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A review on biodegradable biliary stents: materials and future trends

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Bioactive Materials 2022年第11期7卷 488-495页

作者： ge Song Hugh q.Zhao qing Liu Zhongyong Fan Beijing Advanced Medical Technologies Ltd Inc26 Yongwang West RoadBuilding 11DaxingBeijing102609PR China The Institute for Translational Nanomedicine Shanghai East HospitalThe Institute for Biomedical Engineering&Nano ScienceTongji University School of MedicineShanghai200092PR China Department of Materials Science Fudan UniversityShanghai200433PR China

Biliary stricture is defined as the reduction and narrowing of the bile duct lumen, which can be caused by many factors such as cancer and inflammation. Biliary stent placement can effectively alleviate benign and malignant biliary strictures. However, the commonly used plastic or metallic biliary stents are far from ideal and do not satisfy all clinical requirements,although several types of biodegradable biliary stents have been developed and used clinically. In this review, we summarized current development status of biodegradable stents with the emphasis on the stent materials. We also presented the future development trends based on the published literature.

关键词： Biodegradable biliary stent Biliary strictures Polydioxanone Poly(L-lactic acid) Drug-eluting stent

Recent advances in construction of small molecule-based fluorophoredrug conjugates

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Journal of Pharmaceutical Analysis 2020年第5期10卷 434-443页

作者： Wenjie Lang Chaonan Yuan Liquan Zhu Shubo Du Linghui qian Jingyan ge Shao q Yao Key Laboratory of Bioorganic Synthesis of Zhejiang Province College of Biotechnology and BioengineeringZhejiang University of TechnologyHangzhou310014PR China Department of Chemistry National University of Singapore3 Science Drive 3Singapore117543Singapore Institute of Drug Metabolism and Pharmaceutical Analysis College of Pharmaceutical SciencesZhejiang UniversityHangzhou310058China

As a powerful tool to advance drug discovery,molecular imaging may provide new insights into the process of drug effect and therapy at cellular and molecular *** compared with other detection methods,fluorescence-based strategies are highly attractive and can be used to illuminate pathways of drugs’transport,with multi-color capacity,high specificity and good *** conjugates of fluorescent molecules and therapeutic agents create exciting avenues for real-time monitoring of drug delivery and distribution,both in vitro and in *** this short review,we discuss recent developments of small molecule-based fluorophore-drug conjugates,including non-cleavable and cleavable ones,that are capable of visualizing drug delivery.

关键词： Drug delivery Fluorescent monitoring Prodrug Cleavable linker

Mechanical Behavior of Bamboo,and Its Biomimetic Composites and Structural Members:A Systematic Review

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Journal of Bionic Engineering 2024年第1期21卷 56-73页

作者： Shanyu Han Yuyuan He Hanzhou Ye Xueyong Ren Fuming Chen Kewei Liu Sheldon q.Shi ge Wang Institute of Biomaterials for Bamboo and Rattan Resources International Centre for Bamboo and RattanBeijing 100102China Key Laboratory of National Forestry and Grassland Administration/Beijing for Bamboo&Rattan Science and Technology Beijing 100102China National Forestry and Grassland Engineering Technology Center for Wood Resources Recycling College of Materials Science and TechnologyBeijing Forestry UniversityBeijing 100083China International Bamboo and Rattan Organization Beijing 100102China School of Civil Engineering Tsinghua UniversityBeijing 100084China Mechanical Engineering Department University of North TexasDentonTX 762077102USA

Bamboo is a typical biological material widely growing in nature with excellent physical and mechanical *** is lightweight with high strength and *** naturally optimized bamboo structure,which has inspired global material scientists and engineers for decades,is significantly important for the bionic design of novel structural materials with ultra-light,ultra-strong,or ultra-tough and comprehensive *** literature on innovative composite materials and structural members inspired by bamboo are reviewed in this paper,and the research progress and prospects in this field are expounded in three ***,the structural characteristics of the bamboo wall layer along the thickness and height directions are described in terms of chemical composition,gradient structure,pore structure,and hollow structure with variable ***,this paper summarizes the research progress on new composite materials and structural components by applying bamboo’s structural features from the perspective of sustainability,designability,and ***,given the limitations of current research,the biomimetic scientific research on bamboo’s structural characteristics is prospected from the interpretation of bamboo structure,new bamboo-like materials,and structural design optimization perspectives,providing a reference for future research on biomimetic aspects of biomass.

关键词： Bamboo Structural characteristics-Bamboo-like material Physical and mechanical properties

In situ TEM investigation of electron irradiation and aging-induced high-density nanoprecipitates in an Mg-10Gd-3Y-1Zn-0.5Zr alloy

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Journal of Magnesium and Alloys 2024年第5期12卷 1841-1853页

作者： M.Lv H.L.ge q.q.Jin X.H.Shao Y.T.Zhou B.Zhang X.L.Ma Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of Sciences72 Wenhua RoadShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Materials Science and Engineering Research Center Guangxi University of Science and TechnologyLiuzhou 545006China

In-situ electron irradiation and aging are applied to introduce high-density precipitates in an Mg-10Gd-3Y-1Zn-0.5Zr(GWZ1031K,wt.%)alloy to improve the *** results show that the hardness of the Mg alloy after irradiation for 10 h and aging for 9 h at 250℃ is 1.64 GPa,which is approximately 64% higher than that of the samples before being *** is mainly attributed to γ'precipitates on the basal plane after irradiation and the high-density nanoscale β'precipitates on the prismatic plane after aging,which should be closely related to the irradiation-induced homogenous *** latter plays a key role in precipitation *** result paves a way to improve the mechanical properties of metallic materials by tailoring the precipitation through irradiation and aging.

关键词： Mg alloy Electron beam irradiation Hardening Precipitates In-situ TEM

IMPROVEMENT OF DISPERSION ABILITY OF NANOMETER PARTICLES BY MEANS OF PLASMA POLYMERIZATION

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Acta Metallurgica Sinica(English Letters) 2002年第1期15卷 73-76页

作者： G.q. Zhang X.G. Guo Y.M. Liu Y.J. ge Beijing Institute of Printing Beijing 102600 China

In order to find a new way to improve the dispersion ability of nanometer material, an investigation on preparation of thin film with low surface energy on the surface of nanometer material by means of plasma polymerization has been done. Some physical behaviors and chemical constitution of prepared film as well as the influence of polymerized film on nanometer material were tested. All the experimental results showed that this is a possible way to improve the dispersion ability of nanometer materials.

关键词： plasma polymerization nanometer material

Physical Layer Security for UAV Communications:A Comprehensive Survey

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China Communications 2022年第9期19卷 77-115页

作者： Jue Wang Xuanxuan Wang Ruifeng Gao Chengleyang Lei Wei Feng Ning ge Shi Jin Tony q.S.quek School of Information Science and Technology Nantong UniversityNantong 226109China Department of Electronic Engineering Tsinghua UniversityBeijing 100084China China Academy of Electronics and Information Technology Beijing 100041China School of Transportation and Civil Engineering Nantong UniversityNantong 226109China National Mobile Communications Research Laboratory Southeast UniversityNanjing 210096China Information Systems Technology and Design Pillar Singapore University of Technology and DesignSingapore 487372Singapore Nantong Research Institute for Advanced Communication Technologies Nantong 226109China

Due to its high mobility and flexible deployment,unmanned aerial vehicle(UAV)is drawing unprecedented interest in both military and civil applications to enable agile and ubiquitous *** operating in an open environment,UAV communications benefit from dominant line-of-sight links;however,this on the other hand renders the communications more vulnerable to malicious ***,physical layer security(PLS)has been introduced to UAV systems as an important complement to the conventional cryptography-based *** this paper,a comprehensive survey on the current achievements of UAV-PLS is *** first introduce the basic concepts including typical static/-mobile UAV deployment scenarios,the unique air-toground channel and aerial nodes distribution models,as well as various roles that a UAV may act when PLS is ***,we start by reviewing the secrecy performance analysis and enhancing techniques for statically deployed UAV systems,and extend the discussion to the more general scenario where the UAVs’mobility is further *** both cases,respectively,we summarize the commonly adopted methodologies,then describe important works in the litera ture in ***,potential research directions and challenges are discussed to provide an outlook for future works in the area of UAV-PLS.

关键词： physical layer security UAV communications static/mobile UAV deployment air-to-ground channel trajectory optimization

Effects of luteinizing hormone and androgen on the development of rat progenitor Leydig cells in vitro and in vivo

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Asian Journal of Andrology 2013年第5期15卷 685-691页

作者： Jing-Jing Guo Xue Ma Claire q F Wang Yu-Fei ge qing-quan Lian Dianne O Hard Yu-Fei Zhang qiang Dong Yun-Fei Xu Ren-Shan ge The 2nd Affiliated Hospital Wenzhou Medical College Wenzhou 325027 China Population Council & Rockefeller University New York NY 10065 USA Department of Urology West China Hospital Sichuan University Chengdu 610041 China Mudanjiang Medical College M udanjiang 157011 China Department of Urology the Affiliated 10th People's Hospital of Tongji University Shanghai 200072 China

Progenitor Leydig cells are derived from stem cells. The proliferation and differentiation of progenitor Leydig cells significantly contributes to Leydig cell number during puberty. However, the regulation of these processes remains unclear. The objective of the present study was to determine whether luteinizing hormone （LH） or androgen contributes to the proliferation and differentiation of progenitor Leydig cells. Fourteen-day-old male Sprague-Dawley rats were treated for 7 days with NalGlu, which is a gonadotropin- releasing hormone antagonist, to reduce the secretion of LH in the pituitary and thus, androgen in the testis. Rats were co-administered with LH or 7a-methyl-nortestosterone （MENT）, which is an androgen resistant to metabolism by 5a-reductase 1 in progenitor Leydig cells, and the subsequent effects of LH or androgen were measured. 3H-Thymidine was also intravenously injected into rats to study thymidine incorporation in progenitor Leydig cells. Progenitor Leydig cells were examined. NalGlu administration reduced progenitor Leydig cell proliferation by 83%. In addition, LH or MENT treatment restored Leydig cell proliferative capacity to 73% or 50% of control, respectively. The messenger RNA levels of proliferation-related genes were measured using real-time PCR. The expression levels of Igfl, Lifr, Pdgfra, Bcl2, Ccnd3and Pcnawere upregulated by MENT, and those of Pdgfra, Ccnd3and Pcnawere upregulated by LH. Both LH and MENT stimulated the differentiation of progenitor Leydig cells in vitro. We concluded that both LH and MENT were involved in regulating the development of progenitor Leydig cells.

关键词： l utei nizi ng hormone progenitor Leydig cell proliferation testosterone

Isospin dependence of the nuclear binding energy

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Chinese Physics C 2021年第1期45卷 272-279页

作者： Y.q.He J.K.ge G.J.Fu H.Jiang School of Physics Science and Engineering Tongji UniversityShanghai 200092China School of Arts and Sciences Shanghai Maritime UniversityShanghai 201306China

In this paper,we study the symmetry energy and the Wigner energy in the binding energy formula for atomic *** simultaneously extract the I2 symmetry energy and Wigner energy coefficients using the double difference of "experimental" symmetry-Wigner energies,based on the binding energy data of nuclei with A≥*** study of the triple difference formula and the "experimental" symmetry-Wigner energy suggests that the macroscopic isospin dependence of binding energies is explained well by the I2 symmetry energy and the Wigner energy,and further consideration of the I4 term in the binding energy formula does not substantially improve the calculation result.

关键词： symmetry energy i^4 term Wigner energy nuclear binding energy

Adaptive region reaching control of fully actuated ocean surface vessels

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Journal of Control and Decision 2021年第3期8卷 251-259页

作者： X.M.Sun S.S.ge q.Xu Y.Zhou X.W.Zheng School of Engineering Science and Technology Shanghai Ocean UniversityShanghai 201306People’s Republic of China Robotics Institute and School of Computer Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengduPeople’s Republic of China School of Electrical and Computer Engineering National University of SingaporeSingaporeSingapore School of Electronic and Information Engineering Beihang UniversityBeijingPeople’s Republic of China

In this paper,region reaching controller is designed for fully actuated ocean surface vessels to reach a desired target region instead of a *** are not the requirements for both the pre-specified trajectory outside the desired region and the desired pinpoint position inside the desired *** controller design is based on the potential energy function,backstepping recursive design methodology,and the Lyapnov stability analysis *** the target region is specified arbitrarily small,the target region reduces to a point,and hence the region reaching control can be a generalisation of the setpoint *** results are presented to illustrate the performance of the proposed controller.

关键词： Reaching control potential energy function adaptive control backstepping technique Lyapunov stability