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PLGA-based implants for sustained delivery of peptides/proteins:Current status,challenge and perspectives

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Chinese Chemical Letters 2023年第11期34卷 41-51页

作者： Fangfei Hu Jianping qi yi Lu Haisheng He Wei Wu Key Laboratory of Smart Drug Delivery of MOE School of PharmacyFudan UniversityShanghai 201203China Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China Fudan Zhangjiang Institute Shanghai 201203China Center for Medical Research and Innovation Shanghai Pudong HospitalFudan University Pudong Medical CenterShanghai 201399China

Peptide and protein drugs with therapeutic effects suffer from their short half-life and low stability,albeit their high efficiency and *** overcome these demerits,long-acting drug delivery systems have been developed,wherein poly(lactic-co-glycolic acid)(PLGA)implants are most preferred owing to their excellent biodegradability and *** of PLGA based products have been approved since1986,when the first product,named Decapeptyl R,successfully marched into *** meet the increasing demand for delivering various peptides and proteins,different kinds of technologies have been developed for lab-scale fabrication or industrial *** review aims to introduce recent advances of PLGA implants,and give a brief summary of fundamental properties of PLGA,fabrication technologies of peptides/proteins-loaded PLGA implants as well as factors influencing the drug release ***,challenges and future perspectives are also highlighted.

关键词： PLGA Implant Peptide/protein delivery Fabrication technology Drug release

Placental Origins of Preeclampsia:Potential Therapeutic Targets

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Current Medical Science 2019年第2期39卷 190-195页

作者： Jian-li WU Jing JIA Meng-zhou HE Yu zeng Jing-yi ZHANG Er-jiao SHI Shao-yang LAI Xuan ZHOU Lali Mwamaka Sharifu Ling FENG Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 4300030China

Preeclampsia(PE)remains a leading cause of maternal and perinatal morbidity and mortality in obstetrics *** effective treatments to reduce its incidence and severity in clinical practice are currently available.A variety of hypotheses have been generated aiming to explain the origins of PE,notably being the genetic predispositions and placental *** regard to placental dysfunction,much progress has been made in basic research and several potential therapeutic targets have been *** review will discuss in detail the potential therapeutic targets in PE models including uteroplacental blood flow,oxidative stress,vasoactive factors and inflammation/immune response,and introduce the evolving technologies for placental research nowadays.

关键词： preeclampsia placental dysfunction therapeutic targets

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钟嵘《诗品》在英语国家的转译呈现

湖南科技大学学报（社会科学版） 2018年第6期21卷 135-142页

作者：曾诣北京师范大学文学院

目前汉语学界关于英语世界钟嵘《诗品》译介问题的研究尚处于起步阶段。虽然尤未见英语全译本出现,但已然存在三种《诗品序》英译及部分重要的零散英译材料。通过对《诗品》书名诸种英译的比对,可知其分为音译和意译两类。其中,＂诗＂... 详细信息

目前汉语学界关于英语世界钟嵘《诗品》译介问题的研究尚处于起步阶段。虽然尤未见英语全译本出现,但已然存在三种《诗品序》英译及部分重要的零散英译材料。通过对《诗品》书名诸种英译的比对,可知其分为音译和意译两类。其中,＂诗＂的意译主要有＂诗作＂＂诗人＂＂诗歌成就＂这三种不同的侧重;而＂品＂则主要有＂品级-等级＂和＂品评-评价＂这两个维度的区别。另外,现存的三种《诗品序》英译各具特色,关于相应语言风格和错漏情况的初步分析,将为后续的深化研究奠定基础。

关键词：钟嵘《诗品》英语世界译介

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准双椭圆三体模型

中国科学：物理学、力学、天文学 2020年第7期50卷 98-107页

作者：齐毅徐世杰瑞尔森大学航空航天学院多伦多ON M5B 2K3加拿大北京航空航天大学宇航学院北京100191

本文我们提出了日地月准双椭圆三体问题(Quasi-Bielliptic Problem,QBEP)模型.该模型假设月球绕地球的轨道为受太阳引力摄动影响的准椭圆轨道,而地月质心绕太阳的轨道为严格的椭圆.此外我们认为日地月三个天体运行在同一轨道平面内.我... 详细信息

本文我们提出了日地月准双椭圆三体问题(Quasi-Bielliptic Problem,QBEP)模型.该模型假设月球绕地球的轨道为受太阳引力摄动影响的准椭圆轨道,而地月质心绕太阳的轨道为严格的椭圆.此外我们认为日地月三个天体运行在同一轨道平面内.我们推导了月球准椭圆轨道的一阶展开解析表达式需要满足的微分方程,并利用我们提出的计算方法,将微分方程问题转化为线性方程组问题来进行求解.通过比较数值积分结果,我们方法的有效性得到了验证.而后我们详细比较了该解析结果与准双圆模型的差异,同时讨论了两个基准椭圆轨道偏心率对解析结果的影响.

关键词：限制性四体问题准双椭圆模型日地月系统

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催化氧化法脱除燃煤烟气中的单质汞

中国电力 2020年第3期53卷 147-153,166页

作者：齐萌赵毅华北电力大学环境科学与工程学院

提出了一种超价金属化合物二过碘酸合铜(DPC)与过渡金属离子Ni(II)共建的液相催化氧化体系,可将烟气中难溶于水的气态单质汞(Hg^0)转化为易溶于水的氧化态汞(Hg^2+),之后利用湿式吸收设备去除。对影响脱汞效率的关键因素进行了实验研究... 详细信息

提出了一种超价金属化合物二过碘酸合铜(DPC)与过渡金属离子Ni(II)共建的液相催化氧化体系,可将烟气中难溶于水的气态单质汞(Hg^0)转化为易溶于水的氧化态汞(Hg^2+),之后利用湿式吸收设备去除。对影响脱汞效率的关键因素进行了实验研究,结果表明,Ni(II)对脱汞效率有较大促进作用,在最佳实验条件下(DPC为0.18 mmol/L,Ni(II)为4×10^–5 mmol/L,反应温度为45℃,溶液pH为8.5),稳定的平均脱汞效率达到93.3%。烟气中的SO^2–尤其是在高浓度下,对脱汞效率影响较大,而NO对脱汞影响微弱。此外,通过对反应产物的分析,推测了反应体系中的活性支配物种及Ni(II)存在下的反应机理。此工作可为研发新型烟煤烟气脱汞技术,尤其是液相催化氧化脱汞技术提供参考。

关键词：超价金属燃煤烟气单质汞液相催化氧化

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基于交互特征表示的评价对象抽取模型

计算机研究与发展 2021年第1期58卷 224-232页

作者：曾碧卿曾锋韩旭丽商齐华南师范大学软件学院广东佛山528225 华南师范大学计算机学院广州510631

评价对象抽取是对象级情感分析的关键任务之一,评价对象抽取结果会直接影响对象级情感分类的准确率.在评价对象抽取任务中,借助手工特征加强模型性能的方式既消耗时间又耗费人力.针对数据规模小、特征信息不充分等问题,提出一种基于交... 详细信息

评价对象抽取是对象级情感分析的关键任务之一,评价对象抽取结果会直接影响对象级情感分类的准确率.在评价对象抽取任务中,借助手工特征加强模型性能的方式既消耗时间又耗费人力.针对数据规模小、特征信息不充分等问题,提出一种基于交互特征表示的评价对象抽取模型(aspect extraction model based on interactive feature representation,AEMIFR).相比其他模型,AEMIFR模型结合字符级嵌入与单词嵌入,捕获单词的语义特征、字符的形态特征以及字符与词语之间的内在联系.而且,AEMIFR模型获取文本的局部特征表示和上下文依赖特征表示,并学习2种特征表示之间的交互关系,增强2种特征之间的相似特征的重要性,减少无用特征对模型的消极影响,以及学习更高质量的特征表示.最后在SemEval 2014,SemEval 2015,SemEval 2016中的数据集L-14,R-14,R-15,R-16上进行实验,取得具有竞争力的效果.

关键词：评价对象抽取对象级情感分析特征交互自然语言处理神经网络

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纳西族当代散文家杨世光及其创作

云南民族大学学报（哲学社会科学版） 2007年第2期24卷 121-125页

作者：曾绍义四川大学中文系四川成都610068

狙犷与精致互动,古典与现代互动,让散文变得更随意些、潇洒些,也更为文化些,透出大散文的别类美丽。这就是纳西族当代散文家杨世光散文的独特魅力和艺术追求。

关键词：纳西族当代散文家创作风格

Coordinated Control for Harmonic Mitigation of Parallel Voltage-source Inverters

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CES Transactions on Electrical Machines and Systems 2018年第3期2卷 276-283页

作者： Yang qi Jingyang Fang Jiazhe Liu yi Tang school of Electrical and Electronic Engineering Nanyang Technological University50 Nanyang avenueSingapore

The increasing use of power electronic devices can deteriorate the power quality by introducing voltage and current *** islanded microgrids,the presence of nonlinear loads can distort the point of common coupling(PCC)voltage,while the dead-time effect can also bring additional circulating current harmonics among parallel *** simultaneously attenuate the PCC voltage harmonics and suppress the dead-time induced circulating current harmonics,this paper proposes a coordinated control strategy for harmonic mitigation of parallel *** proposed control strategy allows inverter impedances to be properly reshaped at selective harmonic *** a consequence,the PCC voltage harmonics are filtered by the inverter operating in the harmonic compensation mode(HCM),whereas the dead-time induced circulating current harmonics are suppressed by the inverter operating in the harmonic rejection mode(HRM).Experimental results from an islanded microgrid prototype with two parallel inverters are provided to validate the effectiveness of the proposed control strategy.

关键词： Dead-time harmonic mitigation impedance shaping parallel inverters nonlinear load

Research on Hidden Failure Reliability Modeling of Electric Power System Protection

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Energy and Power Engineering 2013年第4期5卷 1377-1382页

作者： Jingjing Zhang Ming Ding Xianjun qi yi Guo School of electrical engineering and automation Hefei University of Technology Hefei China

Aiming at digital relay protection system, a novel hidden failure Markov reliability model is presented for a single main protection and double main protection systems according to hidden failure and protection function under Condition-Based Maintenance (CBM) circumstance and reliability indices such as probability of protection system hidden failure state are calculated. Impacts of different parameters (containing impacts of human errors) to hidden failure state probability and the optimal measures to improve reliability by variable parameter method are also analyzed. It’s demonstrated here that: Compared to a single main protection, double main protection system has an increased hidden failure probability, thus the real good state probability decreases, two main protections’ reliability must be improved at the same time, so configuration of the whole protection system for the component being protected can’t be complicated. Through improving means of on-line self-checking and monitoring system in digital protection system and human reliability, the real application of CBM can decrease hidden failure state probability. Only through this way can we assure that the protection systems work in good state. It has a certain reference value to protection system reliability engineering.

关键词： Double Main Protection System Hidden Failure Markov Method Condition-Based Maintenance (CBM) Human Error