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IMAGInG REDOX STATE HETEROGEnEITY WITHIn InDIVIDUAL EMBRYOnIc STEM cELL cOLOnIES

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Journal of Innovative Optical Health Sciences 2011年第3期4卷 279-288页

作者： HE n.XU RUSSELL c.ADDIS DAVIDA F.GOInGS SHOKO nIOKA BRITTOn cHAncE JOHn D.GEARHART LIn Z.LI Molecular Imaging Laboratory Department of Radiology University of PennsylvaniaSchool of Medicine PhiladelphiaPA 19104USA Institute for Regenerative Medicine and Department of cell and Developmental Biology University of Pennsylvania School of Medicine PhiladelphiaPA 19104USA Britton chance Laboratory of Redox Imaging Johnson Research Foundation Department of Biochemistry and Biophysics University of Pennsylvania School of Medicine PhiladelphiaPA 19104USA Institute of Translational Medicine and Therapeutics University of Pennsylvania PhiladelphiaPA 19104USA

Redox state mediates embryonic stem cell(esc)differentiation and thus offers an important complementary approach to understanding the pluripotency of stem *** redox ratio(nADH/(Fp t nADH)),where nADH is the reduced form of nicotinamide adenine dinucleotide and Fp is the oxidizedflavoproteins,has been established as a sensitive indicator of mitochondrial redox *** this paper,we report our redox imaging data on the mitochondrial redox state of mouse esc(mesc)colonies and the implications *** low-temperature nADH/Fp redox scanner was employed to image mesc colonies grown on a feeder layer of gamma-irradiated mouse embryonicfibroblasts(MEFs)on glass cover *** result showed significant heterogeneity in the mitochondrial redox state within individual mesc colonies(size:~200-440μm),exhibiting a core with a more reduced state than the *** more reduced state positively correlates with the expression pattern of Oct4,a well-established marker of *** observation is thefirst to show the heterogeneity in the mitochondrial redox state within a mesc colony,suggesting that mitochondrial redox state should be further investigated as a potential new biomarker for the stemness of embryonic stem cells.

关键词： Redox imaging pluripotency nADH flavoproteins redox ratio

The Insect Antenna As Sencor

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The Insect Antenna As Sencor

The First Asia—Pacific conference on chemical Ecology

作者： Jan n.c.Van der Pers Syntech / VDP Laboratories P.OBox 1547NL1200 BM HilversumThe Netherlands

＜正＞hi most insects the antenna are primarily sensory appendages containing large numbers of sensilla for different stimulus *** principal sensilla are olfactory,but contact chemoreceptors,mechanoreceptors and thermohygro-receptors are also commonly *** sensilla contain primary receptor neurons,the axons of which transfer the stimulus information coded in sequences of actionpotentials to the antennal lobes. The information received by the olfactory sensilla plays a crucial part in mating behaviour,food and host

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novel approaches for the treatment of ventricular tachycardia

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World Journal of cardiology 2018年第7期10卷 52-59页

作者： Michael Spartalis Eleftherios Spartalis Eleni Tzatzaki Diamantis I Tsilimigras Demetrios Moris christos Kontogiannis Efthimios Livanis Dimitrios c Iliopoulos Vassilis Voudris George n Theodorakis esc Working Group on cardiac cellular Electrophysiology Sophia Antipolis Cedex 06903France Division of cardiology Onassis Cardiac Surgery CenterAthens 17674Greece Laboratory of Experimental Surgery and Surgical Research University of Athens Medical SchoolAthens 11527Greece Department of Surgery Duke UniversityDurhamNC 27710United States Department of clinical Therapeutics “Alexandra”HospitalUniversity of AthensAthens 11528Greece

Ventricular tachycardia(VT) is a crucial cause of sudden cardiac death(ScD) and a primary cause of mortality and morbidity in patients with structural cardiac disease. VT includes clinical disorders varying from benign to lifethreatening. Most life-threatening episodes are correlated with coronary artery disease, but the risk of ScD varies in certain populations, with various underlying heart conditions, specific family history, and genetic variants. The targets of VT management are symptom alleviation, improved quality of life, reduced implantable cardioverter defibrillator shocks, prevention of reduction of left ventricular function, reduced risk of ScD, and improved overall survival. Antiarrhythmic drug therapy and endocardial catheter ablation remains the cornerstone of guideline-endorsed VT treatment strategies in patients with structural cardiac abnormalities. novel strategies such as epicardial ablation, surgical cryoablation, transcoronary alcohol ablation, pre-procedural imaging, and stereotactic ablative radiotherapy are an appealing area of res-earch. In this review, we gathered all recent advances in innovative therapies as well as experimental evidence focusing on different aspects of VT treatment that could be significant for future favorable clinical applications.

关键词： Ventricular tachycardia catheter ablation Epicardial Sudden cardiac death novel techniques Substrate

Spermatophore Formation in Multiple Matings in Plodia interpunctella (Lepidoptera:Pyralidae)——A Possible Role in Pheromone Production Termination

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Spermatophore Formation in Multiple Matings in Plodia interp...

The First Asia—Pacific conference on chemical Ecology

作者： Ryne,c Lfstedt,c Lund University Sweden

Male Lepidoptera produce a spennatophore during *** spennatophore and sperm are transferred to the female bursa copulatnx during copulation and the sperm migrate up to the spennatheca where it is stored(Silberglied et al.,1984).Several possible hypotheses concerning the function of the spennatophore formation have been *** absorption of the spennatophore in many insect females suggests that the spennatophore serves as a nuptial gift to the female(Leopold,1976).However,in higher Lepidoptera the spennatophore contains chitin which may contribute to its extreme durability

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Dual role of lipids for genome stability and pluripotency facilitates full potency of mouse embryonic stem cells

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Protein & cell 2023年第8期14卷 591-602页

作者： Liangwen Zhong Miriam Gordillo Xingyi Wang Yiren Qin Yuanyuan Huang Alexey Soshnev Ritu Kumar Gouri nanjangud Daylon James c.David Allis Todd Evans Bryce carey Duancheng Wen Department of Reproductive Medicine Ronald O.Perelman and Claudia Cohen Center for Reproductive MedicineWeill Cornell MedicineNew YorkNY 10065USA Department of Surgery Weill Cornell Medical College1300 York AvenueNew YorkNY 10065USA Laboratory of chromatin Biology and Epigenetics The Rockefeller UniversityNew YorkNY 10065USA cold Spring Harbor Laboratory Cold Spring HarborNY 11724USA Molecular cytogenetics core.Memorial Sloan Kettering cancer center New YorkNY 10065USA Department of neuroscience Developmental and Regenerative BiologyUniversity of Texas at San AntonioOne UTSA CircleSan AntonioTX 78249USA Gladstone Institutes 1650 Owens StSan FranciscoCA94158USA

While Mek1/2 and Gsk3βinhibition("2i")supports the maintenance of murine embryonic stem cells(escs)in a homogenous naive state,prolonged culture in 2i results in aneuploidy and DnA hypomethylation that impairs developmental ***,2i fails to support derivation and culture of fully potent female *** we find that mouse escs cultured in 2i/LIF supplemented with lipid-rich albumin(AlbuMAx)undergo pluripotency transition yet maintain genomic stability and full potency over long-term ***,lipids in AlbuMAx impact intracellular metabolism including nucleotide biosynthesis,lipid biogenesis,and TcA cycle intermediates,with enhanced expression of DnMT3s that prevent DnA *** induce a formative-like pluripotent state through direct stimulation of Erk2 phosphorylation,which also alleviates X chromosome loss in female ***,both male and female"all-esc"mice can be generated from de novo derived escs using AlbuMAXbased *** findings underscore the importance of lipids to pluripotency and link nutrient cues to genome integrity in early development.

关键词： mouse pluripotent stem cells lipids pluripotency transition genomic stability developmental potency nucleotide pool depletion 2i medium X chromosome loss femaleall-esc mice

Isochrone Fitting of Galactic Globular clusters—Ⅵ.High-latitude clusters nGc 5024 (M53),nGc 5053,nGc 5272 (M3),nGc 5466,and nGc7099 (M30)

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Research in Astronomy and Astrophysics 2024年第6期24卷 170-190页

作者： G.A.Gontcharov S.S.Savchenko A.A.Marchuk c.J.Bonatto O.S.Ryutina M.Yu.Khovritchev V.B.Il'in A.V.Mosenkov D.M.Poliakov A.A.Smirnov central(Pulkovo)Astronomical Observatory Russian Academy of SciencesPulkovskoye chaussee 65/1St.Petersburg 196140Russia Saint Petersburg State University Universitetskij pr.28St.Petersburg 198504Russia Special Astrophysical Observatory Russian Academy of Sciences369167 Nizhnij ArkhyzRussia Departamento de Astronomia Instituto de FísicaUFRGSAv.Bento Gonçalves9500Porto AlegreRSBrazil Saint Petersburg University of Aerospace Instrumentation Bol.Morskaya ul.67ASt.Petersburg 190000Russia Department of Physics and Astronomy Brigham Young UniversityN283 ESCProvoUT 84602USA

We fit various color–magnitude diagrams(cMDs) of the high-latitude Galactic globular clusters nGc 5024(M53),nGc 5053,nGc 5272(M3),nGc 5466,and nGc 7099(M30) by isochrones from the Dartmouth Stellar Evolution Database and Bag of Stellar Tracks and Isochrones for α–enrichment [α/Fe] = +*** the cMDs,we use data sets from Hubble Space Telescope,Gaia,and other sources utilizing,at least,25 photometric filters for each *** obtain the following characteristics with their statistical uncertainties for nGc 5024,nGc 5053,nGc 5272,nGc 5466,and nGc 7099,respectively:metallicities [Fe/H] =-1.93 ± 0.02,-2.08 ± 0.03,-1.60 ± 0.02,-1.95 ± 0.02,and-2.07 ± 0.04 dex with their systematic uncertainty 0.1 dex;ages 13.00 ± 0.11,12.70 ± 0.11,11.63 ± 0.07,12.15 ± 0.11,and 12.80 ± 0.17 Gyr with their systematic uncertainty 0.8 Gyr;distances(systematic uncertainty added) 18.22 ± 0.06 ± 0.60,16.99 ± 0.06 ± 0.56,10.08 ± 0.04 ± 0.33,15.59 ±0.03 ± 0.51,and 8.29 ± 0.03 ± 0.27 kpc;reddenings E(B-V) = 0.023 ± 0.004,0.017 ± 0.004,0.023 ± 0.004,0.023 ± 0.003,and 0.045 ± 0.002 mag with their systematic uncertainty 0.01 mag;extinctions AV= 0.08 ± 0.01,0.06 ± 0.01,0.08 ± 0.01,0.08 ± 0.01,and 0.16 ± 0.01 mag with their systematic uncertainty 0.03 mag,which suggest the total Galactic extinction AV= 0.08 across the whole Galactic dust to extragalactic objects at the north Galactic *** horizontal branch morphology difference of these clusters is explained by their different metallicity,age,mass-loss efficiency,and loss of low-mass members in the evolution of the core-collapse cluster nGc 7099 and loose clusters nGc 5053 and nGc 5466.

关键词： (stars:)Hertzsprung Russell and c-M diagrams (ISM:)dust extinction (Galaxy:)globular clusters:general (Galaxy:)globular clusters:individual(nGc 5024,nGc 5053,nGc 5272,nGc 5466,nGc7099)

Lossless Selection combining Without channel State Information

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Lossless Selection Combining Without Channel State Informati...

2008 IEEE International conference on communications(Icc 2008)

作者： Young Gil Kim norman c.Beaulieu Dept.of Electrical and computer Engineering University of Seoul SeoulKorea 130-743 Dept.of Electrical and computer Engineering University of Alberta Edmonton AlbertaCanada T6G 2G7

A signal-plus-noise （S+n ） energy selection combining （S+n-esc） scheme for binary phase shift keying （BPSK） signaling is proposed. The S+n-esc selects the branch with the maximum S+n energy for detection. The advantage of the S+n-esc is that it requires no channel estimation for diversity branch selection. The bit error rate （BER） performance of the S+n-esc is analyzed for BPSK signaling in independent and identically distributed （i.i.d.） Rayleigh fading channels. We show that the performance of the S+n-esc is the same as conventional signal-to-noise ratio selection combining （SnR-Sc）,which requires estimation of the fading amplitudes for branch selection.

关键词： Diversity reception channel state information Binary phase shift keying Bit error rate channel estimation Signal analysis Performance analysis Fading Signal to noise ratio Amplitude estimation

chemical Ecology and Sensory Physiology of Lady Beetles and Lacewings

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Chemical Ecology and Sensory Physiology of Lady Beetles and ...

The First Asia—Pacific conference on chemical Ecology

作者： Sameul A.Ochieng Kye-chung Park John J.Obrycki Rikard c.Uneliust Thomas c.Baker Department of Entomology lowa State UniversityAmesIowa 50011U.S.A Department of chemistry Royal Institute of TechnologySE- 1 00 44 StockholmSweden

The present study reports the most recent findings in chemical communication systems among predatory insects and their prey/host plant,as well as the underlying mechanisms of *** and transmission electron micrographs on adult antennae of the green lacewing,chrysoperla carnea and the twelve-spotted ladybeetle,coleomegilla maculata show the presence of characteristic olfactory chemoreceptors. Electroantennograms were successfully recorded from antennae of both species in response to

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人胚胎干细胞心肌定向分化的基因表达变化及功能的实验研究

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中华心血管病杂志 2009年第8期37卷 696-700页

作者：曹丰孙冬冬赵力谢小燕 Roger A.Wagner Joseph c.Wu 第四军医大学西京医院心血管内科西安710032 中国人民解放军军事医学科学院输血研究所美国斯坦福大学医学院分子影像中心

缺血性心脏病的发病率和死亡率在我国居高不下。虽然目前缺血性心脏病的治疗手段多样，例如经皮冠状动脉介入治疗（PcI）、冠状动脉旁路移植术（cABG）、药物治疗等，但这些治疗方法仍不能从根本上逆转心肌缺血后心脏功能的进行性下降... 详细信息

缺血性心脏病的发病率和死亡率在我国居高不下。虽然目前缺血性心脏病的治疗手段多样，例如经皮冠状动脉介入治疗（PcI）、冠状动脉旁路移植术（cABG）、药物治疗等，但这些治疗方法仍不能从根本上逆转心肌缺血后心脏功能的进行性下降，许多患者仍不可避免地发生左心室病理性重构及心力衰竭。心脏移植是终末期心力衰竭患者惟一有效的根治手段，但是心脏器官供体缺乏以及左心室辅助装置伴随频繁感染等问题持续出现，使得只有少数患者能够从心脏移植中获益。胚胎干细胞（embryonic stem cell，esc）来源于囊胚中分离出的内细胞团，是在体外培养获得的一种原始多能干细胞。它具有两个基本特点，即体外无限增殖和多向分化潜能。近年来，随者干细胞研究的深入以及细胞治疗的兴起，人们发现干细胞可体外分化为心肌细胞，并能应用于心肌损伤后修复期，这使其成为缺血性心脏病的理想治疗方法之一，具有广阔的应用前景。

关键词：人胚胎干细胞心肌细胞基因表达变化经皮冠状动脉介入治疗实验研究定向分化缺血性心脏病左心室辅助装置