to the protospacer adjacent *** develop a codon-optimized counterpart zhyA3A-CBE5,which exhibits substantially high C-to-T conversion with 1.59-to 3.50-fold improvement compared with the original *** these tools,disease-relevant hereditary mutations can be more efficaciously generated in *** introduce human genetic mutation rpl11^(Q42*)and abcc6a^(R1463C) by zhyA3A-CBE5 in zebrafish,mirroring Diamond-Blackfan anemia and Pseudoxanthoma Elasticum,*** study expands the base editing platform targeting the zebrafish genomic landscape and the application of single-base editors for disease modeling and gene function study.

关键词： Zebrafish Base editor Rad51DBD ZhyA3A-CBE5 PXE syndrome

不同几何尺寸SiC微粒对机床导轨材料GCr15的磨损机制

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表面技术 2025年第1期54卷 140-149页

作者：王奔史忠澳祝天龙张棋沈阳航空航天大学机电工程学院沈阳110000

目的探究不同几何尺寸SiCf/SiC陶瓷基复合材料切屑对机床精密部件磨损性能的影响机制及磨损机理,为机床防护提供理论参考。方法以机床精密部件——导轨运动副为例,利用SiC磨粒代替SiCf/SiC陶瓷基复合材料切屑,采用机床导轨运动副材料GC... 详细信息

目的探究不同几何尺寸SiCf/SiC陶瓷基复合材料切屑对机床精密部件磨损性能的影响机制及磨损机理,为机床防护提供理论参考。方法以机床精密部件——导轨运动副为例,利用SiC磨粒代替SiCf/SiC陶瓷基复合材料切屑,采用机床导轨运动副材料GCr15轴承钢,在不同几何尺寸磨粒条件下进行销盘摩擦磨损试验,采用宏观摩擦因数和微观磨损形貌对磨损表面进行表征,探究磨损机制。结果相较于无磨粒条件下,在加入磨粒后其摩擦因数更高、更不稳定。在磨粒条件下,GCr15轴承钢的磨损表面存在大量的平行凹槽和不规则压痕,并伴随着少量的剥落坑。随着磨粒尺寸的增加,损伤加重,平行凹槽磨损更深、更宽,表面材料的剥落坑更密集,同时,磨粒几何尺寸的增加导致更深的磨痕深度及更高的磨损量。结论磨粒在摩擦界面存在游离和结合等2种运动形式,磨损机制为滚动挤压磨损与滑动开槽磨损的结合,且随着磨粒几何尺寸的增大,磨损机制由磨粒滚动挤压过渡为滑动开槽主导;1μm和5μm磨粒对摩擦进程的影响主要体现在剧烈磨损阶段,而10μm和20μm磨粒对整个进程都有明显影响,且大尺寸磨粒的加入会使摩擦副提前进入剧烈阶段;对比不同条件下的磨损形貌、摩擦因数及磨损量可知,1μm和5μm的磨粒对摩擦的影响较小。

关键词：机床导轨销盘试验三体磨粒磨损摩擦磨损性能磨损机制

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