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Multifunctional zinc ion doped sol-gel derived mesoporous bioactive glass nanoparticles for biomedical applications

Bioactive Materials 2019年第1期4卷 312-321页

作者： Zuzana Neščáková Kai Zheng Liliana Liverani qaisar nawaz Dagmar Galusková Hana Kaňková Martin Michálek Dušan Galusek Aldo R.Boccaccini Dept.of Biomaterials FunGlass-Centre for Functional and Surface Functionalized GlassAlexander Dubček University of TrenčínSlovakia Central Laboratories FunGlass-Centre for Functional and Surface Functionalized GlassAlexander Dubček University of TrenčínSlovakia Institute of Biomaterials Department of Materials Science and EngineeringUniversity of ErlangenNurembergGermany

Mesoporous bioactive glasses have been widely investigated for applications in bone tissue regeneration and,more recently,in soft tissue repair and wound *** this study we produced mesoporous bioactive glass nanoparticles(MBGNs)based on the SiO2-CaO *** the intention of adding subsidiary biological function,MBGNs were doped with Zn2+***-MBGNs with 8 mol%ZnO content were synthesized via microemulsion assisted sol-gel *** synthesized particles were homogeneous in shape and *** exhibited spherical shape,good dispersity,and a size of 130±10 *** addition of zinc precursors did not affect the morphology of particles,while their specific surface area increased in comparison to *** presence of Zn2+ions inhibited the formation of hydroxycarbonate apatite(HCAp)on the particles after immersion in simulated body fluid(SBF).No formation of HCAp crystals on the surface of Zn-MBGNs could be observed after 14 days of ***,powders containing relatively high amount of zinc released Zn2+ions in low concentration(0.6-1.2 mg L^−1)but in a sustained *** releasing feature enables Zn-MBGNs to avoid potentially toxic levels of Zn2+ions,indeed Zn-MBGNs were seen to improve the differentiation of osteoblast-like cells(MG-63).Additionally,Zn-MBGNs showed higher ability to adsorb proteins in comparison to MBGNs,which could indicate a favourable later attachment of *** to their advantageous morphological and physiochemical properties,Zn-MBGNs show great potential as bioactive fillers or drug delivery systems in a variety of applications including bone regeneration and wound healing.

关键词： Bioactive particles Sol-gel synthesis Zinc Bioactivity Ion release Bioactive glass

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Evaluation of Antioxidant and Cytotoxic Capacity of <i>Croton bonplandianum</i>. Baill

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American Journal of Plant Sciences 2013年第9期4卷 1709-1712页

作者： Muhammad Naeem qaisar Bashir Ahmad Chaudary Muhammad Uzair Sajid nawaz Hussain Faculty of Pharmacy Bahauddun Zakariya University Multan Pakistan.

The antioxidant and cytotoxic activities of Methanolic and Dichloromethane extracts of Croton bonplandianum Baill were evaluated in a bid to provide better scientific basis for the isolation of bioactive compounds from the plant. The DPPH and hydroxyl radical scavenging activities of the Methanolic extract were 59.62%, and Dichloromethane extract was not toxic. Gallic acid used as reference compounds showed higher antioxidant activities to the plant extracts. Both methanolic and dichloromethane extracts were evaluated for their brine shrimp lethality. Methanolic extract showed cytotoxic activity in vitro with a LD50 value of 115.76 (0.0048-3.76) μg/ml. Etoposide was used as standard drug. Put together, these results confirm that Croton bonplandianum extracts possess appreciable natural antioxidant and cytotoxic potentials, thereby providing good justification for the isolation of pure bioactive compounds.

关键词： Antioxidant Activity Scavenging Activity Cytotoxic Activity Brine Shrimp Croton bonplandianum

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