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Effects of Tanreqing Injection on ICU Mortality among ICU Patients Receiving Mechanical Ventilation: Time-Dependent Cox Regression Analysis of A Large Registry

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Chinese Journal of Integrative Medicine 2023年第9期29卷 782-790页

作者： WANG Wen HE qiao WANG Ming-qi XU Jia-yue JI Peng ZHANG Rui ZOU Kang SUN Xin Chinese Evidence-Based Medicine Center West China HospitalSichuan UniversityChengdu610041China NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan Chengdu610041China Sichuan Center of Technology Innovation for Real World Data Chengdu610041China Intensive Care Unit West China HospitalSichuan UniversityChengdu610041China Information Center West China HospitalSichuan UniversityChengdu610041China

Objective To assess whether the use of Tanreqing(TRQ)Injection could show improvements in time to extubation,intensive care unit(ICU)mortality,ventilator-associated events(VAEs)and infection-related ventilator associated complication(IVAC)among patients receiving mechanical ventilation(MV).Methods A time-dependent cox-regression analysis was conducted using data from a well-established registry of healthcare-associated infections at ICUs in *** receiving continuous MV for 3 days or more were included.A time-varying exposure definition was used for TRQ Injection,which were recorded on daily *** outcomes included time to extubation,ICU mortality,VAEs and ***-dependent Cox models were used to compare the clinical outcomes between TRQ Injection and non-use,after controlling for the influence of comorbidities/conditions and other medications with both fixed and time-varying *** the analyses of time to extubation and ICU mortality,Fine-Gray competing risk models were also used to measure competing risks and outcomes of *** Overall,7,685 patients were included for the analyses of MV duration,and 7,273 patients for the analysis of ICU *** to non-use,patients with TRQ Injection had a lower risk of ICU mortality(Hazards ratios(HR)0.761,95%CI,0.581–0.997),and was associated with a higher hazard for time to extubation(HR 1.105,95%CI,1.005–1.216),suggesting a beneficial effect on shortened time to *** significant differences were observed between TRQ Injection and non-use regarding VAEs(HR 1.057,95%CI,0.912–1.225)and IVAC(HR 1.177,95%CI,0.929–1.491).The effect estimates were robust when using alternative statistic models,applying alternative inclusion and exclusion criteria,and handling missing data by alternative *** Our findings suggested that the use of TRQ Injection might lower mortality and improve time to extubation among patients receiving MV,even after controlling for the factor tha

关键词： Tanreqing critical care mechanical ventilation mortality ventilator-associated events

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Significant lake expansion has accelerated permafrost degradation on the qinghai-Tibet Plateau

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Journal of Mountain Science 2024年第1期21卷 68-83页

作者： LI qingpeng LIU Wenhui LIU Hairui ZHOU Guanghao SONG Xianteng LI qing LUO Bingnan SONG Bangxu ZHANG qi Department of Geological Engineering Qinghai UniversityXining 810016China College of Eco-Environmental Engineering Qinghai UniversityXining 810016China Xining Center for Integrated Natural Resources Survey China Geological SurveyXining 810000China

In recent years, lakes on the qinghai-Tibet Plateau have become more responsive to climate change. In September 2011, Zonag Lake in Hoh Xil experienced sudden drainage, the water eventually flowed into Yanhu Lake, which caused Yanhu Lake to continue to expand. The potential collapse of Yanhu Lake could directly threaten the operational safety of the adjacent qinghai-Tibet Highway, qinghai-Tibet Railway. To explore the implications of expanding lakes on the surrounding permafrost, we selected Hoh Xil Yanhu Lake on the qinghai-Tibet Plateau to study the effect of lake expansion on permafrost degradation. The permafrost degradation in the Yanhu Lake basin from October 2017 to December 2022 was inverted using Sentinel-1 satellite image data and small baseline subset interferometry synthetic aperture radar(SBAS-In SAR) technology. Additionally, permafrost degradation from February 2007 and February 2010 was analyzed using advanced land observing satellite phased array-type L-band synthetic aperture radar(ALOS PALSAR) satellite images and differential interferometric synthetic aperture radar(D-In SAR) technique. The results showed that the permafrost around Yanhu Lake experienced accelerated degradation. Prior to the expansion of Yanhu Lake, the average annual deformation rate along the line of sight(LOS) direction was 6.7 mm/yr. After the expansion, the rate increased to 20.9 mm/yr. The integration of spatial-temporal distribution maps of surface subsidence, Wudaoliang borehole geothermal data, meteorological data, Yanhu Lake surface area changes, and water level changes supports the assertion that the intensified permafrost degradation could be attributed to lake expansion rather than the rising air temperature. Furthermore, permafrost degradation around Yanhu Lake could impact vital infrastructure such as the adjacent qinghai-Tibet Highway and qinghai-Tibet Railway.

关键词： Lake expansion SBAS-InSAR D-InSAR Permafrost deformation qinghai-Tibet Plateau

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缺血性脑卒中铁死亡特征基因NFE2L2的鉴定与验证

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中国组织工程研究 2025年第7期29卷 1466-1474页

作者：王咪马书杰刘杨齐瑞上海中医药大学附属岳阳中西医结合医院康复医学科上海市200437 上海中医药大学上海市201203 上海市第二康复医院上海市200431

背景:铁死亡与缺血性脑卒中的发病密切相关,靶向铁死亡是一种治疗缺血性脑卒中有前景的方案,但具体调控靶点尚不明确。目的:通过生物信息学和机器学习方法筛选缺血性脑卒中铁死亡相关特征基因,并通过细胞实验进行验证,探讨铁死亡在缺血... 详细信息

背景:铁死亡与缺血性脑卒中的发病密切相关,靶向铁死亡是一种治疗缺血性脑卒中有前景的方案,但具体调控靶点尚不明确。目的:通过生物信息学和机器学习方法筛选缺血性脑卒中铁死亡相关特征基因,并通过细胞实验进行验证,探讨铁死亡在缺血性脑卒中的作用。方法:基于GEO数据库和FerrDb数据库选取符合条件的缺血性脑卒中相关数据集和铁死亡表达数据集,通过t检验筛选铁死亡相关差异基因。对铁死亡相关差异基因进行GO功能富集分析与KEGG信号通路富集分析。通过PPI网络分析和机器学习筛选缺血性脑卒中铁死亡的特征基因,利用ROC分析和GSEA分析探究特征基因的准确性和生物功能。然后进行细胞实验,将HT22细胞分为对照组与缺血性脑卒中组,对照组不作任何干预,缺血性脑卒中组加入0.1 mol/L的H_(2)O_(2)干预24 h诱导细胞氧化应激和铁死亡,通过实时荧光定量RT-PCR和Western Blot验证铁死亡的发生和特征基因表达。结果与结论:(1)共获取45个铁死亡相关差异基因,GO和KEGG富集分析发现差异基因与氧化应激、自噬、铁死亡、脂肪细胞因子信号通路和线粒体代谢密切相关。(2)通过PPI网络中的MCODE插件和cytoHubba插件与机器学习中的LASSO算法和SVM-RFE算法共鉴定出1个铁死亡特征基因核因子E2相关因子2(nuclear factor erythroid 2-related factor 2,NFE2L2)。(3)对NFE2L2进行ROC曲线分析,发现在训练集和验证集中构建的诊断预测模型具有良好的准确性与特异性;对NFE2L2进行GSEA分析,发现特征基因通过免疫、炎症反应、氨基酸代谢及神经因子调控等方面参与缺血性脑卒中发病机制的调控。(4)细胞实验的RT-PCR和Western Blot分析表明,与对照组对比,缺血性脑卒中组中的酰基辅酶A合成酶长链家族成员4 mRNA和蛋白表达水平显著增高(P<0.05),谷胱甘肽过氧化物酶4 mRNA和蛋白表达水平显著降低(P<0.05);与对照组对比,缺血性脑卒中组中特征基因NFE2L2 mRNA和蛋白表达水平显著增高(P<0.05)。(5)上述结果证实,缺血性脑卒中与铁死亡密切相关,靶向特征基因NFE2L2可以为研究和治疗缺血性脑卒中提供一定的思路与方向。

关键词：缺血性脑卒中铁死亡生物信息学 HT22细胞机器学习特征基因细胞实验 NFE2L2 ASCL4 GPX4

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Spatio-temporal differentiation of climate warming(1959-2016)in the middle qinling Mountains of China

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Journal of Geographical Sciences 2020年第4期30卷 657-668页

作者： ZHAO Ting BAI Hongying YUAN Yuan DENG Chenhui qi Guizeng ZHAI Danping Northwest University Xi’an 710127China Shaanxi Key Laboratory of Earth Surface System and Environmental Carrying Capacity College of Urban and Environmental ScienceXi'an 710127China Meteorological Bureau of Shangluo Shangluo 726000ShaanxiChina Xianyang Normal University Xianyang 712000ShaanxiChina

Based on air temperature observation data from 32 meteorological stations, temperature changes in the middle qinling Mountains from 1959 to 2016 were analysed with respect to the north-south, seasonal and altitude differences. Our research mainly showed the following results. The annual temperature(TA) rose approximately 0.26℃/10 a within the past 58 years. This warming trend was stronger on the northern slope than on the southern slope, and a warming trend reversal occurred in 1994 on the northern slope, which was three years earlier than on the southern slope. The temperature changes for the four seasons were not synchronized, and the trend in spring contributed the most to the TA trend, followed by winter, autumn, and summer. The temperature difference between summer and winter(TDSW) decreased significantly over the past 58 years. The temperature change in the middle qinling Mountains was clearly dependent on altitude. With increases in altitude, the TA increased gradually and became stronger while the TDSW decreased gradually and became weaker. Differences in temperature change between the north and south were mainly observed in low-altitude areas. With increase in altitude, the differences gradually tended to disappear.

关键词： air temperature change trend seasonal differences altitude dependence middle qinling Mountains China

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Childhood suffering:hyper endemic echinococcosis in qinghai-Tibetan primary school students,China

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Infectious Diseases of Poverty 2018年第1期7卷 704-713页

作者： Xiu-Min Han qi-Gang Cai Wei Wang Hu Wang qiang Zhang Yong-Shun Wang Hydatid Disease Clinical Research Institute Qinghai Provincial People’s HospitalBuilding No.1Gonghe Road No.2Chengdong districtXining City 810007Qinghai ProvinceChina State Key Laboratory of Plateau Ecology and Agriculture Qinghai Academy of Animal Science and Veterinary MedicineQinghai UniversityXining 810016Qinghai ProvinceChina qinghai Institute for Endemic Disease Prevention and Control Xining 811602Qinghai ProvinceChina Public Health and Family Planning Commission Xining 810007Qinghai ProvinceChina

Background:As part of an ongoing program that aims to use early detection and timely treatment to improve the control of echinococcosis,especially in younger age groups,we undertook a series of active surveys among qinghai-Tibetan children in the qinghai Province of Northwestern China in 2011 and *** significant outcomes that resulted from this study emphasize the need to draw attention to echinococcosis,both alveolar echinococcosis(AE)and cystic echinococcosis(CE),so that policy development is promoted and suitable avenues for control are identified in the highly endemic areas on the Tibetan ***:A total of 19629 primary school students,aged 6-18 years,with a dominant Tibetan background underwent abdominal ultrasound examination,and 86.4%of the compliant students donated 2-5 ml of venous blood for serological *** the abnormal ultrasound results were *** identified as echinococcosis,the disease lesion was assessed according to the WHO-Informal Working Group on Echinococcosis(WHO-IWGE)classification for AE and *** the surveyed students,the prevalence by school was compared among geo-locations,sex and age *** clinical image presentations were analyzed according to lesion number,size,the location in the liver and the classification *** significance was set at P-valueqinghai-Tibetan primary school students reflects a lack of knowledge about Echinococcus *** combina

关键词： Echinococcus Echinococcosis High prevalence Tibetan children qinghai China

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学业情绪视域下个性化数学作业对学生影响的研究

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兵团教育学院学报 2025年第1期35卷 77-84页

作者：何玉琪芜湖职业技术学院人文旅游学院安徽芜湖241006

数学是一门逻辑性强、难度大的学科,符合学生个性发展的数学作业会对学生学习和心理发展起事半功倍的效果。为探究个性化数学作业对学生学业情绪的影响机制,研究针对蚌埠市Y中学200名学生进行调查得出主要研究结论:(1)学生对个性化数学... 详细信息

数学是一门逻辑性强、难度大的学科,符合学生个性发展的数学作业会对学生学习和心理发展起事半功倍的效果。为探究个性化数学作业对学生学业情绪的影响机制,研究针对蚌埠市Y中学200名学生进行调查得出主要研究结论:(1)学生对个性化数学作业持积极态度,不存在性别差异。(2)学生的作业态度和认识、完成方式、评价与积极学业情绪呈正相关,作业量和难易程度呈负相关。(3)通过回归分析发现,作业类型对学业情绪没有影响。最后基于研究结果从学业情绪视角提出提升个性化数学作业的建议,为助力个性化数学作业提供实践借鉴。

关键词：个性化数学作业学业情绪调查研究

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闷黄前日晒处理对黄茶香气的影响

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食品工业科技 2025年第1期46卷 13-21页

作者：陈新颖亓俊然张丽霞山东农业大学园艺科学与工程学院山东泰安271018

为探究在鲜叶低温处理基础上,“日晒”与“闷黄”以及两者相互作用对黄茶香气品质的影响,本文以5℃、18 h低温处理的‘金萱’一芽一叶鲜叶为原料,设置不同时长的闷黄前日晒处理、湿坯闷黄处理以及两者组合处理工艺,对所得茶样通过感官... 详细信息

为探究在鲜叶低温处理基础上,“日晒”与“闷黄”以及两者相互作用对黄茶香气品质的影响,本文以5℃、18 h低温处理的‘金萱’一芽一叶鲜叶为原料,设置不同时长的闷黄前日晒处理、湿坯闷黄处理以及两者组合处理工艺,对所得茶样通过感官审评和顶空固相微萃取-气质联用仪进行分析。结果表明,揉捻叶在光强为1700±50μmol∙m^(-2)∙s^(-1)、室外温度为35±5℃、空气湿度为30%±5%的环境条件下,日晒处理0.5 h,随后在温度45℃、湿度70%的环境下湿坯闷黄3 h获得的黄茶品质最优,与湿坯闷黄3 h的对照茶样相比,其香气物质总量增加91.26%,其中呈甜香和花果香型的酮类、醛类、醇类和酯类物质的含量分别为对照茶样的6.18、5.55、3.79和2.99倍,呈清香型的含硫香气组分含量降低26.72%,提高了‘金萱’黄茶香气浓度,促进其香型的转变。此外,日晒处理和湿坯闷黄处理之间存在相互作用,日晒处理可以有效缩短湿坯闷黄时长,同时湿坯闷黄处理有利于去除日晒处理带来的日腥味,并进一步提升‘金萱’黄茶香气品质。

关键词：黄茶香气日晒处理闷黄

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Quantifying glacial elevation changes in the central qilian Mountains during the early 21^(st) century

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Journal of Mountain Science 2021年第11期18卷 2946-2959页

作者： ZHANG qi-bing MO Cao-hu ZHAO Di JIANG Zong-li CHEN Zhe-fu WU Kun-peng ZHANG Zhen College of Geography and Tourism Hunan University of Arts and ScienceChangde 415000China Hunan Province Key Laboratory of Coal Resources Clean-Utilization and Mine Environment Protection Hunan University of Science and TechnologyXiangtan 411201China Institute of International Rivers and Eco-Security Yunnan UniversityKunming 650091China School of Geomatics Anhui University of Science and TechnologyHuainan 232001China

Glaciers in the central qilian Mountains provide important water resources for the arid Hexi corridor and Qaidam Basin;however,changes in these glaciers interact with climate ***-four bi-static image pairs of TerraSAR-X add-on for Digital Elevation Measurement(TanDEM-X)data,in addition to a Shuttle Radar Topography Mission-C/X band digital elevation model,and the technology of iterative differential synthetic aperture radar interferometry were used to carry out glacier elevation change analysis in the central qilian Mountains in China during 2000–*** elevation changed with an average rate of(−0.47±0.06)m yr^(−1),while changes in elevation of(−0.51±0.06)m yr^(−1) and(−0.44±0.06)m yr^(−1) were found in the northern(including the Zoulangnan,Tuolai,and Tuolainan mountains)and southern(including the Shulenan and Hark mountains)regions,*** mean temperature has risen by 0.51℃(10 yr)^(−1)in the northern region and 0.48℃(10 yr)^(−1) in the southern region during 1989–2014;however,the change in amplitude of annual precipitation was 2.69 mm yr^(−1) in the northern region and 4.77 mm yr^(−1) in the southern region for the same *** changes can be ascribed as major driving factors for the differences in the changes in glacial elevation in the northern and southern *** types of glaciers existed in the region when considering the change in elevation of the glacial tongue and variation in the position of the glacial terminus:surging,advancing,intensively retreating,and slightly retreating *** elevation decreased more than 20 m on the part of glacier tongue,the glacier terminus position had commonly retreated more than 100 m.

关键词： Central qilian Mountains Glacial elevation change Climate change TanDEM-X data Iterative differential synthetic aperture radar interferometry

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Early Paleozoic Magmatism and Crustal Evolution in the North qinling Orogen

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Acta Geologica Sinica(English Edition) 2017年第S1期91卷 121-122页

作者： LIU Bingxiang RUAN Renhao HAN Shen CUI Zikang qi Meng LI Yin School of Resources and Environmental Engineering Anhui University School of Earth and Space Sciences University of Science and Technology of China

1 Introduction The North qinling orogenic belt is characterized by diverse rocks,multi-phase tectonic-magmatic events,which is composed of not only basement rocks of the qinling Group,but also numerous magmatic rocks in

关键词： Early Paleozoic Magmatism and Crustal Evolution in the North qinling Orogen Zhang rock

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A Poisoning Outbreak Caused by Anisodus tanguticus — Maqin County, qinghai Province, China, July 2021

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China CDC weekly 2022年第41期4卷 920-923页

作者： Xuebin Guo qian He Bangguo qi Chenye Sun DongJin Lyu Hongshun Zhang qingHai Center for Disease Control and Prevention Xi’ning CityQinghai ProvinceChina National Institute of Occupational Health and Poison Control Chinese Center for Disease Control and PreventionBeijingChina Chinese Center for Disease Control and Prevention BeijingChina.

Summary What is already known about this topic?Anisodus tanguticus belongs to the Solanaceae *** plant is toxic due to the tropane alkaloids it contains and can cause poisoning when it is ingested or used *** is added by this report?A poisoning outbreak involved 10 patients,and one death was caused by Anisodus *** etiological association of plant exposure and poisoning was confirmed with evidence from an epidemiological investigation,clinical manifestations,plant identification and a toxin analysis.

关键词： fir icu break

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