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Use of the DSI/Ponemah jacketed external telemetry system for ECG assessments in dog telemetry

中国药理学与毒理学杂志 2013年第3期 601-602页

作者： WU Rui qu lin-hai Sue McPHERSON Steve MASON Safety Pharmacology WuXi AppTec(Suzhou) Co.Ltd.

OBJECTIVE To demonstrate that the DSI /Ponemah Jet System(v5.00) can generate high quality ECG data with current methods,enabling cardiovascular function to be assessed in free moving dogs in their home *** Four male beagle dogs were used on this *** electrodes were placed on each animal and were connected to each JET *** JET device was then placed into a pocket of an externally worn animal jacket for each *** JET device transmits to a Bluetooth? *** Bluetooth? receiver can receive signals from up to 6 JET devices depending upon the device *** JET device can transmit data up to 10 meters with negligible interference and no cross-talk exists between *** animals underwent acclimatization to jackets prior to commencement of *** dog was placed into a pen and ECG measurements taken simultaneously using the DSI /Ponemah Jet *** were recorded for 1 hour pre-dose and continually for the following 23 hours under control conditions,then dosed with ascending doses of Moxifloxacin at intervals of 48 hours between each *** AND CONCLUSION Prolonged QT and QTcV(Van de Water's correction) interval was observed for animals dosed at 100 mg·kg-1 from 4-23 h *** QTcV effects(19% increase with 100 mg·kg-1 Moxifloxacin vs control).The DSI telemetry system performed well when testing the dog to the known pharmacological profile of *** sensitively and efficiently acquired ECG data from the beagle dogs and demonstrated the sensitivity of the system to detect test article induced QT *** allows a colony of dogs to be dedicated for toxicology and safety pharmacology *** DSI /ponemah JET system enables flexibility in study design and can be utilized on a range of study types to facilitate high quality ECGs and reduce the requirement for repeat dosing safety pharmacology *** data generated from this investigation demonstrate the DSI /ponemah JET system(v5.

关键词： ECG dog

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Use of respiratory "head out" plethysmographs for evaluation of pulmonary function in rats

Use of respiratory "head out" plethysmographs for evaluation...

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2013年（第三届）中国药物毒理学年会暨药物非临床安全性评价研究论坛

作者： WU Rui qu lin-hai Sue MCPHERSON Steve MASON Safety Pharmacology WuXi AppTec(Suzhou)Co.Ltd.

To evaluate the use of respiratory "head out" plethysmographys for use as a respiratory function assessment tool in rats as part of the respiratory system assessment required under the ICH S7A ***(20 mg ? kg iv) and Theophylline(10 mg·kg iv) were selected for use as reference compounds in this *** Sprague-Dawley rats,approximately 7 -8 weeks of age and in the weight range 246 -303 g were selected as the test *** approximate one week acclimation period preceded the study,during which animals were pre-selected for the suitability by assessment of their ability to stay in the restraint chambers("head-out" plethysmographys) for a target of about 2.5 h-Any rat demonstrating excessive excitability or abnormal breathing patterns were removed from the *** the day of dosing, animals were placed in "head out" plethysmographs and allowed to acclimate to the chambers for at least 5 min prior to each data collection *** following the acclimation period,ventilatory parameters(tidal volume,respiratory rate,and derived respiratory minute volume(RMV) were measured for an approximate 15 min period predose,continuously for the following approximate 2.5 h,then for approximate 15 min at approximately 4 and 24 h *** obtained were consistent with the literature and based on the results of this study,this assay,using respiratory "head out" plethysmographys to assess respiratory function,is considered acceptable for use in Pulmonary assessments under the ICH guideline.

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Use of the DSI/Ponemah jacketed external telemetry system for ECG assessments in dog telemetry

Use of the DSI/Ponemah jacketed external telemetry system fo...

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作者： WU Rui qu lin-hai Sue McPHERSON Steve MASON Safety Pharmacology WuXi AppTec(Suzhou) Co.Ltd

OBJECTIVE To demonstrate that the DSI/Ponemah Jet System(v5.00) can generate high quality ECG data with current methods,enabling cardiovascular function to be assessed in free moving dogs in their home pens. METHODS Four male beagle dogs were used on this *** electrodes were placed on each animal and were connected to each JET *** JET device was then placed into a pocket of an externally worn animal jacket for each *** JET device transmits to a Bluetooth? *** Bluetooth? receiver can receive signals from up to 6 JET devices depending upon the device *** JET device can transmit data up to 10 meters with negligible interference and no cross-talk exists between *** animals underwent acclimatization to jackets prior to commencement of *** dog was placed into a pen and ECG measurements taken simultaneously using the DSI/Ponemah Jet *** were recorded for 1 hour pre-dose and continually for the following 23 hours under control conditions,then dosed with ascending doses of Moxifloxacin at intervals of 48 hours between each *** AND CONCLUSION Prolonged QT and QTcV(Van de Water s correction) interval was observed for animals dosed at 100 mg·kg~(-1) from 4-23 h *** QTcV effects(19%increase with 100 mg·kg~(-1) Moxifloxacin vs control).The DSI telemetry system performed well when testing the dog to the known pharmacological profile of *** sensitively and efficiently acquired ECG data from the beagle dogs and demonstrated the sensitivity of the system to detect test article induced QT changes. DSI allows a colony of dogs to be dedicated for toxicology and safety pharmacology *** DSI/ponemah JET system enables flexibility in study design and can be utilized on a range of study types to facilitate high quality ECGs and reduce the requirement for repeat dosing safety pharmacology *** data generated from this investigation demonstrate the DSI/ponemah JET system(

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Use of the DSI/Ponemah jacketed external telemetry system for ECG assessments in dog telemetry

Use of the DSI/Ponemah jacketed external telemetry system fo...

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2013年（第三届）中国药物毒理学年会暨药物非临床安全性评价研究论坛

作者： WU Rui qu lin-hai Sue McPHERSON Steve MASON Safety Pharmacology WuXi AppTec(Suzhou) Co.Ltd.

OBJECTIVE To demonstrate that the DSI/Ponemah Jet System(v5.00) can generate high quality ECG data with current methods,enabling cardiovascular function to be assessed in free moving dogs in their home pens. METHODS Four male beagle dogs were used on this *** electrodes were placed on each animal and were connected to each JET *** JET device was then placed into a pocket of an externally worn animal jacket for each *** JET device transmits to a Bluetooth? *** Bluetooth? receiver can receive signals from up to 6 JET devices depending upon the device *** JET device can transmit data up to 10 meters with negligible interference and no cross-talk exists between *** animals underwent acclimatization to jackets prior to commencement of *** dog was placed into a pen and ECG measurements taken simultaneously using the DSI/Ponemah Jet *** were recorded for 1 hour pre-dose and continually for the following 23 hours under control conditions,then dosed with ascending doses of Moxifloxacin at intervals of 48 hours between each *** AND CONCLUSION Prolonged QT and QTcV(Van de Waters correction) interval was observed for animals dosed at 100 mg·kg from4-23 h *** QTcV effects(19%increase with 100 mg-kg"1 Moxifloxacin vs control).The DSI telemetry system performed well when testing the dog to the known pharmacological profile of *** sensitively and efficiently acquired ECG data from the beagle dogs and demonstrated the sensitivity of the system to detect test article induced QT changes. DSI allows a colony of dogs to be dedicated for toxicology and safety pharmacology *** DSI/ponemah JET system enables flexibility in study design and can be utilized on a range of study types to facilitate high quality ECGs and reduce the requirement for repeat dosing safety pharmacology *** data generated from this investigation demonstrate the DSI/ponemah JET system(v5.00) pro

关键词： ECG dog

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Use of respiratory "head out" plethysmographs for evaluation of pulmonary function in rats

Use of respiratory "head out" plethysmographs for evaluation...

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作者： WU Rui qu lin-hai Sue MCPHERSON Steve MASON Safety Pharmacology WuXi AppTec(Suzhou)Co.Ltd

To evaluate the use of respiratory "head out" plethysmographys for use as a respiratory function assessment tool in rats as part of the respiratory system assessment required under the ICH S7A ***(20 mg·kg~(-1) iv) and Theophylline(10 mg·kg~(-1)iv) were selected for use as reference compounds in this *** Sprague- Dawley rats,approximately 7 -8 weeks of age and in the weight range 246 -303 g were selected as the test *** approximate one week acclimation period preceded the study,during which animals were pre-selected for the suitability by assessment of their ability to stay in the restraint chambers("head-out" plethysmographys) for a target of about 2.5 h-Any rat demonstrating excessive excitability or abnormal breathing patterns were removed from the *** the day of dosing, animals were placed in "head out" plethysmographs and allowed to acclimate to the chambers for at least 5 min prior to each data collection *** following the acclimation period,ventilatory parameters(tidal volume,respiratory rate,and derived respiratory minute volume(RMV) were measured for an approximate 15 min period predose,continuously for the following approximate 2.5 h,then for approximate 15 min at approximately 4 and 24 h *** obtained were consistent with the literature and based on the results of this study,this assay,using respiratory "head out" plethysmographys to assess respiratory function,is considered acceptable for use in Pulmonary assessments under the ICH guideline.

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Use of respiratory "head out" plethysmographs for evaluation of pulmonary function in rats

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中国药理学与毒理学杂志 2013年第3期 604-604页

作者： WU Rui qu lin-hai Sue MCPHERSON Steve MASON Safety Pharmacology WuXi AppTec(Suzhou) Co.Ltd.

To evaluate the use of respiratory ″head out″ plethysmographys for use as a respiratory function assessment tool in rats as part of the respiratory system assessment required under the ICH S7A ***(20 mg·kg-1 iv) and Theophylline(10 mg·kg-1 iv) were selected for use as reference compounds in this *** SpragueDawley rats,approximately 7-8 weeks of age and in the weight range 246-303 g were selected as the test *** approximate one week acclimation period preceded the study,during which animals were pre-selected for the suitability by assessment of their ability to stay in the restraint chambers(″head-out″ plethysmographys) for a target of about 2.5 h-Any rat demonstrating excessive excitability or abnormal breathing patterns were removed from the *** the day of dosing,animals were placed in ″head out″ plethysmographs and allowed to acclimate to the chambers for at least 5 min prior to each data collection *** following the acclimation period,ventilatory parameters(tidal volume,respiratory rate,and derived respiratory minute volume(RMV) were measured for an approximate 15 min period predose,continuously for the following approximate 2.5 h,then for approximate 15 min at approximately 4 and 24 h *** obtained were consistent with the literature and based on the results of this study,this assay,using respiratory ″head out″ plethysmographys to assess respiratory function,is considered acceptable for use in Pulmonary assessments under the ICH guideline.

关键词： head out Use of respiratory plethysmographs for evaluation of pulmonary function in rats

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三七总皂苷提取工艺研究

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中药材 2006年第6期29卷 593-595页

作者：瞿林海郑明楼宜嘉浙江大学药学院浙江杭州310031

目的:优化三七总皂苷提取工艺。方法:在考察提取溶媒和粒径的前提下,采用正交试验法,以提取物中三七总皂苷含量为考察指标,对影响三七提取的因素进行了考察。结果:提取次数对三七总皂苷得率有显著影响。选择过8目筛的药材,用10倍量70%... 详细信息

目的:优化三七总皂苷提取工艺。方法:在考察提取溶媒和粒径的前提下,采用正交试验法,以提取物中三七总皂苷含量为考察指标,对影响三七提取的因素进行了考察。结果:提取次数对三七总皂苷得率有显著影响。选择过8目筛的药材,用10倍量70%乙醇提取3次,每次1.5h,所得三七总皂苷为85.74±3.16mg/g生药。结论:该工艺简便易行,得率较高,适于大生产。

关键词：三七总皂苷三七提取工艺正交试验

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Boosting bidirectional sulfur conversion enabled by introducing boron-doped atoms and phosphorus vacancies in Ni2P for lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 760-769页

作者： lin Peng Yu Bai Hang Li Meixiu qu Zhenhua Wang Kening Sun Advanced Research Institute of Multidisciplinary Science Beijing Institute of Technology Beijing Key Laboratory of Chemical Power Source and Green Catalysis School of Chemistry and Chemical Engineering Beijing Institute of Technology

Lithium-sulfur （Li-S） batteries have gained great attention due to the high theoretical energy density and low cost,yet their further commercialization has been obstructed by the notorious shuttle effect and sluggish redox ***,we supply a strategy to optimize the electron structure of Ni2P by concurrently introducing B-doped atoms and P vacancies in Ni2P （Vp-B-Ni2P）,thereby enhancing the bidirectional sulfur *** study indicates that the simultaneous introduction of B-doped atoms and P vacancies in Ni2P causes the redistribution of electron around Ni atoms,bringing about the upward shift of d-band center of Ni atoms and effective d-p orbital hybridization between Ni atoms and sulfur species,thus strengthening the chemical anchoring for lithium polysulfides （LiPSs） as well as expediting the bidirectional conversion kinetics of sulfur ***,theoretical calculations reveal that the incorporation of B-doped atoms and P vacancies in Ni2P selectively promotes Li2S dissolution and nucleation ***,the Li-S batteries with Vp-B-Ni2P-separators present outstanding rate ability of 777 m A h g-1at 5 C and high areal capacity of 8.03 mA h cm-2under E/S of 5μL mg-1and sulfur loading of 7.20 mg *** work elucidates that introducing heteroatom and vacancy in metal phosphide collaboratively regulates the electron structure to accelerate bidirectional sulfur conversion.

关键词： Lithium sulfur batteries

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三七总皂苷分离纯化工艺研究

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中国现代应用药学 2007年第2期24卷 118-120页

作者：郑明瞿林海楼宜嘉浙江大学药学院杭州310058

目的研究D-101型大孔吸附树脂分离纯化三七总皂苷的工艺条件及参数。方法以三七总皂苷的含量为考察指标,研究三七总皂苷纯化过程中,D-101型大孔吸附树脂吸附容量、洗脱溶媒及其用量,并用正交试验法优选最佳洗脱条件。结果通过D-101型大... 详细信息

目的研究D-101型大孔吸附树脂分离纯化三七总皂苷的工艺条件及参数。方法以三七总皂苷的含量为考察指标,研究三七总皂苷纯化过程中,D-101型大孔吸附树脂吸附容量、洗脱溶媒及其用量,并用正交试验法优选最佳洗脱条件。结果通过D-101型大孔吸附树脂纯化后,70%乙醇洗脱液干燥后总固物中三七总皂苷纯度可达90%。结论本纯化工艺设计科学合理、成本低、污染少,可作为纯化三七总皂苷成分生产工艺的依据。

关键词：三七总皂苷大孔吸附树脂:分离纯化

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QC8500连续流动注射仪常见故障及日常维护

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山西建筑 2013年第30期39卷 216-217页

作者：曲海琳太原自来水公司山西太原030009

对LACHAT公司的QC8500连续流动注射仪在日常使用过程中出现的常见故障现象进行了原因分析,并根据日常使用经验,对其在实际使用过程中的注意事项进行了总结,为该仪器操作人员处理类似故障提供参考。

关键词： QC8500连续流动注射仪故障处理日常维护

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