检索结果-南通市图书馆

Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 106-112页

作者： Ren-Yi Su Sun-Bin Ling qiao-Nan Shan Xu-Yong Wei rui Wang Chang-Ku Jia Li Zhuang Tian Shen Li-Min Ding Zhi-Dan Xu Lai-Bang Luo Li-Bo Sun Guang-Ming Li Tai-Shi Fang Nan Jiang Kun Zhang Zhao-Jie Su Zhi-Hai Peng Ren Lang Tao Jiang Qiang He Lin-Sen Ye Yang Yang Yu-Ting He Wen-Zhi Guo liu-Gen Lan Xu-Yong Sun Dong Chen Zhi-Shui Chen Da-Wei Zhou Shao-Jun Ye Qi-Fa Ye Min Tian Jian-Hua Shi Bo Wang Jiang liu Qian Lu Wei Rao Jin-Zhen Cai Tao Lv Jia-Yin Yang Pu-Sen Wang Lin Zhong Jing-Sheng Ma Qi-Gen Li Sheng-Dong Wu Chang-Jiang Lu Cai-De Lu Dong-Hua Zhang Xuan Wang Zi-Qiang Li Mu-Jian Teng Jun-Jie Li Wen-Tao Jiang Jian-Hua Li Quan-Bao Zhang Ning-Qi Zhu Zheng-Xin Wang Kang He Qiang Xia Shao-Hua Song Zhi-Ren Fu Wei Qiu Guo-Yue Lv rui-Peng Song Ji-Zhou Wang Zheng Wang Jian Zhou Gang Chen Ying-Peng Zhao Li Li Ze-Min Hu Qi-Jie Luo Zhong-Zhou Si Bin Xie xiao-Shun He Zhi-Yong Guo Shu-Sen Zheng xiao Xu Department of Hepatobiliary and Pancreatic Surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Transplantation Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China Liver Transplantation Center Beijing You’an HospitalCapital Medical UniversityBeijing 100069China Department of Hepatic Surgery National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518112China Department of General Surgery Xiang’an Hospital of Xiamen UniversityXiamen 361000China Deartment of Hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Hepatic Surgery and Liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Liver Transplantation The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Hepatobiliary Diseases of Wuhan university Transplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary Surgery The First Affiliated Hos

Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.

关键词： Sirolimus Immunosuppressive agents Hepatocellular carcinoma Liver transplantation Conversion

LaCoO_(3)钙钛矿型催化剂的制备及其光催化降解盐酸四环素的研究

在线全文

学校读者我要写书评

暂无评论

现代化工 2023年第3期43卷 163-170页

作者：牛紫嫣郭世龙乔枫瑞王晋杨彩凤王彦谦刘振民高闯基王潇潇太原科技大学化学工程与技术学院煤矸石高值利用山西省重点实验室山西太原030024

以硝酸钴、硝酸镧及柠檬酸为原料,采用水热合成法制备4种不同物质的量的比的钙钛矿型催化剂LaCoO_(3)。利用XRD、SEM、TEM、FT-IR、XPS、H_(2)-TPR等表征手段对合成的钙钛矿型催化剂LaCoO_(3)进行物化性质表征,并以盐酸四环素(TCHC)为... 详细信息

以硝酸钴、硝酸镧及柠檬酸为原料,采用水热合成法制备4种不同物质的量的比的钙钛矿型催化剂LaCoO_(3)。利用XRD、SEM、TEM、FT-IR、XPS、H_(2)-TPR等表征手段对合成的钙钛矿型催化剂LaCoO_(3)进行物化性质表征,并以盐酸四环素(TCHC)为目标降解物,在可见光照射下进行光催化降解反应,并分析光催化降解机理。结果表明,4种催化剂对TCHC的降解率均达到80%以上,在20℃下可见光照射1 h后,n[La(NO_(3))_(3)]∶n[Co(NO_(3))_(2)]∶n(柠檬酸)=1∶1∶6的LaCoO_(3)催化剂对TCHC的降解效果最好,降解率达到89.29%。

关键词：钙钛矿催化剂钴酸镧光催化盐酸四环素

Paired quasi-periodic pulsations of hard X-ray emission in a solar flare

在线全文

学校读者我要写书评

暂无评论

science china(Physics,Mechanics & Astronomy) 2023年第5期66卷 195-206页

作者： Hai-Sheng Zhao Dong Li Shao-Lin Xiong Yan-Qiu Zhang Yang Su Wei Chen Yi Zhao xiao-Bo Li Jia-Cong liu Wen-Xi Peng rui qiao Xin-qiao Li Xiang-Yang Wen Li-Ming Song Shi-Jie Zheng Xin-Ying Song xiao-Yun Zhao Yue Huang Shuang-Nan Zhang Shuo xiao Ce Cai Zheng-Hua An Can Chen Gang Chen Wei Chen Yan-Qi Du Min Gao Ke Gong Dong-Ya Guo Zhi-Wei Guo Jian-Jian He Bin Li Chao Li Chao-Yang Li Gang Li Jian-Hui Li Lu Li Qing-Xin Li Yan-Guo Li Jing Liang xiao-Hua Liang Jin-Yuan Liao xiao-Jing liu Ya-Qing liu Qi Luo Xiang Ma Bin Meng Ge Ou Dong-Li Shi Jing-Yan Shi Gong-Xing Sun Xi-Lei Sun You-Li Tuo Chen-Wei Wang Hui Wang Jin Wang Jin-Zhou Wang Ping Wang Wen-Shuai Wang Hong Wu Sheng-Lun Xie Yan-Bing Xu Yu-Peng Xu Wang-Chen Xue Sheng Yang Min Yao Jian-Ying Ye Qi-Bin Yi Chao-Yue Zhang Da-Li Zhang Fan Zhang Fei Zhang Hong-Mei Zhang Kai Zhang Peng Zhang xiao-Lu Zhang Zhen Zhang Guo-Ying Zhao Shi-Yi Zhao Chao Zheng Xing Zhou Yue Zhu Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China university of Chinese Academy of sciences Beijing 100049China Department of Astronomy Beijing Normal UniversityBeijing 100875China School of Computing and Artificial Intelligence Southwest Jiaotong UniversityChengdu 611756China Physics and Space science College China West Normal UniversityNanchong 637002China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Institute of Astrophysics Central China Normal UniversityWuhan 430079China School of Physics Changchun University of Science and TechnologyChangchun 130022China College of Physics and Engineering Qufu Normal UniversityQufu 273165China College of Physics sciences&technology Hebei UniversityBaoding 071002China

We investigate high time resolution data obtained by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)during the flare event on 2022 April 21 at 01:52 *** subpeaks with durations of 4-6 s have been detected in the hard X-ray precursor phase,and the key feature is that they appear in pairs and seem like double-peak *** subpeaks are rarely observed in hard X-ray band and confirmed by the microwave obtained by Nobeyama Radio Polarimeters(NoRP)and Radio Solar Telescope Network(RSTN).While an exponential function can describe the continuum component of the time profile from the precursor to part of the impulsive *** periods of quasi-periodic pulsations(QPPs)are detected to be about 7.3 and 12.8 s for the precursor and impulsive phase,respectively,with at least 95%confidence *** paired QPPs are assumed to be double-peak QPPs and then the scenario of current loop coalescence model is found to be in good agreement with our *** precursor phase can be interpreted as the oscillating coalescence of two islands,while the impulsive phase can be interpreted as more islands to coalesce one by one to form larger islands.

关键词： solar flare QPPs loop coalescence circular-ribbon flare

在线全文

学校读者我要写书评

暂无评论

基于反射滤波器实现载波重用无源光网络设计

光通信研究 2021年第5期5期(13)卷 31-35页

作者：狄晗陈新桥刘晓蕊霍恺丽中国传媒大学信息与通信工程学院北京100024 中国传媒大学数据科学与智能媒体学院北京100024

载波重用技术是降低无源光网络(PON)成本的一种重要方法,也是提高PON传输容量的主要方法。文章设计了一种PON系统结构,系统采用了副载波重用(SCM)和波分复用(WDM)的联合复用技术,极大地提高了PON的传输容量。在系统中采用无源反射滤波... 详细信息

载波重用技术是降低无源光网络(PON)成本的一种重要方法,也是提高PON传输容量的主要方法。文章设计了一种PON系统结构,系统采用了副载波重用(SCM)和波分复用(WDM)的联合复用技术,极大地提高了PON的传输容量。在系统中采用无源反射滤波器实现载波重用,极大地降低了系统成本。文章采用Optisystem光子模拟软件搭建出了基于反射滤波器实现载波重用的SCM/WDM-PON系统结构,SCM采用3和6 GHz作为射频副载波,WDM采用范围为193.1~194.5 THz、波长间隔为200 GHz的8个波长为光载波,用户上下行传输的数据速率为1 Gbit/s。文章还研究了反射滤波器的反射系数、光载波功率和传输距离对上下行数据传输性能的影响,得到了当反射滤波器的反射系数为97%、光载波功率为5 dBm和传输距离<27.2 km时,系统总体性能最优的结论。

关键词：无源光网络副载波重用波分复用载波重用反射滤波器

在线全文

学校读者我要写书评

暂无评论

热带臭虫及温带臭虫形态与分子鉴定

中国媒介生物学及控制杂志 2018年第6期29卷 576-581页

作者：刘德星邱德义李婷婷张瑞玲刘春晓岳巧云中山出入境检验检疫局检验检疫技术中心广东中山528403 泰山医学院山东泰安271016 深圳国际旅行卫生保健中心广东深圳518000 中山大学生命科学学院广东广州510275

目的建立近似种热带臭虫与温带臭虫形态学和分子鉴定的方法。方法 2017年7月在深圳市某大学集体宿舍和山东省泰安某大学集体宿舍分别发现并采集到热带臭虫和温带臭虫。比较热带臭虫与温带臭虫外部形态特征及线粒体基因细胞色素C氧化酶... 详细信息

目的建立近似种热带臭虫与温带臭虫形态学和分子鉴定的方法。方法 2017年7月在深圳市某大学集体宿舍和山东省泰安某大学集体宿舍分别发现并采集到热带臭虫和温带臭虫。比较热带臭虫与温带臭虫外部形态特征及线粒体基因细胞色素C氧化酶亚基Ⅰ(COI)基因、16S rDNA和核糖体基因28S rDNA、ITS2的序列,构建(Neighbor-Joining,NJ)进化树。结果虽然热带臭虫与温带臭虫成虫的外部形态相似,但仍可以从前胸背板、翅基、足和腹部的细微特征区别进行鉴定,COI、16S rDNA、28S rDNA、ITS2 4个基因的DNA序列种内差异均2%,在构建的4个基因NJ进化树中,2个种均能各自聚为一支,且支持率均达100%。结论热带臭虫和温带臭虫成虫可以利用外部形态鉴定,并能用常规的分子标记进行分子鉴定。形态和分子相结合的鉴定方法,为仅依赖形态特征难以区分的近似种的鉴定提供了一个高效的方法。

关键词：热带臭虫温带臭虫形态与分子鉴定

在线全文

学校读者我要写书评

暂无评论

真菌中赖氨酸生物合成途径研究进展

微生物学通报 2020年第3期47卷 915-922页

作者：蒋佩钰尚晓冬宋春艳王瑞娟于海龙李巧珍章炉军刘建雨谭琦上海市农业科学院食用菌研究所国家食用菌工程技术研究中心上海201403 上海海洋大学食品学院上海201306

本文综述了真菌中赖氨酸的生物合成途径及途径中的关键基因——酵母氨酸脱氢酶基因,详细介绍了赖氨酸从头合成途径,阐述了酵母氨酸脱氢酶的作用机理及理化性质,以期为探索赖氨酸合成途径及途径中的基因提供资料和思路。

关键词：真菌赖氨酸生物合成酵母氨酸脱氢酶

The Solar Upper Transition Region Imager(SUTRI)Onboard the SATech-01 Satellite

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2023年第6期23卷 153-171页

作者： Xianyong Bai Hui Tian Yuanyong Deng Zhanshan Wang Jianfeng Yang xiaofeng Zhang Yonghe Zhang Runze Qi Nange Wang Yang Gao Jun Yu Chunling He Zhengxiang Shen Lun Shen Song Guo Zhenyong Hou Kaifan Ji Xingzi Bi Wei Duan xiao Yang Jiaben Lin Ziyao Hu Qian Song Zihao Yang Yajie Chen Weidong qiao Wei Ge Fu Li Lei Jin Jiawei He xiaobo Chen xiaocheng Zhu Junwang He Qi Shi liu liu Jinsong Li Dongxiao Xu rui liu Taijie Li Zhenggong Feng Yamin Wang Chengcheng Fan Shuo liu Sifan Guo Zheng Sun Yuchuan Wu Haiyu Li Qi Yang Yuyang Ye Weichen Gu Jiali Wu Zhe Zhang Yue Yu Zeyi Ye Pengfeng Sheng Yifan Wang Wenbin Li Qiushi Huang Zhong Zhang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Astronomy and Space science University of Chinese Academy of SciencesBeijing 101408China School of Earth and Space sciences Peking UniversityBeijing 100871China Key Laboratory of Solar Activity and Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China Tongji university Institute of Precision Optical EngineeringSchool of Physics Science and EngineeringKey Laboratory of Advanced Micro-Structured Materials MOEShanghaiChina Xi'an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi'an 710119China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201304China Yunnan Observatories Chinese Academy of SciencesKunming650011China

The Solar Upper Transition Region Imager(SUTRI)onboard the Space Advanced technology demonstration satellite(SATech-01),which was launched to a Sun-synchronous orbit at a height of~500 km in 2022 July,aims to test the on-orbit performance of our newly developed Sc/Si multi-layer reflecting mirror and the 2k×2k EUV CMOS imaging camera and to take full-disk solar images at the Ne VII 46.5 nm spectral line with a filter width of~3 *** employs a Ritchey-Chrétien optical system with an aperture of 18 *** on-orbit observations show that SUTRI images have a field of view of~416×416 and a moderate spatial resolution of~8″without an image stabilization *** normal cadence of SUTRI images is 30 s and the solar observation time is about16 hr each day because the earth eclipse time accounts for about 1/3 of SATech-01's orbit ***15 GB data is acquired each day and made available online after *** images are valuable as the Ne VII 46.5 nm line is formed at a temperature regime of~0.5 MK in the solar atmosphere,which has rarely been sampled by existing solar *** observations will establish connections between structures in the lower solar atmosphere and corona,and advance our understanding of various types of solar activity such as flares,filament eruptions,coronal jets and coronal mass ejections.

关键词： Sun:transition region Sun:UV radiation Sun:activity space vehicles:instruments

新工科背景下关于本科培养方案的思考与调研--以山东科技大学环境工程专业为例

在线全文

学校读者我要写书评

暂无评论

教育教学论坛 2021年第45期 17-20页

作者：张文睿刘音乔延路曹晓强胡术刚山东科技大学安全与环境工程学院〔安全与应急管理学院〕山东青岛266590

环境工程专业教育从开办以来受到了高校的极大重视,经过近20年的发展,国内在本科环境工程专业的培养方面取得了显著成就。在新工科建设背景下,根据人才培养方案的制定要求和标准,对比分析国内同类高校环境工程专业的培养方案,同时收集... 详细信息

环境工程专业教育从开办以来受到了高校的极大重视,经过近20年的发展,国内在本科环境工程专业的培养方面取得了显著成就。在新工科建设背景下,根据人才培养方案的制定要求和标准,对比分析国内同类高校环境工程专业的培养方案,同时收集了多家毕业生工作单位的反馈意见,针对山东科技大学环境工程专业人才培养方案的调研报告进行了分析和思考,对标工程教育认证标准,提出环境工程专业2020级本科培养方案的修订思路,可进一步提高本科生的培养质量。

关键词：环境工程本科教学人才培养工程教育

甘油/CO_(2)合成碳酸甘油酯的研究进展

在线全文

学校读者我要写书评

暂无评论

当代化工 2022年第7期51卷 1683-1686页

作者：乔枫瑞李若萱邱成鹏牛紫嫣王晋王潇潇潘瑞丽钱成刘振民太原科技大学化学与生物工程学院山西太原030024 中国石油西南油气田公司四川成都610000

碳酸甘油酯是一种高附加值的甘油衍生物,以甘油与CO_(2)为原料合成碳酸甘油酯已成为实现生物柴油副产物甘油和温室气体CO_(2)综合利用的有效途径之一。总结了甘油/CO_(2)法合成碳酸甘油酯的热力学分析,认为采用耦合反应是实现该合成过... 详细信息

碳酸甘油酯是一种高附加值的甘油衍生物,以甘油与CO_(2)为原料合成碳酸甘油酯已成为实现生物柴油副产物甘油和温室气体CO_(2)综合利用的有效途径之一。总结了甘油/CO_(2)法合成碳酸甘油酯的热力学分析,认为采用耦合反应是实现该合成过程的有效方法。详细阐述了无机/有机碱催化剂、离子液体催化剂、单组分金属氧化物催化剂、复合氧化物催化剂和负载型固体碱催化剂对碳酸甘油酯合成及其反应活性的影响。最后对碳酸甘油酯的应用进行了展望。

关键词：甘油二氧化碳碳酸甘油酯热力学催化剂