Developability assessment of the therapeutic antibodies studies: are they druggable?

作     者：Chen Fu Qiu-Chen Chen 

作者机构：Department of PharmacologySchool of PharmacyChina Medical UniversityShenyang 110122China Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluationChina Medical UniversityShenyang 110122China 

出 版 物：《Cancer Advances》 (TMR肿瘤进展)

年 卷 期：2024年第7卷第4期

页      面：1-10页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Shenyang City-School Joint Funding Project(No.2400022093) Liaoning Province Education Department Scientific Research Funding Project(No.LJKZ0777) 

主　　题：antibodies therapeutics research and development progress 

摘      要：In recent years,with the continuous development of biotechnology and medical science and technology,therapeutic antibodies,as new biologics,have shown great potential and have become a research hotspot in the fields of oncology,autoimmune diseases,cardiovascular and *** antibodies refer to drugs or therapeutic methods for the treatment of diseases with specificity,high affinity and high efficiency antibody molecules prepared by biotechnological *** this paper,we will systematically review the types of therapeutic antibodies,research progress,problems in research and development,mechanisms of action,and challenges faced in clinical applications.