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Follicle-stimulating hormone as a predictor for sperm retrieval rate in patients with nonobstructive azoospermia, a systematic review and meta-analysis

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Asian Journal of Andrology 2015年第2期17卷 281-284,I0010页

作者： qi yang yan-ping huang hong-xiang wang kai hu yi-xin wang yi-ran huang bin chen Department of Urology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai institute of Andrology Shanghai 200127 China.

Noninvasive parameters for predicating sperm retrieval rate （SRR） are desirables. Follicle-stimulating hormone （FSH） has been an important predictor since the first years of testicular sperm extraction. Recent studies showed continuous interests in FSH, with both pros and cons. Thus, we conducted a meta-analysis to evaluate the diagnostic value of FSH as a predictor for patients with nonobstructive azoospermia （NOA） taking testicular sperm retrieval. Eligible diagnosis tests were identified from electronic databases （Cochrane Central Register of Controlled Trials, Medline, and EMBASE） without language restrictions. The database search, quality assessment, and data extraction were performed independently by two reviewers. The reference standard was the sperm retrieval result. Diagnostic value of FSH were explored by area under receiver operation characteristics （ROC） curve using Review Manager, version 5.1.0 （Cochrane Collaboration, Oxford, UK） and Meta-DiSc, version 1.4. Meta regression will be done if there is heterogeneity. Then, we find 11 tests including a total of 1350 patients met the inclusion criteria. Our pooled analysis showed that the area under ROC curve of FSH was 0.72 ~ 0.04. Meta regression analyses showed that region and average age have an influence on the diagnostic value. FSH showed more diagnostic value with patients in East Asia and with younger patients. We concluded that FSH had moderate value in independently predicating SRR in men with NOA （area under curve 〉0.7）. More detailed diagnosis tests should be anticipated in the future to confirm the diagnostic value of other noninvasive parameters.

关键词： follicule-stimulating hormone meta-analysis nonobstructive azoospermia testicular sperm retrieval

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XELOX(capecitabine plus oxaliplatin)plus bevacizumab(anti-VEGF-A antibody)with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer:a multicenter,open-label,randomized,controlled,phase 3 trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2104-2113页

作者： qiu-Zhong Pan Jing-Jing Zhao Liang Liu Dong-Sheng Zhang Li-ping wang Wen-Wei hu De-Sheng Weng xiang Xu yi-Zhuo Li yan Tang Wei-hong Zhang Jie-Yao Li Xiao Zheng qi-Jing wang Yong-qiang Li Tong xiang Li Zhou Shuang-Ning yang chen Wu Rong-xing huang Jia He Wei-Jiao Du Lu-Jun chen Yue-Na Wu bin Xu qiong Shen yi Zhang Jing-Ting Jiang Xiu-Bao Ren Jian-Chuan Xia State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060PR China Department of Biotherapy Sun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060PR China Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerTianjin 300060PR China Key Laboratory of Cancer Immunology and Biotherapy Tianjin 300060PR China Department of Biotherapy/Immunology Tianjin Medical University Cancer Institute and HospitalTianjin 300060PR China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060PR China Department of Oncology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052PR China Department of Tumor Biological Treatment the Third Affiliated Hospital of Soochow UniversityChangzhouJiangsu 213003PR China Jiangsu Engineering Research Center for Tumor Immunotherapy ChangzhouJiangsu 213003PR China Institute for Cell Therapy of Soochow University ChangzhouJiangsu 213003PR China Department of Stem Cell&Regenerative Medicine State Key Laboratory of TraumaBurn and Combined InjuryDaping HospitalArmy Medical UniversityChongqing 400042PR China Imaging Diagnosis and Interventional Center Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060PR China

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer(mCRC),but the prognosis remains *** phase 3 trial(***:NCT03950154)assessed the efficacy and adverse events(AEs)of the combination of PD-1 blockade-activated DC-CIK(PD1-T)cells with XELOX plus bevacizumab as a first-line therapy in patients with mCRC.A total of 202 participants were enrolled and randomly assigned in a 1:1 ratio to receive either first-line XELOX plus bevacizumab(the control group,n=102)or the same regimen plus autologous PD1-T cell immunotherapy(the immunotherapy group,n=100)every 21 days for up to 6 cycles,followed by maintenance treatment with capecitabine and *** main endpoint of the trial was progression-free survival(PFS).The median follow-up was 19.5 *** PFS was 14.8 months(95%CI,11.6-18.0)for the immunotherapy group compared with 9.9 months(8.0-11.8)for the control group(hazard ratio[HR],0.60[95%CI,0.40-0.88];p=0.009).Median overall survival(OS)was not reached for the immunotherapy group and 25.6 months(95%CI,18.3-32.8)for the control group(HR,0.57[95%CI,0.33-0.98];p=0.043).Grade 3 or higher AEs occurred in 20.0%of patients in the immunotherapy group and 23.5%in the control groups,with no toxicity-associated deaths *** addition of PD1-T cells to first-line XELOX plus bevacizumab demonstrates significant clinical improvement of PFS and OS with well tolerability in patients with previously untreated mCRC.

关键词： PD1 immunotherapy bevacizumab

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Paired quasi-periodic pulsations of hard X-ray emission in a solar flare

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Science China(Physics,Mechanics & Astronomy) 2023年第5期66卷 195-206页

作者： Hai-Sheng Zhao Dong Li Shao-Lin Xiong yan-qiu Zhang yang Su Wei chen yi Zhao Xiao-Bo Li Jia-Cong Liu Wen-Xi Peng Rui qiao xin-qiao Li xiang-yang Wen Li-Ming Song Shi-Jie Zheng xin-ying Song Xiao-Yun Zhao Yue huang Shuang-Nan Zhang Shuo Xiao Ce Cai Zheng-hua An Can chen Gang chen Wei chen yan-qi Du Min Gao Ke Gong Dong-Ya Guo Zhi-Wei Guo Jian-Jian He bin Li Chao Li Chao-yang Li Gang Li Jian-hui Li Lu Li qing-xin Li yan-Guo Li Jing Liang Xiao-hua Liang Jin-Yuan Liao Xiao-Jing Liu Ya-qing Liu qi Luo xiang Ma bin Meng Ge Ou Dong-Li Shi Jing-yan Shi Gong-xing Sun Xi-Lei Sun You-Li Tuo chen-Wei wang hui wang Jin wang Jin-Zhou wang ping wang Wen-Shuai wang hong Wu Sheng-Lun Xie yan-bing Xu Yu-Peng Xu wang-chen Xue Sheng yang Min Yao Jian-ying Ye qi-bin yi Chao-Yue Zhang Da-Li Zhang Fan Zhang Fei Zhang hong-Mei Zhang kai Zhang Peng Zhang Xiao-Lu Zhang Zhen Zhang Guo-ying Zhao Shi-yi Zhao Chao Zheng xing Zhou Yue Zhu Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China Department of Astronomy Beijing Normal UniversityBeijing 100875China School of Computing and Artificial Intelligence Southwest Jiaotong UniversityChengdu 611756China Physics and Space Science College China West Normal UniversityNanchong 637002China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Institute of Astrophysics Central China Normal UniversityWuhan 430079China School of Physics Changchun University of Science and TechnologyChangchun 130022China College of Physics and Engineering Qufu Normal UniversityQufu 273165China College of Physics Sciences&Technology Hebei UniversityBaoding 071002China

We investigate high time resolution data obtained by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)during the flare event on 2022 April 21 at 01:52 *** subpeaks with durations of 4-6 s have been detected in the hard X-ray precursor phase,and the key feature is that they appear in pairs and seem like double-peak *** subpeaks are rarely observed in hard X-ray band and confirmed by the microwave obtained by Nobeyama Radio Polarimeters(NoRP)and Radio Solar Telescope Network(RSTN).While an exponential function can describe the continuum component of the time profile from the precursor to part of the impulsive *** periods of quasi-periodic pulsations(QPPs)are detected to be about 7.3 and 12.8 s for the precursor and impulsive phase,respectively,with at least 95%confidence *** paired QPPs are assumed to be double-peak QPPs and then the scenario of current loop coalescence model is found to be in good agreement with our *** precursor phase can be interpreted as the oscillating coalescence of two islands,while the impulsive phase can be interpreted as more islands to coalesce one by one to form larger islands.

关键词： solar flare QPPs loop coalescence circular-ribbon flare

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2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents

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Science Bulletin 2018年第23期63卷 1558-1564页

作者： cheng wang Yaqi Li ying Liao hong Tian Min huang xiangyu Dong Lin Shi Jinghui Sun hongfang Jin Junbao Du Jindou An Jie chen Mingwu chen qi chen Sun chen Yonghong chen Zhi chen Adolphus kai-tung Chau Junbao Du Zhongdong Du Junkai Duan hongyu Duan xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han bing He Zhixu He Xiufen hu yimin hua Guoying huang Min huang ping huang Yujuan huang hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang hua Peng Yuming qin Jie Shen Lin Shi Kun Sun Jinghui Sun hong Tian Jie Tian cheng wang hong wang Lei wang Jinju wang Wendi wang Yuli wang Rongzhou Wu Tianhe Xia yanyan Xiao Chunhong Xie yanlin xing Zhenyu Xiong Baoyuan Xu yi Xu hui yan Shiwei yang qijian yi Xia Yu Xianyi Yu Yue Yuan hongyan Zhang huili Zhang Li Zhang qingyou Zhang Xi Zhang yanmin Zhang Zhiwei Zhang Cuifen Zhao bin Zhou hua Zhu Department of Pediatric Cardiovasoloy Children's Medical CenterThe Second Xiangya HospitalCentral South UniversityChangsha 410071China Department of Pediatrics Peking University First HospitalBeijing 100034China Department of Pediatric Cardiology Children's Hospital of Fudan UniversityShanghai 201102China Department of Pediatric Cardiology Shanghai Children's HospitalShanghai 207102China of Pediatrics the 2nd Hospital of Lanzhou UniversityLanzhou 730020China Department of Pediatric Cardiology Capital Institute of PediatricsBezjing 100020China Department of Pediatrics Jilin University First HospitalChangchun 130021China Chinese Pediatric Cardiology Society Chinese Pediatric Society(CPCS)Chinese Medical Association(CMA)China Committee on Pediatric Syncope Pediatricians BranchChinese Medical Doctor Association(CMDA)China Pediatric Cardiology Society Beijing Pediatric SocietyBeijing Medical Association(BMA)China Committee on Pediatric Cardiology Chinese College of Cardiovascular PhysiciansChinese Medical Doctor Association(CMDA)China

Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department *** syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up.

关键词： CPCS Children Adolescent syncope

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10B-doped MCP detector developed for neutron resonance imaging at Back-n white neutron source

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Nuclear Science and Techniques 2024年第8期35卷 58-68页

作者： qiang Li Li‑Jiao wang Jing‑Yu Tang xiang‑Biao qiu Zhen chen Mao‑Yuan Zhao Chang‑Jun Ning kai Pan Wei Xu Tao Li Su‑Peng Lu Han yi Rui‑Rui Fan Chang‑qing Feng Rong Zhang Xiao‑yang Sun qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao ping Cao qi‑ping chen Yong‑Hao chen Zeng‑qi Cui An‑Chuan Fan Fan‑Zhen Feng Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑cheng He yang hong yi‑Wei hu Han‑Xiong huang Wei Jiang Zhi‑Jie Jiang Zheng‑Yao Jin Ling Kang Bo Li Gong Li Xiao Li yang Li Jie Liu Rong Liu Shu‑bin Liu yi‑Na Liu Guang‑Yuan Luan Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑hui Song Kang Sun Zhi‑xin Tan Sheng‑Da Tang Jin‑cheng wang Peng‑cheng wang Zhao‑hui wang Zhong‑Wei Wen Xiao‑Guang Wu Xuan Wu Cong Xia Yong‑Ji Yu Guo‑hui Zhang Hang‑Chang Zhang Lin‑Hao Zhang qi‑Wei Zhang Xian‑Peng Zhang Yu‑Liang Zhang Yue Zhang Zhi‑Yong Zhang Zhi‑Hao Zhou Ke‑Jun Zhu Chong Zou Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China North Night Vision Science and Technology(Nanjing)Research Institute Co.Ltd Nanjing 211106China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China China Academy of Engineering Physics Institute of Nuclear Physics and ChemistryMianyang 621900China USTC archaeometry lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China China Shipbuilding Trading Co. LtdBeijing 100044China

Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron *** complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and ***,the progression of NRI technology has been sluggish since its inception in the 1980s,particularly considering the limited studies analyzing the neutron energy range above *** white neutron source(Back-n)at the China Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to ***-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low *** this study,we report the development of a 10B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the *** heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1–100 eV energy range;the more difficult medium-weight elements such as iron,copper,and aluminum with resonance peaks in the 1–100 keV energy range can also be *** particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time.

关键词： Neutron resonance imaging 10B doped MCP detector White neutron source Sample nuclide identification

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Lung-protective Ventilation in Patients with Brain Injury： A Multicenter Cross-sectional Study and Questionnaire Survey in China

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Chinese Medical Journal 2016年第14期129卷 1643-1651页

作者： Xu-ying Luo ying-hong hu xiang-Yuan Cao yan Kang Li-ping Liu Shou-hong wang Rong-Guo Yu xiang-You Yu Xia Zhang Bao-Shan Li Zeng-xiang Ma yi-bing Weng Heng Zhang De-Chang chen Wei chen Wen-Jin chen Xiu-Mei chen bin Du Mei-Li Duan Jin hu Yun-Feng Hoang Gui-Jun Jia Li-hong Li Yu-Min Liang bing-Yu qin Xian-Dong wang Jian Xiong Li-Mei yan Zheng-ping yang chen-Ming Dong Dong-xin wang qing-Yuan Zhan Shuang-Lin FU Lin Zhao qi-bing huang ying-Guang Xie Xiao-Bo huang Guo-bin Zhang wang-bin Xu Yuan Xu YaLing Liu He-Ling Zhao Rong-qing Sun Ming Sun qing-hong cheng xin Qu Xiao-Feng yang Ming Xu Zhong-hua Shi Han chen Xuan He yan-Lin yang Guang-qiang chen Xiu-Mei Sun Jian-xin Zhou Department of Critical Care Medicine Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Critical Care Medicine Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China Department of Critical Care Medicine General Hospital of Ningxia Medical University Yinchuan Ningxia 750004 China Department of Critical Care Medicine West China Hospital Sichuan University Chengdu Sichuan 610041 China Neurological Intensive Care Unit Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Critical Care Medicine Guangdong General Hospital Guangzhou Guangdong 510000 China Surgical Intensive Care Unit Fujian Province Hospital Fuzhou Fujian 350000 China Department of Critical Care Medicine First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang 830054 China Department of Critical Care Medicine Bethune International Peace Hospital Shijiazhuang Hebei 050000 China Department of Critical Care Medicine Yuncheng Central Hospital Yuncheng Shanxi 044000 China Department of Emergency and Critical Care Medicine Cangzhou People's Hospital Cangzhou Hebei 061000 China Department of Critical Care Medicine Beijing Luhe Hospital Capital Medical University Beijing 101100 China Department of Critical Care Medicine First Hospital of China Medical University Shenyang Liaoning 110000 China Department of Critical Care Medicine Shanghai Changzheng Hospital Shanghai 200000 China Department of Critical Care Medicine Beijing Shijitan Hospital Capital Medical University Beijing 100038 China Department of Critical Care Medicine Xuanwu Hospital Capital Medical University Beijing 100053 China Department of Critical Care Medicine Miyun County Hospital Beijing 100038 China Medical Intensive Care Unit Peking Union Medical College Hospital Beijing 101500 China Department of Critical Care Medicine Beijing Friendship Hospital Capital Medical University Beijing 100050 Chin

Background： Over the years, the mechanical ventilation （MV） strategy has changed worldwide. The aim of the present study was to describe the ventilation practices, particularly lung-protective ventilation （LPV）, among brain-injured patients in China. Methods： This study was a multicenter, 1-day, cross-sectional study in 47 Intensive Care Units （ICUs） across China. Mechanically ventilated patients （18 years and older） with brain injury in a participating ICU during the time of the study, including traumatic brain injury, stroke, postoperation with intracranial tumor, hypoxic-ischemic encephalopathy, intracranial infection, and idiopathic epilepsy, were enrolled. Demographic data, primary diagnoses, indications for MV, MV modes and settings, and prognoses on the 60th day were collected. Multivariable logistic analysis was used to assess factors that might affect the use of LPV. Results： A total of 104 patients were enrolled in the present study, 87 （83.7%） of whom were identified with severe brain injury based on a Glasgow Coma Scale 〈8 points. Synchronized intermittent mandatory ventilation （SIMV） was the most frequent ventilator mode, accounting for 46.2% of the entire cohort. The median tidal volume was set to 8.0 ml/kg （interquartile range [IQR], 7.0-8.9 ml/kg） of the predicted body weight; 50 （48.1%） patients received LPV. The median positive end-expiratory pressure （PEEP） was set to 5 cmH20 （IQR, 5-5 cmH20）. No PEEP values were higher than 10 cmH20. Compared with partially mandatory ventilation, supportive and spontaneous ventilation practices were associated with LPV. There were no significant differences in mortality and MV duration between patients subjected to LPV and those were not. Conclusions： Among brain-injured patients in China, SIMV was the most frequent ventilation mode. Nearly one-half of the brain-injured patients received LPV. Patients under supportive and spontaneous ventilation were more likely to receive LPV.

关键词： Brain Injury Epidemiology Lung-protective Ventilation Mechanical Ventilation

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Identification of a novel coronavirus causing severe pneumonia in human:a descriptive study

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Chinese Medical Journal 2020年第9期133卷 1015-1024页

作者： Li-Li Ren Ye-Ming wang Zhi-qiang Wu Zi-Chun xiang Li Guo Teng Xu Yong-Zhong Jiang yan Xiong Yong-Jun Li xing-wang Li hui Li Guo-hui Fan Xiao-ying Gu yan Xiao hong Gao Jiu-yang Xu Fan yang xin-Ming wang Chao Wu Lan chen yi-Wei Liu Bo Liu Jian yang Xiao-Rui wang Jie Dong Li Li Chao-Lin huang Jian-ping Zhao yi hu Zhen-Shun cheng Un-Lin Liu Zhao-hui qian Chuan qin qi Jin bin Cao Jian-Wei wang National Health Commission of the People’s Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineNational Clinical Research Center for Respiratory DiseasesChina-Japan Friendship HospitalBeijing 100029China Institute of Respiratory Medicine Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100029China National Health Commission of the People’s Republic of China Key Laboratory of Systems Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Vision Medicals Co. LtdGuangzhouGuangdong 510000China hubei Provincial Center for Disease Control and Prevention WuhanHubei 430079China Wuhan Center for Disease Control and Prevention WuhanHubei 430022China Clinical and Research Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Institute of Clinical Medical Sciences China-Japan Friendship HospitalBeijing 100029China Institute of Laboratory Animal Science Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100021China Department of Basic Medical Sciences Tsinghua University School of MedicineBeijing 100084China Wuhan Jinyintan Hospital WuhanHubei 430022China Department of Pulmonary and Critical Care Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Sciences and TechnologyWuhanHubei 430030China Department of Pulmonary and Critical Care Medicine The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430014China Department of Respiratory Medicine Zhongnan Hospital of Wuhan UniversityWuhanHubei 430071China

Background:human infections with zoonotic coronaviruses(CoVs),including severe acute respiratory syndrome(SARS)-CoV and Middle East respiratory syndrome(MERS)-CoV,have raised great public health concern ***,we report a novel batorigin CoV causing severe and fatal pneumonia in ***:We collected clinical data and bronchoalveolar lavage(BAL)specimens from five patients with severe pneumonia from Wuhan Jinyintan Hospital,hubei province,*** acids of the BAL were extracted and subjected to next-generation *** isolation was carried out,and maximum-likelihood phylogenetic trees were ***:Five patients hospitalized from December 18 to December 29,2019 presented with fever,cough,and dyspnea accompanied by complications of acute respiratory distress *** radiography revealed diffuse opacities and *** of these patients *** results revealed the presence of a previously unknownβ-CoV strain in all five patients,with 99.8%to 99.9%nucleotide identities among the *** isolates showed 79.0%nucleotide identity with the sequence of SARS-CoV(GenBank NC_004718)and 51.8%identity with the sequence of MERS-CoV(GenBank NC_019843).The virus is phylogenetically closest to a bat SARS-like CoV(SL-ZC45,GenBank MG772933)with 87.6%to 87.7%nucleotide identity,but is in a separate ***,these viruses have a single intact open reading frame gene 8,as a further indicator of bat-origin ***,the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV,indicating that these viruses might use the same ***:A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans.

关键词： Bat-origin Coronavirus Zoonotic transmission Pneumonia Etiology Next-generation sequencing

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Status of aquatic organisms resources and their environments in yangtze River system(2017-2021)

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Aquaculture and Fisheries 2024年第5期9卷 833-850页

作者： Haile yang Li Shen Yongfeng He huiwu Tian Lei Gao Jinming Wu Zhigang Mei Nian Wei Lin wang Tingbing Zhu Feifei hu Jinling Gong hongchun Du xinbin Duan huatang Deng Daoqun wang Fengyue Zhu Yunfeng Li Fan Wu huijun Ru yan Zhang Junyi Li Junlin yang Yuntao Zhou Dongdong Fang yinping wang Danqing Lin yanping yang Peijie Li Silei Liu Jian yang ping Zhuang Sikai wang Tao Zhang Gang yang Wenbo yang Lilai Yuan Kun Cao Shuo Xu huiyuan Liu Zhiqiang Liang Chongrui wang hong Li Xiping Yuan xin yang yilong Fu yanping Zhang Haixin Zhang Zhiying Tao Sheng wang Xiaoping Gao binsong Jin Kemao Li Guojie wang Shenglong Jian yingqin Li chenjiang Xue Chunyun Lei Shaowei Xue yi Sun bin Zhu Ke Shao xingkun hu Meihua Xiong Jun Du bin He Tao yan yingying huang Yuanchao Zou Biwen Xie Yongming wang bin Li Fei Liu Yaoyao Zhang Fei Fan Zhijian wang Jing huang Haoran Gu Hailong Ge yan Dan yan Li Shuqiao wang Chuang Zhang Lu Zhou Xue wang Sheng Zeng yan xiang Xugang He Jianhui qin chengxing Xia Jie Hou yifu Shi Lifang Gao Zhiqiang Zhu hongbao Shen Yun Du Xuejun Duan Jiawu Xiong Deguo yang Shaoping Liu Zhaohui Ni hui Zhang kai Liu Feng Zhao yingren Li Jianwei wang qiwei Wei yangtze River Fisheries Research Institute Chinese Academy of Fishery SciencesWuhan430223China Institute of Hydrobiology Chinese Academy of SciencesWuhan430072China Fishery Resource and Environment Research Center Chinese Academy of Fishery SciencesBeijing100141China Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization Ministry of Agriculture and Rural AffairsFreshwater Fisheries Research CenterChinese Academy of Fishery SciencesWuxi214081China East China Sea Fisheries Research Institute Chinese Academy of Fishery SciencesShanghai200090China Institute of Fisheries Engineering Chinese Academy of Fishery SciencesBeijing100141China hunan Fisheries Science Institute Changsha410153China Jiangxi Fisheries Research Institute Nanchang330039China Jiujiang Academy of Fishery Sciences Jiujiang332000China School of Life Sciences Nanchang UniversityNanchang330031China qinghai Provincial Fishery Technology Extension Center Xining810012China Yunnan Academy of Fishery Sciences Kunming650111China Institute of Hydroecology Ministry of Water Resources and Chinese Academy of SciencesWuhan430079China Fisheries Institute Sichuan Academy of Agricultural SciencesChengdu611731China School of Life Sciences Neijiang Normal UniversityNeijiang641100China School of Life Sciences Southwest UniversityChongqing400715China Chongqing Fishery Sciences Research Institute Chongqing401120China Guizhou Fisheries Research Institute Guiyang550025China College of Fisheries Huazhong Agricultural UniversityWuhan430072China hubei Fisheries Science Research Institute Wuhan430070China Shaanxi Fisheries Research Institute Xi’an710086China Innovation Academy for Precision Measurement Science and Technology Chinese Academy of SciencesWuhan430077China Nanjing Institute of Geography and Limnology Chinese Academy of SciencesNanjing210008China Central South Inventory and Planning Institute of State Forestry and Grassland Administration Changsha410014China

The yangtze River is the mother river of *** promote the aquatic ecosystem protection of the great river,the Project of yangtze Fisheries Resources and Environment Investigation(2017-2021)supported by the Ministry of Agriculture and Rural Affairs,*** carried out by 24 institutes and universities that located in the yangtze River basin surveys the status of(1)fish species composition and spatial distribution,(2)current fish abundance,(3)endangered fishes,(4)yangtze finless porpoise,(5)aquatic eco-environments,(6)water-level fluctuation areas,(7)capture fisheries and recreational fisheries of the yangtze River mainstream and 10 of its main tributaries,including Yalong River,Heng River,Min River(including Dadu River),Chishui River,Tuo River,Jialing River,Wu River,Han River,Dongting Lake and Poyang *** results showed that there were 443 fish species(belonging to 163 genus,37 families,and 18 orders)before 2017,but only 323 fish species(including 15 new recorded exotic species)were recorded in the project of *** them,Cyprinus carpio,Carassius auratus,Hypophthalmichthys molitrix,Pelteobagrus fulvidraco,Coilia brachygnathus,Silurus asotus,Saurogobio dabryi,Ctenopharyngodon idellus,Pelteobagrus nitidus,Hemiculter leucisculus,Siniperca chuatsi,Coreius heterodon,Culter alburnus,Parabramis pekinensis,and Aristichthys nobilis were the dominant species across the whole yangtze River *** is estimated that there were 886 million individuals weighing 124.8 million kg,merely equivalent to 27.3%of the resources in 1950s,30.9%of the resources in 1960s,or 58.7%of the resources in *** the new list of protected fishes that recorded in the yangtze River system,only 15 of 29 were collected in this project of *** gladius has been affirmed to be Extinct by International Union for Conservation of Nature(IUCN).The wild individuals of Tenualosa reevesii and Luciobrama macrocephalus have disappeared for many years and maybe have been extinct

关键词： Fishes yangtze finless porpoise Resources Aquatic ecosystem Fisheries Background investigation yangtze river system

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Consensus on the digestive endoscopic tunnel technique

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World Journal of Gastroenterology 2019年第7期25卷 744-776页

作者： Ning-Li Chai hui-kai Li En-qiang Linghu Zhao-Shen Li Shu-Tian Zhang Yu Bao Wei-Gang chen Philip WY Chiu Tong Dang Wei Gong Shu-Tang Han Jian-Yu Hao Shui-xiang He bing hu1 bing hu2 Xiao-Jun huang Yong-hui huang Zhen-Dong Jin Mouen A Khashab James Lau Peng Li Rui Li De-Liang Liu Hai-Feng Liu Jun Liu Xiao-Gang Liu Zhi-Guo Liu ying-Cai Ma Gui-Yong Peng Long Rong Wei-hong Sha Pateek Sharma Jian-qiu Sheng Shui-Sheng Shi Dong Wan Seo Si-Yu Sun Gui-qi wang Wen wang qi Wu hong Xu Mei-Dong Xu Ai-Ming yang Fang Yao hong-Gang Yu ping-hong Zhou bin Zhang Xiao-Feng Zhang Ya-qi Zhai Department of Gastroenterology and Hepatology Chinese PLA General HospitalBeijing 100853China Department of Gastroenterology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Gastroenterology the First Affiliated Hospital of Xi’an Jiao Tong UniversityXi’an 710000Shaanxi ProvinceChina Department of Gastroenterology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Endoscopy Eastern Hepatobiliary Surgical Hospital Affiliated to Naval Medical UniversityShanghai 200438China Department of Gastroenterology the Second Hospital of Lanzhou UniversityLanzhou 730030Gansu ProvinceChina Department of Gastroenterology Peking University Third HospitalBeijing 100191China Division of Gastroenterology and Hepatology the Johns Hopkins University School of MedicineBaltimoreMD 21218United States Department of Gastrointestinal Endoscopy Prince of Wales Hospitalthe Chinese University of Hong KongHong KongChina Department of Gastroenterology the First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Gastroenterology Second Xiangya Hospital of Central South UniversityChangsha 410000Hunan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 200433China Department of Gastroenterology General Hospital of Chinese People’s Armed Police ForcesBeijing 100039China Division of Gastroenterology Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Gastroenterology Sichuan Provincial People’s HospitalChengdu 610072Sichuan ProvinceChina Department of Gastroenterology Xijing HospitalAir Force Medical UniversityXi’an 710032Shaanxi ProvinceChina Department of Digestion Qinghai Provincial People’s HospitalXining 810007Qinghai ProvinceChina Department of Gastroenterology Southwest HospitalArmy Medical UniversityChongqing 400038China Department of Gastroenterology Peking Univ

With the digestive endoscopic tunnel technique(DETT), many diseases that previously would have been treated by surgery are now endoscopically curable by establishing a submucosal tunnel between the mucosa and muscularis propria(MP). Through the tunnel, endoscopic diagnosis or treatment is performed for lesions in the mucosa, in the MP, and even outside the gastrointestinal(GI) *** present, the tunnel technique application range covers the following:(1)Treatment of lesions originating from the mucosal layer, e.g., endoscopic submucosal tunnel dissection for oesophageal large or circular early-stage cancer or precancerosis;(2) treatment of lesions from the MP layer, per-oral endoscopic myotomy, submucosal tunnelling endoscopic resection, etc.; and(3) diagnosis and treatment of lesions outside the GI tract, such as resection of lymph nodes and benign tumour excision in the mediastinum or abdominal cavity. With the increasing number of DETTs performed worldwide, endoscopic tunnel therapeutics, which is based on DETT, has been gradually developed and optimized. However, there is not yet an expert consensus on DETT to regulate its indications, contraindications, surgical procedure, and postoperative *** International DETT Alliance signed up this consensus to standardize the procedures of DETT. In this consensus, we describe the definition, mechanism,and significance of DETT, prevention of infection and concepts of DETTassociated complications, methods to establish a submucosal tunnel, and application of DETT for lesions in the mucosa, in the MP and outside the GI tract(indications and contraindications, procedures, pre-and postoperative treatments, effectiveness, complications and treatments, and a comparison between DETT and other operations).

关键词： Digestive endoscopic tunnel technique Endoscopic submucosal tunnel dissection Per-oral endoscopic myotomy Submucosal tunnelling endoscopic resection Gastrointestinal tract

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The DIRECT consortium and the REST-meta-MDD project:towards neuroimaging biomarkers of major depressive disorder

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Psychoradiology 2022年第1期2卷 32-42页

作者： Xiao chen bin Lu hui-Xian Li Xue-ying Li Yu-Wei wang Francisco Xavier Castellanos Li-ping Cao Ning-Xuan chen Wei chen Yu-qi cheng Shi-Xian Cui Zhao-Yu Deng yi-Ru Fang qi-Yong Gong Wen-bin Guo Zheng-Jia-yi hu Li Kuang Bao-Juan Li Le Li Tao Li Tao Lian yi-Fan Liao yan-Song Liu Zhe-Ning Liu Jian-ping Lu qing-hua Luo hua-qing Meng Dai-hui Peng Jiang qiu Yue-Di Shen Tian-Mei Si yan-qing Tang Chuan-Yue wang Fei wang hua-Ning wang kai wang xiang wang ying wang Zi-Han wang Xiao-ping Wu Chun-Ming Xie Guang-Rong Xie Peng Xie Xiu-Feng Xu hong yang Jian yang Shu-qiao Yao Yong-qiang Yu Yong-Gui Yuan Ke-rang Zhang Wei Zhang Zhi-Jun Zhang Jun-Juan Zhu Xi-Nian Zuo Jing-ping Zhao Yu-Feng Zang the DIRECT consortium Chao-Gan yan CAS Key Laboratory of Behavioral Science Institute of PsychologyChinese Academy of SciencesBeijing 100101China International Big-Data Center for Depression Research Chinese Academy of SciencesBeijing 100101China Magnetic Resonance Imaging Research Center Institute of PsychologyChinese Academy of SciencesBeijing 100101China Department of Psychology University of Chinese Academy of SciencesBeijing 100049China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Graduate University of Chinese Academy of SciencesBeijing 101408China Department of Child and Adolescent Psychiatry NYU Grossman School of MedicineNew YorkNY 10016USA Nathan Kline Institute for Psychiatric Research OrangeburgNew YorkNY 10962USA 9Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510370China Capital Normal University Beijing 100089China Department of Psychiatry Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310020ZhejiangChina Department of Psychiatry First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai 200030China huaxi MR Research Center(HMRRC) Department of RadiologyWest China Hospital of Sichuan UniversityChengduSichuan 610044China Research Unit of Psychoradiology Chinese Academy of Medical SciencesChengduSichuan 610052China Department of Psychiatry and National Clinical Research Center for Mental DisordersThe Second Xiangya Hospital of Central South UniversityChangsha 410011HunanChina Department of Psychiatry The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Xijing Hospital of Air Force Military Medical University Xi’anShaanxi 710032China Center for Cognitive Science of Language Beijing Language and Culture UniversityBeijing 100083China Affiliated Mental Health Center&Hangzhou Seventh People’s Hospital Zhejiang University School of

Despite a growing neuroimaging literature on the pathophysiology of major depressive disorder(MDD),repro-ducible findings are lacking,probably reflecting mostly small sample sizes and heterogeneity in analytic *** address these issues,the Depression Imaging REsearch ConsorTium(DIRECT)was *** REST-meta-MDD project,pooling 2428 functional brain images processed with a standardized pipeline across all participating sites,has been the first effort from *** this review,we present an overview of the moti-vations,rationale,and principal findings of the studies so far from the REST-meta-MDD *** from the first round of analyses of the pooled repository have included alterations in functional connectivity within the default mode network,in whole-brain topological properties,in dynamic features,and in functional *** well-powered exploratory observations have also provided the basis for future longitudinal hypothesis-driven *** these fruitful explorations,DIRECT has proceeded to its second stage of data sharing that seeks to examine ethnicity in brain alterations in MDD by extending the exclusive Chinese original sample to other ethnic groups through international collaborations.A state-of-the-art,surface-based preprocessing pipeline has also been introduced to improve *** images from patients with bipolar disorder and schizophrenia will be included to identify shared and unique abnormalities across diag-nosis *** addition,large-scale longitudinal studies targeting brain network alterations following antidepressant treatment,aggregation of diffusion tensor images,and the development of functional magnetic resonance imaging-guided neuromodulation approaches are *** these endeavours,we hope to accelerate the translation of functional neuroimaging findings to clinical use,such as evaluating longitudinal effects of antidepressant medications and developing individualized

关键词： major depressive disorder DIRECT R-fMRI database neuroimaging

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