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Chlorophyllide-a Oxygenase 1(OsCAO1) Over-Expression Affects Rice Photosynthetic Rate and Grain Yield

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Rice science 2023年第2期30卷 87-91,I0002-I0006页

作者： HU Ping MA Jie KANG Shujing LI Sanfeng WU Xianmei zeng Longjun LU Caolin he Rui he Huiying SHANG Lianguang RAO Yuchun ZHU xudong XIONG Guosheng qian qian GUO Longbiao WANG Yuexing State Key Laboratory of Rice Biology China National Rice Research InstituteHangzhou 310006China Shenzhen Branch Guangdong Laboratory for Lingnan Modern Agriculture/Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs/Agricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China Plant Phenomics Research Center Nanjing Agricultural UniversityNanjing 210095China College of Chemistry and Life Sciences Zhejiang Normal UniversityJinhua 321004China

Leaf color and photosynthesis are important factors for rice growth and ***,improving the photosynthetic rate is an effective approach for increasing rice *** isolated a gene,chlorophyllide-a oxygenase 1(OsCAO1),which... 详细信息

关键词： OsCAO1 development Oxygen

Schiff-base silver nanocomplexes formation on natural biopolymer coated mesoporous silica contributed to the improved curative effect on infectious microbes

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Nano Research 2021年第8期14卷 2735-2748页

作者： Ling Cai Yanqiang Huang Yuanyuan Duan Qiao Liu Qilan Xu Jia Jia Jianming Wang qian Tong Peipei Luo Yujie Wen Luming Peng qian Wu xudong Hang Huijun Jiang Ping Zhu Yanmei Yang Boshen Zhou Liping zeng Hongkai Bi Jin Chen Center for Global health The Key Laboratory of Modern ToxicologyMinistry of EducationSchool of Public HealthNanjing Medical UniversityNanjing 211166China Department of Pathogen Biology Jiangsu Key Laboratory of Pathogen BiologyNanjing Medical UniversityNanjing 211166China Research Center for the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for Nationalities Baise 533000China The Laboratory Center for Basic Medical Sciences Nanjing Medical UniversityNanjing 211166China Key Laboratory of Mesoscopic Chemistry of MOE and Collaborative Innovation Center of Chemistry for Life Sciences School of Chemistry and Chemical Engineering Nanjing UniversityNanjing 210023China School of Pharmacy Nanjing Medical UniversityNanjing 211166China Department of Gastroenterology Sir Run Run HospitalNanjing Medical UniversityNanjing 211166China Key Laboratory of Antibody Technique of National health Commission Nanjing Medical UniversityNanjing 211166China

Infectious microbes that spread easily in healthcare facilities remain as the severe threat for the public health,especially among immunocompromised *** the intricate problem of dramatic increase in resistance to common biocides,the development of safe and efficient biocide formulated agents to alleviate drug resistance is highly *** this study,Schiff-base ligands were successfully formed on natural biopolymer of epsilon-poly-L-lysine(ε-PL)decorated aldehyde functionalized mesoporous silica SBA-15(CHO-SBA-15)for the selective coordination of silver ions,which was affirmed by various physicochemical *** the identified broad-spectrum antibacterial activities,the as-prepared Schiff-base silver nanocomplex(CHO-SBA-15/ε-PL/Ag,CLA-1)exhibited an improved inhibitory effect on infectious pathogen growth typified by Escherichia coli and Staphylococcus aureus in comparison with two control silver complexes without Schiff-base conjugates,SBA-15/ε-PL/Ag and CHO-SBA-15/Ag,*** addition,CLA-1 remarkably inhibited the growth of Mycobacterium tuberculosis due to the excellent antimicrobial activity of silver ***,CLA-1 kills Candida albicans cells,inhibits biofilm formation,and eliminates preformed biofilms,with no development of resistance during continuous serial *** antifungal activity is connected to disruption of bacterial cell membranes and increased levels of intracellular reactive oxygen *** mouse models of multidrug-resistant *** infection,CLA-1 exhibited efficient in vivo fungicidal efficacy superior to two antifungal drugs,amphotericin B and ***,CLA-1 treatment induces negligible toxicity against normal tissues with ***,this study reveals the pivotal role of the molecular design of Schiff-base silver nanocomplex formation on biopolymer surface-functionalized silica mesopores as a green and efficient nanoplatform to tackle infectious microbes.

关键词： biopolymer drug delivery mesoporous silica silver nanoparticles antimicrobial drug resistance

Probing surface structure on two-dimensional metal-organic layers to understand suppressed interlayer packing

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Nano Research 2020年第11期13卷 3151-3156页

作者： Peican Chen Yi Liu Xuefu Hu Xiaolin Liu En-Ming You xudong qian Jiawei Chen Liangping Xiao Lingyun Cao Xinxing Peng Zhongming zeng Yibing Jiang Song-Yuan Ding Honggang Liao Zhaohui Wang Da Zhou Cheng Wang IChem State Key Laboratory of Physical Chemistry of Solid SurfacesCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China School of Mathematical Sciences and Fujian Provincial Key Laboratory of Mathematical Modeling and High-Performance Scientific Computation Xiamen UniversityXiamen361005China

Two-dimensional metal-organic layers(MOLs)from alternatively connected benzene-tribenzoate ligands and Zr6(μ3-O)_(4)(μ3-OH)_(4) or Hf6(μ3-O)_(4)(μ3-OH)_(4) secondary building units can be prepared in gram scale via solvothermal ***,the reason why the monolayers did not pack to form thick crystals is *** we investigated the surface structure of the MOLs by a combination of sum-frequency generation spectroscopy,nanoscale infrared microscopy,atomic force microscopy,aberration-corrected transmission electron microscopy,and compositional *** found a partial coverage of the monolayer surface by dangling tricarboxylate ligands,which prevent packing of the *** finding illustrates low-density surface modification as a strategy to prepare new two-dimensional materials with a high percentage of exposed surface.

关键词： metal-organic frameworks metal-organic layers surface structure two-dimensional(2D)materials solvothermal synthesis

Annual cost of illness of stomach and esophageal cancer patientsin urban and rural areas in China： A multi-center study

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Chinese Journal of Cancer Research 2018年第4期30卷 439-448页

作者： Zhixun Yang Hongmei zeng Ruyi Xia qian Liu Kexin Sun Rongshou Zheng Siwei Zhang Changfa Xia he Li Shuzheng Liu Zhiyi Zhang Yuqin Liu Guizhou Guo Guohui Song Yigong Zhu Xianghong Wu Bingbing Song Xianzhen Liao Yanfang Chen Wenqiang Wei guihua Zhuang Wanqing Chen National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China School of Public health Xi'an Jiaotong University Health Science Center Xi'an 710061 China henan Office for Cancer Control and Research the Affiliated Cancer Hospital of Zhengzhou University Henan Cancer Hospital Zhengzhou 450008China Gansu Wuwei Tumor Hospital Wuwei 733000 China Cancer Epidemiology Research Center Gansu Provincial Cancer HospitalLanzhou 730050 China Linzhou Cancer Hospital Linzhou 456500 China Cixian Cancer Institute Handan 056500 China Luoshan Center for Disease Control and Prevention Xinyang 464299 China Center for Disease Control and Prevention of Sheyang County Sheyang 224300China heilongjiang Office for Cancer Control and Research Harbin Medical University Cancer Hospital Harbin 150081 China Hunan Office for Cancer Control and Research Hunan Cancer Hospital Changsha 410006 China Yueyang Lou District Center for Disease Prevention and Control Yueyang 414021 China

Objective： Stomach and esophageal cancer are imposing huge threats to the health of Chinese people whereasthere were few studies on the financial burden of the two ***： Costs per hospitalization of all patients with stomach or esophageal cancer discharged betweenSeptember 2015 and August 2016 in seven cities/counties in China were collected, together with their demographicinformation and clinical details. Former patients in the same hospitals were sampled to collect information onannual direct non-medical cost, indirect costs and annual number of hospitalization. Annual direct medical cost wasobtained by multiplying cost per hospitalization by annual number of hospitalization. Annual cost of illness （ACI）was obtained by adding the average value of annual direct medical cost, direct non-medical cost and indirect cost,stratified by sex, age, clinical stage, therapy and pathologic type in urban and rural areas. Costs per hospitalizationwere itemized into eight parts to calculate the proportion of each part. All costs were converted to 2016 US dollars（1 USD：6.6423 RMB）.Results： Totally 19,986 cases were included, predominately male. Mean ages of stomach cancer and urbanpatients were lower than that of esophageal cancer and rural patients. ACI of stomach and esophageal cancerpatients were $10,449 and $13,029 in urban areas, and $2,927 and $3,504 in rural areas, respectively. Greater ACIwas associated with male, non-elderly patients as well as those who were in stage I and underwent *** medicine fee took the largest proportion of cost per ***： The ACI of stomach and esophageal cancer was tremendous and varied substantially among thepopulation in China. Preferential policies of medical insurance should be designed to tackle with this burden andfurther reduce the health care inequalities.

关键词： Cost of illness stomach neoplasms esophageal neoplasms China

A Strigolactone Biosynthesis Gene Contributed to the Green Revolution in Rice

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Molecular Plant 2020年第6期13卷 923-932页

作者： Yuexing Wang Lianguang Shang Hong Yu Longjun zeng Jiang Hu Shen Ni Yuchun Rao Sanfeng Li Jinfang Chu Xiangbing Meng Lei Wang Ping Hu Jijun Yan Shujing Kang Minghao Qu Hai Lin Tao Wang Quan Wang Xingming Hu Hongqi Chen Bing Wang Zhenyu Gao Longbiao Guo Dali zeng xudong Zhu Guosheng Xiong Jiayang Li qian qian State Key Laboratory of Rice Biology China National Rice Research InstituteHangzhou 310006China Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China State Key Laboratory of Plant Genomics and National Center for Plant Gene Research(Beijing)Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Plant Phenomics Research Center Nanjing Agricultural UniversityNanjing 210095China College of Chemistry and Life Sciences Zhejiang Normal UniversityJinhua 321004China

Plant architecture is a complex agronomic trait and a major factor of crop yield,which is affected by several important ***(SLs)are identified as a new class hormoneinhibiting branching in many plant species and have been shown to be involved in various developmental *** and chemical modulation of the SL pathway is recognized as a promising approach to modify plant ***,whether and how the genes involved in the SL pathway could be utilized in breeding still remain ***,we demonstrate that a partial loss-of-function allele of the SL biosynthesis gene,HIGH TILLERING AND DWARF 1/DWARF17(HTD1/D17),which encodes CAROTENOID CLEAVAGE DIOXYGENASE 7(CCD7),increases tiller number and improves grain yield in *** found that the HTD1 gene had been widely utilized and co-selected with Semidwarf 1(SD1),both contributing to the improvement of plant architecture in modern rice varieties since the Green Revolution in the *** how phytohormone pathway genes regulate plant architecture and how they have been utilized and selected in breeding will lay the foundation for developing the rational approaches toward improving crop yield.

关键词： rice strigolactones tiller number Green Revolution

TEOS对有机硅基耐高温热控涂层的性能影响

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表面技术 2024年第20期53卷 175-182页

作者：谢轩宇曹茜曾鲜程旭东武汉理工大学武汉430000

目的研究不同组分有机硅基耐高温热控涂层的微观结构及光谱吸收/发射性能的演变规律,揭示涂层成分对涂层性能的影响机制。方法以正硅酸四乙酯、甲基三乙氧基硅烷、二甲基二乙氧基硅烷、3-(异丁烯酰氧)丙基三甲氧基硅烷为基料原料,以TiO_... 详细信息

目的研究不同组分有机硅基耐高温热控涂层的微观结构及光谱吸收/发射性能的演变规律,揭示涂层成分对涂层性能的影响机制。方法以正硅酸四乙酯、甲基三乙氧基硅烷、二甲基二乙氧基硅烷、3-(异丁烯酰氧)丙基三甲氧基硅烷为基料原料,以TiO_(2)、云母为功能颜料,采用溶胶-凝胶法通过有机、无机杂化得到一种耐高温热控涂层,并对涂层的物相、表面微观结构、光学性能和热稳定性进行了测试表征。结果所制得的热控涂层均具有较低的太阳吸收比以及较高的半球发射率,当TEOS物质的量比为8时,涂层具有最低的太阳吸收比和最高的半球发射率,其值分别为0.209和0.901。涂层在600℃高温下,Si—O—Si转变为SiO_(2),部分涂层表面出现微裂纹,但未与基体脱落。TEOS物质的量比为8的涂层经高温处理后的太阳吸收比最小,半球发射率最大,其值分别为0.169和0.894。结论室温固化后涂层的太阳吸收比和半球发射率与TEOS的含量有关,太阳吸收比随着TEOS含量的增多而减少,半球发射率随着TEOS含量增多而增大。并且涂层的热稳定性随着TEOS含量的增多而增大。

关键词： SiO_(2)/有机硅复合溶胶-凝胶法太阳吸收比半球发射率有机涂料

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混合型肝癌的MRI表现与病理分型的对照分析

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中华放射学杂志 2017年第10期51卷 761-765页

作者：钱旭东汪禾青盛若凡杨丽曾蒙苏纪元韩晶浙江省新昌县人民医院放射科 312500 上海市影像医学研究所复旦大学附属中山医院放射科复旦大学上海医学院影像学系复旦大学附属中山医院病理科

目的探讨不同病理分型混合型肝癌（cHCC-CC）的MRI表现.方法回顾性分析经手术病理证实为cHCC-CC的29例患者资料,经典型20例（24个病灶）,干细胞型9例（10个病灶）.患者术前行肝脏MRI平扫及增强扫描检查.观察病灶的形态特征、信号特征... 详细信息

目的探讨不同病理分型混合型肝癌（cHCC-CC）的MRI表现.方法回顾性分析经手术病理证实为cHCC-CC的29例患者资料,经典型20例（24个病灶）,干细胞型9例（10个病灶）.患者术前行肝脏MRI平扫及增强扫描检查.观察病灶的形态特征、信号特征,并测量17例（22个病灶）的ADC值.采用独立样本t检验和Fisher确切概率法比较经典型及干细胞型cHCC-CC患者间影像表现的差异.结果经典型和干细胞型cHCC-CC的最大径分别为（3.8±2.5）、（4.5±1.8）cm,差异无统计学意义（t=0.749,P=0.462）.7个病灶T1WI为不均匀高信号,27个病灶T1WI为低信号.17个病灶T2WI以中央低信号为主,为高低混杂信号.增强扫描动脉期21个病灶表现为周边环形强化,13个病灶表现为弥漫不均匀强化.17个病灶强化方式表现为快进快出,17个表现为反转强化.25个病灶可见假包膜.经典型和干细胞型cHCC-CC的动脉强化方式和胆管扩张差异有统计学意义（P均〈0.05）,形状、边界、T1WI高信号、T2WI低信号、病灶内脂肪、淋巴结肿大、强化类型、假包膜和静脉癌栓发生率差异均无统计学意义（P均〉0.05）.cHCC-CC病灶DWI均表现为高信号,经典型和干细胞型cHCC-CC病灶的ADC值分别为（1.60±0.39）×10-3、（1.41±0.52）×10^-3mm^2/s,二者差异无统计学意义（t=-1.005,P=0.326）.结论 cHCC-CC的MRI表现具有一定特征性,但依靠MRI表现不易区分经典型和干细胞型cHCC-CC.

关键词：肝脏肿瘤磁共振成像混合型肝癌

锦绣黄桃漆酶基因PpLAC7的克隆、亚细胞定位及表达分析

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华北农学报 2024年第5期39卷 72-79页

作者：龚意辉张灿美周桂花陈玫羽谭倩皮水勤曾永贤湖南人文科技学院农业与生物技术学院湖南娄底417000

为克隆锦绣黄桃漆酶基因PpLAC7序列,分析PpLAC7基因序列信息及其在果肉褐变中的作用。以锦绣黄桃为试材,采用同源克隆方法从锦绣黄桃中获得漆酶基因PpLAC7的cDNA序列。采用生物信息学软件对PpLAC7基因的启动子元件、蛋白质理化性质、蛋... 详细信息

为克隆锦绣黄桃漆酶基因PpLAC7序列,分析PpLAC7基因序列信息及其在果肉褐变中的作用。以锦绣黄桃为试材,采用同源克隆方法从锦绣黄桃中获得漆酶基因PpLAC7的cDNA序列。采用生物信息学软件对PpLAC7基因的启动子元件、蛋白质理化性质、蛋白质二级、三级结构、系统发育进化树和同源氨基酸序列比对进行分析。此外还对PpLAC7基因进行亚细胞定位以及在果肉褐变过程中的表达规律进行了分析。生物信息学分析表明,PpLAC7的启动子区域含有光响应元件、茉莉酸响应元件、干旱响应元件、种子特异性调控等元件。PpLAC7基因全长为1692 bp,其蛋白质共编码563个氨基酸,分子质量为61.867 ku,总原子数为8621个,亲水系数为-0.028,理论等电点为5.95,不稳定指数为36.48,脂溶性指数为87.26。PpLAC7蛋白的α-螺旋、延长链、β-转角、无规则卷曲分别占氨基酸总数的14.74%,28.77%,6.22%,50.27%。进化树结果显示,PpLAC7基因与苹果MdLAC7基因具有较高的同源性,PpLAC7基因的氨基酸序列同样含有3个典型的铜离子结构域。亚细胞定位结果表明,PpLAC7定位于内质网。PpLAC7基因在锦绣黄桃果肉褐变过程中呈大量上调表达。结合锦绣黄桃果肉褐变指数与PpLAC7表达量的关系,推测PpLAC7可能在锦绣黄桃果肉褐变过程中起重要的作用。

关键词：锦绣黄桃 PpLAC7基因果肉褐变基因克隆生物信息学分析亚细胞定位

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临床护士正念水平与职业倦怠及主观幸福感的相关性研究

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护理研究（上旬版） 2017年第6期31卷 1982-1985页

作者：曾巍钱小芳刘桂华泉州医学高等专科学校 362000 福建医科大学护理学院 350004 福建省妇幼保健院 350001

[目的]调查妇幼专科医院临床护士正念水平、职业倦怠与主观幸福感的现状,并分析三者之间的相关性。[方法]采用正念注意觉知量表、护士职业倦怠量表及主观幸福感指数量表,对福州市某妇幼专科三级甲等医院的332名临床一线护士进行调查。[... 详细信息

[目的]调查妇幼专科医院临床护士正念水平、职业倦怠与主观幸福感的现状,并分析三者之间的相关性。[方法]采用正念注意觉知量表、护士职业倦怠量表及主观幸福感指数量表,对福州市某妇幼专科三级甲等医院的332名临床一线护士进行调查。[结果]临床护士的正念水平总分为(53.88±10.63)分,处于中等水平;职业倦怠总分为(129.47±19.73)分,主观幸福感总均分为(9.88±1.99)分;不同年龄临床护士的正念水平,不同年龄、护龄、婚姻状况和技术职称的临床护士职业倦怠差异有统计学意义(P<0.05);正念水平与职业倦怠呈负相关(r=-0.445,P<0.001),与主观幸福感呈正相关(r=0.336,P<0.001),职业倦怠与主观幸福感呈负相关(r=-0.439,P<0.001)。[结论]临床护士的主观幸福感和职业倦怠与正念水平相关,应针对不同人群特征采取针对性措施提高临床护士的正念水平,有助于缓解职业倦怠,提升主观幸福感,同时也为护理人力资源管理寻求有效干预策略拓展新视角。

关键词：护士正念职业倦怠主观幸福感护理人力资源管理