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肌萎缩侧索硬化蛋白激活小胶质细胞NLRP3炎性体

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神经损伤与功能重建 2022年第1期17卷 F0003-F0003页

作者： Vandana Deora John D Lee Eduardo AAlbornoz Luke McAlary Cyril J Jagaraj Avril A b Robertson Julie D Atkin Matthew A Cooper Kate Schroder Justin J Yerbury Richard Gordon Trent MWoodruff School of biomedical Sciences Faculty of MedicineThe University of QueenslandSt.LuciaQueenslandAustralia University of queensland Centre for Clinical Research Faculty of MedicineThe University of QueenslandHerstonQueenslandAustralia Institute for Molecular bioscience and Centre for Inflammation and Disease ResearchThe University of QueenslandSt.LuciaQueenslandAustralia School of Chemistry and Molecular biosciences Faculty of ScienceMedicine and HealthUniversity of WollongongWollongongNew South WalesAustralia Illawarra Health and Medical Institute University of WollongongWollongongNew South WalesAustralia Faculty of Medicine and Health Sciences Department of Biomedical SciencesCentre for MND ResearchMacquarie UniversityNew South WalesAustralia School of Chemistry and Molecular biosciences The University of QueenslandSt.LuciaQueenslandAustralia

小胶质细胞NLRP3炎症小体激活正在成为神经退行性变期间神经炎症的关键因素。β-淀粉样蛋白和α-突触核蛋白等致病蛋白的聚集体可触发小胶质细胞NLRP3激活,并导致半胱氨酸天冬氨酸酶激活和白介素-1β分泌。半胱氨酸天冬氨酸酶和白介素-... 详细信息

小胶质细胞NLRP3炎症小体激活正在成为神经退行性变期间神经炎症的关键因素。β-淀粉样蛋白和α-突触核蛋白等致病蛋白的聚集体可触发小胶质细胞NLRP3激活,并导致半胱氨酸天冬氨酸酶激活和白介素-1β分泌。半胱氨酸天冬氨酸酶和白介素-1β均促进肌萎缩侧索硬化(ALS)小鼠SOD1G93A模型的疾病进展,这提示小胶质细胞NLRP3在该进程中起作用。然而,先前的研究表明SOD1G93A模型小鼠的小胶质细胞并不表达NLRP3,并且SOD1G93A蛋白在小胶质细胞中产生白介素-1β不依赖于NLRP3。本研究展示了使用Nlrp3-GFP基因敲入小鼠,在SOD1G93A小鼠中小胶质细胞表达NLRP3。结果表明,聚集和可溶性SOD1G93A均以剂量和时间依赖性方式激活小鼠原代小胶质细胞中的炎性体,导致半胱氨酸天冬氨酸酶和白介素-1β裂解、ASC斑点形成和白介素-1β分泌。重要的是,SOD1G93A不能诱导缺乏Nlrp3的小胶质细胞或用特异性NLRP3抑制剂MCC950预处理的小胶质细胞分泌白介素-1β,这证实NLRP3是介导SOD1诱导的小胶质细胞白介素-1β分泌的关键炎性体复合物。在TDP-43q331K ALS小鼠模型中也观察到小胶质细胞NLRP3上调,并且TDP-43野生型和突变蛋白也能以NLRP3依赖性方式激活小胶质细胞炎症小体。从机制上,本研究确定活性氧簇和ATP的产生是SOD1G93A介导的NLRP3激活所需的关键事件。总之,本研究的数据表明ALS小胶质细胞表达NLRP3,病理性ALS蛋白激活了小胶质细胞NLRP3炎性体。因此,抑制NLRP3可能是阻止小胶质细胞神经炎症和ALS疾病进展的潜在治疗方法。

关键词：白介素-1β 胶质细胞先天免疫运动神经元病

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典型半乳糖血症患儿口服半乳糖的高耐受性:饮食的影响

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世界核心医学期刊文摘（儿科学分册） 2005年第4期1卷 26-26页

作者： bosch A. M. bakker H. D. Wenniger-Prick L.J. M. D. b. Dr. F. A. Wijburg 王一飞 Academic Medical Center University of Amsterdam Department of Pediatrics (G8 -205) PO Box 22660 1100 DD Amsterdam Netherlands

目的:研究限制典型半乳糖血症患者从水果和蔬菜等少量摄取外源性半乳糖的相关因素。方法:笔者进行一个为期6周的研究。对3名q188R突变的纯合子青少年患者添加严格限制的半乳糖饮食,并不断增加口服半乳糖的量,直到给予600mg/d的最大量。... 详细信息

目的:研究限制典型半乳糖血症患者从水果和蔬菜等少量摄取外源性半乳糖的相关因素。方法:笔者进行一个为期6周的研究。对3名q188R突变的纯合子青少年患者添加严格限制的半乳糖饮食,并不断增加口服半乳糖的量,直到给予600mg/d的最大量。每周进行包括全面的眼科检查和实验室研究在内的体格检查。结果:在这些研究中没有发现有明显的临床或生化指标的改变。结论:这些研究进一步表明试图将微量半乳糖排除在饮食之外是不正确的。一旦给予自由饮食,就有必要进行长期的随访研究。

关键词：典型半乳糖血症眼科检查随访研究体格检查纯合子生化指标外源 weekly intake mutation

一种适于软硬开关应用的具有坚固体二极管的新型650V超结器件

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电力电子 2010年第5期8卷 45-47,44页

作者： G.Aloise M.-A.Kutschak D.Zipprick H.Kapels A.Ludsteck-Pechloff 查祎英高一星胡冬青 Infineon Technologies Austria AG Infineon Technologies AG 北京工业大学电控学院

新型CoolMOS^(TM) 650V CFD技术为具有高性能体二极管的高压功率MOSFET确立了一个新基准。新型器件综合了多方优势,包括高达650V阻断电压、极低的R_(dson)、容性损耗低、同时还改善了体二极管在反向恢复过程,特别是软硬转换应用时的坚... 详细信息

新型CoolMOS^(TM) 650V CFD技术为具有高性能体二极管的高压功率MOSFET确立了一个新基准。新型器件综合了多方优势,包括高达650V阻断电压、极低的R_(dson)、容性损耗低、同时还改善了体二极管在反向恢复过程,特别是软硬转换应用时的坚固度。随着性能的提高,将介绍列入参数表的q_(rr)和t_(rr)的最大值。本文还研究了改善体二极管坚固度的相关因素。这种具有快恢复体二极管的新型超结器件系列的优点,在HID半桥拓扑中尤为突出。它也可用于DPAK封装。

关键词：体二极管器件综合应用硬开关功率MOSFET CFD技术阻断电压恢复过程

一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)

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中华神经外科疾病研究杂志 2014年第5期13卷 433-433页

作者： barbano R Palumbo O Pasculli b Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P Laboratory of Oncology "IRCCS Casa Sollievo della Sofferenza" Laboratory of Genetics "IRCCS Casa Sollievo della Sofferenza" Department of biosciences Biotechnology and BiopharmaceuticsUniversity of Bari "Aldo Moro" LTTA Department of MorphologySurgery and Experimental MedicineHuman Anatomy BranchUniversity of Ferrara Department of Neurosurgery "IRCCS Casa Sollievo della Sofferenza " Department of Pathology "IRCCS Casa Sollievo della Sofferenza" Unit of biostatistics "IRCCS Casa Sollievo della Sofferenza" Department of Oncology "IRCCS Casa Sollievo della Sofferenza" CIR Laboratory for Molecular Medicine and biotechnology University Campus Biomedico

Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade ***-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GbM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GbM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas.

关键词：神经外科学疾病临床研究医学

Refined families of Dothideomycetes:orders and families incertae sedis in Dothideomycetes

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Fungal Diversity 2020年第6期105卷 17-318页

作者： Sinang Hongsanan Kevin D.Hyde Rungtiwa Phookamsak Dhanushka N.Wanasinghe Eric H.C.McKenzie V.Venkateswara Sarma Robert Lücking Saranyaphat boonmee Jayarama D.bhat Ning-Guo Liu Danushka S.Tennakoon Dhandevi Pem Anuruddha Karunarathna Shu-Hua Jiang Gareth E.b.Jones Alan J.L.Phillips Ishara S.Manawasinghe Saowaluck Tibpromma Subashini C.Jayasiri Diana Sandamali Ruvishika S.Jayawardena Nalin N.Wijayawardene Anusha H.Ekanayaka Rajesh Jeewon Yong-Zhong Lu Chayanard Phukhamsakda Asha J.Dissanayake Xiang-Yu Zeng Zong-Long Luo qing Tian Kasun M.Thambugala Dongqin Dai Milan C.Samarakoon K.W.Thilini Chethana Damien Ertz Mingkwan Doilom Jian-Kui(Jack)Liu Sergio Pérez-Ortega Ave Suija Chanokned Senwanna Subodini N.Wijesinghe Mekala Niranjan Sheng-Nan Zhang Hiran A.Ariyawansa Hong-bo Jiang Jin-Feng Zhang Chada Norphanphoun Nimali Ide Silva Vinodhini Thiyagaraja Huang Zhang Jadson D.P.bezerra Ricardo Miranda-González AndréAptroot Hiroyuki Kashiwadani Dulanjalee Harishchandra Emmanuël Sérusiaux Pranami DAbeywickrama Dan-Feng bao bandarupalli Devadatha Hai-Xia Wu Kwang Hee Moon Cecile Gueidan Felix Schumm Digvijayini bundhun Ausana Mapook Jutamart Monkai Chitrabhanu S.bhunjun Putarak Chomnunti Satinee Suetrong Napalai Chaiwan Monika C.Dayarathne Jing Yang Achala R.Rathnayaka Jian-Chu Xu Jiesheng Zheng Gang Liu Yao Feng Ning Xie Guangdong Provincial Key Laboratory for Plant Epigenetics Shenzhen Key Laboratory of Microbial Genetic EngineeringCollege of Life Science and OceanographyShenzhen UniversityShenzhen 518060People’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand CAS Key Laboratory for Plant Diversity and biogeography of East Asia(KLPb) Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China East and Central Asia Regional Office World Agroforestry Centre(ICRAF)Kunming 650201YunnanPeople’s Republic of China Centre for Mountain Futures(CMF) Kunming Institute of BotanyKunming 650201YunnanPeople’s Republic of China Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50002Thailand Institute of Plant Health Zhongkai University of Agriculture and EngineeringHaizhu DistrictGuangzhou 510225People’s Republic of China World Agroforestry Centre East and Central Asia132 Lanhei RoadKunming 650201YunnanPeople’s Republic of China Manaaki Whenua-Landcare Research Private Mail Bag 92170AucklandNew Zealand Fungal biotechnology Lab Department of BiotechnologySchool of Life SciencesPondicherry UniversityKalapetPondicherry 605014India School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand botanischer Garten und botanisches Museum Freie Universität BerlinKönigin-Luise-Straße 6-814195 BerlinGermany 13128/1-J Azad Co-Op Housing SocietyCurcaP.O.Goa Velha 403108India Faculty of Agriculture Natural Resources and EnvironmentNaresuan UniversityPhitsanulok 65000Thailand Guizhou Key Laboratory of Agricultural biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006People’s Republic of China School of Life Science and Technology University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101People’s Republic of C

Numerous new taxa and classifications of Dothideomycetes have been published following the last monograph of families of Dothideomycetes in 2013.A recent publication by Honsanan et *** 2020 expanded information of families in Dothideo-mycetidae and Pleosporomycetidae with modern *** this paper,we provide a refined updated document on orders and families incertae sedis of *** family is provided with an updated description,notes,including figures to represent the morphology,a list of accepted genera,and economic and ecological *** also provide phylogenetic trees for each *** this study,31 orders which consist 50 families are assigned as orders incertae sedis in Dothideomycetes,and 41 families are treated as families incertae sedis due to lack of molecular or morphological *** new order,Catinellales,and four new families,Catinellaceae,Morenoinaceae Neobuelliellaceae and Thyrinulaceae are *** genera(Neobuelliella,Pseudomicrothyrium,Flagellostrigula,Swinscowia,Macroconstrictolumina,Pseudobogoriella,and Schummia)are *** new species(Acrospermum urticae,bogoriella complexoluminata,Dothiorella ostryae,Dyfrolomyces distoseptatus,Macroconstrictolumina megalateralis,Patellaria microspora,and Pseu-domicrothyrium thailandicum)are introduced base on morphology and phylogeny,together with two new records/reports and five new collections from different *** new combinations are also provided in this paper.

关键词： Abrothallales Ascrospermales Asterinales botryosphaeriales Catinellales Cladoriellales Collemopsidiales Dyfrolomycetales Eremithallales Eremomycetales Jahnulales Kirschsteiniotheliales Lembosinales Lichenotheliales Microthyriales Minutisphaerales Monoblastiales Murramarangomycetales new family new genera new order new species Parmulariales Patellariales Phaeotrichales Phylogeny Stigmatodiscales Strigulales Superstratomycetales Taxonomy Trypetheliales Tubeufiales Valsariales Venturiales Zeloasperisporiales

肌萎缩性侧索硬化蛋白激活小胶质细胞NLRP3炎性小体

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神经损伤与功能重建 2020年第9期15卷 F0003-F0003页

作者： Vandana Deora John D Lee Eduardo AAlbornoz Luke McAlary Cyril J Jagaraj Avril A b Robertson Julie D Atkin Matthew A Cooper Kate Schroder Justin J Yerbury Richard Gordon Trent MWoodruff 杜一星(编译) School of biomedical Sciences Faculty of MedicineThe University of QueenslandSt.LuciaQueenslandAustralia University of queensland Centre for Clinical Research Faculty of MedicineThe University of QueenslandHerstonQueenslandAustralia Institute for Molecular bioscience and Centre for Inflammation and Disease ResearchThe University of QueenslandSt.LuciaQueenslandAustralia School of Chemistry and Molecular biosciences Faculty of ScienceMedicine and HealthUniversity of WollongongWollongongNew SouthWalesAustralia Illawarra Health and Medical Institute University ofWollongongWollongongNew SouthWalesAustralia Faculty of Medicine and Health Sciences Department of Biomedical SciencesCentre for MND ResearchMacquarie UniversityNew SouthWalesAustralia School of Chemistry and Molecular biosciences The University of QueenslandSt.LuciaQueenslandAustralia 不详

小胶质细胞NLRP3炎性小体激活正在成为神经退行性变过程中神经炎症的关键因素。诸如β-淀粉样蛋白和α-突触核蛋白之类的致病性蛋白质聚集体触发小胶质NLRP3激活,从而导致半胱天冬酶-1激活和IL-1β的分泌。在小鼠肌萎缩性侧索硬化症(ALS... 详细信息

小胶质细胞NLRP3炎性小体激活正在成为神经退行性变过程中神经炎症的关键因素。诸如β-淀粉样蛋白和α-突触核蛋白之类的致病性蛋白质聚集体触发小胶质NLRP3激活,从而导致半胱天冬酶-1激活和IL-1β的分泌。在小鼠肌萎缩性侧索硬化症(ALS)的SOD1G93A模型中,半胱天冬酶-1和IL-1β均促进疾病进展,提示小胶质NLRP3在该进程中发挥作用。然而先前的研究表明,SOD1G93A小鼠小胶质细胞不表达NLRP3,SOD1G93A蛋白在小胶质细胞中产生独立于NLRP3的IL-1β。本研究论证了使用Nlrp3-GFP基因敲入小鼠,在SOD1G93A小鼠中小胶质细胞表达NLRP3。本研究显示聚集和可溶性SOD1G93A均可激活小鼠原代小胶质细胞中的炎性小体,导致半胱天冬酶-1和IL-1β裂解,ASC斑点形成以及呈剂量和时间依赖性的IL-1β分泌。重要的是,SOD1G93A无法从缺乏Nlrp3的小胶质细胞或者用特异性NLRP3抑制剂MCC950预处理的小胶质细胞中诱导IL-1β分泌,从而证实NLRP3是介导SOD1诱导的小胶质细胞IL-1β分泌的关键炎症小体复合物。在TDP-43q331K ALS小鼠模型中也观察到小胶质NLRP3上调,TDP-43野生型和突变蛋白亦可以NLRP3依赖性的方式激活小胶质炎性小体。从机制上讲,本研究确定了活性氧簇和ATP的生成是SOD1G93A介导的NLRP3激活所需的关键事件。总之,本研究的数据表明ALS小胶质细胞表达NLRP3,而病理ALS蛋白激活小胶质NLRP3炎性小体。因此,NLRP3抑制可能是阻止小胶质细胞神经炎症和ALS疾病进展的潜在治疗方法。

关键词：白介素-1β 胶质细胞先天免疫运动神经元病

Gammasphere上裂变丰中子核核结构若干前沿领域的新进展(Ⅱ:第三和第四部分)(英文)

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原子核物理评论 2010年第3期27卷 363-389页

作者：罗亦孝 J.H.Hamilton J.O.Rasmussen A.V.Ramayya C.Goodin A.V.Daniel N.J.Stone 朱胜江 J.K.Hwang 刘少华 C.J.beyer 李科 H.L.Crowell D.Al mehed S.Frauendorf A.Covello V.Di mitrov 张敬业车兴来姜卓 D.Fong A.Gelberg I.Stefanescu A.Gargano E.F.Jones P.M.Gore I.Y.Lee G.M.Ter-Akopian Yu.Ts.Oganessian M.A.Stoyer R.Donangelo 马文超 J.D.Cole J.Kormicki 张学谦 S.C.Wu J.Gilat T.N.Ginter S.J.Asztalos Physics Department Vanderbilt University Nashville TN 37235 USA Lawrence berkeley National Laboratory Berkeley CA 94720 USA Flerov Laboratory for Nuclear Reactions JINR Dubna Russia Joint Institute for Heavy Ion Research Oak Ridge TN 37831 USA Department of Physics Oxford University Oxford OX1 3PU United Kingdom Department of Physics and Astronomy University of Tennessee Knoxville Tennessee 37996 USA Physics Department Tsinghua University Beijing 100084 China Department of Physics University of Notre Dame Notre Dame IN 46556 USA Institut far Strahlenphysik FZD-Rossendorf Postfach 510119 D-01314 Dresden Germany Dipartimento di Scienze Fisiche Universita di Napoli Federico II and Istituto Nazionale di Fisica Nuclear Complesso Universitario di Monte S. Angelo Via Cintia 80126 Napoli Italy Idaho Accelerator Center Idaho State University Pocatello ID-83209-8263 USA Institut fur Kernphysik Universitat zu Koln 50937 Kdln Germany Department of Chemistry and biochemistry University of Maryland MD 20742 USA Lawrence Livermore National Laboratory Livermore CA 94550 USA Instituto de Fisica Facultad de Ingenieria C. C. 30 11300 Montevideo Uruguay Mississippi State University Drawer 5167 Mississippi State MS 39762 USA Idaho National Laboratory Bldg. IRCPL MS2114 Idaho Falls ID 83415 USA Department of Physics National Tsing Hua University Hsinchu Taiwan 30013 China National Superconducting Cyclotron Laboratory Michigan State University East Lansing Michigan 48824 USA Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA

使用Gammasphere多探测器系统对252Cf裂变源瞬发γ射线进行γ-γ-γ和γ-γ(θ)符合测量,A～100(Z～40,N>56)丰中子核区关于形状过渡、形状共存和形状突变的深入研究获得了新的进展。奇-Z核的系统研究揭示了从Z=39(Y)同位素的轴对称大... 详细信息

使用Gammasphere多探测器系统对252Cf裂变源瞬发γ射线进行γ-γ-γ和γ-γ(θ)符合测量,A～100(Z～40,N>56)丰中子核区关于形状过渡、形状共存和形状突变的深入研究获得了新的进展。奇-Z核的系统研究揭示了从Z=39(Y)同位素的轴对称大四极形变到Z=43(Tc),44(Ru)和45(Rh)同位素中具有中等四极形变之大三轴形变的过渡。Nb(Z=41)同位素具有过渡核的特征。根据邻近同位素和同中素带交叉信息的系统性及推转壳模型(CSM)计算,Tc和Rh偶-N同位素中观察到的带交叉产生于一对h11/2中子的转动顺排。首次观察到100Nb(Z=41,N=59)的高自旋能级纲图和形变态,从而证实了100Nb中的形状共存,并确认,在Nb同位素链上,基态形状突变发生于N=58(球形)到N=59(大形变);而在Sr(Z=38),Y(Z=39)和Zr(Z=40)各同位素链上,基态形状突变均发生于N=59(球形)到N=60(大形变)。100Nb具有大形变基态,同现有理论预言相矛盾,其大形变的基态及转动带所具有的很大的和不规则的转动惯量具有重要的理论意义。对奇-质子Cs(Z=55)和La(Z=57)丰中子同位素八极激发的详细研究,发现了141,143,144Cs同位素链上电二极矩D0随中子数增加而减小的急剧变化,此前在145,147La中观察到的电二极矩D0的较缓和的减小似乎亦很陡地下延至148La。在Cs和La同位素中观察到的电二极矩D0的急剧下降很可能同偶-质子核146ba和224Ra中观察到的电二极矩D0的急剧下降相类似,后者已获反射非对称平均场壳修正理论的成功解释。实验证明,141Cs具有很大电二极矩D0。141Cs和142Xe中观测到的很大的电二极矩D0和仅在141Cs中观察到的电二极矩D0的simplex量子数相关性需要进一步的理论研究。根据转动频率比值ω-(I)/ω+(I)的检定,同Xe同位素一样,认定Cs同位素中包括号143Cs的八极激发为八极振动,而在La同位素中存在八极形变。

关键词：形状过渡轴对称形状三轴形变形状突变带交叉奇-质子八极激发 b(E1)/b(E2)比值电二极矩D0 二极矩的下降八极振动 Cs,La同位素