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First-principles study on the electronic structure of Pb_(10−x)Cu_(x)(PO_(4))_(6)O(x=0,1)

Journal of Materials Science & Technology 2024年第4期171卷 66-70页

作者： Junwen Lai Jiangxu Li Peitao Liu Yan Sun Xing-qiu chen Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China

Recently,Lee et *** the experimental discovery of room-temperature ambient-pressure super-conductivity in a Cu-doped lead-apatite(LK-99)(arXiv:2307.12008,arXiv:2307.12037).Remarkably,the claimed superconductivity can persist up to 400 K at ambient *** the experimental im-plication,the electronic structure of LK-99 has not yet been ***,we investigate the electronic structures of LK-99 and its parent compound using first-principles calculations,aiming to elucidate the doping effects of *** results reveal that the parent compound Pb_(10)(PO_(4))_(6)O is an insulator,while Cu doping induces an insulator-metal transition and thus volume *** band structures of LK-99 around the Fermi level are featured by a half-filled flat band and a fully-occupied flat *** two very flat bands arise from both the 2p orbitals of 1/4-occupied O atoms and the hybridization of the 3d orbitals of Cu with the 2p orbitals of its nearest-neighboring O ***,we observe four van Hove singularities on these two flat ***,we show that the flat band structures can be tuned by including electronic correlation effects or by doping different *** find that among the considered doping elements(Ni,Cu,Zn,Ag,and Au),both Ni and Zn doping result in the gap opening,whereas Au exhibits doping effects more similar to Cu than *** work establishes a foundation for fu-ture studies to investigate the role of unique electronic structures of LK-99 in its claimed superconducting properties.

关键词： First-principles calculations Density functional theory Electronic structur e Superconductivity Flat bands Strongly correlated electrons

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Thymic carcinoid with multiple bone metastases:A case report

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World Journal of Clinical Cases 2024年第13期12卷 2275-2280页

作者： Chun-Qiao chen Ming-Yue Huang Min Pan qiu-qiu chen Fei-Fei Wei Hui Huang Department of Oncology People’s Hospital of GuilinGuilin 541000Guangxi Zhuang Autonomous RegionChina

BACKGROUND Thymic carcinoid(TC)is a rare entity among anterior mediastinal *** are neuroendocrine carcinomas that constitute approximately 2%–5%of all thymic epithelial *** SUMMARY The study reported a rare TC with multiple bone metastases.A 77-year-old man presented with a 2-month history of lower back pain and weight loss of 5 *** resonance imaging scans revealed damage to the lumbar spine,sacrocaudal vertebrae and iliac crest,suggesting bone metastasis;computed tomography(CT)scan of the thorax showed a calcified anterior mediastinal mass;positron emission tomography-CT demonstrated multiple abnormal bone signals;and laboratory work-up showed no endocrine ***-needle aspiration biopsy revealed predominantly single small,round to oval cells with scant cytoplasm and some loose clusters,suggesting endocrine *** pathological diagnosis was atypical carcinoid,which tend to originate from the thymus and was classified as intermediate-highly *** patient underwent anlotinib-targeted ***(12 mg)was administered daily for 2 wk,after which the patient was allowed to rest for 21 ***-up CT after one year demonstrated that the tumor had shrunk by approximately 29%after *** has a long stable disease benefit of more than 2.5 *** These findings demonstrated that anlotinib is a promising treatment regimen for patients with TC and multiple bone metastases.

关键词： Thymic carcinoid Anlotinib Multitargeted tyrosine kinase inhibitor Bone metastasis Case report

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Local quantum Fisher information and quantum correlation in the mixed-spin Heisenberg XXZ chain

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Frontiers of physics 2024年第2期19卷 235-245页

作者： Peng-Fei Wei Qi Luo Huang-qiu-chen Wang Shao-Jie Xiong Bo Liu Zhe Sun School of Physics Hangzhou Normal UniversityHangzhou 310036China Zhejiang Institute of Modern Physics and School of Physics Zhejiang UniversityHangzhou 310027China School of Information and Electrical Engineering Hangzhou City UniversityHangzhou 310015China Zhejiang Provincial Key Laboratory of Urban Wetlands and Regional Change Hangzhou 311121China

We study the local quantum Fisher information(LQFI)in the mixed-spin Heisenberg XXZ *** the maximal and minimal LQFI are studied and the former is essential to determine the accuracy of the quantum parameter estimation,the latter can be well used to characterize the discord-type quantum *** investigate the effects of the temperature and the anisotropy parameter on the maximal LQFI and thus on the accuracy of the parameter *** we make use of the minimal LQFI to study the discord-type correlations of different site *** dimensions of the subsystems cause different values of the minimal LQFI which reflects the asymmetry of the discord-type *** addition,the site pairs at different positions of the spin chains have different minimal LQFI,which reveals the influence of the surrounding spins on the bipartite quantum *** results show that the LQFI obtained through a simple calculation process provides a convenient way to investigate the discord-type correlation in high-dimensional systems.

关键词： local quantum Fisher information quantum correlation mixed-spin Heisenberg XXZ chain

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NLRP3-mediated autophagy dysfunction links gut microbiota dysbiosis to tau pathology in chronic sleep deprivation

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Zoological Research 2024年第4期45卷 857-874页

作者： Na Zhao Xiu chen qiu-Gu chen Xue-Ting Liu Fan Geng Meng-Meng Zhu Fu-Ling Yan Zhi-Jun Zhang Qing-Guo Ren Department of Neurology School of MedicineSoutheast UniversityNanjingJiangsu 210009China Department of Neurology Affiliated Zhongda HospitalSoutheast UniversityNanjingJiangsu 210009China

Emerging evidence indicates that sleep deprivation(SD)can lead to Alzheimer’s disease(AD)-related pathological changes and cognitive ***,the underlying mechanisms remain *** the present study,we identified the existence of a microbiota-gut-brain axis in cognitive deficits resulting from chronic SD and revealed a potential pathway by which gut microbiota affects cognitive functioning in chronic *** findings demonstrated that chronic SD in mice not only led to cognitive decline but also induced gut microbiota dysbiosis,elevated NLRP3 inflammasome expression,GSK-3βactivation,autophagy dysfunction,and tau hyperphosphorylation in the *** with the“SD microbiota”replicated the pathological and behavioral abnormalities observed in chronic sleep-deprived ***,both the deletion of NLRP3 in NLRP3-/-mice and specific knockdown of NLRP3 in the hippocampus restored autophagic flux,suppressed tau hyperphosphorylation,and ameliorated cognitive deficits induced by chronic SD,while GSK-3βactivity was not regulated by the NLRP3 inflammasome in chronic ***,deletion of NLRP3 reversed NLRP3 inflammasome activation,autophagy deficits,and tau hyperphosphorylation induced by GSK-3βactivation in primary hippocampal neurons,suggesting that GSK-3β,as a regulator of NLRP3-mediated autophagy dysfunction,plays a significant role in promoting tau ***,gut microbiota dysbiosis was identified as a contributor to chronic SD-induced tau pathology via NLRP3-mediated autophagy dysfunction,ultimately leading to cognitive ***,these findings highlight GSK-3βas a regulator of NLRP3-mediated autophagy dysfunction,playing a critical role in promoting tau hyperphosphorylation.

关键词： Chronic sleep deprivation Tau pathology NLRP3 inflammasome Autophagy GSK-3β Microbiota-gut-brain axis

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Developability assessment of the therapeutic antibodies studies: are they druggable?

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Cancer Advances 2024年第4期7卷 1-10页

作者： chen Fu qiu-chen chen Department of Pharmacology School of PharmacyChina Medical UniversityShenyang 110122China Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation China Medical UniversityShenyang 110122China

In recent years,with the continuous development of biotechnology and medical science and technology,therapeutic antibodies,as new biologics,have shown great potential and have become a research hotspot in the fields of oncology,autoimmune diseases,cardiovascular and *** antibodies refer to drugs or therapeutic methods for the treatment of diseases with specificity,high affinity and high efficiency antibody molecules prepared by biotechnological *** this paper,we will systematically review the types of therapeutic antibodies,research progress,problems in research and development,mechanisms of action,and challenges faced in clinical applications.

关键词： antibodies therapeutics research and development progress

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Exploration of potential biomarkers and therapeutic targets for trauma-related acute kidney injury

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Chinese Journal of Traumatology 2024年第2期27卷 97-106页

作者： Peng Qi Meng-Jie Huang Wei Wu Xue-Wen Ren Yong-Zhi Zhai chen qiu Hai-Yan Zhu Department of Emergency First Medical Center of Chinese PLA General HospitalBeijing100853China Department of Nephrology.First Medical Center of Chinese PLA General Hospital Beijing100853China Department of Anesthesiology.First Medical Center of Chinese PLA General Hospital Beijing100853China Department of Orthopedics Fourth Medical Center of Chinese PLA General HospitalBeijing100853China

Purpose:Acute kidney injury(AKI)is one of the most common functional injuries observed in trauma ***,certain trauma medications may exacerbate renal ***,the early detection of trauma-related AKI holds paramount importance in improving trauma ***:Qualified datasets were selected from public databases,and common differentially expressed genes related to trauma-induced AKI and hub genes were identified through enrichment analysis and the establishment of protein-protein interaction(PPI)***,the specificity of these hub genes was investigated using the sepsis dataset and conducted a comprehensive literature review to assess their *** raw data from both datasets were downloaded using R software(version 4.2.1)and processed with the"affy"package19 for correction and ***:Our analysis revealed 585 upregulated and 629 downregulated differentially expressed genes in the AKI dataset,along with 586 upregulated and 948 downregulated differentially expressed genes in the trauma ***,the establishment of the PPI network and subsequent topological analysis highlighted key hub genes,including CD44,CD163,TIMP metallopeptidase inhibitor 1,cytochrome b-245 beta chain,versican,membrane spanning 4-domains A4A,mitogen-activated protein kinase 14,and early growth response ***,their receiver operating characteristic curves displayed areas exceeding 75%,indicating good diagnostic ***,our findings postulated a unique molecular mechanism underlying trauma-related ***:This study presents an alternative strategy for the early diagnosis and treatment of trauma-related AKI,based on the identification of potential biomarkers and therapeutic ***,this study provides theoretical references for elucidating the mechanisms of trauma-related AKI.

关键词： Trauma Acutekidney injury Bioinformatic analysis Differentially expressed genes Biomarker

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Developing a diagnostic model for predicting prostate cancer: a retrospective study based on Chinese multicenter clinical data

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Asian Journal of Andrology 2024年第1期26卷 34-40页

作者： Chang-Ming Wang Lei Yuan Xue-Han Liu Shu-qiu chen Hai-Feng Wang Qi-Fei Dong Bin Zhang Ming-Shuo Huang Zhi-Yong Zhang Jun Xiao Tao Tao Department of Urology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Radiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Core Facility Center for Medical Sciences The First Affiliated Hospital of USTcDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Urology Affiliated Zhongda Hospital of Southeast UniversityNanjing 210009China Department of Urology Shanghai East HospitalTongji University School of MedicineShanghai 200120China Department of Urology Shanghai Changhai HospitalSecond Military Medical UniversityShanghai 200000China Department of Urology Affiliated Anhui Provincial Hospital of Anhui Medical UniversityHefei 230001China

The overdiagnosis of prostate cancer(PCa)caused by nonspecific elevation serum prostate-specific antigen(PSA)and the overtreatment of indolent PCa have become a global problem that needs to be solved *** aimed to construct a prediction model and provide a risk stratification system to reduce unnecessary *** this retrospective study,clinical data of 1807 patients from three Chinese hospitals were *** final model was built using stepwise logistic regression *** apparent performance of the model was assessed by receiver operating characteristic curves,calibration plots,and decision curve ***,a risk stratification system of clinically significant prostate cancer(csPCa)was created,and diagnosis-free survival analyses were *** multivariable screening and evaluation of the diagnostic performances,a final diagnostic model comprised of the PSA density and Prostate Imaging-Reporting and Data System(PI-RADS)score was *** validation in the development cohort and two external cohorts showed excellent discrimination and ***,we created a risk stratification system using risk thresholds of 0.05 and 0.60 as the cut-off *** follow-up results indicated that the diagnosis-free survival rate for csPCa at 12 months and 24 months postoperatively was 99.7%and 99.4%,respectively,for patients with a risk threshold below O.05 after the initial negative prostate biopsy,which was significantly better than patients with higher *** diagnostic model and risk stratification system can achieve a personalized risk calculation of *** provides a standardized tool for Chinese patients and physicians when considering thenecessity of prostatebiopsy.

关键词： nomogram prostate biopsy prostate cancer Prostate Imaging-Reporting and Data System prostate-specific antigen density

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Incidence and warning signs for complications of human brucellosis: a multi-center observational study from China

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Infectious Diseases of Poverty 2024年第1期13卷 53-62页

作者： Qing-Nan Shi Hui-Jie Qin Qiao-Shan Lu hu Li Zhong-Fa Tao Meng-Guang Fan Mu-Heta Aishan Zeng-Qiang Kou qiu-Lan chen Wen-Wu Yin Yan-Ping Zhang National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases Chinese Center for Disease Control and PreventionChangbai RoadChangping DistrictBejing 102206China School of Public Health Guangxi Medical UniversityNanningChina Nanning Center for Disease Control and Prevention NanningChina Guizhou Center for Disease Control and Prevention GuiyangChina Inner Mongolia Center for Disease Control and Prevention HohhotChina Xinjiang Uighur Autonomous Region Center for Disease Control and Prevention UrumqiChina Shandong Center for Disease Control and Prevention JinanChina

Background Brucellosis is a severe zoonotic disease that is often overlooked, particularly in impoverished countries. Timely identification of focal complications in brucellosis is crucial for improving treatment outcomes. However, there is currently a lack of established indicators or biomarkers for diagnosing these complications. Therefore, this study aimed to investigate potential warning signs of focal complications in human brucellosis, with the goal of providing practical parameters for clinicians to aid in the diagnosis and management of *** A multi-center cross-sectional study was conducted in China from December 2019 to August 2021. The study aimed to investigate the clinical characteristics and complications of patients with brucellosis using a questionnaire survey and medical record system. The presence of warning signs for complications was assessed using univariate and multivariate logistic regression models. Receiver operating characteristic (ROC) curves and the area under the curve (AUC) were used for variable screening and model *** A total of 880 participants diagnosed with human brucellosis were enrolled. The median age of the patients was 50 years [interquartile range (IQR): 41.5-58.0], and 54.8% had complications. The most common organ system affected by complications was the osteoarticular system (43.1%), with peripheral arthritis (30.0%), spondylitis (16.6%), paravertebral abscess (5.0%), and sacroiliitis (2.7%) being the most prevalent. Complications in other organ systems included the genitourinary system (4.7%), respiratory system (4.7%), and hematologic system (4.6%). Several factors were found to be associated with focal brucellosis. These factors included a long delay in diagnosis [odds ratio (OR) = 3.963, 95% confidence interval(CI): 1.906-8.238 for > 90 days], the presence of underlying disease (OR = 1.675, 95%CI: 1.176-2.384), arthralgia (OR = 3.197, 95%CI: 1.986-5.148), eye bulging pain (OR = 3.482, 95%CI:

关键词： Brucellosis Complications Clinical spectrum Warning signs

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Loss of monopolar spindle-binding protein 3B expression promotes colorectal cancer malignant behaviors by activation of target of rapamycin kinase/autophagy signaling

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World Journal of Gastroenterology 2024年第26期30卷 3229-3246页

作者： Juan Sun Jin-Xiu Zhang Meng-Shi Li Meng-Bin Qin Ruo-Xi cheng Qing-Ru Wu qiu-Ling chen Dan Yang Cun Liao Shi-Quan Liu Jie-An Huang Department of Gastroenterology The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530007Guangxi Zhuang Autonomous RegionChina Department of Colorectal&Anal Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Monopolar spindle-binding protein 3B(MOB3B)functions as a signal transducer and altered MOB3B expression is associated with the development of human *** To investigate the role of MOB3B in colorectal cancer(CRC).METHODS This study collected 102 CRC tissue samples for immunohistochemical detection of MOB3B expression for association with CRC *** overexpression and knockdown of MOB3B expression were induced in CRC cell lines,changes in cell viability,migration,invasion,and gene expression were *** cell autophagy was detected using transmission electron microscopy,while nude mouse xenograft experiments were performed to confirm the in-vitro *** MOB3B expression was reduced in CRC vs normal tissues and loss of MOB3B expression was associated with poor CRC *** of MOB3B protein in vitro attenuated the cell viability as well as the migration and invasion capacities of CRC cells,whereas knockdown of MOB3B expression had the opposite effects in CRC *** the molecular level,microtubule-associated protein light chain 3 II/I expression was elevated,whereas the expression of matrix metalloproteinase(MMP)2,MMP9,sequestosome 1,and phosphorylated mechanistic target of rapamycin kinase(mTOR)was downregulated in MOB3B-overexpressing RKO *** contrast,the opposite results were observed in tumor cells with MOB3B *** nude mouse data confirmed these in-vitro findings,i.e.,MOB3B expression suppressed CRC cell xenograft growth,whereas knockdown of MOB3B expression promoted the growth of CRC cell *** Loss of MOB3B expression promotes CRC development and malignant behaviors,suggesting a potential tumor suppressive role of MOB3B in CRC by inhibition of mTOR/autophagy signaling.

关键词： Colorectal cancer Monopolar spindle-binding protein 3B Mechanistic target of rapamycin kinase Autophagy Prognosis

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Phospholipase A2 enzymes PLA2G2A and PLA2G12B as potential diagnostic and prognostic biomarkers in cholangiocarcinoma

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 289-306页

作者： chen qiu Yu-Kai Xiang Xuan-Bo Da Hong-Lei Zhang Xiang-Yu Kong Nian-Zong Hou cheng Zhang Fu-Zhou Tian Yu-Long Yang Center of Gallbladder Disease Shanghai East HospitalInstitute of Gallstone DiseaseSchool of MedicineTongji UniversityShanghai 200092China General Surgery Center Chengdu Military General HospitalChengdu 610083Sichuan ProvinceChina

BACKGROUND Phospholipase A2(PLA2)enzymes are pivotal in various biological processes,such as lipid mediator production,membrane remodeling,bioenergetics,and maintaining the body surface ***,these enzymes play a significant role in the development of diverse *** To systematically and comprehensively explore the expression of the PLA2 family genes and their potential implications in cholangiocarcinoma(CCA).METHODS We conducted an analysis of five CCA datasets from The Cancer Genome Atlas and the Gene Expression *** study identified differentially expressed genes between tumor tissues and adjacent normal tissues,with a focus on PLA2G2A and *** Set Enrichment Analysis was utilized to pinpoint associated ***,relevant hub genes and microRNAs for PLA2G2A and PLA2G12B were predicted,and their correlation with the prognosis of CCA was *** PLA2G2A and PLA2G12B were discerned as differentially expressed in CCA,manifesting significant variations in expression levels in urine and serum between CCA patients and healthy *** expression of PLA2G2A was correlated with poorer overall survival in CCA ***,the study delineated pathways and miRNAs associated with these *** Our findings suggest that PLA2G2A and PLA2G12B may serve as novel potential diagnostic and prognostic markers for *** increased levels of these genes in biological fluids could be employed as non-invasive markers for CCA,and their expression levels are indicative of prognosis,underscoring their potential utility in clinical settings.

关键词： PLA2G2A PLA2G12B Diagnostic Prognostic biomarkers cholangiocarcinoma

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