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海藻多糖/可溶性大豆多糖对稻虾米淀粉理化特性及消化特性的影响

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粮食与油脂 2024年第6期37卷 34-38页

作者：苏振华黄宏辉邓树华陈渠玲吴安琪范文倩湖南省粮油产品质量监测中心/国家粮食-稻谷产后工程技术研究中心湖南长沙410008 湖南省粮食和物资科研设计院湖南长沙410008 南县农业农村局湖南益阳413200

将不同质量比的海藻多糖(SA)/可溶性大豆多糖(SSPS)与稻虾米淀粉混合制备出不同稻虾米淀粉样品,并对各淀粉样品的营养特性、水合特性、糊化特性、凝胶特性及消化特性进行探究。结果表明:随着SSPS占比的增加,淀粉凝胶复合体系的峰值黏度... 详细信息

将不同质量比的海藻多糖(SA)/可溶性大豆多糖(SSPS)与稻虾米淀粉混合制备出不同稻虾米淀粉样品,并对各淀粉样品的营养特性、水合特性、糊化特性、凝胶特性及消化特性进行探究。结果表明:随着SSPS占比的增加,淀粉凝胶复合体系的峰值黏度、最低黏度、最终黏度、衰减值、回生值均逐渐降低,水合特性先升高后降低,硬度先减小后增大。当SA与SSPS质量比为3∶1时,稻虾米淀粉中的抗性淀粉含量较高,淀粉凝胶复合体系的吸水性指数、溶解率和膨胀度最大,硬度最小,能有效抑制稻虾米淀粉回生及改善其凝胶特性。

关键词：稻虾米淀粉海藻多糖可溶性大豆多糖理化特性消化特性

Design and analysis of an untethered micro flapping robot which can glide on the water

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Science China(Technological Sciences) 2022年第8期65卷 1749-1759页

作者： CHEN YanHong LIU YiDe LIU TaiShan LI hua qu ShaoXing YANG Wei State Key Laboratory of Fluid Power&Mechatronic System Key Laboratory of Soft Machines and Smart Devices of Zhejiang ProvincesCenter for X-MechanicsDepartment of Engineering MechanicsZhejiang UniversityHangzhou 310027China

Flapping-wing flying insects possess various advantages,such as high agility and efficiency.The design and manufacture of insect-scale flapping-wing micro aerial vehicle(FWMAV)have attracted increasing attention in recent decades.Due to the limitations of size and weight,the FWMAV with an onboard battery which can fully mimic insect flight has not been achieved.In this work,we design and fabricate a highly integrated flapping-wing microrobot named Robomoth.The Robomoth consists of a carbon chassis,customized power and control devices,and two piezoelectric ceramic actuators symmetrically distributed in the thorax and controlled individually.It weighs 2.487 g,spans 5.9 cm in length,possesses 9 cm of wingspan,and carries a 0.355 g rechargeable lithium battery.We demonstrate the mobility of the Robomoth through untethered gliding and making turns on the water surface.A simplified dynamic model of the flapping system is proposed to explain the relationship between the driving frequency and the flapping amplitude.The Robomoth is one new untethered bioinspired flapping-wing robot that can perform stable water surface motion,which holds potential applications such as search and rescue on the water.The robot can also provide insight for designing insect-scale flying vehicles.

关键词： micro/nanorobots biologically inspired robots flapping-wing flying piezoelectric ceramic actuator

Tfh/Tfr细胞免疫平衡在血液恶性肿瘤中的研究进展

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中国现代医学杂志 2024年第13期34卷 57-62页

作者：张冉冉张瑞曲建华新疆医科大学第一附属医院血液病中心(新疆维吾尔自治区血液病研究所) 新疆乌鲁木齐830054

滤泡辅助性T细胞(Tfh)和滤泡调节性T细胞(Tfr)是新发现的具有相互拮抗作用的CD4+T细胞亚群。在淋巴结生发中心发挥功能和体液免疫形成过程中,Tfh细胞辅助浆细胞的抗体生成,而Tfr细胞具有抑制Tfh细胞和B细胞功能。Tfh/Tfr细胞免疫平衡对... 详细信息

滤泡辅助性T细胞(Tfh)和滤泡调节性T细胞(Tfr)是新发现的具有相互拮抗作用的CD4+T细胞亚群。在淋巴结生发中心发挥功能和体液免疫形成过程中,Tfh细胞辅助浆细胞的抗体生成,而Tfr细胞具有抑制Tfh细胞和B细胞功能。Tfh/Tfr细胞免疫平衡对维持生发中心的形成、诱导B细胞成熟及抗体的产生等具有十分重要的意义。Tfh/Tfr细胞平衡与自身免疫疾病、实体肿瘤及部分血液系统疾病的进展密切相关,而其在血液恶性肿瘤中的作用尚不清楚。该文就Tfh/Tfr细胞的免疫平衡紊乱在血液恶性肿瘤中的最新研究进展进行综述,为恶性血液肿瘤的发病机制和免疫治疗指明新的方向。

关键词：骨髓增生异常综合征淋巴瘤多发性骨髓瘤白血病滤泡辅助性T细胞滤泡调节性T细胞

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我国基层医疗诊断编码实施现况与优化策略

中国全科医学 2024年第16期27卷 1935-1941页

作者：周英达瞿怡倩李笑飞卓书雄杨郗金花于德华上海市普陀区真如镇街道社区卫生服务中心 200333 上海市浦东新区南码头社区卫生服务中心 200125 同济大学附属杨浦医院全科医学科上海市200090 同济大学医学院全科医学研究中心上海市200090 上海市全科医学与社区卫生发展研究中心 200090

随着基层医药卫生体制改革的不断深化,基层卫生信息标准化建设愈发被重视。基层医疗诊断编码作为基层卫生信息化建设的重要环节,在提高基层医疗管理效率、促进基层医疗质量控制、有效收集基层医疗数据等方面都起着至关重要的作用。但我... 详细信息

随着基层医药卫生体制改革的不断深化,基层卫生信息标准化建设愈发被重视。基层医疗诊断编码作为基层卫生信息化建设的重要环节,在提高基层医疗管理效率、促进基层医疗质量控制、有效收集基层医疗数据等方面都起着至关重要的作用。但我国长期以来沿用综合性医院使用的疾病分类作为基层医疗诊断编码使用,不仅导致基层医疗诊断不规范、无法统计的混乱状态,更可能造成基层医疗收集、记录、分析的数据出现缺失和误差。本文通过梳理国内外基层医疗诊断编码发展的历史沿革,指出当前我国基层医疗诊断编码所面临的5个主要问题:各方对基层医疗诊断编码的重视程度不足、缺乏统一的基层医疗诊断编码导致我国基层医疗功能与质量发展受限、我国基层医疗诊断编码与何种国际基层分类匹配存在分歧、基层医疗诊断编码本土化面临的诸多挑战及我国缺乏评价与优化基层医疗诊断编码的人才与工具。并在此基础上,结合国外基层医疗诊断编码的发展过程,提出我国各方应重视基层医疗诊断编码的发展,在进一步推动基层医疗信息建设与国际接轨的同时,基于目前试行的国际疾病分类编码(ICD)-11与基层医疗保健国际分类(ICPC)-3分类尽快制定全国统一的基层医疗诊断编码标准,并通过建立健全的基层医疗诊断编码人才培养体系,为我国基层医疗诊断编码的进一步实施和优化提供保障。

关键词：临床编码诊断编码基层医疗国际疾病分类法疾病分类信息标准化建设卫生服务管理

Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS-CoV-2 Omicron strain infection in China:A national multicenter survey of 35,566 individuals

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 113-120页

作者： Meng-Fan Liu Rui-Xia Ma Xian-Bao Cao hua Zhang Shui-Hong Zhou Wei-Hong Jiang Yan Jiang Jing-Wu Sun Qin-Tai Yang Xue-Zhong Li Ya-Nan Sun Li Shi Min Wang Xi-Cheng Song Fu-quan Chen Xiao-Shu Zhang Hong-quan Wei Shao-Qing Yu Dong-Dong Zhu Luo Ba Zhi-Wei Cao Xu-Ping Xiao Xin Wei Zhi-Hong Lin Feng-Hong Chen Chun-Guang Shan Guang-Ke Wang Jing Ye Shen-Hong qu Chang-Qing Zhao Zhen-Lin Wang hua-Bin Li Feng Liu Xiao-Bo Cui Sheng-Nan Ye Zheng Liu Yu Xu Xiao Cai Wei huang Ru-Xin Zhang Yu-Lin Zhao Guo-Dong Yu Guang-Gang Shi Mei-Ping Lu Yang Shen Yu-Tong Zhao Jia-Hong Pei Shao-Bing Xie Long-Gang Yu Ye-Hai Liu Shao-Wei Gu Yu-Cheng Yang Lei Cheng Jian-Feng liu Graduate School of Beijing University of Chinese Medicine BeijingChina Department of Otorhinolaryngology Head and Neck Surgery China-Japan Friendship HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First People's Hospital of YinchuanYinchuanChina Department of Otorhinolaryngology The First People's Hospital of Yunnan ProvinceKunmingChina Department of Otorhinolaryngology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Xiangya Hospital Central South UniversityChangshaChina Department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Qingdao UniversityQingdaoChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of USTCHefeiChina Department of Otorhinolaryngology Head and Neck Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Qilu Hospital of Shandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Otolaryngology The Second Hospital of Shandong UniversityShandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery Peking University People's HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery Yantai Yuhuangding HospitalQingdao UniversityYantaiChina Department of Otorhinolaryngology Head and Neck Surgery Xijing HospitalThe Fourth Military Medical UniversityXi'anChina Gansu Provincial Center for Disease Control and Prevention LanzhouChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of China Medical UniversityShenyangChina Department of Otorhinolaryngology Head and Neck Surgery Tongji Hospit

Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in China.Methods:This study was conducted by 45 tertiary Grade-A hospitals in China.Online and offline questionnaire data were obtained from patients infected with COVID-19 between December 28,2022,and February 21,2023.The collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory disorders.Results:Complete questionnaires were obtained from 35,566 subjects.The overall incidence of olfactory and taste dysfunction was 67.75%.Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste dysfunction.Having received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such dysfunction.Before infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the survey.The median duration of dysosmia and dysgeusia was 15 and 12 days,respectively,with 0.5%of patients having symptoms lasting for more than 28 days.The overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying symptoms.Conclusions:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in China.Incidence and prognosis are influenced by several factors,including sex,SARS-CoV-2 vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.

关键词： epidemiologic studies incidence olfactory disorders prognosis SARS-CoV-2 taste disorders

基于智能手机的可视化生物传感器在即时检测中的研究进展

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分析化学 2024年第2期52卷 145-156页

作者：向宪昕孙华悦柴会宁喻琨曲丽君张光耀张学记青岛大学纺织服装学院智能可穿戴技术研究中心省部共建生物多糖纤维成形与生态纺织国家重点实验室青岛理工大学环境与市政工程学院深圳大学生物医学工程学院

人体生理指标是衡量健康与否的重要标准。传统的检测方法通常要求单独的实验室、复杂的操作流程且耗费较长的检测时间，难以满足快速诊断和居家健康监测的需求，因此亟需开发便携、快速和精准的现场检测技术。即时检测（Point-of-care t... 详细信息

人体生理指标是衡量健康与否的重要标准。传统的检测方法通常要求单独的实验室、复杂的操作流程且耗费较长的检测时间，难以满足快速诊断和居家健康监测的需求，因此亟需开发便携、快速和精准的现场检测技术。即时检测（Point-of-care testing, POCT）区别于传统实验室检测的主要特征是不需要实验室繁杂的分析过程即可实现生物分子的快速原位检测。智能手机作为日常生活广泛使用的通讯工具，具有独立的操作系统，内置存储功能，还配备高清摄像头，在POCT可视化检测方面有巨大的应用潜力。将各种生物传感技术与智能手机相结合已经发展成为POCT领域的一个新方向。本文对近年来基于智能手机的可视化生物传感器在POCT中的研究进展进行了评述，包括比色传感器、荧光传感器、化学发光传感器和电化学发光传感器等，总结了目前基于智能手机可视化生物传感器在POCT应用中面临的问题，并对其未来发展前景进行了展望。

关键词：智能手机可视化生物传感器即时检测评述

Different compression sutures combined with intracameral air injection for acute corneal hydrops

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International Journal of Ophthalmology(English edition) 2022年第9期15卷 1538-1543页

作者： Xin Liu hua Li Shen qu Qiao Yu Hui Lin Yan-Long Bi Department of Ophthalmology Tongji HospitalSchool of MedicineTongji UniversityShanghai 200092China Department of Ophthalmology Guizhou Provincial People’s HospitalGuiyang 550002Guizhou ProvinceChina

·AIM:To evaluate the efficacy and safety of full-thickness sutures combined with intracameral air injection(FTS-AI)versus pre-Descemet’s membrane sutures combined with intracameral air injection(PDS-AI)in the management of acute corneal hydrops in keratoconus.·METHODS:The research included 8 patients(8 eyes)suffering from acute corneal hydrops caused by keratoconus.Four patients were randomly assigned to FTS-AI.And the other four were randomly assigned to PDS-AI.Corneal oedema,visual acuity,corneal thickness were assessed during follow-up.·RESULTS:The demographics,preoperative duration of symptoms and severity of corneal hydrops between the two groups were not significantly different.The mean corneal oedema resolution time after FTS-AI and PDSAI were 11±1.15 and 15±1.41 d,respectively(P=0.005).The maximum corneal thickness of the scarred region decreased in both groups at one week postoperatively(P<0.05).No obvious difference was found in the mean maximal corneal thickness between the two groups postoperatively.The BCVA improved significantly after FTS-AI and PDS-AI at three months postoperatively.No obvious difference was found in the BCVA after FTS-AI and PDS-AI at three months postoperatively.·CONCLUSION:FTS-AI and PDS-AI are safe and effective therapies to accelerate the resolution of corneal oedema in acute corneal hydrops secondary to keratoconus.Despite faster resolution of corneal oedema in the FTS-AI group,we recommend PDS-AI to avoid potential endothelium cell damage.

关键词： keratoconus acute corneal hydrops fullthickness sutures pre-Descemet’s membrane sutures intracameral air injection

小麦烯醇化酶基因ENO2的可变翻译分析和原核表达

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生物技术通报 2024年第5期40卷 112-119页

作者：张娜刘梦楠屈展帆崔祎平倪嘉瑶王华忠天津师范大学生命科学学院天津市动植物抗性重点实验室天津300387

【目的】鉴定重要农作物小麦(Triticum aestivum L.)上参与糖酵解的烯醇化酶家族成员ENO2编码基因TaENO2,分析TaENO2的可变翻译特征及产物蛋白的烯醇化酶活性。【方法】采用生物信息学方法鉴定小麦基因组中的TaENO2基因;选择1个TaENO2... 详细信息

【目的】鉴定重要农作物小麦(Triticum aestivum L.)上参与糖酵解的烯醇化酶家族成员ENO2编码基因TaENO2,分析TaENO2的可变翻译特征及产物蛋白的烯醇化酶活性。【方法】采用生物信息学方法鉴定小麦基因组中的TaENO2基因;选择1个TaENO2为代表,以原生质体为受体通过外源表达方法分析该基因的可变翻译产物,通过原核表达和亲和层析过程纯化该基因的重组蛋白产物并测定其烯醇化酶活性。【结果】小麦的六倍体基因组中含有3个部分同源的TaENO2基因,3个基因的产物蛋白含有保守的烯醇化酶活性中心,编码烯醇化酶蛋白序列第94位甲硫氨酸残基(M94)的ATG密码子(ATG^(M94))是潜在的内部可变翻译起始位点。在原生质体中,外源导入的TaENO2表达出定位于细胞质和细胞核的全长产物烯醇化酶和定位于细胞核的N端截短产物转录抑制因子TaMBP-1两种蛋白,而外源导入的突变ATG^(M94)后的TaENO2基因只表达全长产物烯醇化酶。获得了纯度较高的可溶性重组蛋白GST-TaENO2,该重组蛋白在体外能够催化由2-磷酸-甘油酸(2-PGA)向磷酸烯醇丙酮酸(PEP)转变的烯醇化酶反应。【结论】小麦基因组含有3个烯醇化酶ENO2编码基因TaENO2。在外源表达的情况下,TaENO2表现可变翻译特征,可分别从第一起始密码子和内部ATG^(M94)密码子处起始表达出全长形式的烯醇化酶蛋白和N端截短形式的TaMBP-1蛋白。原核表达的重组蛋白GST-TaENO2具有体外烯醇化酶活性。

关键词：小麦烯醇化酶 ENO2 可变翻译原核表达

Isolated scaphoid dislocation:A case report and review of literature

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World Journal of Clinical Cases 2022年第8期10卷 2559-2568页

作者： Si-Da Liu Bao-Sheng Yin Feng Han hua-Jun Jiang Wei qu Department of Orthopedics The First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina

BACKGROUND Isolated dislocations of the scaphoid are extremely rare types of injuries,commonly associated with severe ligament disruptions,and are occasionally misdiagnosed.Treatment options for dislocations of the scaphoid mainly include closed reduction,with or without internal fixation,and open reduction with ligament repair.CASE SUMMARY A 59-year-old male worker sustained a twisting trauma of his right wrist,caused by a moving belt while he was operating a machine.When he presented at our emergency department,the patient complained of swelling,tenderness,and restriction of movement of the right wrist.Radiographs confirmed a primary complex partial radial dislocation of the scaphoid and some chip fractures of the capitate and hamate.Closed reduction with K-wire internal fixation was performed with the assistance of arthroscopy,and an excellent prognosis was achieved.CONCLUSION Arthroscopy-assisted reduction is a minimally invasive method to reduce the dislocated scaphoid and maintain the blood supply.

关键词： Isolated scaphoid dislocation Classification Delayed diagnose Treatment options Wrist arthroscopy Case report