Use of the DSI/Ponemah jacketed external telemetry system for ECG assessments in dog telemetry
作者单位：Safety PharmacologyWuXi AppTec(Suzhou) Co.Ltd.
会议名称：《2013年（第三届）中国药物毒理学年会暨药物非临床安全性评价研究论坛》
会议日期：2013年
学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学]
摘 要：OBJECTIVE To demonstrate that the DSI/Ponemah Jet System(v5.00) can generate high quality ECG data with current methods,enabling cardiovascular function to be assessed in free moving dogs in their home pens. METHODS Four male beagle dogs were used on this *** electrodes were placed on each animal and were connected to each JET *** JET device was then placed into a pocket of an externally worn animal jacket for each *** JET device transmits to a Bluetooth? *** Bluetooth? receiver can receive signals from up to 6 JET devices depending upon the device *** JET device can transmit data up to 10 meters with negligible interference and no cross-talk exists between *** animals underwent acclimatization to jackets prior to commencement of *** dog was placed into a pen and ECG measurements taken simultaneously using the DSI/Ponemah Jet *** were recorded for 1 hour pre-dose and continually for the following 23 hours under control conditions,then dosed with ascending doses of Moxifloxacin at intervals of 48 hours between each *** AND CONCLUSION Prolonged QT and QTcV(Van de Waters correction) interval was observed for animals dosed at 100 mg·kg from4-23 h *** QTcV effects(19%increase with 100 mg-kg1 Moxifloxacin vs control).The DSI telemetry system performed well when testing the dog to the known pharmacological profile of *** sensitively and efficiently acquired ECG data from the beagle dogs and demonstrated the sensitivity of the system to detect test article induced QT changes. DSI allows a colony of dogs to be dedicated for toxicology and safety pharmacology *** DSI/ponemah JET system enables flexibility in study design and can be utilized on a range of study types to facilitate high quality ECGs and reduce the requirement for repeat dosing safety pharmacology *** data generated from this investigation demonstrate the DSI/ponemah JET system(v5.00) pro