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APP违法违规收集个人信息评估系统

吉林大学学报（信息科学版） 2024年第3期42卷 537-543页

作者：李凯李雨王乐枭张晓晴国家计算机网络应急技术处理协调中心辽宁分中心网络安全处沈阳110036

为提高人工检测违法违规收集个人信息的效率,基于正则表达式语义分析和机器学习技术,开发了APP(Application)违法违规收集个人信息评估系统。对线上APP进行违法违规检测,生成检测算法和规则,重点解决了隐私政策半自动化获取、APP检测引... 详细信息

为提高人工检测违法违规收集个人信息的效率,基于正则表达式语义分析和机器学习技术,开发了APP(Application)违法违规收集个人信息评估系统。对线上APP进行违法违规检测,生成检测算法和规则,重点解决了隐私政策半自动化获取、APP检测引擎、定制ROM(Read Only Memory)的动态沙箱等技术难点。利用开发的原型系统对各大应用平台上架APP进行常态化技术检测,检测结果表明,该系统大幅提升了违法违规收集个人信息APP综合治理研判效率。

关键词：移动互联网应用程序个人信息保护语义分析机器学习

维普期刊数据库博看期刊

Dynamic evolution of transposable elements,demographic history,and gene content of paleognathous birds

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Zoological Research 2021年第1期42卷 51-61页

作者： Zong-Ji wang Guang-Ji Chen Guo-Jie Zhang qi Zhou Institute of Animal Sex and Development Zhejiang Wanli UniversityNingboZhejiang 315100China MOE Laboratory of Biosystems Homeostasis&Protection Life Sciences InstituteZhejiang UniversityHangzhouZhejiang 310058China Department of Neuroscience and Developmental Biology University of ViennaVienna 1090Austria BGI-Shenzhen Beishan Industrial ZoneShenzhenGuangdong 518083China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Section for Ecology and Evolution Department of BiologyUniversity of CopenhagenCopenhagen DK-2100Denmark Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650223China Center for Reproductive Medicine The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiang 310058China

Palaeognathae includes ratite and tinamou species that are important for understanding early avian ***,we analyzed the whole-genome sequences of 15 paleognathous species to infer their demographic histories,which are presently *** found that most species showed a reduction of population size since the beginning of the last glacial period,except for those species distributed in Australasia and in the far south of South *** degrees of contraction and expansion of transposable elements(TE)have shaped the paleognathous genome architecture,with a higher transposon removal rate in tinamous than in *** repeat family,AviRTE,likely underwent horizontal transfer from tropical parasites to the ancestor of little and undulated tinamous about 30 million years *** analysis of gene families identified rapid turnover of immune and reproductionrelated genes but found no evidence of gene family changes underlying the convergent evolution of flightlessness among *** also found that mitochondrial genes have experienced a faster evolutionary rate in tinamous than in ratites,with the former also showing more degenerated W *** result can be explained by the Hill-Robertson interference affecting genetically linked W chromosomes and ***,we reconstructed the evolutionary history of the Palaeognathae populations,genes,and *** findings of co-evolution between mitochondria and W chromosomes highlight the key difference in genome evolution between species with ZW sex chromosomes and those with XY sex chromosomes.

关键词： Paleognaths Demographic history Transposable elements Gene families Mitochondria

A Panel of Genes Identified as Targets for 8q24.13-24.3 Gain Contributing to Unfavorable Overall Survival in Patients with Hepatocellular Carcinoma

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Current Medical Science 2018年第4期38卷 590-596页

作者： Kun ZHAO Yu ZHAO Jia-yi ZHU Hui DONG Wen-ming CONG Yi YU Hui wang Zhong-Zheng ZHU qing XU Department of Oncology Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai 200072 China Shanghai Clinical College of Anhui Medical University Shanghai 200072 China Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Pathology Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China

Copy number aberrations （CNAs） in chromosome arm 8q have been associated with unfavorable clinical outcomes of several cancers and progressive tumor characteristics of hepatocellular carcinoma （HCC）. This study was to identify correlation of CNAs in 8q with clinical outcomes of HCC patients, and further screen for differentially expressed genes in outcome-related CNAs. Array comparative genomic hybridization and expression arrays were performed to detect CNAs and expression levels, respectively. The correlations between CNAs in 8q and outcomes were analyzed in 66 patients, with a median follow-up time of 45.0 months （range, 2.6-108.6 months）. One hundred and nine cases were further evaluated to identify differentially expressed genes in the potential outcome-related CNAs. Copy number gain in 8q was observed in 22 （33.3%） of the 66 HCC cases. The most recurrent gains （with frequencies 〉20%） were 8q 13.3-21.3, 8q21.3-23.3, 8q23.3-24.13, 8q24.13-24.3, and 8q24.3. Survival analysis showed that 8q24.13-24.3 gain was significantly associated with reduced overall survival （P=0.010）. Multivariate Cox analysis identified 8q24.13- 24.3 gain as an independent prognostic factor for poor overall survival （HR=2.47; 95% CI=1.16-5.26; P=0.019）. A panel of 17 genes within the 8q24.13-24.3 region, including ATAD2, SqLE, PVT1, ASAP1, and NDRG1 were significantly upregulated in HCCs with 8q24.13-24.3 gain compared to those without. These results suggest that copy number gain at 8q24.13-24.3 is an unfavorable prognostic marker for HCC patients, and the potential oncogenes ATAD2, SqLE, PVT1, ASAP1, and NDRG1 within the regional gain, may contribute coordinately to the 8q24.13-24.3 gain-related poor prognosis.

关键词： chromosome 8 copy number aberration hepatocellular carcinoma prognosis gene expression

Malignant peritoneal mesothelioma

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World Journal of Gastrointestinal Surgery 2009年第1期1卷 38-48页

作者： Stine Munkholm-Larsen Christopher q Cao Tristan D Yan University of Sydney Department of Cardiothoracic SurgeryRoyal Prince Alfred Hospital Baird Institute for Applied Heart and Lung Surgical

Malignant mesothelioma is a highly aggressive *** incidence of malignant mesothelioma is increasing *** malignant peritoneal mesothelioma(DMPM) represents one-fourth of all *** of asbestos exposure with DMPM has been observed,especially in *** great majority of patients present with abdominal pain and distension,caused by accumulation of tumors and ascitic ? *** the past,DMPM was considered a pre-terminal condition;therefore attracted little *** invariably died from their disease within a ***,several prospective trials have demonstrated a median survival of 40 to 90 mo and 5-year survival of 30% to 60% after combined treatment using cytoreductive surgery and perioperative intraperitoneal *** remarkable improvement in survival has prompted new search into the medical science related to DMPM,a disease previously ignored as *** review article focuses on the key advances in the epidemiology,diagnosis,staging,treatments and prognosis of DMPM that have occurred in the past decade.

关键词： Asbestos Cisplatin Cytoreductive surgery Doxorubicin Intraperitoneal chemotherapy Mesothelin Pemetrexed Peritoneal mesothelioma Peritonectomy

Mechanistic Study of Oxidoreductase Aprq Involved in Biosynthesis of Aminoglycoside Antibiotic Apramycin

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Chinese Journal of Chemistry 2021年第7期39卷 1923-1926页

作者： Jinxiu wang Suze Ma Wei Ding Tuo Chen qi Zhang State Key Laboratory of Cryospheric Science Key Laboratory of Extreme Environmental Microbial Resources and EngineeringNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouGansu730000 China Department of Chemistry Fudan UniversityShanghai200433 China University of Chinese Academy of Sciences Beijing100049 China State Key Laboratory of Microbial Metabolism School of Life Sciences&BiotechnologyShanghai Jiao Tong UniversityShanghai200240 China

Main observation and conclusion The aminoglycoside antibiotic apramycin contains a unique bicyclic octose moiety,and biosynthesis of this moiety involves an oxidoreductase *** other known“q”series proteins involved in aminoglycosides biosynthesis,Aprq does not work with an aminotransferase partner,and performs a four-electron oxidation that converts a CH2OH moiety to a carboxylate group.

关键词： Biosynthesis Flavin Flavoprotein Oxidase Enzyme mechanism

Characterization of the first prototype CMOS pixel sensor developed for the CEPC vertex detector

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Radiation Detection Technology and Methods 2019年第3期3卷 222-230页

作者： L.J.Chen H.B.Zhu X.C.Ai M.Fu R.Kiuchi Y.Liu Z.A.Liu X.C.Lou Y.P.Lu q.Ouyang X.Shi J.Tao K.wang N.wang C.F.Yang Y.Zhang Y.Zhou institute of high energy physics chinese academy of sciences19b yuquan roadshijingshan districtbeijingchina university of chinese academy of sciences no.19(a)yuquan roadshijingshan districtbeijingchina state key laboratory of particle detection and electronics 19b yuquan roadshijingshan districtbeijingchina deutsches elektronen-synchrotron(desy) notkestraße 8522607 hamburggermany university of science and technology of china no.96jinzhai road baohe districthefeianhuichina ocean university of china no.238 songling roadqingdao 266100china

Purpose CMOS pixel sensor has become extremely attractive for future high-performance tracking *** has been proposed for the vertex detector at the Circular Electron Positron Collider,which will allow precision measurements of the properties of the Higgs *** meet the stringent requirements for low power consumption,it is necessary to optimize the pixel sensor diode geometry to reach a high charge-over-capacitance ratio that allows reduction in analog power *** Collection electrode size and footprint are two critical elements in sensor diode geometry and have deciding impacts on the charge collection performance.A prototype CMOS pixel sensor,named JadePix-1,has been developed with pixel sectors implemented with different electrode sizes and footprints,and its charge collection performance has been characterized with radioactive *** Charge-to-voltage conversion gains for pixel sectors under test have been calibrated with low-energy *** results have been obtained for equivalent noise charge(below 10e−),charge collection efficiency(around 40%),charge-over-capacitance ratio(above 0.015 V)and signal-to-noise ratio(higher than 55).Conclusion Small collection electrode size and large footprint are preferred to achieve high charge-over-capacitance ratio that promises low analog power *** studies on sensor performance before and after irradiation,combined with this work,will conclude the diode geometry optimization.

关键词： CMOS pixel sensor CEPC Power consumption Diode geometry Charge-over-capacitance ratio

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简单的逻辑学

作者： (美)D.q.麦克伦尼(D.q. McInerny)

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Aurora-A 激酶的研究进展

中国肿瘤临床 2014年第4期41卷 272-275页

作者：郑向前(综述) 高明(综述) 任秀宝(综述) Jin q.Cheng(审校) 天津医科大学肿瘤医院甲状腺颈部肿瘤科国家肿瘤临床医学研究中心天津市肿瘤免疫与生物治疗重点实验室天津市肿瘤防治重点实验室天津市300060 天津医科大学肿瘤医院生物治疗科美国莫菲特癌症中心分子肿瘤实验室

Aurora激酶家族是一组近年来发现的调节中心体和微管功能的丝氨酸/苏氨酸蛋白激酶,在细胞有丝分裂的正常进程中起着非常重要的作用。相关研究表明在一些实体肿瘤如乳腺癌、卵巢癌、食管癌、结肠癌、肺癌及膀胱癌等肿瘤中均出现Aurora-A... 详细信息

Aurora激酶家族是一组近年来发现的调节中心体和微管功能的丝氨酸/苏氨酸蛋白激酶,在细胞有丝分裂的正常进程中起着非常重要的作用。相关研究表明在一些实体肿瘤如乳腺癌、卵巢癌、食管癌、结肠癌、肺癌及膀胱癌等肿瘤中均出现Aurora-A基因的高表达。目前,Aurora-A激酶作为肿瘤治疗的一个新的靶点,已经逐渐引起人们重视,其小分子抑制剂的研究和使用,尤其是与化疗药物的联合应用,将成为今后恶性肿瘤治疗的新方向。本文对近几年国内外在Aurora-A激酶的研究,对其生物学功能、与肿瘤的关系及其抑制剂的研究进展进行综述。

关键词： Aurora-A激酶小分子抑制剂靶向治疗

意象解构:中国澳门郑家大屋灰塑壁画艺术的视觉文化解读

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梧州学院学报 2024年第2期34卷 18-29页

作者：王天甲郑亮陈以乐章晨曦澳门科技大学人文艺术学院中国澳门氹仔999078 湖北工业大学艺术设计学院湖北武汉430068

该文聚焦于中国澳门郑家大屋中的灰塑和壁画艺术,运用意象学理论对其独特的视觉符号和文化寓意进行深刻解析。通过对灰塑中的花鸟、人物形象和壁画中的传统故事场景的详细解读,揭示了这些艺术作品如何反映了广府文化的特征和屋主的社会... 详细信息

该文聚焦于中国澳门郑家大屋中的灰塑和壁画艺术,运用意象学理论对其独特的视觉符号和文化寓意进行深刻解析。通过对灰塑中的花鸟、人物形象和壁画中的传统故事场景的详细解读,揭示了这些艺术作品如何反映了广府文化的特征和屋主的社会地位,强调了意象学理论在解读传统建筑装饰艺术中的应用价值,为保护和传承我国澳门地区独特的文化遗产提供了新的视角和理论支持。

关键词：中国澳门郑家大屋意象学理论灰塑壁画