检索结果-南通市图书馆

Study of station and attitude maneuver of submergence rescue vehicle

在线全文

学校读者我要写书评

暂无评论

Journal of Marine Science and Application 2007年第1期6卷 15-20页

作者： zheng Ke-wei bian xin-qian SHI Xiao-cheng College of Automation Harbin Engineering University Harbin 150001 China

It is an important control process to operate motion of an submergence rescue vehicle(SRV). Seeing that the motion of the submergence rescue vehicle is special, it is necessary to employ non-linear predictive control system. For this reason, continuous dynamic performance of the system, the logical components and the operative restraints are expressed as the non-linear equations of state with the inequality restraints, and the model principle of hybrid system is introduced. The conclusion shows that it comes true to exactly control position and attitude of the SRV by means of non-linear model predictive control. The test in a model basin has also proved that the above methods are efficient.

关键词： naval gun lock-breechblock cam artillery cartridge extractor

Impact of EBV infection and immune function assay for lymphoproliferative disorder in pediatric patients after liver transplantation: A single-center experience

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2020年第1期19卷 3-11页

作者： Tian qin Xiang-qian Gu Seog-Song Jeong Yan-Yan Song Jin-Chuan Liu Jian-xin zheng Feng Xue qiang Xia Department of Liver Surgery Renji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200127China Department of Biostatistics Institute of Medical SciencesShanghai Jiaotong University School of MedicineShanghai 200025China

Background:Post-transplant lymphoproliferative disorder(PTLD)is a lethal complication after pediatric liver transplantation,but information regarding risk factors for the development of PTLD remains *** study was to identify characteristics and risk factors of ***:A total of 705 pediatric patients who underwent liver transplantation between January 2017 and October 2018 were *** of clinical characteristics and Epstein-Barr virus(EBV)infection on the development of PTLD was *** addition,ImmuKnow assay was adopted in partial patients to analyze the immune ***:Twenty-five(3.5%)patients suffered from PLTD with a median time of 6 months(3–14 months)after *** high tacrolimus(TAC)level was found in 2 fatal cases at PTLD *** infection was found in 468(66.4%)patients.A higher peak EBV DNA loads(>9590 copies/mL)within 3 months was a significant indicator for the onset of *** addition,the ImmuKnow assay demonstrated that overall immune response was significantly lower in patients with EBV infection and PTLD(P<0.0001).The cumulative incidence of PTLD was also higher in patients with lower ATP value(≤187 ng/mL,P<0.05).Conclusions:A careful monitoring of EBV DNA loads and tacrolimus concentration might be supportive in prevention of PTLD in pediatric patients after liver *** addition,application of the ImmuKnow assay may provide guidance in reducing immunosuppressive agents in treatment of PTLD.

关键词： Post-transplant lymphoproliferative disor Pediatric liver transplantation Epstein-Barr virus

Proteomic Analysis of Cucumber Defense Rresponses Induced by Propamocarb

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2013年第11期12卷 2022-2035页

作者： WU Peng qin Zhi-wei WU Tao ZHOU Xiu-yan xin Ming GUO qian-qian College of Horticulture Northeast Agricultural University

Propamocarb is an agricultural chemical that has been widely used to protect cucumber plants from downy mildew. To understand the mechanisms of cucumber defense responses to propamocarb, we investigated the physiological and proteomic responses of the cucumber line D0351 with propamocarb application. We found that after treatment with propamocarb, the activities of detoxifying enzymes （glutathione reductase, GR; glutathione S-tramsferase, GST） and soluble sugar content of cucumber fruit were signiifcantly increased, but malonaldehyde （MDA） content was signiifcantly reduced. To identify components of propamocarb responsive signaling, we compared the high resolution two-dimensional gel electrophoresis （2-DE） protein proifles of control and propamocarb-treated fruits, and identiifed 18 differentially expressed （13 up-regulated and 5 down-regulated） proteins induced by propamocarb which were determined by matrix-assisted laser desorption/ionization time-of-lfight mass spectrometry （MALDI-TOF-MS）. The majority of the proteins had functions related to detoxication, energy and transport, protein biosynthesis, regulating reactions and defending against stresses. A real-time quantitative reverse transcriptional-polymerase chain reaction （qRT-PCR） was used to compare transcript and protein accumulation patterns for 18 candidate proteins, and the expression of 14 was consistent at both transcript and protein levels. The responses of cucumber proteome to propamocarb seemed complex; the identified proteins may play an important role in regulating adaptation activities following exposure to propamocarb. Data presented herein may shed light on understanding cucumber fruit defense responses under propamocarb treatment.

关键词： cucumber fungicide propamocarb proteomics qRT-PCR

基于试井法的水驱气藏水侵识别及水侵规律研究

在线全文

学校读者我要写书评

暂无评论

中外能源 2025年第1期30卷 57-64页

作者：范昭宇王琴宋兆杰张骞韩鑫周鑫中海石油(中国)有限公司海南分公司海南海口570300 中国石油大学(北京)非常规油气科学技术研究院北京102249

为尽可能避免因气井过早见水造成气藏采收率降低,采用不稳定试井法研究水侵过程气水边界的动态变化,采用数值试井法研究气藏的水侵规律。结果表明,气藏水侵后体现为能量补给,压力导数曲线末端下掉;从气区到水侵区后流体流动性变差,压力... 详细信息

为尽可能避免因气井过早见水造成气藏采收率降低,采用不稳定试井法研究水侵过程气水边界的动态变化,采用数值试井法研究气藏的水侵规律。结果表明,气藏水侵后体现为能量补给,压力导数曲线末端下掉;从气区到水侵区后流体流动性变差,压力导数曲线末端上翘。边、底水推进在气井试井曲线上的动态反映特征使压力导数曲线呈现时间差异性,水离气井越近,压力导数变化时间越早。单一方向水驱的边水响应特征是压力导数曲线上翘,环绕水驱的边水响应特征是压力导数曲线先下凹后上翘。在相同累产下,配产越高,气水边界距离越小,气水边界推进速度越快。采气速度越大,无水采气时间越短。无水采出程度随采气速度的增大先上升后下降。在相同采出程度下,采气速度越高,气水边界推进速度越快;储层渗透率越大,气水边界距离越小,气水边界推进速度越快。

关键词：不稳定试井数值试井水驱气藏水侵采出程度气水边界

Quantitative analysis of retinal intermediate and deep capillary plexus in patients with retinal deep vascular complex ischemia

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2021年第7期14卷 1025-1033页

作者： xin-xin Li Tian-Wei qian Ya-Nan Lyu Xun Xu Su-qin Yu Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong UniversityShanghai 200080China National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus DiseaseShanghai 200080China Shanghai Engineering Center for Visual Science and Photomedicine Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghai 200080China

AIM: To quantitatively analyze the retinal intermediate and deep capillary plexus(ICP and DCP) in patients with retinal deep vascular complex ischemia(RDVCI), using 3D projection artifacts removal(3D PAR) optical coherence tomography angiography(OCTA).METHODS: RDVCI patients and gender-and agematched healthy controls were assessed and underwent OCTA examinations. The parafoveal vessel density(PFVD) of retinal deep vascular complex(DVC), ICP, and DCP were analyzed, and the percentage of reduction(PR) of PFVD was ***: Twenty-four eyes in 22 RDVCI patients(20 in acute phase and 4 in chronic phase) and 24 eyes of 22 healthy subjects were enrolled as the control group. Significant reduction of PFVD in DVC, ICP, and DCP was observed in comparison with the controls(DVC: acute: 43.59%±6.58% vs 49.92%±5.49%, PR=12.69%;chronic: 43.50%±3.33% vs 51.20%±3.80%, PR=15.04%. ICP: acute: 40.28%±7.91% vs 46.97%±7.14%, PR=14.23%;chronic: 41.48%±2.87% vs 46.43%±3.29%, PR=10.66%. DCP: acute: 45.44%±8.27% vs 51.51%±9.97%, PR=11.79%;chronic: 37.78%±3.48% vs 51.73%±5.17%, PR=26.97%;all P<0.05). No significant PR difference was found among DVC, ICP, and DCP of RDVCI in acute phase(P=0.812), but significant difference in chronic phase(P=0.006, DVC vs DCP, ICP vs DCP). No significant difference in PR between acute and chronic phases in the DVC(P=0.735) or ICP(P=0.681) was found, but significant difference in the DCP(P=0.041).CONCLUSION: The PFVD of DVC, ICP, and DCP in RDVCI is significantly decreased in both acute and chronic phases. ICP impairment is stabilized from acute to chronic phase in RDVCI, whereas subsequent DCP impairment is uncovered and can be explained by ischemia-reperfusion damage.

关键词： intermediate and deep capillary plexus 3D projection artifacts removal optical coherence tomography angiography retinal deep vascular complex ischemia

Simulation on venting process and valve opening control method for gas trunk pipelines

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2022年第6期19卷 3016-3028页

作者： Li-Li Zuo An-Tai Jin qian Chen qin-Long Dong Yuan-xin Li Si-Rui Zhao National Engineering Laboratory for Pipeline Safety/Beijing Key Laboratory of Urban Oil and Gas Distribution Technology China University of Petroleum(Beijing)Beijing102249China Petro China Planning&Engineering Institute Beijing100083China National Petroleum and Natural Gas Pipe Network Group Beijing Pipeline Co. Ltd.Beijing100101China

Determining the venting time of a gas trunk pipeline segment provides an important basis for formulating an emergency plan in the advent of unexpected *** the natural gas venting process corresponds to the transient flow,it is necessary to establish a transient hydraulic-thermal simulation model in order to determine the venting *** this paper,based on two kinds of venting scenarios in which there is only one venting point in the venting system of a gas trunk pipeline segment—namely,where the venting point is either at one of the two ends or at the junction of two gas trunk pipeline segments—transient hydraulic-thermal simulation models are *** models consist of gas flow governing equations,the gas state equation,gas physical property equations,initial conditions,and appropriate boundary *** implicit central difference method is used to discretize the gas flow partial differential equations,and the trust-region-dogleg algorithm is used to solve the equations corresponding to each time step,in order to dynamically simulate the whole venting *** judgment condition for the end of the venting process is that the average pressure of gas trunk pipeline segment is less than 0.11 MPa(actual pressure).Comparing the simulation results of the proposed model with those of the OLGA software and real operational data,we find that the venting time error is less than 10%.On this basis,a venting valve opening control principle is proposed,which prevents the venting noise from exceeded the specified noise value(85 d B)in the venting design of domestic gas pipeline *** established calculation model for venting time(dynamic simulation model)for a gas trunk pipeline segment and the proposed opening control principle of venting valve provide reference for the optimal operation of gas pipeline venting systems.

关键词： Gas pipeline Venting time Transient simulation Implicit central difference method Valve Opening Control Method

Numerical investigation on the fatigue failure characteristics of waterbearing sandstone under cyclic loading

在线全文

学校读者我要写书评

暂无评论

Journal of Mountain Science 2021年第12期18卷 3348-3365页

作者： ZHU Chun HE Man-chao JIANG Bei qin xin-zhan YIN qian ZHOU Yu School of Earth Sciences and Engineering Hohai UniversityNanjing 210098China State Key Laboratory for Geomechanics&Deep Underground Engineering Beijing 100083China Key Laboratory of Rock Mechanics and Geohazards of Zhejiang Province Shaoxing UniversityShaoxing 312000China School of Civil Environmental and Mining EngineeringThe University of AdelaideAdelaide 5005SAAustralia

The strength of sandstone decreases significantly with higher water content attributing to softening *** scenario can pose a severe threat to the stability of reservoirs of pumped storage power stations developed from abandoned mines,especially when subjected to the cyclic loading condition caused by the repeated drainage and storage of water(fatigue damage).Based on this,it is essential to focus on the fatigue failure *** this study,the mineral composition of the used sandstone of Ruineng coal mine in Shanxi Province,China,was first tested to elucidate the rock softening mechanism after absorbing ***,a numerical model for replicating the mechanical behavior of water-bearing sandstone was established using twodimensional particle flow code(PFC2D)with a novel contact ***,16 uniaxial cyclic loading simulations with distinct loading parameters related to reservoir conditions(loading frequency,amplitude level,and maximum stress level)and different water contents were *** numerical results show that all these three loading parameters affect the failure characteristics of sandstone,including irreversible strain,damage evolution,strain behavior,and fatigue *** influence degree of these three parameters on failure behavior increases in the order of maximum stress level,loading frequency,and amplitude ***,for the samples with different water contents,their failure characteristics are similar under the same loading ***,the failure mode is almost unaffected by the loading parameters,while the water content plays a significant role and causing the transformation from the tensile splitting with low water content to the shear failure with higher water content.

关键词： Discrete element simulation Waterbearing sandstone Cyclic loading parameters Fatigue failure characteristics Water content

Role of transport polarization in electrocatalysis:A case study of the Ni-cluster/Graphene interface

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2021年第33期92卷 120-128页

作者： Fang bian xin Ge Wu Shan Shan Li Gao Wu qin Xiang Ying Meng Yin Wang Hong Wei Yang School of Materials Science and Engineering Northeastern UniversityShenyang 110819China College of Sciences Northeastern UniversityShenyang 110819China Research Center for Metallic Wires Northeastern UniversityShenyang 110819China The State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China International Centre of Quantum and Molecular Structures and Department of Physics Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals Kunming Precious Metals New Materials Technology Co.Ltd.Kunming 650106China

As cathodes,iron-series(Fe,Co,Ni)clusters supported by carbon materials exhibit outstanding electrocatalytic reduction activities in many electrocatalytic *** date,this general characteristic of ironseries clusters that should be related to the inherent attributes of these electrodes has not been fully understood from the perspectives of thermodynamics and electronic structure *** transport is a necessary process in electrocatalysis,and therefore,the study of the change of the electronic state in electron transport is beneficial for understanding this general characteristic of iron-series cluster *** this work,the electron transport properties,including the conductivity and transport spin-polarization at the Ni-cluster/graphene interface are carefully investigated as an example of carbon-supported iron-series *** first-principles calculations within the framework of the nonequilibrium Green’s function density functional theory(NEGF-DFT),we reveal that the electronic transport states of the coupled Ni-cluster/graphene are strongly changed compared to those of their isolated Ni-cluster and graphene *** is found that graphene dominates the overall conductivity of the interface,while the morphology of Ni-clusters controls the spin polarization *** spin polarization can lead to the self-excitation effect of the electrons that raises the energy of the electronic system,improves the thermodynamics of the reduction reaction and promotes catalytic *** work hints that iron-series elements(Fe,Co,Ni)based electrodes may generally show transport polarization that is likely to give rise to a high electrocatalytic reduction activity and such transport polarizability can be used as a new factor in the further exploration and design for electrocatalytic materials.

关键词： First-principles calculations electrocatalysis non-equilibrium electron injection transport polarization Ni-cluster/graphene

Interaction between insulin-like growth factor binding protein-related protein 1 and transforming growth factor beta 1 in primary hepatic stellate cells

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2017年第4期16卷 395-404页

作者： Xiu-qing Li qian-qian Zhang Hai-Yan Zhang Xiao-Hong Guo Hui-qin Fan Li-xin Liu Department of Gastroenterology and Hepatology The First Clinical Hospital of Shanxi Medical University Experimental Center of Science and Research The First Clinical Hospital of Shanxi Medical University Key Laboratory of Cell Physiology Provincial Department of the Ministry of EducationShanxi Medical UniversityTaiyuan 030001China

BACKGROUND: We previously showed that insulin-like growth factor binding protein-related protein 1 (IGFBPrP1) is a novel mediator in liver fibrosis. Transforming growth factor beta 1 (TGF beta 1) is known as the strongest effector of liver fibrosis. Therefore, we aimed to investigate the detailed interaction between IGFBPrP1 and TGF beta 1 in primary hepatic stellate cells (HSCs). METHODS: We overexpressed TGF beta 1 or IGFBPrP1 and inhibited TGF beta 1 expression in primary HSCs for 6, 12, 24, 48, 72, and 96 hours to investigate their interaction and observe the accompanying expressions of a-smooth muscle actin (alpha-SMA), collagen I, fibronectin, and phosphorylated-mothers against decapentaplegic homolog 2/3 (p-Smad2/3). RESULTS: We found that the adenovirus vector encoding the TGF beta 1 gene (AdTGF beta 1) induced IGFBPrP1 expression while that of alpha-SMA, collagen I, fibronectin, and TGF beta 1 increased gradually. Concomitantly, AdIGFBPrP1 upregulated TGF beta 1, alpha-SMA, collagen I, fibronectin, and p-Smad2/3 in a time-dependent manner while IGFBPrP1 expression was decreased at 96 hours. Inhibition of TGF beta 1 expression reduced the IGFBPrP1-stimulated expression of alpha-SMA, collagen I, fibronectin, and p-Smad2/3. CONCLUSIONS: These findings for the first time suggest the existence of a possible mutually regulation between IGFBPrP1 and TGF beta 1, which likely accelerates liver fibrosis progression. Furthermore, IGFBPrP1 likely participates in liver fibrosis in a TGF beta 1-depedent manner, and may act as an upstream regulatory factor of TGF beta 1 in the Smad pathway.

关键词： insulin-like growth factor binding protein related protein 1 transforming growth factor in primary hepatic stellate cells alpha-smooth muscle actin extracellular matrix Smad pathway