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Research on software development of air temperature prediction in coal face

Journal of Coal Science & Engineering(China) 2011年第3期17卷 294-297页

作者： qin yue-ping liu hong-bo wang ke liu jiang-yue State key Laboratory of Coal Resources and Safe Mining China University of Mining and Technology （Beijing） Beijing 100083 China

With ever-increasing depth of coal mine and the continuous improvement of mechanization, heat damage has become one of the major disasters in coal mine exploitation. Established the temperature prediction models suitable for different kinds of tunnels through analysis of the heat of shafts, roadways and working faces. The average annual air temperature prediction equation from the inlets of shafts to the working faces was derived. The formula was deduced using combine method of iteration and direct calculation. The method can improve the precision of air temperature prediction, so we could establish the whole pathway air temperature prediction model with high precision. Emphasizing on the effects of leakage air to air temperature of working face and using the ideology of the finite difference method and considering the differential equation of inlet and outlet at different stages, this method can significantly improve the accuracy of temperature prediction. Program development uses Visual Basic 6.0 Language, and the Origin software was used to fit the relevant data. The predicted results shows that the air temperature generally tends to rapidly increase in the air inlet, then changes slowly on working face, and finally increases sharply in air outlet in the condition of goaf air leakage. The condition is in general consistent with the air temperature change tendency of working face with U-type ventilation system. The software can provide reliable scientific basis for reasonable ventilation, cooling measures and management of coal mine thermal hazards.

关键词： finite difference method coal face air temperature prediction prediction methods

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In-flight Energy Calibration of the GECAM Gamma-ray Detectors

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Research in Astronomy and Astrophysics 2024年第10期24卷 48-57页

作者： Rui Qiao Dong-Ya Guo Wen-Xi Peng Yan-Qiu Zhang Shuo Xiao Shao-Lin Xiong Chao Zheng Chao-Yang Li Jia-Cong liu wang-Chen Xue Jian-Jian He Zheng-Hua An Da-Li Zhang Xin-Qiao Li Li-Ming Song Shi-Jie Zheng ke Gong Ya-qing liu Xin-Ying Song Xiao-Yun Zhao Xiang-Yang Wen Yan-Bing Xu Xiang Ma Xiao-bo Li ping wang yue Huang Ce Cai Qi-Bin Yi Yi Zhao Chen-Wei wang Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China China West Normal University Nanchong 637002China Xiangtan University Xiangtan 411105China Beijing Normal University Beijing 100875China

The Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)mission is designed to monitor the Gamma-Ray Bursts(GRBs)associated with gravitational waves and other high-energy transient *** mission consists of two microsatellites which are planned to operate at the opposite sides of the *** GECAM satellite could detect and localize GRBs in about 8 keV-5 MeV with its 25 Gamma-Ray Detectors(GRDs).In this work,we report the in-flight energy calibration of GRDs using the characteristic gamma-ray lines in the background spectra,and show their performance evolution during the commissioning ***,a preliminary cross-calibration of energy response with Fermi GBM data is also presented,validating the energy response of GRDs.

关键词： (stars:)gamma-ray burst:general instrumentation:detectors methods:data analysis

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Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da Tang Yong-Hao Chen Jing-Yu Tang Rui-Rui Fan Qiang Li Gong Li Dong liu Zheng-Yao Jin Xing-Zhu Cui Tian-Xiang Chen Yi-Wei Yang Rong liu Han Yi Yang Li Zhen Yang Qi An Hao-Fan Bai jiang-bo Bai Jie Bao ping Cao Qi-ping Chen Zhen Chen Zeng-Qi Cui An-Chuan Fan Chang-qing Feng Fan-Zhen Feng ke-qing Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-Cheng He Yang hong Yi-Wei Hu Han-Xiong Huang Wei-Hua Jia Hao-yu jiang Wei jiang Zhi-jie jiang Ling Kang bo Li Chao Li Jia-Wen Li Xiao Li Jie liu Shu-Bin liu Guang-Yuan Luan Chang-Jun Ning Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Xin Tan Li-Jiao wang Peng-Cheng wang Zhao-Hui wang Zhong-Wei Wen Xiao-Guang Wu Xuan Wu Li-Kun Xie Yong-Ji Yu Guo-Hui Zhang Lin-Hao Zhang Mo-Han Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-Liang Zhang yue Zhang Zhi-Yong Zhang Mao-Yuan Zhao Lu-ping Zhou Zhi-Hao Zhou ke-Jun Zhu Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China State key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry Laboratory University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the China Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method

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Study of the response of 10B-doped MCP to wide-energy range neutrons from eV to MeV

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Nuclear Science and Techniques 2024年第8期35卷 132-141页

作者： Qiang Li Li‑Jiao wang Xiang‑Biao Qiu Jing‑Wen Li Wei Xu Tao Li Ze‑Bin Lin Chang‑Jun Ning Yong‑Hao Chen Rui‑Rui Fan Kang Sun Jing‑Yu Tang Rong Zhang Han‑Tao Jing bo Mei Qi An Hao‑Fan Bai jiang‑bo Bai Jie Bao ping Cao Qi‑ping Chen Zhen Chen Zeng‑Qi Cui An‑Chuan Fan Chang‑qing Feng Fan‑Zhen Feng ke‑qing Gao Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑Cheng He Yang hong Yi‑Wei Hu Han‑Xiong Huang Wei‑Hua Jia Hao‑Yu jiang Wei jiang Zhi‑Jie jiang Zheng‑Yao Jin Ling Kang bo Li Chao Li Gong Li Jia‑Wen Li Xiao Li Yang Li Jie liu Rong liu Shu‑Bin liu Guang‑Yuan Luan Bin‑Bin Qi Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑Hui Song Zhi‑Xin Tan Sheng‑Da Tang Peng‑Cheng wang Zhao‑Hui wang Zhong‑Wei Wen Xiao‑Guang Wu Xuan Wu Li‑Kun Xie Yi‑Wei Yang Han Yi Yong‑Ji Yu Guo‑Hui Zhang Lin‑Hao Zhang Mo‑Han Zhang Qi‑Wei Zhang Xian‑Peng Zhang Yu‑Liang Zhang yue Zhang Zhi‑Yong Zhang Mao‑Yuan Zhao Lu‑ping Zhou Zhi‑Hao Zhou ke‑Jun Zhu Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China North Night Vision Science&Technology(Nanjing)Research Institute Co.Ltd. Nanjing 211106China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temporal resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCP with 10 mol%10B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the China Spallation Neutron *** neutron detection efficiency was calibrated at 1 eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 10 B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.

关键词： Neutron radiation image 10B-doped MCP Neutron response Wide-energy range neutrons

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10B-doped MCP detector developed for neutron resonance imaging at Back-n white neutron source

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Nuclear Science and Techniques 2024年第8期35卷 58-68页

作者： Qiang Li Li‑Jiao wang Jing‑Yu Tang Xiang‑Biao Qiu Zhen Chen Mao‑Yuan Zhao Chang‑Jun Ning Kai Pan Wei Xu Tao Li Su‑Peng Lu Han Yi Rui‑Rui Fan Chang‑qing Feng Rong Zhang Xiao‑Yang Sun Qi An Hao‑Fan Bai jiang‑bo Bai Jie Bao ping Cao Qi‑ping Chen Yong‑Hao Chen Zeng‑Qi Cui An‑Chuan Fan Fan‑Zhen Feng Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑Cheng He Yang hong Yi‑Wei Hu Han‑Xiong Huang Wei jiang Zhi‑Jie jiang Zheng‑Yao Jin Ling Kang bo Li Gong Li Xiao Li Yang Li Jie liu Rong liu Shu‑Bin liu Yi‑Na liu Guang‑Yuan Luan Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑Hui Song Kang Sun Zhi‑Xin Tan Sheng‑Da Tang Jin‑Cheng wang Peng‑Cheng wang Zhao‑Hui wang Zhong‑Wei Wen Xiao‑Guang Wu Xuan Wu Cong Xia Yong‑Ji Yu Guo‑Hui Zhang Hang‑Chang Zhang Lin‑Hao Zhang Qi‑Wei Zhang Xian‑Peng Zhang Yu‑Liang Zhang yue Zhang Zhi‑Yong Zhang Zhi‑Hao Zhou ke‑Jun Zhu Chong Zou Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China North Night Vision Science and Technology(Nanjing)Research Institute Co.Ltd Nanjing 211106China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China China Academy of Engineering Physics Institute of Nuclear Physics and ChemistryMianyang 621900China USTC archaeometry lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China China Shipbuilding Trading Co. LtdBeijing 100044China

Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron *** complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and ***,the progression of NRI technology has been sluggish since its inception in the 1980s,particularly considering the limited studies analyzing the neutron energy range above *** white neutron source(Back-n)at the China Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to ***-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low *** this study,we report the development of a 10B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the *** heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1–100 eV energy range;the more difficult medium-weight elements such as iron,copper,and aluminum with resonance peaks in the 1–100 keV energy range can also be *** particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time.

关键词： Neutron resonance imaging 10B doped MCP detector White neutron source Sample nuclide identification

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The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-Yun Zhao Shao-Lin Xiong Xiang-Yang Wen Xin-Qiao Li Ce Cai Shuo Xiao Qi Luo Wen-Xi Peng Dong-Ya Guo Zheng-Hua An ke Gong Jin-Yuan Liao Yan-Qiu Zhang yue Huang Lu Li Xing Wen Fei Zhang Jing Duan Chen-Wei wang Dong-Li Shi Peng Zhang Qi-Bin Yi Chao-Yang Li Yan-Bing Xu Xiao-Hua Liang Ya-qing liu Da-Li Zhang Xi-Lei Sun Fan Zhang Gang Chen Huan-Yu wang Sheng Yang Xiao-Jing liu Min Gao Mao-Shun Li Jin-Zhou wang Xing Zhou Yi Zhao wang-Chen Xue Chao Zheng Jia-Cong liu Xing-bo Han Jin-Ling Qi Jia Huang ke-ke Zhang Can Chen Xiong-Tao Yang Dong-Jie Hou Yu-Sa wang Rui Qiao Xiang Ma Xiao-bo Li ping wang Xin-Ying Song Li-Ming Song Shi-Jie Zheng Bing Li hong-Mei Zhang yue Zhu Wei Chen Jian-Jian He Zhen Zhang Jin Hou hong-Jun wang Yan-Chao Hao Xiang-Yu wang Zong-Yuan Yang Zhi-Long Wen Zhi Chang Yuan-Yuan Du Rui Gao Xiao-Fei Lan Yan-Guo Li Gang Li Xu-Fang Li Fang-Jun Lu hong Lu Bin Meng Feng Shi Hui wang Hui-Zhen wang Yu-Peng Xu Jia-Wei Yang Xue-Juan Yang Shuang-Nan Zhang Chao-yue Zhang Cheng-Mo Zhang Zhi-Cheng Tang Cheng Cheng key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun University of Science and Technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

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基于功效实验-网络药理学-HPLC探讨大黄-桃仁配伍活血化瘀的物质基础及分子作用机制

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药学学报 2024年第7期59卷 2126-2134页

作者：朱琳刘莹申洁李柏睿岳可心沈霞平凡陕西中医药大学药学院陕西西咸新区712046 陕西省秦岭中草药应用开发工程技术研究中心陕西西咸新区712046 西安交通大学第一附属医院药学部陕西西安710061

本研究整合功效实验、网络药理学和HPLC探讨大黄-桃仁药对(Rhei Radix et Rhizoma-Persicae Semen combination,RRR-PS)配伍发挥活血化瘀作用的功效物质群及分子作用机制。建立大鼠血瘀证模型,进行血液流变指标和凝血四项综合评价,结果... 详细信息

本研究整合功效实验、网络药理学和HPLC探讨大黄-桃仁药对(Rhei Radix et Rhizoma-Persicae Semen combination,RRR-PS)配伍发挥活血化瘀作用的功效物质群及分子作用机制。建立大鼠血瘀证模型,进行血液流变指标和凝血四项综合评价,结果显示,与模型组相比,RRR-PS组大鼠的全血黏度、血沉、红细胞聚集指数等指标均明显回调(P<0.01)。网络药理学发现RRR-PS通过作用于钙调蛋白1(CALM1)、一氧化氮合酶2(NOS2)、糖皮质激素受体(NR3C1)等靶点,调控血小板活化、过氧化物酶体增殖物激活受体(PPAR)、血管内皮生长因子(VEGF)等信号通路发挥活血化瘀的功效,并发现关键成分:番泻苷B、儿茶素、大黄素、大黄酚、大黄酸、芦荟大黄素、大黄素甲醚、没食子酸。运用HPLC探究关键成分的溶出率,结果发现RRR-PS配伍后,儿茶素、大黄素、大黄酚、大黄素甲醚4种主要功效物质含量均显著提高(P<0.01)。综上所述,RRR-PS活血化瘀功效显著,其作用机制与促进血管生成、抗凝血、抗血栓、抗炎有关;功效发挥与RRR-PS配伍后,溶剂系统改变,儿茶素、大黄素、大黄酚、大黄素甲醚大量溶出相关。研究结果可进一步为后续RRR-PS配伍活血化瘀功效物质及作用机制研究提供参考。动物实验已获得陕西中医药大学实验动物委员会批准(批准号:SUCMDL20210309002)。

关键词：大黄-桃仁药对血瘀证活血化瘀分子机制中药功效物质

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Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS-CoV-2 Omicron strain infection in China:A national multicenter survey of 35,566 individuals

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 113-120页

作者： Meng-Fan liu Rui-Xia Ma Xian-Bao Cao Hua Zhang Shui-hong Zhou Wei-hong jiang Yan jiang Jing-Wu Sun qin-Tai Yang Xue-Zhong Li Ya-Nan Sun Li Shi Min wang Xi-Cheng Song Fu-Quan Chen Xiao-Shu Zhang hong-Quan Wei Shao-qing Yu Dong-Dong Zhu Luo Ba Zhi-Wei Cao Xu-ping Xiao Xin Wei Zhi-hong Lin Feng-hong Chen Chun-Guang Shan Guang-ke wang Jing Ye Shen-hong Qu Chang-qing Zhao Zhen-Lin wang Hua-Bin Li Feng liu Xiao-bo Cui Sheng-Nan Ye Zheng liu Yu Xu Xiao Cai Wei Huang Ru-Xin Zhang Yu-Lin Zhao Guo-Dong Yu Guang-Gang Shi Mei-ping Lu Yang Shen Yu-Tong Zhao Jia-hong Pei Shao-Bing Xie Long-Gang Yu Ye-Hai liu Shao-Wei Gu Yu-Cheng Yang Lei Cheng Jian-Feng liu Graduate School of Beijing University of Chinese Medicine BeijingChina Department of Otorhinolaryngology Head and Neck Surgery China-Japan Friendship HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First People's Hospital of YinchuanYinchuanChina Department of Otorhinolaryngology The First People's Hospital of Yunnan ProvinceKunmingChina Department of Otorhinolaryngology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Xiangya Hospital Central South UniversityChangshaChina Department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Qingdao UniversityQingdaoChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of USTCHefeiChina Department of Otorhinolaryngology Head and Neck Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Qilu Hospital of Shandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Otolaryngology The Second Hospital of Shandong UniversityShandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery Peking University People's HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery Yantai Yuhuangding HospitalQingdao UniversityYantaiChina Department of Otorhinolaryngology Head and Neck Surgery Xijing HospitalThe Fourth Military Medical UniversityXi'anChina Gansu Provincial Center for Disease Control and Prevention LanzhouChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of China Medical UniversityShenyangChina Department of Otorhinolaryngology Head and Neck Surgery Tongji Hospit

Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in ***:This study was conducted by 45 tertiary Grade-A hospitals in *** and offline questionnaire data were obtained from patients infected with COVID-19 between December 28,2022,and February 21,*** collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory ***:Complete questionnaires were obtained from 35,566 *** overall incidence of olfactory and taste dysfunction was 67.75%.Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste *** received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such *** infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the *** median duration of dysosmia and dysgeusia was 15 and 12 days,respectively,with 0.5%of patients having symptoms lasting for more than 28 *** overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying ***:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in *** and prognosis are influenced by several factors,including sex,SARS-CoV-2 vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.

关键词： epidemiologic studies incidence olfactory disorders prognosis SARS-CoV-2 taste disorders

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Intensivists’response to hyperoxemia in mechanical ventilation patients:The status quo and related factors

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World Journal of Emergency Medicine 2021年第3期12卷 202-206页

作者： Zi-wei ke yue jiang Ya-ping Bao Ye-qin Yang Xiao-mei Zong Min liu Xiang-yun Guan Zhong-qiu Lu Department of Emergency Medicine the First Affi liated Hospital of Wenzhou Medical UniversityWenzhou 325000China Department of Nursing Taizhou Hospital of Zhejiang ProvinceTaizhou 317000China Operating Room the First Affi liated Hospital of Wenzhou Medical UniversityWenzhou 325000China Faculty of Nursing Wenzhou Medical UniversityWenzhou 325000China Yiwu Hospital Affi liated to Wenzhou Medical University Yiwu 322000China

BACKGROUND:Due to the still sparse literature in China,the investigation of hyperoxemia management is ***,we aim to conduct a retrospective study to provide more information about hyperoxemia management in intensive care unit(ICU)***:We retrospectively screened the medical records of adult patients(age≥18 years)who required mechanical ventilation(MV)≥24 hours from January 1,2018,to December 31,*** arterial blood gas(ABG)tested during MV was retrieved,and MV settings were *** median arterial partial pressure of oxygen(PaO2)>120 mmHg(1 mmHg=0.133 kPa)was defined as mild to moderate hyperoxemia,and PaO2>300 mmHg as extreme ***’response to hyperoxemia was assessed based on the reduction of fraction of inspired oxygen(FiO2)within one hour after hyperoxemia was *** logistic regression analysis was performed to determine the independent factors associated with the intensivists’response to ***:A total of 592 patients were fi nally *** median Acute Physiology and Chronic Health Evaluation II(APACHE II)score was 21(15-26).The PaO2,arterial oxygen saturation(SaO2),FiO2,and positive end expiratory pressure(PEEP)were 96.4(74.0-126.0)mmHg,97.8%(95.2%-99.1%),0.4(0.4-0.5),and 5(3-6)cmH2O,*** 174(29.39%)patients had PaO2>120 mmHg,and 19(3.21%)patients had extreme hyperoxemia at PaO2>300 *** cases of mild to moderate hyperoxemia with FiO2≤0.4,only 13(2.20%)patients had a decrease in FiO2 within one *** multivariable logistic regression analysis showed that a positive response was independently associated with FiO2(odds ratio[OR]1.09,95%confi dence interval[CI]1.06-1.12,P<0.001),PaO2(OR 1.01,95%CI 1.00-1.01,P=0.002),and working shifts(OR 5.09,95%CI 1.87-13.80,P=0.001).CONCLUSIONS:Hyperoxemia occurs frequently and is neglected in most cases,particularly when mild to moderate hyperoxemia,hyperoxemia with lower FiO2,hyperoxemia during night and middle-night shif

关键词： Mechanical ventilation Hyperoxemia Fraction of inspired oxygen Arterial blood gas Intensive care unit

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Potential quality evaluation approach for the absolute growth years’ wild and transplanted Astragali Radix based on anti-heart failure efficacy

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Chinese Journal of Natural Medicines 2020年第6期18卷 460-471页

作者： LI ke ZHANG Rui LI Shu-Ying liu yue-Tao LI Ai-ping liu Xiao-Jie DU Guan-Hua qin Xue-Mei Modern Research Center for Traditional Chinese Medicine Shanxi UniversityTaiyuan 030006China College of Chemistry and Chemical Engineering Shanxi UniversityTaiyuan 030006China key Laboratory of Chemical Biology and Molecular Engineering Ministry Shanxi UniversityTaiyuan 030006China Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

The quality of Astragali Radix(AR) was closely related to the growth period. However, the current commodity grades of AR were only divided by diameter but not directly related to the growth period, which leads to the contradiction between the grade standard and the quality evaluation index. Therefore, solving this problem will be the key for the quality evaluation of AR. The present study established a potential quality evaluation approach for the absolute growth years’ wild Astragali Radix(WAR) and transplanted Astragali Radix(TAR) based on the chemical components and anti-heart failure efficacy through adopting a bare-handed sections approach to rapidly identify the growth years of WAR. In this study, the absolute growth years of WAR were obtained by identifying the growth rings of 1–6 growth years root through the methods. The contents of flavonoids and saponins in 2–6 growth years’ WAR were determined by HPLC-UV-ELSD. The contents of 12 chemical components and the anti-fatigue failure effects of WAR(4-year-old)and TAR were compared on rat models of heart failure induced by doxorubicin. Meanwhile, NMR-based untargeted metabolomics studies were performed to investigate the regulative effects of WAR and TAR. The result shows that the numbers of growth rings were consistent with the actual growth periods of AR. The HPLC-UV-ELSD determination indicated that the content of total flavonoids in WAR was significantly higher than that in TAR. Pharmacodynamics analysis revealed that the effects of WAR on cardiac function parameters(EF, FS and LVIDs), contents of serum CK and BNP were superior to those of TAR. 13 metabolites of heart were identified that had a higher rate of change in WAR group than TAR. Overall, a rapid identification method for the growth years of WAR was established, and the fact that WAR were significantly better than TAR in the heart failure rats was first proved in the paper. This study provided a scientific basis for establishing a novel commodity sp

关键词： Astragali Radix Growth rings Chemical analysis Anti-heart failure

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