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Multiple microRNAs control ecdysone signaling in the midgut of Spodoptera litura

Insect Science 2020年第6期27卷 1208-1223页

作者： Wei Luo Li-Xia Huang Shuang-Kang qin xian Zhang qi-Li Feng jun Gu Li-Hua Huang Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Institute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhouChina Guangzhou Key Laboratory of Insect Development Regulation and Application Research Institute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhouChina Hubei Key Laboratory of Application of Plant-Cancer Active Ingredients School of Chemistry and Life SciencesHubei University of EducationWuhanChina

Metamorphosis is one of the most important physiological processes in *** is regulated by a serial of ecdysone cascade ***,lots o f microRNAs(miRNAs)were investigated in insects;however,their function in metamorphosis is largely *** the present study,the dynamics of a small RNA population was investigated by RNA sequencing from the midgut of a lepidopteran pest Spodoptera litura during larval-pupal metamorphosis.A total of 101 miRNAs were identified,and 75 miRNAs were differentially expressed during the metamorphic *** relationship between these differentially expressed miRNAs and 12 ecdysone cascade genes was analyzed by four classical software programs,and a multiple-to-multiple regulatory network was found to exist between these miRNAs and their *** them,miR-14-3p and its two targets(EcR and E75)were chosen for further ***-14-3p had higher expression level in the 6 th instar larvae as compared with either the prepupae or pupae,which was opposite to that of both EcR and E75,two ecdysone cascade *** reporter assay confirmed that both EcR and E75 were regulated by ***,the 3'untranslated regions are nearly identical to each other among different transcript variants of the ecdysone cascade genes,including EcR,USP,E75,E74,E78,E93,Hr3,Hr4,Hr39,K rhl and F ***,different transcript variants of one ecdysone cascade gene could be regulated by the same mi *** above data suggest that the ecdysone signaling pathway is under the tight control of *** findings expand our understanding of the mechanism of insect metamorphosis and may also provide a novel possibility for the control of pest insects in the future.

关键词： ecdysone EcR E75 metamorphosis microRNA midgut

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THS-GWNN:a deep learning framework for temporal network link prediction

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Frontiers of Computer Science 2022年第2期16卷 174-176页

作者： xian MO jun PANG Zhiming LIU College of Computer&Information Science Southwest UniversityChongqing 400715China Faculty of Science Technology and Medicine&Interdisciplinary Centre for SecurityReliability and TrustUniversity of LuxembourgEsch-sur-Alzette L-4364Luxembourg

1 Introduction and main contributions Link prediction for temporal networks aims to evaluate the likelihood of the future linkage among nodes,which has significant applications in social networks,biological networks and traffic analysis[1],*** embedding[2]is an important analytical tool for temporal network link prediction,which helps us better understand network evolution[3].How to encode high-dimensional and non-Euclidean network information is a crucial problem for node embedding in temporal *** of the challenges is to reveal the spatial structure at each timestamp and the temporal property over time[4].Some existing work[5]shows that extracting the spatial relation of each node can be used as a valid feature representation for each ***,the emergence of deep learning techniques[4,5]brings new insights for learning temporal properties,but most models using deep learning still fail to achieve satisfying prediction accuracy.

关键词： network prediction networks

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BZR1 Interacts with HY5 to Mediate Brassinosteroid- and Light-Regulated Cotyledon Opening in Arabidopsis in Darkness

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Molecular Plant 2016年第1期9卷 113-125页

作者： qian-Feng Li jun-xian He School of Life Sciences and State Key Laboratory of Agrobiotechnology The Chinese University of Hong Kong 186 Science Center (South) Shatin New TerritoriesHong Kong Special Administration Region China Key Laboratory of Plant Functional Genomics of Ministry of Education and Key Laboratory of Crop Genetics and Physiology Agricultural College YangzhouUniversity Jiangsu 225009 China

Light and brassinosteroid （BR） are two central stimuli that regulate plant photomorphogenesis. Although previous phenotypic and physiological studies have implied possible interactions between BR and light in regulating photomorphogenesis, the underlying molecular mechanism（s） remain largely unknown. In the present study, we identified a physical connection between the BR and light signaling pathways, which was mediated by the BR-regulated transcription factor BZR1 and light-regulated transcription factor HY5 in Arabidopsis thaliana. Genetic evidence showed that the gain-of-function bzrl-lD mutant in the BR signaling pathway and loss-of-function hy5-215 mutant in the light signaling pathway exhibited closed cotyledons under BR-deficient and dark-grown conditions and both bzrl-lD and hy5-215 mutants were able to suppress the cotyledon opening phenotype of the BR-insensitive mutants bril-5 and bin2-1. Biochemical studies demonstrated that BZR1 interacts with HY5 both in vitro and in vivo and ectopic expression of HY5 considerably reduces the accumulation of BZR1 protein. In addition, HY5 specifically interacts with the dephosphorylated form of BZR1 and attenuates BZRI＇s transcriptional activity in regulating its target genes related to cotyledon opening. Our study provides a molecular framework for coordination of BR and light signals in regulating cotyledon opening, an important process in photomor- phogenesis in plants.

关键词： photomorphogenesis brassinosteroid light HY5 BZR1 Arabidopsis thaliana

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Management of children with COVID-19: experiences from China

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World Journal of Pediatrics 2020年第3期16卷 217-218页

作者： Si-Yun Xu Li-Li Yang qi qi xian-jun Wang Yi-Cheng Xie Zheng-Yan Zhao qiang Shu Children's Hospital Zhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children's Regional Medical CenterHangzhou 310052China

The coronavirus disease 2019 (COVID-19) global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major public health *** a special population,children have special respiratory tract structure characteristics,immature immune system,and susceptibility to respiratory virus ***,it is highly important for clinicians to treat the infected children cautiously despite most pediatric patients have milder symptoms and better prognosis compared with the adult patients.

关键词： respiratory acute patients

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Energy-Work Connection Integration Scheme for Nonholonomic Hamiltonian Systems

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Communications in Theoretical Physics 2008年第11期50卷 1041-1046页

作者： WANG xian-jun FU Jing-Li Department of Physics Henan Institute of Education Zhengzhou 450014 China Institute of Mathematical Physics Zhejiang Sci-Tech University Hangzhou 310018 China

This paper focuses on studying a new energy-work relationship numericM integration scheme of nonholonomic Hamiltonian systems. The signal-stage numerical, multi-stage and parallel composition numerical integration schemes are presented. The high-order energy-work relation scheme of the system is constructed by a parallel connection of n multi-stage schemes of order 2, its order of accuracy is 2n. The connection, which is discrete analogue of usual case, between the change of energy and work of nonholonomic constraint forces is obtained for nonholonomie Hamiltonian systems. This paper also gives that there is smaller error of the scheme when taking a large number of stages than a less one. Finally, an applied example is discussed to illustrate these results.

关键词： numerical integration differential equation high-order scheme energy-work relationship nonholonomic Hamiltonian system

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Social responsibilities of a pediatric journal:considerations and future directions

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World Journal of Pediatrics 2021年第1期17卷 1-2页

作者： Li-Li Yang xian-jun Wang qi qi Si-Yun Xu Yi-Cheng Xie Zheng-Yan Zhao qiang Shu National Clinical Research Center for Child Health National Children's Regional Medical CenterChildren's HospitalZhejiang University School of MedicineHangzhou 310052China

***,the former editor of JAMA,elucidated many social responsibilities for medical journal editing as early as 1987[1].During the pandemic,a medical journal should highlight its social responsibilities in publishing high-qual-ity contents,promoting education to the health care pro-viders and providing readers with the timely and accurate information[1].At the time of this editorial published,the global cases of coronavirus disease 2019(COVID-19)had surpassed 85 *** pandemic and its resulting eco-nomic,health,and educational disruptions have affected all aspects of the youth's lives[2].Quarantine and social isola-tion,increased risks of child abuse and neglect,financially and psychologically stressed family members have led to negative mental outcomes in children and adolescents.

关键词： journal editor publishing

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A Finite-Dimensional Completely Integrable System Associated with Boussinesq Hierarchy

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Communications in Theoretical Physics 2009年第12期52卷 1081-1086页

作者： CHEN Lan-Xin ZHANG jun-xian China University of Mining and Technology Beijing 100083 China Shijiazhuang University Shijiazhuang 050035 China

In this paper, a new completely integrable system related to the complex spectral problem -φ xx＋（i/4）wpx＋（i/4）（wp）x＋（1/4）vφ=iλφxand the constrained flows of the Boussinesq equations axe generated. According to the viewpoint of Hamiltonian mechanics, the Euler-Lagrange equations and the Legendre transformations, a reasonable Jacobi-Ostrogradsky coordinate system is obtained. Moreover, by means of the constrained conditions between the potentiaJ u, v and the eigenfunction φ, the involutive representations of the solutions for the Boussinesq equation hieraxchy axe given.

关键词： eigenvalue problem constraint flow symplectic manifold completely integrability involutive representation

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Motion constraint Markov network model for multi-target tracking

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Optoelectronics Letters 2008年第5期4卷 375-378页

作者： WU Ming-jun PENG xian-rong ZHANG qi-heng LU Gang FAN Zhi-hua Institute of Optics and Electronics Chinese Aeademy of Sciences Chengdu 610209 China Graduate School of Chinese Academy of Sciences Beijing 100039 China

A typical Markov network for modeling the interaction among targets can handle the error merge problem,but it suffers from the labeling problem due to the blind competition among collaborative trackers. In this paper,we propose a motion constraint Markov network model for multi-target tracking. By augmenting the typical Markov network with an ad hoc Markov chain which carries motion constraint prior,this proposed model can overcome the blind competition and direct the label to the corresponding target even in the case of severe occlusion. In addition,the motion constraint prior is formu-lated as a local potential function and can be easily incorporated in the joint distribution representation of the novel model. Experimental results demonstrate that our model is superior to other methods in solving the error merge and labeling problems simultaneously and efficiently.

关键词：网络模型多目标跟踪交互作用运动约束

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Symmetries and Mei Conserved Quantities for Nonholonomic Systems with Servoconstraints

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Communications in Theoretical Physics 2009年第1期51卷 1-5页

作者： XIA Li-Li WANG xian-jun ZHAO xian-Lin Department of Physics Henan Institute of Education Zhengzhou 450014 China

This paper concentrates on studying the symmetries and a new type of conserved quantities called Mei conserved quantities for Nonholonomic Systems with Servoconstraints. The criterions of the Mei symmetry, the Noether symmetry, and the Lie symmetry are given. The conditions and the forms of the Mei conserved quantities deduced from these three symmetries are obtained. An example is given to illustrate the appfication of the results.

关键词： nonholonomic systems servoconstraints symmetry conserved quantity

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Tackling Osteoarthritic Knee Pain with Electroacupuncture

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Chinese Journal of Integrative Medicine 2018年第11期24卷 803-805页

作者： CHEN jun LIU xian-xiang Academy of Integrative Medicine Fujian University of Traditional Chinese Medicine

Electroacupuncture（EA） has been widely used in pain relief. Clinical evidence has revealed its unique advantages and effectiveness in alleviating pain. Studies on EA and pain relief have revealed that EA displays greater analgesic effects for different types of pain in comparison to manual acupuncture. Here, we reviewed the clinical application and mechanism of EA in treating osteoarthritic knee pain and its influence factors in curative effect.

关键词： electroacupunture osteoarthritic knee pain clinical application mechanismof action

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