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FibroScan-aspartate transaminase:A superior non-invasive model for diagnosing high-risk metabolic dysfunction-associated steatohepatitis

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World Journal of Gastroenterology 2024年第18期30卷 2440-2453页

作者： Jing-Ya Yin Tian-Yuan Yang Bing-qing Yang Chen-Xue Hou Jun-Nan Li Yue Li qi wang Center of Liver Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Pathology Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Beijing institute of infectious disease Beijing 100015China Beijing Key Laboratory of Emerging Infectious Diseases Institute of Infectious DiseasesBeijing Ditan HospitalCapital Medical UniversityBeijing 100015China

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)with hepatic histological NAFLD activity score≥4 and fibrosis stage F≥2 is regarded as“at risk”non-alcoholic steatohepatitis(NASH).Based on an international consensus,NAFLD and NASH were renamed as metabolic dysfunction-associated steatotic liver disease(MASLD)and metabolic dysfunction-associated steatohepatitis(MASH),respectively;hence,we introduced the term“high-risk MASH”.Diagnostic values of seven non-invasive models,including FibroScan-aspartate transaminase(FAST),fibrosis-4(FIB-4),aspartate transaminase to platelet ratio index(APRI),*** high-risk MASH have rarely been studied and compared in *** To assess the clinical value of seven non-invasive models as alternatives to liver biopsy for diagnosing high-risk *** A retrospective analysis was conducted on 309 patients diagnosed with NAFLD via liver biopsy at Beijing Ditan Hospital,between January 2012 and December *** screening for MASLD and the exclusion criteria,279 patients wereincluded and categorized into high-risk and non-high-risk MASH *** threshold values of each model,sensitivity,specificity,positive predictive value(PPV),and negative predictive values(NPV),were *** operating characteristic curves were constructed to evaluate their diagnostic efficacy based on the area under the curve(AUROC).RESULTS MASLD diagnostic criteria were met by 99.4%patients with *** MASLD population was analyzed in two cohorts:Overall population(279 patients)and the subgroup(117 patients)who underwent liver transient elastography(FibroScan).In the overall population,FIB-4 showed better diagnostic efficacy and higher PPV,with sensitivity,specificity,PPV,NPV,and AUROC of 26.9%,95.2%,73.5%,72.2%,and ***,Forns index,and aspartate transaminase to alanine transaminase ratio(ARR)showed moderate diagnostic efficacy,whereas S index and gamma-glutamyl transpeptidase to platelet ratio(GPR)were relatively *** the sub

关键词： Metabolic dysfunction-associated steatotic liver disease High-risk metabolic dysfunction-associated steatohepatitis Non-invasive models Liver biopsy Diagnostic value

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Indications of pro-inflammatory cytokines in laparoscopic and open liver resection for early-stage hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 257-264页

作者： Kevin Tak-Pan Ng Li Pang Jia-qi wang Wong Hoi She Simon Hing-Yin Tsang Chung Mau Lo Kwan Man Tan To Cheung Department of Surgery HKU-SZH&School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina

Background:Our clinical practice of laparoscopic liver resection(LLR)had achieved better short-term and long-term benefits for patients with hepatocellular carcinoma(HCC)over open liver resection(OLR),but the underlying mechanisms are not *** study was to find out whether systemic inflammation plays an important ***:A total of 103 patients with early-stage HCC under liver resection were enrolled(LLR group,n=53;OLR group,n=50).The expression of 9 inflammatory cytokines in patients at preoperation,postoperative day 1(POD1)and POD7 was quantified by Luminex Multiplex *** relationships of the cytokines and the postoperative outcomes were compared between LLR and ***:Seven of the circulating cytokines were found to be significantly upregulated on POD1 after LLR or OLR compared to their preoperative *** to OLR,the POD1 levels of granulocytemacrophage colony-stimulating factor(GM-CSF),interleukin-6(IL-6),IL-8,and monocyte chemoattractant protein-1(MCP-1)in the LLR group were significantly *** POD1 levels of these cytokines were significantly correlated with longer operative time and higher volume of blood loss during *** levels of these cytokines were positively associated with postoperative liver injury,and the length of hospital ***,a high level of IL-6 at POD1 was a risk factor for HCC recurrence and poor disease-free survival after liver ***:Significantly lower level of GM-CSF,IL-6,IL-8,and MCP-1 after liver resection represented a milder systemic inflammation which might be an important mechanism to offer better short-term and long-term outcomes in LLR over OLR.

关键词： Laparoscopic liver resection Open liver resection Hepatocellular carcinoma Postoperative cytokines Inflammatory responses

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The Epidemiological Characteristics of Mpox Cases-China,2023

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China CDC weekly 2024年第26期6卷 619-623页

作者： Ruiqi Ren Chao Li Wenqing Bai Yali wang Dan Li Fan Ding Niu Yan qi wang Nijuan Xiang Lianmei Jin Lei Zhou Wenling wang Fan Lyu Peilong Li Dapeng Zhang Yan Li Quanyi wang Qun Li Guoqing Shi National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases Chinese Center for Disease Control and PreventionBeijingChina Chinese Center for Disease Control and Prevention BeijingChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Guangdong Provincial Center for Disease Control and Prevention Guangzhou CityGuangdong ProvinceChina Beijing Municipal Center for Disease Prevention and Control BeijingChina

Summary What is already known about this topic?Since May 2022,a global outbreak of mpox has emerged in more than 100 non-endemic *** of December 2023,over 90,000 cases had been *** outbreak has predominantly affected men who have sex with men(MSM),with sexual contact identified as the principal mode of *** is added by this report?Since June 2023,China has faced an occurrence of mpox,predominantly affecting the MSM *** 90%of those affected reported engaging in homosexual behavior within 21 days prior to symptom onset,a trend that aligns with the global outbreak *** prompt identification of cases,diligent tracing of close contacts,and the implementation of appropriate management strategies have successfully mitigated the spread of mpox virus in *** are the implications for public health practice?We propose that mpox is transmitted locally within *** from our experiences in controlling the virus spread,it is crucial to investigate and formulate effective surveillance and educational ***,we must encourage high-risk populations to promptly seek medical care upon the onset of symptoms.

关键词： prompt Drawing spread

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中国交通枢纽城市生态交通效率时空特征分析

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交通运输系统工程与信息 2024年第1期24卷 14-23页

作者：汪玲王琪唐磊大连交通大学交通运输工程学院辽宁大连116028

为探究中国交通枢纽城市生态交通效率的发展水平及其时空特征,寻求综合交通运输体系绿色低碳发展的有效路径,以中国20个国际性综合交通枢纽城市作为研究对象,采用超效率EBM(Epsilon-Based Measure)模型测度其生态交通效率,并运用核密度... 详细信息

为探究中国交通枢纽城市生态交通效率的发展水平及其时空特征,寻求综合交通运输体系绿色低碳发展的有效路径,以中国20个国际性综合交通枢纽城市作为研究对象,采用超效率EBM(Epsilon-Based Measure)模型测度其生态交通效率,并运用核密度估计法、标准差椭圆法和Dagum基尼系数探析其时空演变和区域差异特征。结果表明:2011—2021年,中国国际性综合交通枢纽城市的生态交通效率总体发展较好,但未达到有效水平,从比较不同交通功能的枢纽城市来看,国际枢纽海港城市大于国际铁路枢纽城市大于国际航空枢纽城市;随着中国早期各类交通基础设施的提速建设和后期绿色低碳交通发展战略的逐步实施,总体生态交通效率先下降后上升,各城市间极化现象不稳定,但高效率值的城市增多;空间分布呈现西南-东北格局,具有从西南向东北集聚的趋势;沿海区域枢纽城市的效率整体高于内陆区域枢纽城市,总体区域差异和区域间差异均为先扩大后缩小,总体区域差异的主要根源在于区域内差异。

关键词：综合运输生态交通效率超效率EBM模型时空特征国际性综合交通枢纽城市

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CNT array-induced nanobubble assembly,nanodisk fabrication and enhanced spectral detection of CNT bundle density

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Nano Research 2024年第8期17卷 7737-7745页

作者： Zhiyuan Xia Ziming Ye Bo Zhao Tingsong Zhang qi wang Kun Chen Meng Li Xiaobing Kong Yu-qing Zheng Enzheng Shi Yuanyuan Shang Anyuan Cao School of Materials Science and Engineering Peking UniversityBeijing 100871China School of Integrated Circuits Peking UniversityBeijing 100871China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China School of Engineering Westlake UniversityHangzhou 310024China

Alignment,functionalization and detection of carbon nanotube(CNT)bundles are vital processes for utilizing this onedimensional nanomaterial in ***,we report a polymer-assisted wet shearing method to acquire super-aligned craterpatterned CNT arrays by nanobubble(NB)self-assembly with a"migrate and aggregation"mechanism and use craters to controllably mold even-sized nanodisks periodically along CNT bundles with tunable *** green,low-cost method can be extended to diverse substrates and fabricate different *** an example,the Ag-nanodisk-patterned CNT arrays are utilized as substrates of surface-enhanced Raman scattering(SERS)for rhodamine 6G(R6G)and methylene blue(MB)in which a linear correlation is found between the SERS intensity and the CNT bundle density due to the periodic distribution of hot spots,enabling a spectral detection of CNT bundles and their densities by conventional dye *** from routine morphological characterization,this spectral method possesses an enhanced accuracy and a detection range of 0.1–2μm^(–1),showing its uniqueness in the detection of CNT bundle density since the intensity of traditional spectral merely relates to the quantity of CNTs,exhibiting its potential in future CNT-bundle-based electronics.

关键词： CNT arrays nanobubbles self-assembly nanodisks surface-enhanced Raman scattering(SERS)

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TBC1D1 is an energy-responsive polarization regulator of macrophages via governing ROS production in obesity

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Science China Life Sciences 2024年第9期67卷 1899-1914页

作者： qi wang Ping Rong Wen Zhang Xinyu Yang Liang Chen Ye Cao Minjun Liu Weikuan Feng qian Ouyang qiaoli Chen Hailong Li Hui Liang Fanguo Meng Hong-Yu wang Shuai Chen State Key Laboratory of Pharmaceutical Biotechnology Department of Cardiology Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Model Animal Research CenterSchool of Medicine Nanjing University MOE Key Laboratory of Model Animal for Disease Study Department of Endocrinology Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Model Animal Research Center School of Medicine Nanjing University College of Life Science Anhui Medical University Redox Medical Center for Public Health Medical College of Soochow University Department of General Surgery First Affiliated Hospital Nanjing Medical University

Energy status is linked to the production of reactive oxygen species（ROS） in macrophages, which is elevated in obesity. However, it is unclear how ROS production is upregulated in macrophages in response to energy overload for mediating the development of obesity. Here,we show that the Rab-GTPase activating protein（Rab GAP） TBC1D1, a substrate of the energy sensor AMP-activated protein kinase（AMPK）,is a critical regulator of macrophage ROS production and consequent adipose inflammation for obesity development. TBC1D1 deletion decreases, whereas an energy overload-mimetic non-phosphorylatable TBC1D1S231AAmutation increases, ROS production and M1-like polarization in macrophages. Mechanistically, TBC1D1 and its downstream target Rab8a form an energy-responsive complex with NOX2 for ROS generation. Transplantation of TBC1D1S231Abone marrow aggravates diet-induced obesity whereas treatment with an ultra-stable Tt SOD for removal of ROS selectively in macrophages alleviates both TBC1D1S231Amutation-and diet-induced obesity. Our findings therefore have implications for drug discovery to combat obesity.

关键词： TBC1D1 AMPK Rab8a NOX2 ROS inflammation macrophage obesity

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Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang Gao Xinyue wang Shijie Su Weicheng Feng Yaona Lai Kongli Huang Dandan Cao qi wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

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Prohibitin 1 inhibits cell proliferation and induces apoptosis via the p53-mediated mitochondrial pathway in vitro

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 398-413页

作者： Juan-Juan Shi Yi-Kai wang Mu-qi wang Jiang Deng Ning Gao Mei Li Ya-Ping Li Xin Zhang Xiao-Li Jia Xiong-Tao Liu Shuang-Suo Dang Wen-Jun wang Department of Infectious Diseases The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina Department of Operating Room The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina

BACKGROUND Prohibitin 1(PHB1)has been identified as an antiproliferative protein that is highly conserved and ubiquitously expressed,and it participates in a variety of essential cellular functions,including apoptosis,cell cycle regulation,prolifera-tion,and *** evidence indicates that PHB1 may play an important role in the progression of hepatocellular carcinoma(HCC).However,the role of PHB1 in HCC is *** To investigate the effects of PHB1 on the proliferation and apoptosis of human HCC cells and the relevant mechanisms in *** HCC patients and healthy individuals were enrolled in this study according to the inclusion and exclusion criteria;then,PHB1 levels in the sera and liver tissues of these participates were determined using ELISA,RT-PCR,and *** HepG2 and SMMC-7721 cells were transfected with the pEGFP-PHB1 plasmid and PHB1-specific shRNA(shRNA-PHB1)for 24-72 *** prolif-eration was analysed with an MTT *** cycle progression and apoptosis were analysed using flow cytometry(FACS).The mRNA and protein expression levels of the cell cycle-related molecules p21,Cyclin A2,Cyclin E1,and CDK2 and the cell apoptosis-related molecules cytochrome C(Cyt C),p53,Bcl-2,Bax,caspase 3,and caspase 9 were measured by real-time PCR and Western blot,*** Decreased levels of PHB1 were found in the sera and liver tissues of HCC patients compared to those of healthy individuals,and decreased PHB1 was positively correlated with low differentiation,TNM stage III-IV,and alpha-fetoprotein≥400μg/*** of PHB1 significantly inhibited human HCC cell proliferation in a time-dependent *** revealed that the overexpression of PHB1 arrested HCC cells in the G0/G1 phase of the cell cycle and induced *** proportion of cells in the G0/G1 phase was significantly increased and the proportion of cells in the S phase was decreased in HepG2 cells that were transfected with pEGFP-PHB1 compar

关键词： Prohibitin 1 Hepatocellular carcinoma cells Apoptosis Cell cycle Mitochondrial pathway

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Discrimination of polysorbate 20 by high-performance liquid chromatography-charged aerosol detection and characterization for components by expanding compound database and library

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Journal of Pharmaceutical Analysis 2024年第5期14卷 722-732页

作者： Shi-qi wang Xun Zhao Li-Jun Zhang Yue-Mei Zhao Lei Chen Jin-Lin Zhang Bao-Cheng wang Sheng Tang Tom Yuan Yaozuo Yuan Mei Zhang Hian Kee Lee Hai-Wei Shi Jiangsu Institute for Food and Drug Control Nanjing210019China School of Pharmacy China Pharmaceutical UniversityNanjing211112China School of Pharmacy Nanjing University of Chinese MedicineNanjing210046China Chinese Pharmacopoeia Commission Beijing100061China Nanjing Well Pharmaceutical Group Co. Ltd.Nanjing210018China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiangJiangsu212003China University of Massachusetts Amherst Amherst01003USA Department of Chemistry National University of SingaporeSingapore117543Singapore

Analyzing polysorbate 20(PS20)composition and the impact of each component on stability and safety is crucial due to formulation variations and individual *** similar structures and polarities of PS20 components make accurate separation,identification,and quantification *** this work,a high-resolution quantitative method was developed using single-dimensional high-performance liquid chromatography(HPLC)with charged aerosol detection(CAD)to separate 18 key components with multiple *** separated components were characterized by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UHPLC-Q-TOF-MS)with an identical gradient as the HPLC-CAD *** polysorbate compound database and library were expanded over 7-time compared to the commercial *** method investigated differences in PS20 samples from various origins and grades for different dosage forms to evaluate the composition-process ***-Q-TOF-MS identified 1329 to 1511 compounds in 4 batches of PS20 from different *** method observed the impact of 4 degradation conditions on peak components,identifying stable components and their tendencies to ***-CAD and UHPLC-Q-TOF-MS results provided insights into fingerprint differences,distinguishing quasi products.

关键词： Polysorbate 20 Component Database Discrimination Degradation

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Compound extreme inundation risk of coastal wetlands caused by climate change and anthropogenic activities in the Yellow River Delta,China

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Advances in Climate Change Research 2024年第1期15卷 134-147页

作者： Xiao-Li wang Ai-qing FENG Xi-Yong HOU qing-Chen CHAO Bai-Yuan SONG Yu-Bin LIU qi-Guang wang He XU Yu-Xin ZHANG Dong Li Li-Jie DONG Yu GUO CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China Shandong Key Laboratory of Coastal Environmental Processes Yantai 264003China China Meteorological Administration Key Laboratory for Climate Prediction Studies National Climate CentreBeijing 100081China Tongji Urban Planning Design Research Institute Shanghai 200092China School of Geography and Tourism Qilu Normal UniversityJinan 250200China China Meteorological Administration Training Centre China Meteorological AdministrationBeijing 10008China University of Chinese Academy of Sciences Beijing 100049China Marine Science and Technology College Zhejiang Ocean UniversityZhoushan 316022China

The coastal wetlands of the Yellow River Delta(YRD)in China are crucial for their valuable resources,environmental significance,and economic ***,these wetlands are also vulnerable to the dual threats of climate change and human *** substantial attention to the historical shifts in YRD's coastal wetlands,uncertainties remain regarding their future trajectory in the face of compound risks from climate change and anthropogenic *** on a range of remote sensing data sources,this study undertakes a comprehensive investigation into the evolution of YRD's coastal wetlands between 2000 and ***,the potential fate of coastal wetlands is thoroughly analyzed through the Land Use/Cover Change(LUCC)simulation using System Dynamic-Future Land Use Simulation(SD-FLUS)model and the extreme water levels projection integrated future sea-level rise,storm surge,and astronomical high tide in 2030,2050,and 2100 under scenarios of SSP1-2.6,SSP2-4.5,and *** revealed that YRD's coastal wetlands underwent a marked reduction,shrinking by 1688.72 km²from 2000 to *** decline was mostly attributed to the substantial expansion in the areas of artificial wetlands(increasing by 823.78 km2),construction land(increasing by 767.71 km²),and shallow water(increasing by 274.58 km²).Looking ahead to 2030-2100,the fate of coastal wetlands appears to diverge based on different *** the SSP1-2.6 scenario,the area of coastal wetland is projected to experience considerable *** contrast,the SSP5-8.5 scenario anticipates a notable decrease in coastal *** to the inundated area suffered from the current extreme water levels,the study projects a decrease of 6.8%-10.6%in submerged coastal wetlands by 2030 and 9.4%-18.2%by 2050 across all *** 2100,these percentages are projected to decrease by 0.4%(SSP2-4.5)and 27.1%(SSP5-8.5),but increase by 35.7%(SSP1-2.6).Results suggest that coastal wetlands in th

关键词： Climate change Anthropogenic activities Compound extreme risk Coastal wetlands Yellow River Delta

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