Multifunctional zinc ion doped sol-gel derived mesoporous bioactive glass nanoparticles for biomedical applications

作     者：Zuzana Neščáková Kai Zheng Liliana Liverani Qaisar Nawaz Dagmar Galusková Hana Kaňková Martin Michálek Dušan Galusek Aldo R.Boccaccini 

作者机构：Dept.of BiomaterialsFunGlass-Centre for Functional and Surface Functionalized GlassAlexander Dubček University of TrenčínSlovakia Central LaboratoriesFunGlass-Centre for Functional and Surface Functionalized GlassAlexander Dubček University of TrenčínSlovakia Institute of BiomaterialsDepartment of Materials Science and EngineeringUniversity of ErlangenNurembergGermany 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2019年第4卷第1期

页      面：312-321页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 10[医学] 

基　　金：This project has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No 739566 and in the frame of the project Centre for Functional and Surface Functionalized Glass(CEGLASS) ITMS code is 313011R453,operational program Research and innovation,co-funded from European Regional Development Fund The financial support of this work by the grant VEGA 2/0026/17 and APVV 15/0014 is also gratefully acknowledged 

主　　题：Bioactive particles Sol-gel synthesis Zinc Bioactivity Ion release Bioactive glass 

摘      要：Mesoporous bioactive glasses have been widely investigated for applications in bone tissue regeneration and,more recently,in soft tissue repair and wound *** this study we produced mesoporous bioactive glass nanoparticles(MBGNs)based on the SiO2-CaO *** the intention of adding subsidiary biological function,MBGNs were doped with Zn2+***-MBGNs with 8 mol%ZnO content were synthesized via microemulsion assisted sol-gel *** synthesized particles were homogeneous in shape and *** exhibited spherical shape,good dispersity,and a size of 130±10 *** addition of zinc precursors did not affect the morphology of particles,while their specific surface area increased in comparison to *** presence of Zn2+ions inhibited the formation of hydroxycarbonate apatite(HCAp)on the particles after immersion in simulated body fluid(SBF).No formation of HCAp crystals on the surface of Zn-MBGNs could be observed after 14 days of ***,powders containing relatively high amount of zinc released Zn2+ions in low concentration(0.6-1.2 mg L^−1)but in a sustained *** releasing feature enables Zn-MBGNs to avoid potentially toxic levels of Zn2+ions,indeed Zn-MBGNs were seen to improve the differentiation of osteoblast-like cells(MG-63).Additionally,Zn-MBGNs showed higher ability to adsorb proteins in comparison to MBGNs,which could indicate a favourable later attachment of *** to their advantageous morphological and physiochemical properties,Zn-MBGNs show great potential as bioactive fillers or drug delivery systems in a variety of applications including bone regeneration and wound healing.