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Activation of TRPV4 inhibits delayed rectifier voltage-gated potassium channels in hippocampal pyramidal neurons

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Activation of TRPV4 inhibits delayed rectifier voltage-gated...

Recent progress in constructing fluorinated solid-electrolyte interphases for stable lithium metal anodes

2019中国生理学会学术年会暨张锡钧基金第十五届全国青年优秀生理学学术论文交流会及第十三届全国青年生理学工作者学术会议

作者：周丽 Weixing Xu yaoyao qin Dong An Lei Chen Department of Physiology Nanjing Medical University

Voltage-gated potassium channels(VGPCs) play an important role in regulating neuronal *** of VGPCs mediates outward potassium(K+) current, which is responsible for membrane repolarization and thus controls the duration, shape and firing frequency of action potentials(APs).In hippocampal neurons, voltage-gated potassium current consists of two components: the delayed rectifier(IK) and fast transient K+ current(IA), which can be separated by their biophysical and pharmacologic *** of TRPV4 has been reported to modulate hippocampal neuronal excitability, but whether activation of TRPV4 could modulate IK in hippocampal neurons remained *** this reason, we explored the effect of TRPV4 activation on IK in hippocampal pyramidal neurons and on the expression of delayed rectifier K+ channel subunits in ***, we reported that application of TRPV4 agonist GSK1016790 A markedly decreased IK in hippocamal CA1 pyramidal neurons and this effect could be blocked by TRPV4 specific antagonist HC-067047 or ***1016790 A had no effect on the voltagedependent activation curve of IK but shifted the voltage-dependent inactivation curve to the hyperpolarizing *** also found that GSK1016790 A-induced inhibition of IK was markedly attenuated by extracellular regulated protein kinase(ERK) antagonist U0126, but was unaffected by protein kinase C or protein kinase A antagonist, indicating that ERK signaling pathway is selectively involved in TRPV4 activation-induced inhibition of ***, the protein levels of Kv1.1 and Kv1.2 in hippocampus decreased in the mice that were intracerebroventricularly injected with GSK1016790 *** conclude that activation of TRPV4 may inhibit delayed rectifier potassium channels function and expression in hippocampus, which may slow down the repolarization of *** present results provide more evidence for the mechanisms underlying TRPV4-regulated hippocampal neuronal excitability.

关键词： transient receptor potential vanilloid 4 delayed rectifier voltage-gated potassium channel hippocampus

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 270-291页

作者： Di Zhang Pengfei Lv Wei qin Xin He Yuanhua He Civil Aircraft Fire Science and Safety Engineering Key Laboratory of Sichuan Province College of Civil Aviation Safety EngineeringCivil Aviation Flight University of ChinaGuanghan 618307China School of Chemical Engineering Sichuan UniversityChengdu 610065China

Lithium metal batteries(LMBs)are emerging as a promising energy storage solution owing to their high energy density and specific ***,the non-uniform plating of lithium and the potential rupture of the solid-electrolyte interphase(SEI)during extended cycling use may result in dendrite growth,which can penetrate the separator and pose significant short-circuit *** a stable SEI is essential for the long-term operation of the ***-rich SEI has garnered significant attention for its ability to effectively passivate electrodes,regulate lithium deposition,and inhibit electrolyte *** the structural components and preparation methods of existing fluorinated SEI is crucial for optimizing lithium metal anode *** paper reviews the research on optimizing LiF passivation interfaces to protect lithium metal *** focuses on four types of compositions in fluorinated SEI that work synergistically to enhance SEI *** instance,combining compounds with LiF can further enhance the mechanical strength and ionic conductivity of the *** metals with LiF significantly improves electrochemical performance at the SEI/anode interface,with a necessary focus on reducing electron tunneling ***,incorporating polymers with LiF offers balanced improvements in interfacial toughness and ionic conductivity,though maintaining structural stability over long cycles remains a critical area for future *** alloys combined with LiF increase surface energy and lithium affinity,challenges such as dendrite growth and volume expansion *** summary,this paper emphasizes the crucial role of interfacial structures in LMBs and offers comprehensive guidance for future design and development efforts in battery technology.

关键词： LiF lithium metal anodes solid-electrolyte interphase interface cycling stability

Electrocatalytic cleavage of a lignin β-O-4 model compound and coupling with nitrogen-containing aromatics using Prussian blue analogue-derived nickel–cobalt spinel

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Journal of Energy Chemistry 2025年第1期100卷 628-636页

作者： Yi Qi Xueying Chen Bowen Liu Xuliang Lin Xueqing Qiu Yanlin qin Guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light Industry Guangdong University of Technology Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Guangdong Basic Research Center of Excellence for Ecological Security and Green Development Guangdong University of Technology

Electrochemical conversion of lignin for the production of high-value heterocyclic aromatic compounds has great *** demonstrate the targeted synthesis and cation modulation of NiCo2O4spinel nanoboxes,synthesized via cation exchange and calcination *** catalysts exhibit excellent efficacy in the electrocatalytic conversion of lignin model compounds,specifically 2-phenoxy-1-phenylethanol,into nitrogen-containing aromatics,achieving high conversion rates and *** catalysts were synthesized via a cation exchange and calcination oxidation process,using Prussian blue nanocubes as *** porous architecture and polymetallic composition of the NiCo2O4spinel demonstrated superior performance in electrocatalytic oxidative coupling,achieving a 99.2 wt%conversion rate of the 2-phenoxy-1-phenylethanol with selectivities of 37.5 wt%for quinoline derivatives and 31.5 wt%for *** innovations include the development of a sustainable one-pot synthesis method for quinoline derivatives,the elucidation of a multistage reaction pathway involving CAO bond cleavage,hydroxyaldol condensation,and CAN bond formation,and a deeper mechanistic understanding derived from DFT *** work establishes a new strategy for lignin valorization,offering a sustainable route to produce high-value nitrogen-containing aromatics from renewable biomass under mild conditions,without the need for additional reagents.

关键词： Spinel Biomass valorization Electrocatalysis Lignin oxidation Coupling

The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying Chen Yinyi Xiong qin Zhou Ling-Qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian qin Yuxin Jin Yiming qin Feifei Yuan Hongbin Lu Jianzhong Hu Yong Cao Chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

目标导向液体治疗对老年患者长时间腹部手术后急性肾损伤的影响

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中华麻醉学杂志 2024年第2期44卷 155-159页

作者：秦窈窈郑兰张鼎新张鹏慧李廉钰张佳齐张玮玮山西医科大学麻醉学院太原030001 山西医科大学第五临床医学院、山西省人民医院麻醉科太原030012

目的评价目标导向液体治疗(GDFT)对老年患者长时间腹部手术后急性肾损伤(AKI)的影响。方法通过电子病历数据库检索2016年10月1日至2022年6月30日在山西省人民医院择期首次接受腹部手术的老年胃肠道肿瘤患者,性别不限,年龄≥65岁,手术时... 详细信息

目的评价目标导向液体治疗(GDFT)对老年患者长时间腹部手术后急性肾损伤(AKI)的影响。方法通过电子病历数据库检索2016年10月1日至2022年6月30日在山西省人民医院择期首次接受腹部手术的老年胃肠道肿瘤患者,性别不限,年龄≥65岁,手术时间≥8 h,ASA分级Ⅱ或Ⅲ级。根据术中是否采用GDFT分为常规液体治疗组(C组)和GDFT组(G组)。C组术中维持BP≥90/60 mmHg或MAP≥65 mmHg,尿量≥30 ml/h。G组维持SVV≤13%、CI≥2.5 L·min^(-1)·m^(-2)。记录患者一般资料、术中液体使用量、尿量、出血量、血管活性药物使用情况、腹腔热灌注情况和手术时间;记录术后72 h内AKI及术后其他并发症(肺炎、吻合口瘘、手术部位感染、感染性休克、心律失常)的发生情况,记录术后住院时间以及术后30 d死亡情况。结果共纳入125例患者,C组41例,G组84例。19例患者发生术后AKI,发生率为15.2%。与C组比较,G组术中晶体液用量、总输液量、尿量减少,血管活性药物使用率增加(P0.05)。结论 GDFT可降低老年患者长时间腹部手术后AKI的发生风险。

关键词：补液疗法老年人急性肾损伤预后腹部肿瘤

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超声测量气道参数预测困难面罩通气的准确性

中华麻醉学杂志 2023年第10期43卷 1210-1213页

作者：张佳齐张玮玮郭浩薛莹高建辉秦窈窈王妮荣余淑珍山西医科大学麻醉学院太原030001 山西医科大学第五临床医学院、山西省人民医院麻醉科太原030012

目的评价超声测量气道参数预测困难面罩通气(DMV)的准确性。方法择期行气管插管全麻手术患者96例,年龄18~90岁,BMI 16~39 kg/m2,ASA分级Ⅰ或Ⅱ级。术前1 d时行临床气道评估,记录改良Mallampati分级、甲颏间距和上唇咬合试验分级。麻醉... 详细信息

目的评价超声测量气道参数预测困难面罩通气(DMV)的准确性。方法择期行气管插管全麻手术患者96例,年龄18~90岁,BMI 16~39 kg/m2,ASA分级Ⅰ或Ⅱ级。术前1 d时行临床气道评估,记录改良Mallampati分级、甲颏间距和上唇咬合试验分级。麻醉诱导前30 min采用超声测量髁状突活动度、舌纵截面积及舌横径,计算舌体积(舌纵截面积与舌横径的乘积)。麻醉诱导后行面罩通气,面罩通气困难分级≥Ⅲ级为DMV,根据是否发生DMV分为2组:非DMV组(NDMV组)和DMV组。将组间差异有统计学意义的临床气道评估指标和超声测量气道参数与DMV行Spearman相关分析;采用受试者工作特征曲线下面积(AUC)评价各指标预测DMV的准确性,确定临界值,计算准确率、灵敏度、特异度、阳性预测值和阴性预测值。结果改良Mallampati分级、上唇咬合试验分级、舌纵截面积、舌横径、舌体积与DMV呈正相关,甲颏间距和髁状突活动度呈负相关(P70%,特异度均>90%,阳性预测值分别为92.31%、88.46%。结论超声测量髁状突活动度和舌体积可准确预测DMV。

关键词：超声检查呼吸,人工喉面罩预测

Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi Han Tang Jianian Hu Siying Kang Song qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

The gut-eye axis:from brain neurodegenerative diseases to age-related macular degeneration

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Neural Regeneration Research 2025年第10期20卷 2741-2757页

作者： Qianzi Jin Suyu Wang Yujia Yao qin Jiang Keran Li Department of Ophthalmology The Affiliated Eye Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina The Fourth School of Clinical Medicine Nanjing Medical UniversityNanjingJiangsu ProvinceChina

Age-related macular degeneration is a serious neurodegenerative disease of the retina that significantly impacts ***,the specific pathogenesis remains unclear,and effective early treatment options are consequently *** microbiome is defined as a large ecosystem of microorganisms living within and coexisting with a *** intestinal microbiome undergoes dynamic changes owing to age,diet,genetics,and other *** dysregulation of the intestinal flora can disrupt the microecological balance,resulting in immunological and metabolic dysfunction in the host,and affecting the development of many *** recent decades,significant evidence has indicated that the intestinal flora also influences systems outside of the digestive tract,including the ***,several studies have demonstrated the critical role of the gut-brain axis in the development of brain neurodegenerative diseases,including Alzheimer’s disease and Parkinson’s ***,the role of the“gut-eye axis”has been confirmed to play a role in the pathogenesis of many ocular ***,age-related macular degeneration and many brain neurodegenerative diseases have been shown to share several risk factors and to exhibit comparable *** such,the intestinal flora may play an important role in age-related macular *** the above context,the present review aims to clarify the gut-brain and gut-eye connections,assess the effect of intestinal flora and metabolites on age-related macular degeneration,and identify potential diagnostic markers and therapeutic ***,direct research on the role of intestinal flora in age-related macular degeneration is still relatively limited,while studies focusing solely on intestinal flora are insufficient to fully elucidate its functional role in age-related macular ***-on-a-chip technology has shown promise in clarifying the gut-eye interactions,while integrating analysis of the inte

关键词： age-related macular degeneration biological agents blinding eye disease dietary nutrition fecal microbial transplantation gut-eye axis intestinal flora metabolite microecology neurodegenerative disease