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Normalized glandular dose coefficients for digital breast tomosynthesis using detailed Chinese breast models

Nuclear Science and Techniques 2024年第5期35卷 42-59页

作者： Jia-Hao Wang Rui qiu An-kang Hu Ye-qi Liu Zhen Wu Hui Zhang Jun-Li Li Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle and Radiation Imaging Ministry of EducationTsinghua UniversityBeijing 100084China Joint institute of Tsinghua university Nuctech Company Limited BeijingBeijing 100084China

The rise in breast cancer diagnoses among Chinese women has necessitated the use of X-ray breast screening,which carries a radiation *** study aimed to provide a dosimetry protocol for the Chinese female population to replace the traditional standard that utilizes simplified breast models,for the accurate estimation of the mean glandular dose of a patient undergoing digital breast tomosynthesis(DBT).The first set of detailed Chinese female breast models and representative breast parameters was *** backscatter radiation and computational efficiency,we improved the combination of these models and the Chinese reference adult female whole-body voxel *** acquisition for four commercial DBT systems that are widely employed in china was simulated using the Monte Carlo method to obtain the normalized glandular dose coefficients of DBT(D_(gN)^(DBT))and the glandular depth dose(D_(g)^(dep)(z))for different breast characteristics and X-ray *** calculated a series of D_(gN)^(DBT) values for breasts with different percentage mass glandularities(5%,25%,50%,75%,and 100%)and compressed breast thicknesses(2,3,4,5,6,and 7 cm)at various tube potentials(25,28,30,32,35,and 49 kV)and target/filter combinations(W/Rh,W/Al,Mo/Mo,Rh/Rh,and Rh/Ag).The parameter dependence of the breast characteristics and beam conditions on D_(gN)^(DBT) in detailed breast models was *** D_(gN)^(DBT) results were 14.6-51.0%lower than those of the traditional dosimetry standard in *** difference in D_(gN)^(DBT) was mainly due to a decrease in the depth of the main energy deposition area caused by the glandular distribution along the depth *** results obtained in this study may be used to improve breast dosimetry in china and provide more detailed information on risk assessment during DBT.

关键词： Digital breast tomosynthesis Normalized glandular dose coefficients Detailed breast model Monte Carlo simulation

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Regulating electrochemical performances of lithium battery by external physical field

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Rare Metals 2024年第6期43卷 2391-2417页

作者： Shi-kang Wang Shuai Wu Yi-Cheng Song Hassanien Gomaa Cui-Hua An qi-Bo Deng Ning Hu School of Mechanical Engineering School of Materials Science and EngineeringHebei University of TechnologyTianjin 300401China Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai 200444China Department of Chemistry Faculty of ScienceAl-Azhar UniversityAssiut 71524Egypt Tianjin Key Laboratory of Power Transmission and Safety Technology for New Energy Vehicles Tianjin 300401China State Key Laboratory of Reliability and Intelligence Electrical Equipment Key Laboratory of Advanced Intelligent Protective Equipment TechnologyMinistry of EducationHebei University of TechnologyTianjin 300130China

Lithium batteries have always played a key role in the field of new energy ***,non-controllable lithium dendrites and volume dilatation of metallic lithium in batteries with lithium metal as anodes have limited their ***,a large number of studies have shown that the electrochemical performances of lithium batteries can be enhanced through the regulation of external physical ***,it significantly hinders the growth of lithium dendrites and promoting the reaction *** review summarizes recent innovations in the investigation of various physical fields of lithium *** application of magnetic field in the synthesis of lithium battery electrode materials is *** influence factors and regulation mechanism of various physical fields on the electrochemical performance of lithium batteries are reviewed *** addition,the current research status and existing challenges,along with future directions for the evolution of lithium batteries,are minutely discussed and *** strategies for the further evolution of lithium batteries have also been provided.

关键词： Lithium battery External field assist Reaction kinetics Lithium dendrite

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The chemical structures,biosynthesis,and biological activities of secondary metabolites from the culinary-medicinal mushrooms of the genus Hericium:a review

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Chinese Journal of Natural Medicines 2024年第8期22卷 676-698页

作者： qi Jianzhao WU Jing kang Shijie GAO Jingming Hirokazu Kawagishi LIU Hongwei LIU Chengwei Key Laboratory for Enzyme and Enzyme-Like Material Engineering of Heilongjiang College of Life ScienceNortheast Forestry UniversityHarbin 150040China Shaanxi Key Laboratory of Natural Products&Chemical Biology College of Chemistry&PharmacyNorthwest A&F UniversityYangling 712100China Faculty of Agriculture Shizuoka UniversityShizuoka 422-8529Japan State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

Fungal phytochemicals derived from higher fungi,particularly those from the culinary-medicinal genus Hericium,have gained significant attention in drug discovery and *** review aims to provide a comprehensive analysis of the chemical structures,biosynthetic pathways,biological activities,and pharmacological properties of monomeric compounds isolated from Hericium *** the past 34 years,253 metabolites have been identified from various Hericium species,including cyathane diterpenes,alkaloids,benzofurans,chromenes,phenols,pyrones,steroids,and other miscellaneous *** investigations into the biosynthesis of erinacines,a type of cyathane diterpene,have led to the discovery of novel cyathane *** research has highlighted the biological activities and pharmacological properties of Hericium-derived compounds,with particular emphasis on their neuroprotective and neurotrophic effects,immunomodulatory capabilities,anti-cancer activity,antioxidant properties,and antimicrobial *** A,in particular,has been extensively ***,transcriptomic,and proteomic analyses of Hericium species have facilitated the discovery of new compounds and provided insights into enzymatic reactions through genome *** diverse chemical structures and biological activities of Hericium compounds underpin their potential applications in medicine and as dietary *** review not only advances our understanding of Hericium compounds but also encourages further research into Hericium species within the realms of medicine,health,functional foods,and agricultural *** broad spectrum of compound types and their diverse biological activities present promising opportunities for the development of new pharmaceuticals and edible products.

关键词： Hericium Secondary metabolites Biological activity Biosynthesis

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Enhancing undulation of soft robots in granular media:A numerical and experimental study on the effect of anisotropic scales

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Biomimetic Intelligence & Robotics 2024年第2期4卷 63-70页

作者： Longchuan Li Chaoyue Zhao Shuqian He qiukai qi Shuai kang Shugen Ma College of Information Science and Technology Bejing University of Chemical TechnologyBejing 100029China School of Engineering Mathematics and Technology University of BristolBristol BS81THUK College of Mechanical and Electrical Engineering Beijing University of Chemical TechnologyBeijing 100029China Thrust of Robotics and Autonomous Systems The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511453China

Generating efficient locomotion in granular media is important,although it is difficult for *** by the fact that sand vipers usually have saw-like scales,in this study,we design a soft undulation robot with tangential anisotropic friction to enhance the undulation performance of soft robots in granular media.A mathematical model was derived and numerical simulations were conducted accordingly to investigate the effectiveness of tangential friction anisotropy for undulation gait generation in granular *** particular,we introduce a pseudo-rigid-body dynamics model consisting of links and joints while simulating the pneumatic actuation method to more closely approximate the response of soft ***,a soft snake-like robot was fabricated,and its forward and reverse undulations were compared in two sets of controlled *** consistency between the experimental results and the numerical simulations confirms that tangential anisotropic friction induces a propulsive effect in undulation,thereby increasing the robot's locomotion *** discovery provides new insights into the design of undulation robots in granular environments.2024 The Author(s).Published by Elsevier *** behalf of Shandong *** is an open access articleunder the CCBY license(http://***/licenses/by/4.0/).

关键词： Granular media Anisotropicity Pseudo-rigid-body model Soft robot Undulation

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Bio-inspired barnacle cement coating of biodegradable magnesium alloy for cerebrovascular application

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Rare Metals 2024年第10期43卷 5164-5185页

作者： Hang Li Fei Wang Xiao-Jing Sun Liu-Jie qi Jing-An Li Mujahid Iqbal Shao-kang Guan School of Material Science and Engineering Zhengzhou University Henan Key Laboratory of Advanced Magnesium Alloy&Key Laboratory of Materials Processing and Mold (Ministry of Education) Zhengzhou University Department of Physics University of Agriculture Faisalabad

Ischemic stroke is increasing worldwide, and stent intervention has gradually become one of the effective treatments. Owing to its good mechanical properties and biocompatibility, biodegradable Mg-Zn-Y-Nd alloy(ZE21B) has good application prospects in vascular ***, too fast degradation and delayed endothelialization are the bottleneck problem to limit its further application. In this study, the bio-inspired coating barnacle cement cp19k is constructed on ZE21B surface through electrostatic spraying to improve the corrosion resistance and pro-endothelialization ability. The coating was evaluated through electrochemistry, static immersion corrosion,in vitro blood experiments and cell experiments. Cp19k effectively improved the corrosion resistance of the substrate ZE21B, reduced the degradation rate, improved endothelial cell proliferation and migration capabilities,inhibited smooth muscle cells proliferation and regulated contractile phenotype, inhibited macrophage adhesion,regulated macrophage M2 phenotype, and reduced the expression of inflammatory factor of TNF-a and inhibited fibroplasia in vivo. Our data indicated that the barnacle cement cp19k coating had potential application on the surface modification of Mg alloy cerebrovascular stent.

关键词： Barnacle cement cp19k Biodegradable magnesium alloy Cerebrovascular stent M2 phenotype Pro-endothelialization

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Renewable conversion of coal gangue to 13-X molecular sieve for Cd^(2+)-containing wastewater adsorption performance

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Rare Metals 2024年第2期43卷 702-710页

作者： Le kang Si-Fan Liu Da-Wei Yi Kai Wang Hui-Ling Du Hao-qi Huang Peng Chen College of Materials Science and Engineering Xi’an University of Science and TechnologyXi’an710054China School of Electrical Engineering Weihai Innovation Research InstituteQingdao UniversityQingdao266000China School of Metallurgy Northeastern UniversityShenyang110819China School of Materials and Chemical Engineering Tongren UniversityTongren554300China

Using coal gangue(CG)as raw material,a new type of all solid-waste-based 13-X molecular sieve material was controllably prepared by alkali fusion-hydrothermal *** synthetic molecular sieve was used as a solid adsorbent to treat Cd^(2+)-containing wastewater,and its adsorption behavior on Cd^(2+)in aqueous solution was studied and *** microstructure and morphology of the molecular sieve were investigated by X-ray diffraction(XRD),field emission scanning electron microscopy(FESEM)and specific surface area *** results show that the synthesized 13-X molecular sieve has higher Brunauer–Emmett–Teller(BET)specific surface area with higher crystallinity and higher adsorption capacity for the heavy metal Cd^(2+).The adsorption process of Cd^(2+)by molecular sieve conforms to the Langmuir isotherm adsorption equation and Lagergren pseudo-second-order rate *** with thermodynamic calculation,it can be concluded that the adsorption process is physically monolayer,spontaneous and *** this study,a low-cost and naturally available synthesis method of 13-X molecular sieve is *** with its adsorption mechanism for Cd^(2+),it provides a feasible and general method for removing heavy metal ions from coal gangue and also provides a new way for the utilization of coal gangue with high added value.

关键词： Coal gangue Hydrothermal synthesis 13-X molecular sieve Adsorption Wastewater containing Cd^(2+)

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Depth First:Optimal Path Discovery Between Designated Nodes in Random Ring-Based Graphs

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china Communications 2024年第9期21卷 225-241页

作者： Li qi Xu Jiasheng Zhang Haonan kang Huquan Fu Luoyi Long Fei Wang Xinbing Department of Electronic Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Computer Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Media Convergence Production Technology and Systems Xinhua News AgencyBeijing 100077China

This paper focuses on optimally determining the existence of connected paths between some given nodes in random ring-based *** as a fundamental underlying structure in network modeling,ring topology appears as commonplace in many realistic *** this,we consider graphs composed of rings,with some possible connected paths between *** prior knowledge of the exact node permutations on rings,the existence of each edge can be unraveled through edge testing at a unit cost in one *** problem examined is that of determining whether the given nodes are connected by a path or separated by a cut,with the minimum expected costs *** the problem into different cases based on different topologies of the ring-based networks,we propose the corresponding policies that aim to quickly seek the paths between nodes.A common feature shared by all those policies is that we stick to going in the same direction during edge searching,with edge testing in each step only involving the test between the source and the node that has been tested *** simple searching rule,interestingly,can be interpreted as a delightful property stemming from the neat structure of ring-based networks,which makes the searching process not rely on any sophisticated *** prove the optimality of the proposed policies by calculating the expected cost incurred and making a comparison with the other class of *** effectiveness of the proposed policies is also verified through extensive simulations,from which we even disclose three extra intriguing findings:i)in a onering network,the cost will grow drastically with the number of designated nodes when the number is small and will grow slightly when that number is large;ii)in ring-based network,Depth First is optimal in detecting the connectivity between designated nodes;iii)the problem of multi-ring networks shares large similarity with that of two-ring networks,and a larger number of ties between ri

关键词： connectivity analysis cost minimization path discover ring-based graph

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Hepatocellular SETDB1 Regulates Hepatic Ischemia-Reperfusion Injury through Targeting Lysine Methylation of ASK1 Signal

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research 2024年第3期6卷 305-317页

作者： kang Xia Tianyu Wang Zhongbao Chen Jiayu Guo Bo Yu qi Chen Tao qiu Jiangqiao Zhou Shusen Zheng Department of Organ Transplantation Renmin Hospital of Wuhan UniversityWuhanChina Department of Urology Renmin Hospital of Wuhan UniversityWuhanChina. Department of general surgery Renmin Hospital of Wuhan UniversityWuhanChina Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryFirst Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Key Laboratory of Combined Multi-Organ Transplantation Ministry of Public HealthHangzhouChina Key Laboratory of Organ Transplantation HangzhouZhejiang ProvinceChina Key Laboratory of the Diagnosis and Treatment of Organ Transplantation CAMSHangzhouChina.

Background: Hepatic ischemia-reperfusion injury (HIRI) stands as an unavoidable complication arising from liver surgery, profoundly intertwined with its prognosis. The role of lysine methyltransferase SET domain bifurcated 1 (SETDB1) in HIRI remains elusive, despite its confirmation as a potential therapeutic target for diverse diseases. Here, we investigated the mechanism by which SETDB1 regulated HIRI. Methods: RNA sequencing data were used to identify the expression and potential targets of SETDB1 through bioinformatics analysis. To elucidate the impact of SETDB1 on HIRI, both an in vivo model of HIRI in mice and an in vitro model of hepatocyte hypoxia/reoxygenation were established. Biochemical and histological analyses were used to investigate the influence of SETDB1 on liver damage mediated by HIRI. Chromatin immunoprecipitation and coimmunoprecipitation were implemented to explore the in-depth mechanism of SETDB1 regulating HIRI. Results: We confirmed that hepatocellular SETDB1 was up-regulated during HIRI and had a close correlation with HIRI-related inflammation and apoptosis. Moreover, inhibition of SETDB1 could mitigate HIRI-induced liver damage, inflammation, and apoptosis. Through our comprehensive mechanistic investigation, we revealed that SETDB1 interacts with apoptosis-signal-regulating kinase 1 (ASK1) and facilitates the methylation of its lysine residues. Inhibition of SETDB1 resulted in reduced phosphorylation of ASK1, leading to a marked suppression of downstream c-Jun N-terminal kinase (JNK)/p38 signaling pathway activation. The therapeutic effect on inflammation and apoptosis achieved through SETDB1 inhibition was nullified by the restoration of JNK/p38 signaling activation through ASK1 overexpression. Conclusions: The findings from our study indicate that SETDB1 mediates lysine methylation of ASK1 and modulates the activation of the ASK1–JNK/p38 pathway, thus involved in HIRI-induced inflammation and apoptosis. These results suggest that SETD

关键词： SETDB1 inflammation ASK1

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In Situ Deposition of Drug and Gene Nanoparticles on a Patterned Supramolecular Hydrogel to Construct a Directionally Osteochondral Plug

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Nano-Micro Letters 2024年第1期16卷 341-359页

作者： Jiawei kang Yaping Li Yating qin Zhongming Huang Yifan Wu Long Sun Cong Wang Wei Wang Gang Feng Yiying qi Department of Orthopaedic Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhou City 310009Zhejiang ProvincePeople’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310027People’s Republic of China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311215ZhejiangPeople’s Republic of China The Affiliated Nanhua Hospital Orthopedic Research CentreHengyang Medical SchoolUniversity of South ChinaHengyang 421001HunanPeople’s Republic of China Department of Radiology Jining No.1 People’s HospitalJining Medical UniversityJining 272000ShandongPeople’s Republic of China

The integrated repair of bone and cartilage boasts advantages for osteochondral restoration such as a long-term repair effect and less deterioration compared to repairing cartilage *** multifactorial,spatially oriented scaffolds to stimulate osteochondral regeneration,has immense ***,targeted drugs,namely kartogenin@polydopamine(KGN@PDA)nanoparticles for cartilage repair and miRNA@calcium phosphate(miRNA@CaP)NPs for bone regeneration,were in situ deposited on a patterned supramolecular-assembled 2-ureido-4[lH]-pyrimidinone(UPy)modified gelation hydrogel film,facilitated by the dynamic and responsive coordination and complexation of metal ions and their *** hydrogel film can be rolled into a cylindrical plug,mimicking the Haversian canal structure of natural *** resultant hydrogel demonstrates stable mechanical properties,a self-healing ability,a high capability for reactive oxygen species capture,and controlled release of KGN and *** vitro,KGN@PDA and miRNA@CaP promote chondrogenic and osteogenic differentiation of mesenchymal stem cells via the JNK/RUNX1 and GSK-3β/β-catenin pathways,*** vivo,the osteochondral plug exhibits optimal subchondral bone and cartilage regeneration,evidenced by a significant increase in glycosaminoglycan and collagen accumulation in specific zones,along with the successful integration of neocartilage with subchondral *** biomaterial delivery approach represents a significant toward improved osteochondral repair.

关键词： Osteochondral regeneration Oriented hydrogel Kartogenin miRNA-26a

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Sulfur doped iron-nitrogen-hard carbon nanosheets as efficient and robust noble metal-free catalysts for oxygen reduction reaction in PEMFC

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Journal of Energy Chemistry 2024年第2期89卷 422-433,I0010页

作者： Bin Liu Jiawang Li Bowen Yan qi Wei Xingyu Wen Huarui Xie Huan He Pei kang Shen Zhi Qun Tian Collaborative Innovation Center of Sustainable Energy Materials School of Physical Science and TechnologyGuangxi UniversityGuangxi Key Laboratory of Electrochemical Energy MaterialsState Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite StructuresNanning 530004GuangxiChina

Transition metal-nitrogen-carbon(M-N-C)as a promising substitute for the conventional noble metalbased catalyst still suffers from low activity and durability for oxygen reduction reaction(ORR)in proton exchange membrane fuel cells(PEMFCs).To tackle the issue,herein,a new type of sulfur-doped ironnitrogen-hard carbon(S-Fe-N-HC)nanosheets with high activity and durability in acid media were developed by using a newly synthesized precursor of amide-based polymer with Fe ions based on copolymerizing two monomers of 2,5-thiophene dicarboxylic acid(TDA)as S source and 1,8-diaminonaphthalene(DAN)as N source via an amination *** as-synthesized S-Fe-N-HC features highly dispersed atomic Fe Nxmoieties embedded into rich thiophene-S doped hard carbon nanosheets filled with highly twisted graphite-like microcrystals,which is distinguished from the majority of M-N-C with soft or graphitic carbon *** unique characteristics endow S-Fe-N-HC with high ORR activity and outstanding durability in 0.5 M H_(2)SO_(4).Its initial half-wave potential is 0.80 V and the corresponding loss is only 21 m V after 30,000 ***,its practical PEMFC performance is a maximum power output of 628.0 mW cm^(-2)and a slight power density loss is 83.0 m W cm^(-2)after 200-cycle practical ***,theoretical calculation shows that the activity of Fe Nxmoieties on ORR can be further enhanced by sulfur doping at meta-site near FeN_(4)*** results evidently demonstrate that the dual effect of hard carbon substrate and S doping derived from the precursor platform of amid-polymers can effectively enhance the activity and durability of Fe-N-C catalysts,providing a new guidance for developing advanced M-N-C catalysts for ORR.

关键词： Transition metal-nitrogen-carbon Oxygen reduction reaction Hard carbon Amide based polymer reaction Proton exchange membrane cells

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