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Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

WIDE-BAND LASER CLADDING: WEAR AND CORROSION RESISTANCE OF A Ni-BASED ALLOy

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Acta Metallurgica Sinica(English Letters) 1997年第5期10卷 445-452页

作者： Pan, q.y. Huang, W.D. li, y.M. lin, X. Zhou, y.H. yang, X.C. Northwestern Polytechnical Univ Xi'an China

A novel wide-band laser cladding system, with high rate of cladding, has been developed in the present work. The system mainly consisted of a 5kW CO2 laser, an automatic powder feeder and a wide-band scanning rotative polygon mirror which can produce a linear or rectangular focused laser beam. Using this system, a Ni-Cr-Si-B alloy powder was cladded on the surface of type 321 austenitic stainless steel in order to improve its wear and corrosion resistance. The pitting corrosion, high temperature oxidation and wear tests were conducted in order to evaluate the properties of the laser cladded layer. The results demonstrated that the cladded layer can significantly improve the adhesive wear and pitting corrosion resistance of the substrate. Moreover, the cladded layer exhibited good oxidation resistance, which is almost the same as that of GMR-235D Ni-based superalloy.

关键词： Boron Chromium alloys Cladding (coating) Laser applications Nickel alloys Silicon alloys Wear resistance

STUDy OF DyNAMIC RECRySTALliZATION OF LOW CARBON STEEL IN THIN SLAB CONTINUOUS ROLliNG PROCESS

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Acta Metallurgica Sinica(English Letters) 2006年第4期19卷 265-270页

作者： X.K. liang X.J. Sun q.y. liu H. Dong State Key Laboratory of Advanced Steel Processes and Products Central Iron and Steel Research Institute Beijing 100081 China

Combined with the technological characteristics of thin slab continuous rolling process （TSCR）, dynamic recrystallization of an extremely coarse austenite of low carbon steel is studied by Thermecmaster-Z hot simulator. By the analysis of true stress-strain curves and the observation of microstructures at different deformation stages, the critical stress and critical strain are determined under different deformation conditions. The effect of Z parameter on dynamic recrystallization of coarse austenite is studied. The microstructure evolution in real production is also discussed.

关键词： TSCR (thin slab continuous rolling process) coarse austenite dynamic recrystallization

EXPERIMENTAL STUDy ON BED RESISTANCE CHARACTERISTICS OF NONUNIFORM SEDIMENT

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Journal of Hydrodynamics 2000年第4期12卷 66-74页

作者： Zhou, G.D. liu, q.y. Wang, G.X. Hui, y.J. Pang, D.M. Tsinghua Univ. Beijing 100084 China

Under natural circumstances, the bed of fluvial river is composed of nonuniform sediment, and its nonuniform property influences very much the bed resistance and flow characteristics. By using a one-dimensional laser velocimeter, flume experiments are carried out to analyze the resistance characteristics of open channel flow with the bed sediment composed of different representative particles and having different nonuniform properties. By means of separating factors, the factors affecting the bed resistance, including particle diameter, nonuniform property and flow conditions, are studied. A great number of laboratory test results and field data from other investigators have been analyzed.

关键词： Sediments

REACTION PROBABIliTIES OF ENERGETIC SPECIES AT GROWING DIAMOND FILM SURFACES By MOLECULAR DyNAMICS SIMULATION

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Acta Metallurgica Sinica(English Letters) 2002年第1期15卷 131-135页

作者： q.y. Zhang E. Bauer- Grosse State Key Laboratory for Materials Modification by Laser Ion and Electron Beams Dalian University of Technology Dalian 116024 China Surface Science and Engineering Laboratory Ecole des Mines de Nancy Parc de Saurupt 54042 Nancy Cedex France

A Molecular Dynamics (MD) simulation with Tersoff empirical many-bodypotential has been employed to investigate the growth processes of diamond film with energeticspecies deposition. In the present study, we have studied the reaction probabilities of energeticspecies with energies of 0.1 e V to 10eV at the substrate temperature of 1100K. In the cases of thediamond growth on the surface with H passivation, the reaction probability of hydrocarbon speciesconsiderably increases when the species energy is higher than 2eV. This means that the diamond filmcan grow in the case of high incident species energy without the process of hydrogen abstraction,which is needed in the case of incident species with low energy. The reaction mechanism of energeticspecies on hydrogen passivated diamond surface is also discussed.

关键词： molecular dynamics simulation diamond film growth reaction probability

A Review of Botulism in China

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Biomedical and Environmental Sciences 1990年第3期3卷 326-336页

作者： GAO q.y. HUANG y.F. WU J.G. liU H.D. XIA H.q Institute of Food Safety Control and Inspection Ministry of Public Health 29 Nan Wei Road Beijing 100050 Sanitary and Antiepidemic Station of Urumqi City Urumqi Xinjiang Autonomous Region Sanitary and Antiepidemic Station of Tachen District Tachen Xinjiang Autonomous Region Pipeline Bureau Hospital Ministry of Petroleum Langfang HebeiPeople's Republic of China

The epidemiological characteristics and etiology of botulisin in China, as well as the distribution of different types of Clustridium bolulinum in China; are *** 1989, 15 provinces and autonomous regions reported the occurrence of *** were 2861 cases involved in 745 *** the cases 421 died, with a case fatality of 14.7%.The main epidemiological characteristics of botulism in China are: (i) the major foods causing botulism are homemade fermented bean products which accounted for 62.6% of the cases; (ii) the incubation period is longer (3 h-54 days) than that described in the western literature (mostly 2-7 days); (iii) the peak occurrence is from February to May; (iv) the progression of symptoms and signs is slower than that of western *** types of *** the exception of type G, have been found in *** distribution of various types of *** is significantly different between southern and northern China; this is related to the latitude and is correlated with the prevalence of this *** of the botulism outbreaks occurred above 30° north latitude in northern China and outbreaks rarely occurred below 30° north *** surveys showed that the average detection rate of C bolulinum spores in soil and foods in the northern parts of China was 14.8%.while it was only 2.5% in the *** types A, B, *** F, which are involved in human botulism, were frequently found in the North, while types C and D, which are involved only in animal intoxication, were found more frequently in the south. 1990 Academic ***.

关键词： In A Review of Botulism in China

INFLUENCE OF SIliCON IN STEELS ON GALVANIZED COATINGS

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Acta Metallurgica Sinica(English Letters) 2006年第2期19卷 85-90页

作者： C.S. Che J.T. Lu G. Kong q.y. Xu J.H. Chen College of Materials Science and Engineering South China University of Technology Guangzhou 510640 China

After steel sheets （0.37wt%Si） pre-electroplated with a thin layer of pure Fe were immersed in molten zinc for various time, the change in the microstructure of the galvanized coating on the steel and the change of α-Fe/Г interface were studied. The EDS （energy dispersive sepectroscopy） resuits show that excessive silicon accumulates on the surface of the steel substrate due to the low solubility of silicon in the Г layer after the Fe layer is depleted by the increasing growth of the compound layers. With the movement of α-Fe/Г interface towards the substrate by the Fe/Zn reaction, silicon-rich α-Fe peels off from the substrate and breaks into particles. The particles, much like an inert marker in a Kirkendall effect experiment, move towards the δ layer through the Г layer because silicon-rich α-Fe can not be adsorbed in the Г layer. On reaching the 8/F interface, the particles quickly dissolve in the δ layer, and accelerate its growth, resulting in the gradual disappearance of the Г layer. At the same time, the normal coating is quickly changed into coatings typical of reactive steels as silicon dissolved in the δ layer soon diffuses toward the ζ layer. A similar process may happen in the initial stage of galvanizing reactive steels on a small scale, although it is hard to be observed.

关键词： Zn coating intermetallics steel electrodeposition

Strain Growth in Containment Vessels

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Transactions of Tianjin University 2006年第B09期12卷 193-198页

作者： DONG q li q M ZHENG J y School of Mechanical Aerospace and Civil Engineering The University of Manchester PO Box 88 Manchester M60 1QD UK Institute of Chemical Machinery Zhejiang University Hangzhou 310027 China

Strain growth is a phenomenon observed in containment vessels subjected to internal blast loading. The elastic response of the vessel may become larger in a later stage compared to its response during the initial stage. The dynamic responses of infinitely long cylindrical containment vessels subjected to uniformly-distributed internal blast loading are studied using LS-DyNA. The development of bending modes and the interaction between the breathing mode and bending modes are observed. The methodology developed for dynamic elastic buckling analysis is employed to study the strain growth phenomenon in explosion containment vessels. It is shown that the dynamic instable vibration of a containment vessel is the basic mechanism of strain growth.

关键词： strain growth containment vessel dynamic response impulsive loading

On the mechanism of Si-promoted destabilization of TiC_(x)particles in Al alloys

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Journal of Materials Science & Technology 2023年第34期165卷 17-26页

作者： H.Dong y.C.Guo y.Z.Chen F.Xia q.q.Guo q.Chen G.L.li J.y.Zhao y.Zhong J.P.li School of Materials and Chemical Engineering Xi’an Technological UniversityXi’an 710021China State Key Lab.of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China School of Science Xi’an University of Science and TechnologyXi’an 710054China

TiC_(x)is an excellent composite strengthening particle and grain refiner for Al ***,the stability of TiC_(x)is poor when solute Si exists in Al alloy melts,which significantly depresses its strengthening and grain refining *** this work,the destabilization mechanisms of the TiC_(x)particles in Al-Si alloy melt with a composition of Al-7Si-7.5TiC were explored via experiments,first-principles calculations and thermodynamic *** experimental results show that Si atoms diffuse into TiC_(x)and Ti atoms are released into the Al melt to form a Ti-rich transition zone during the insulation of TiC_(x)in Al-Si melt,and the TiAlySiz and Al_(4)C_(3)phases are solidified in the Ti-rich zone and at Ti-rich zone/TiC_(x)interface,*** first principles calculations show that the low formation energy of C vacancies facilitates the rapid diffusion of Si atoms in TiC_(x),while the doping of Si atoms reduces the energy barrier of diffusion of Ti atoms in TiC_(x)and promotes the formation of Ti-rich *** thermodynamic calculations show that the wide crystallization temperature range of the destabilized product TiAlySiz phase is the key to continuous decomposition of TiC_(x)*** addition,the driving force of the main destabilization reaction of TiC_(x)in the Al-Si alloys is about 44 times higher than that in the Al alloys without Si *** indicates that the presence of solute Si remarkably promotes the subsequent decomposition process of TiC_(x)in the Al-Si alloy melts.

关键词： Al-Si alloy TiC_(x)particles Destabilization First principles calculations Thermodynamics